Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress

Cardiovascular Research

Volumn 41, Issue 1, 1999, Pages 126-134

  Bowes, Joanne ^a   McDonald, Michelle C ^a   Piper, Julie ^a   Thiemermann, Christoph ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

H9c2 cells; Heart; Rat; Reactive oxygen species; Reperfusion injury

Indexed keywords

1,5 DIHYDROXYISOQUINOLINE; 3 AMINOBENZAMIDE; 3 AMINOBENZOIC ACID; ENZYME INHIBITOR; HYDROGEN PEROXIDE; ISOQUINOLINE DERIVATIVE; LACTATE DEHYDROGENASE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINIC ACID; NITROBLUE TETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HEART MUSCLE REPERFUSION; ISOLATED HEART; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

AMINOBENZOIC ACIDS; ANIMALS; BENZAMIDES; CELL DEATH; CELL LINE; ENZYME INHIBITORS; HEART; HYDROGEN PEROXIDE; ISOQUINOLINES; MALE; MYOCARDIAL REPERFUSION INJURY; NIACIN; NIACINAMIDE; OXIDATIVE STRESS; PERFUSION; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR;

EID: 0032904328     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(98)00221-1     Document Type: Article

References (28)

1. Kukreja RC, Hess ML. The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection. Cardiovasc Res 1992;6:641-655.
2. Flaherty JT. Myocardial injury mediated by oxygen free radicals. Am J Med 1991;91:3C79S-3C85S.
3. Wang PH, Zweier JL. Measurement of nitric oxide and peroxynitrite generation in the post-ischaemic heart. Evidence for peroxynitrite-mediated reperfusion injury. J Biol Chem 1996;271:29223-29230.
4. Zweier JL, Flaherty JT, Weisfeldt ML. Direct measurement of free radical generation following reperfusion of ischaemic myocardium. Proc Natl Acad Sci 1986;84:1404-1407.
5. Henry TD, Archer SL, Nelson D, Weir EK, From AH. Enhanced chemiluminescence as a measure of oxygen-derived free radical generation during ischaemia and reperfusion. Circ Res 1988;67:1453-1461.
6. Bolli R, Patel BS, Jeroudi MO, Lai EK, McCay PB. Demonstration of free radical generation in 'stunned' myocardium of intact dogs with the use of the spin trap alpha-phenyl-N-tert-butyl nitrone. J Clin Invest 1988;82:476-485.
7. Bernier M, Hearse DJ, Manning AS. Reperfusion-induced arrhythmias and oxygen-derived free radicals: studies with 'anti-free radical' interventions and a free-radical generating system in the isolated perfused rat heart. Circ Res 1986;58:331-340.
8. Manning AS, Coltart DJ, Hearse DJ. Ischaemia and reperfusion-induced arrhythmias in the rat. Effects of xanthine oxidase inhibition with allopurinol. Circ Res 1984;55:545-548.
9. Ambrosio G, Becker LC, Hutchins GM, Weisman HT, Weisfeldt ML. Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury. Circ 1986;74:1424-1433.
10. Ambrosio G, Zweier JL, Jacobus WE, Weisfeldt ML, Flaherty JT. Improvement of post-ischaemic myocardial function and metabolism induced by administration of deferoxamine at the time of re-flow: the role of iron in the pathogenesis of reperfusion injury. Circ 1987;76:906-915.
11. Jolly SR, Kane WJ, Bailie MB, Abrams GD, Lucchesi BR. Canine myocardial reperfusion injury. Its reduction by combined administration of superoxide dismutase and catalase. Circ Res 1984;54:277-285.
12. Lautier D, Lagveux J, Thibodeau J, Menard L, Poirer GG. Molecular and biochemical features of poly (ADP-ribose) metabolism. Mol Cell Biochem 1993;122:171-193.
13. Schraufstatter IU, Hyslop PA, Hinshaw DB, et al. Hydrogen peroxide induced injury and its prevention by inhibitors of poly (ADP-ribose) polymerase. Proc Natl Acad Sci USA 1986;83:4908-4912.
14. Carson DA, Set S, Wasson B, Carrera CJ. DNA strand breaks, NAD metabolism and programmed cell death. Exp Cell Res 1986;164:273-281.
15. Schraufstatter IU, Hinshaw DB, Hyslop PA, Spragg RG, Cochrane CG. DNA strand breaks activate poly adenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin Invest 1986;77:1312-1320.
16. Berger NA. Symposium; cellular response to DNA damage: the role of poly (ADP-ribose). Rad Res 1985;101:4-15.
17. Thiemermann C, Bowes J, Myint F, Vane JR. Inhibition of the activity of poly (ADP-ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc Natl Acad Sci USA 1997;94:679-683.
18. Zingarelli B, Cuzzocrea S, Zsengeller Z, Salzman AL, Szabo C. Protection against myocardial ischaemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase. Cardiovasc Res 1997;36:205-215.
19. Banasik M, Komura H, Shimoyama M, Ueda K. Specific inhibitors of poly (ADP-ribose) synthetase and mono (ADP-ribosyl) transferase. J Biol Chem 1992;267:1569-1575.
20. Laight DW, Andrews TJ, Haj-Yehia AI, Carrier MJ, Anggard EE. Microassay of superoxide anion scavenging activity in vitro. Environ Toxicol Pharmacol 1997;3:65-68.
21. Nachlas MM, Schnitka TK. Macroscopic identification of early myocardial infarcts by alterations in dehydrogenase activity. Am J Pathol 1963;42:379-422.
22. Okamoto T, Adachi K, Muraishi A, et al. Induction of DNA breaks in cardiac myoblast cells by norepinephrine. Biochem Mol Biol Int 1996;38:821-827.
23. Gilad E, Zingarelli B, Salzman AL, Szabo C. Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblats in vitro. J Mol Cell Cardiol 1997;29:2585-2597.
24. Schraufstatter IU, Hyslop PA, Jackson JH, Cochrane CG. Oxidant-induced DNA damage of target cells. J Clin Invest 1988;82:1040-1050.
25. Lucchesi BR, Werns SW, Fantone JC. The role of the neutrophil and free radicals in ischaemic myocardial injury. J Mol Cell Cardiol 1989;21:1241-1251.
26. Szabo C, Lim LHK, Cuzzocrea S, et al. Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects. J Exp Med 1997;186:1041-1049.
27. Jackson JH, Gajewski E, Schraufstatter IU, et al. Damage to the bases in DNA induced by stimulated human neutrophils. J Clin Invest 1989;84:1644-1649.
28. Thies RL, Autor AP. Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly (ADP-ribose) polymerase activation causing NAD depletion and altered energy balance. Arch Biochem Biophys 1991;286:353-363.