Synthetic CD4 exocyclics inhibit binding of human immunodeficiency virus type 1 envelope to CD4 and virus replication in T lymphocytes

Nature Biotechnology

Volumn 15, Issue 2, 1997, Pages 150-154

  Zhang, Xin ^a   Gaubin, Muriel ^b   Briant, Laurence ^b   Srikantan, Vasantha ^c   Murali, Ramachandran ^a   Saragovi, Uri ^d   Weiner, David ^a   Devaux, Christian ^b   Autiere, Monica ^b   Piatier Tonneau, Dominique ^b   Greene, Mark I ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CNRS   (France)

^c Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

AIDS; CD4 and HIV gpl20 interaction; Rational drug design

Indexed keywords

CD4 ANTIGEN; GLYCOPROTEIN GP 120;

ARTICLE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SYNCYTIUM; T LYMPHOCYTE; VIRUS ADSORPTION; VIRUS INHIBITION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANTIGENS, CD; ANTIGENS, CD4; DRUG DESIGN; GIANT CELLS; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; T-LYMPHOCYTES; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031052394     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0297-150     Document Type: Article

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