Enkephalin analog prodrugs: Assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 3, 1996, Pages 1366-1375

  Greene, Diana L ^a   Hau, Vincent S ^a   Abbruscato, Thomas J ^a   Bartosz, Hubert ^b   Misicka, Aleksandra ^b   Lipkowski, Andrjej W ^b   Hom, Sharon ^a   Gillespie, Terrence J ^a   Hruby, Victor J ^b   Davis, Thomas P ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b University of Arizona ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; 4 AMINOBENZOIC ACID DERIVATIVE; ACTINONIN; AMASTATIN; ARPHAMENINE B; BACITRACIN; BESTATIN; CAPTOPRIL; CYTOSOL AMINOPEPTIDASE; EDETIC ACID; ENKEPHALIN DERIVATIVE; ENKEPHALIN[2 DEXTRO PENICILLAMINE 5 CYSTEINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; ENZYME INHIBITOR; MICROSOMAL AMINOPEPTIDASE; PRODRUG; PUROMYCIN; THIMET OLIGOPEPTIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG HALF LIFE; DRUG METABOLISM; DRUG PENETRATION; DRUG TARGETING; DRUG TRANSFORMATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; SERUM;

ANALGESICS; ANIMALS; BLOOD-BRAIN BARRIER; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; MICE; MICE, INBRED STRAINS; PERMEABILITY; PRODRUGS; TIME FACTORS;

EID: 12644261424     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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