Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper

Neuroscience

Volumn 30, Issue 2, 1989, Pages 515-520

  Szallasi, A ^a   Blumberg, P M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; NEUROTOXIN;

ANIMAL EXPERIMENT; FEMALE; HYPOTHERMIA; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; CAPSAICIN; DITERPENES; FEMALE; HYPOTHERMIA; INFLAMMATION; PAIN; RATS; RATS, INBRED STRAINS;

EID: 0024382437     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-4522(89)90269-8     Document Type: Article

References (27)

1. Structure-activity Relations of Polyfunctional Diterpenes of the Daphnane Type. I. Revised Structure For Resiniferatoxin and Structure-activity Relations of Resini-feronol and Some of its Esters
2. The neuropharmacology of capsaicin: review of some recent observations
3. Thermoregulatory effects of resiniferatoxin in the mouse: comparison with capsaicin
4. Different biological targets for resiniferatoxin and phorbol 12-myristate 13-acetate
5. Specific binding of phorbol ester tumor promoters
6. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem cell stimulation in rats and cats
7. Phorbol ester induction of 8-lipoxygenase in inbred SENCAR(SSIN) but not C57BL/6J mice correlated with hyperplasia, edema, and oxidant generation but not ornithine decarboxylase induction
8. Capsaicin and nociception in the rat and mouse: possible role of substance P
9. Effects of single doses of capsaicin on nociceptive thresholds in the rodent
10. Structure-activity relationships in diterpene esters irritant and cocarcinogenic to mouse skin
11. Resiniferatoxin and other esters of novel polyfunctional diterpenes from Euphorbia resinifera and unispina
12. Biological assays for irritant tumor-initiating and -promoting activities. I, Kinetics of the irritant response in relation to the inititiation promoting activity of polyfunctional diterpenes representing tigliane and some daphnane types
13. Pain and inflammation induced by nicotine, acetylcholine and structurally related compounds and their prevention by desensitizing agents.
14. DIRECT EVIDENCE FOR NEUROGENIC INFLAMMATION AND ITS PREVENTION BY DENERVATION AND BY PRETREATMENT WITH CAPSAICIN
15. Desensitization with capsaicin and related acylamides as a tool for studying the function of pain receptors
16. Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea-pigs.
17. Capsaicin — A Literature Survey
18. Evan's Blue fluorescence: quantitative and morphological evaluation of vascular permeability in animal tissues
19. Vascular protein leakage in various tissues induced by substance P, capsaicin, bradykinin, serotonin, histamine, and by antigen challenge
20. The permanent anatomical effects of neonatal capsaicin on somatosensory nerves
21. A new aromatic ester diterpene from Euphorbia poisonii
22. Investigations into the skin-irritant properties of resiniferonol ortho esters
23. Dose response relationship in the thermoregulatory effects of capsaicin
24. Sensory effects of capsaicin congeners I. Relationship between chemical structure and pain-producing potency of pungent agents
25. Pharmacologic actions of capsaicin: apparent involvement of substance P and serotonin
26. Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia
27. Tumor initiators and promoters in the induction of Epstein-Barr virus