Recent advances in understanding of vanilloid receptors: A therapeutic target for treatment of pain and inflammation in skin

Journal of Investigative Dermatology Symposium Proceedings

Volumn 2, Issue 1, 1997, Pages 56-60

  Biro, Tamas ^a   Acs, Gcza ^a   Acs, Peter ^a   Modarres, Shayan ^a   Blumberg, Peter M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Capsaicin; Resiniferatoxin

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE RECEPTOR; SUBSTANCE P; VANILLOID RECEPTOR;

ANTIINFLAMMATORY ACTIVITY; CONFERENCE PAPER; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; RECEPTOR AFFINITY; SKIN INFLAMMATION; STRUCTURE ACTIVITY RELATION;

EID: 0030818329     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1038/jidsymp.1997.12     Document Type: Conference Paper

References (56)

1. Acs G, Palkovits M, Blumberg PM: Comparison of [3H]resiniferatoxin binding by the vanilloid (capsaicin) receptor in dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and vagal nerve and urinary bladder of the rat. Life Sei 55:1017-1026, 1994a
2. 3Hjresiniferatoxin binding by the human vanilloid (capsaicin) receptor. Mol Brain Res 23:185-190. 1994b
3. 3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation, and ventral thalamus membrane preparations. Life Sei 59:1899-1908, 1996a
4. Acs G, Lee J, Marquez VE, Blumberg PM: Distinct structure-activity relations for stimulation of 4sCa uptake and for high affinity binding in cultured adult rat dorsal root ganglion neurones and dorsal root ganglion membranes. Mol Brain Res 35:173-182, 1996b
5. Amann R, Maggi CA: Ruthenium red as a capsaicin antagonist. Life Sei 49:849-856, 1991
6. Anke H, Sterner O: Comparison of the antimicrobial and cytotoxic activities of twenty unsaturated sesquiterpene dialdehydes from plants and mushrooms. Planta Aîed 57:344-346, 1991
7. Bernstein JE: Capsaicin in the treatment of dermatologie disease. Cutis 39:352-353, 1987
8. Bernstein JE, Korman NJ, Bickers DR, Dahl MV, Millikan LE: Topical capsaicin treatment of chronic posthcrpetic neuralgia. J Am AcaJ Dennatol 21:265-270, 1989
9. Bcvan SJ, Hothi S, Hughes IF, Rang HP, Shah K, Walpole CSJ, Yeats JC: Capsazepinc: a competitive antagonist of the sensory neurone excitant capsaicin. BrJPhannacol 107:544-552, 1992
10. Bjerring P, Arendt-Niclsen L: Inhibition of histamine skin flare reaction following repeated topical applications of capsaïcïn. Allergy 45:121-125, 1990
11. Breneman DL, Cardone JS, Blumsack RF, Lather RM. Searle EA, Pollack VE: Topical capsaicin for treatment of hemodJalysis-related pruritus. J Am Acad Dennatol 26:91-94, 1992
12. Burrows NP, Morris PG: Treatment of PUVA-induccd skin pain with capsaicin, BrJ Dennatol 131:584-585, 1994
13. Campbell E, Bcvan S, Dray A: Clinical applications of capsaicin and analogs. In: Wood JN (ed) Capsaicin in the Study of Pain. Academic Press, London, 1993, pp 255-272
14. Darsow U, Lorenz J, Bromm B, RingJ: Pruritus circumscriptus sine materia: a sequel of postzosteric neuralgia. Evaluation by quantitative psychophysical examination and laser-evoked potentials. Acta Derm Venereal (Stockh) 76:45-47, 1996
15. Dickcnson A, Hughes C, Rueff" A, Dray A: A spinal mechanism of action is involved in the antinociception produced by the capsaicin analogue NE 19550 (olvanil). Pain 43:353-362, 1990
16. Dray A, Bettaney J, Rueff A, Walpole CSJ, Wrigglesworth R: NE-19550 and NE-21610, aminociceptive capsaicin analogues: studies on nociceptive fibres of die neonatal tail in vitro. EnrJ Phamacol 181:289-293, 1990
17. Driedger PE, Blumberg PM: Different biological targets for resiniferatoxin and phorbol 12-m>"ristate 13-acetate. Canter Rts 40:1400-1404, 1980a
18. Driedger PE, Blumberg PM: Specific binding of phorbol ester tumor promoters. Proc Natl Acad Sei USA 77:567-571, 1980b
19. Ellis CN, Berberian B, Sulica VI, Dodd \VA, Jarratt MT, Katz HI, Prawcr S, Krueger G, Rex IH Jr, Wolf JE: A double-blind evaluation of topical capsaicin in pruritic psoriasis comments. J Ant Acad Dennatol 29:438-442, 1993
20. Goso C, Evangelista S, Tramontana M, Manzini S, Blumberg PM, Szallasi A: Topical capsaicin administration protects against trinitrobenzene sulfuric acid (TNB)-induccd colitis in the rat: characterization of the vanilloid (capsaicin) receptor involved. EttrJ Pharntatol 249:185-190, 1993
21. Hayes AG, Oxford A, Reynolds M, Shingler AH, Skingle M, Smith C, Tyers MB: The effects of a series of capsaicin analogues on nociception and body temperature in the rat. Life Sd 26:1241-1248, 1984
22. Hecker E: Structure-activity relationships in diterpene esters irritant and cocarcinogenic to mouse skin. In: Slaga TJ, Sivak A, Boutwell RK (eds.) Carcinogenesis, Mechanism of Tumor Promotion and Cocarcinogenesis. Vol. 2. Raven Press, New York, 1978, pp 11-48
23. Hergenhahn M, Adolph W, Hecker E: Resiniferatoxin and other esters of novel polyfunctional ditcrpcnes from Euphorbia resinifera and unispina. Tetrahedron Lett 19:1595-1598, 1975
24. Holzer P: Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Phannacol Rev 43:143-200, 1991
25. Husz S, Toth-Kasa I, Obal F, Jancso G: A possible pathomcchanism of the idiopathic cold contact urticaria. Acta Physiol Hung 77:209-215, 1991
26. Knight TE, Hayashi T: Solar (brachioradial) pruritus - response to capsaicin. Int J Dennatol 33:206-209. 1994
27. Leibsohn E: Treatment of notalgia paresthctica with capsaicin. Cutis 49:335-336, 1992
28. Lotti T, Teofoli P, Tsampau D; Treatment of aquagenic pruritus topical with capsaicin cream. J Am Acad Dennatol 30:232-235, 1994
29. Maggi CA, Patacchini R, Tramontana M, Amann R, Giuliani S, Santicioli P: Similarities and differences in the action of resinifera toxin and capsaicin on central and peripheral endings of primary sensory neurons, Netiroscicnce 37:531-539, 1990
30. Oh U, Hwang SW, Kim D: Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons. J Nettrosci 16:1659-1667, 1996
31. Rains C, Bryson HM: Topical capsaicin. A review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy and osteoarthritis. Dmgs A&ing 7:317-328, 1995
32. Rumsfield JA; West DP: Topical capsaicin in dermatologie and peripheral pain disorders. DICP 25:381-387, 1991
33. Stanbeny LR. Bourne N, Bravo FJ, Bernstein DI: Capsaicin-sensitive peptidergic neurons are involved in the zosterifonn spread of herpes simplex virus infection. J Med Virol 38:142-146, 1992
34. Sterner O, Bergman R, Kihlberg J, Wickberg B: The sesquiterpenes of Lactarius vellereus and their role in the proposed chemical defense system. J Nat Prod 48:279-288, 1985
35. Szallasi A, Blumberg PM: Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, die irritant constituent in red pepper. Neitrosctence 30:515-520, 1989
36. Szallasi A, Blumberg PM: Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes. Brain Res 524:106-111, 1990
37. Szallasi A, Blumberg PM: Characterization of vanilloid receptors in the dorsal horn of pig spinal cord. Brain Res 547:335-338, 1991
38. Szallasi A, Goso C: Characterization by [3H]resiniferatoxin binding of a human vanilloid (capsaicin) receptor in post-mortem spinal cord. Ncttrosd Lett 165:101-104,1994
39. Szallasi A, Sharkey NA, Blumberg PM: Structure/activity analysis of resiniferatoxin analogs. Phytother Res 3:253-257, 1989a
40. Szallasi A, Joo F, Blumberg PM: Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotcnt capsaicin analog. Brain Res 503:68-72, 1989b
41. Szallasi A, Szolcsanyi J, Szallasi Z, Blumberg PM: Inhibition of [3H]resiniferatoxin binding to rat dorsal root ganglion membranes as a novel approach in evaluating compounds with capsaicin-like activity!! Naunyn Schmiedeber^'s Arch Pharmacol 344:551-556, 1991
42. Szallasi A, Lewin NA, Blumberg PM: Identification of alpha-1-acid glycoprotein (orosomucoid) as a major vanilloid binding protein in serum. J Pharmacol Exp TJter 262:883-888, 1992
43. Szallasi A, Lewin NA, Blumberg PM: Vanilloid (capsaicin) receptor in the rat: positive cooperativity of resinifcratoxin binding and its modulation by reduction and oxidation. J Phartnacol Exp Tlier 266:678-683, 1993a
44. Szallasi A, Goso C, Blumberg PM, Manzini S: Competitive inhibition by capsazepine of [3H]resiniferatoxin binding to central (spinal cord and dorsal root ganglia) and peripheral (urinary bladder and airways) vanilloid (capsaicin) receptors in the rat. J Pharmacol Exp Tlier 267:728-733, 1993b
45. Szallasi A, Conte B, Goso C, Blumberg PM and Manzini S: Characterization of a peripheral vanilloid (capsaïcîn) receptor in the urinary bladder of the rat. Life Sei 52:221-226, 1993c
46. Szallasi A, Jonassohn M, Acs G, Biro T, Acs P, Blumberg PM, Sterner O: Pungent terpenoids possessing an unsaturated 1,4-dialdehyde moiety stimulate capsaicinscnsirive neurons in a vanilloid receptor-mediated fashion. Br J Pharmacol 119:283-290, 1996
47. Szolcsanyi J, Jancso-Gabor A: Sensory effects of capsaicin congeners. I. Relationship between chemical structure and pain-producing potency of pungent agents. Arziteimittelforschung 25:1877-1881, 1975
48. Szolcsanyi J: Capsaicin type pungent agents producing pyrexia. In: Milton AS (ed.) Handbook of Expcrimctital Pharmacology. Vol. 60. Springer Verlag, Berlin, 1982, pp 437-478
49. Walpole CSJ, Wrigglesworth R, Bevan S, Campbell E, Dray A, James IF, Perkins MN, Reid DJ, Winter J: Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 1. The aromatic "A-region". J Afed Cltcm 36:2362-2372, 1993a
50. Walpole CSJ, Wrigglesworth R, Bevan S, Campbell E, Dray A, James IF, Masdin KJ, Perkins MN, Winter J: Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 2. The amide bond "B-region".J.A/f
51. Walpole CSJ, Wrigglesworth R, Bevan S. Campbell E, Dray A, James IF, Masdin KJ, Perkins MN, Winter J: Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 3. The hydrophobic side-chain "C-region."_/ Med Client 36:2391-2389, 1993c
52. Walpole CSJ, Bevan S, Bloomfield G, Breckenridge R, James IF, Ritchie T, Szallasi A, Winter J, Wrigglesworth R: Similarities and differences in die structure-activity relationships of capsaicin and resiniferatoxin analogues. J Med Client 39:2939-2952, 1996
53. Wist E, Risberg T: Topical capsaicin in treatment of hyperalgesia, allodynia and dysesthetic pain caused by malignant tumour infiltration of the skin. Acta Oiicol 32:343, 1993
54. WoodJN, Winter J, James IF, Rang HP, Yeats J, Bevan S: Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J Natrosd 8:3208-3220, 1988
55. Zhang WY, Li Wan Po A: The effectiveness of topically applied capsaicin. A mcta-analysis. EitrJ Clin Pliannacol 46:517-22, 1994
56. zur Hausen H, Bomkamm GW, Schmidt RJ, Hecker E: Tumor initiators and promoters in the induction of Epstein-Barr virus. Proc Natl Acad Sei USA 76:782-785, 1979