Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock

British Journal of Pharmacology

Volumn 128, Issue 6, 1999, Pages 1339-1345

  McDonald, Michelle C ^a   Filipe, Helder Mota ^a   Thiemermann, Christoph ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Haemorrhagic shock; Multiple organ failure; Oxygen radicals; Poly (ADP ribose) polymerase; Trauma

Indexed keywords

3 AMINOBENZAMIDE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; ENZYME INHIBITOR; ISOQUINOLINE DERIVATIVE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINIC ACID; TRIACYLGLYCEROL LIPASE; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; HEMORRHAGIC SHOCK; INTRAVENOUS DRUG ADMINISTRATION; LIVER INJURY; MALE; MEAN ARTERIAL PRESSURE; MULTIPLE ORGAN FAILURE; NEUROMUSCULAR DISEASE; NONHUMAN; PANCREAS INJURY; PRIORITY JOURNAL; RAT; RESUSCITATION; TRIACYLGLYCEROL LIPASE BLOOD LEVEL; UREA BLOOD LEVEL;

EID: 0032714161     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702928     Document Type: Article

References (44)

1. AALTO, T.K. & RAIVIO, K.O. (1993). Nucleotide depletion due to reactive oxygen metabolites in endothelial cells: effects of antioxidants. Pediatric Res., 34, 572-576.
2. ALLAN, G., CAMBRIDGE, D., LEE-TSANG-TANG, L., VAN WAY, C.W. & WHITING, M.V. (1986). The protective action of allopurinol in an experimental model of haemorrhagic shock and reperfusion. Br. J. Pharmacol., 89, 149-155.
3. BANASIK, M., KOMURA, H., SHIMOYAMA, M. & UEDA, K. (1992). Specific inhibitors of poly (ADP-ribose) synthetase and mono (ADP-ribosyl) transferase. J. Biol. Chem., 267, 1569-1575.
4. BAUE, A.E. (1993). The multiple organ or system failure syndrome. In: Schlag, G. & Redl, H. (eds). Pathophysiology of Shock, Sepsis and Organ Failure. Springer Verlag: Berlin, pp. 1004-1018.
5. BERGER, N.A. (1985). Poly(ADP-ribose) in the cellular response to DNA damage. Rad. Res., 101, 4-15.
6. BOWES, J., PIPER, J. & THIEMERMANN, C. (1998). Inhibitors of the activity of poly (ADP-ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts. Br. J. Pharmacol., 124, 1760-1766.
7. BOWES, J., MCDONALD, M.C., PIPER, J. & THIEMERMANN, C. (1999). Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress. Cardiovasc. Res., 41, 126-134.
8. CARSON, D.A., SET, S., WASSON, B. & CARRERA, C.J. (1986). DNA strand breaks, NAD metabolism and programmed cell death. Exp. Cell. Res., 164, 273-281.
9. CHATTERJEE, P.K., CUZZOCREA, S. & THIEMERMANN, C. (1999). Inhibitors of poly (ADP-ribose) synthetase protect rat proximal tubular cells against hydrogenperoxide-mediated oxidant stress. Kidney Int., 56, 973-984.
10. CUZZOCREA, S., ZINGARELLI, B., COSTANTINO, G., SZABO, A., SALZMAN, A.L., CAPUTI, A.P. & SZABO, C. (1997). Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Br. J. Pharmacol., 121, 1065-1074.
11. DAUGHTERS, K., WAXMAN, K., GASSEL, A. & ZOMMER, S. (1996). Anti-oxidant treatment for shock: vitamin E but not vitamin C improves survival. Am. Surg., 62, 789-792.
12. ELIASSON, M.J.L., SAMPEI, K., MANDIR, A.S., HURN, P.D., TRAYSTMAN, R.J., BAO, J., PIEPER, A., WANG, Z., DAWSON, T.M., SNYDER, S.H. & DAWSON, V.L. (1997). Poly (ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischaemia. Nature Med., 3, 1089-1095.
13. FAN, J., MARSHALL, J.C., JIMENEZ, M., SHEK, P.N., ZAGORSKI, J. & ROTSTEIN, O.D. (1998). Hemorrhagic shock primes for increased expression of cytokine-induced neutrophil chemoattractant in the lung: role in pulmonary inflammation following lipopolysaccharide. J. Immunol., 161, 440-447.
14. FLAHERTY, J.L. & WESFELDT, M.L. (1988). Reperfusion injury. Free Radic. Biol. Med., 5, 409-419.
15. FLECKENSTEIN, A.E., SMITH, S.L., LINSEMAN, K.L., BEUVING, L.J. & HALL, E.D. (1991). Comparison of the efficacy of mechanistically different antioxidants in the rat hemorrhagic shock model. Circ. Shock, 35, 223-230.
16. GRUPP, I.L., JACKSON, T.M., HAKE, P., GRUPP, G. & SZABO, C. (1999). Protection against hypoxia reoxygenation in the absence of poly (ADP-ribose) synthetase in isolated working hearts. J. Mol. Cell. Cardiol., 31, 297-303.
17. HAMANO, K., TSUBOI, H., SEYAMA, A. & ESATO, K. (1993). Shock-reinfusion injury to the central organs and the effect of free radical scavengers in the rat. Surg. Today, 23, 891-896.
18. HELLER, B., WANG, Z.Q., WAGNER, E.F., RADONS, J., BURKLE, A., FEHSEL, K., BURKART, V. & KOLB, H. (1995). Inactivation of the poly(ADP-ribose)polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J. Biol. Chem., 270, 11176-11180.
19. HYSLOP, P.A., HINSHAW, D.B., HALSEY, W.A., SCHRAUFSTATTER, I.U., SAUERHEBER, R.D., SPRAGG, R.G., JACKSON, J.H. & COCHRANE, C.G. (1988). Mechanisms of oxidant-mediated cell injury: The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. J. Biol. Chem., 263, 1665-1675.
20. IKAI, K. & UEDA, K. (1983). Immunohistochemical demonstration of poly (adenosine diphosphate-ribose) synthetase in bovine tissues. J. Histochem. Cytochem., 31, 1261-1264.
21. LAUTIER, D., LAGVEUX, J., THIBODEAU, J., MENARD, L. & POIRER, G.G. (1993). Molecular and biochemical features of poly (ADP-ribose) metabolism. Mol. Cell. Biochem., 122, 171-193.
22. MANNION, D., FITZPATRICK, G.J. & FEELEY, M. (1994). Role of xanthine oxidase inhibition in survival from hemorrhagic shock. Circ. Shock, 42, 39-43.
23. MCCORD, J.M. (1985). Oxygen-derived free radicals in post-ischaemic tissue injury. N. Engl. J. Med., 312, 159-163.
24. MOTA-FILIPE, H., MCDONALD, M., CUZZOCREA, S. & THIEMERMANN, C. (1999). A membrane-permeable radical scavenger reduces the organ injury in hemorrhagic shock. Shock, 12, 255-261.
25. NUNES, F.A., KUMAR, C., CHANCE, B. & BRASS, C.A. (1995). Chemiluminescent measurement of increased free radical formation after ischaemia-reperfusion. Dig. Dis. Sci., 40, 1045-1053.
26. REDL, H., GASSER, H., SCHLAG, G. & MARZI, I. (1993). Involvement of oxygen radicals in shock related cell injury. Br. Med. Bull., 49, 556-565.
27. SANAN, S., SHARMA, G., MALHOTRA, R., SANAN, D.P., JAIN, P. & VADHERA, P. (1989). Protection by desferrioxamine against histopathological changes of the liver in the post-oligaemic phase of clinical haemorrhagic shock in dogs: correlation with improved survival rate and recovery. Free Radic. Res. Commun., 6, 29-38.
28. SCHRAUFSTATTER, I.U., HINSHAW, D.B., HYSLOP, P.A., SPRAGG, R.G. & COCHRANE, C.G. (1986b). DNA strand breaks activate poly adenosine diphosphate -ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J. Clin. Invest., 77, 1312-1320.
29. SCHRAUFSTATTER, I.U., HYSLOP, P.A., HINSHAW, D.B., SPRAGG, R.G., SKLAR, L.A. & COCHRANE, C.G. (1986a). Hydrogen peroxide induced injury and its prevention by inhibitors of poly (ADP-ribose) polymerase. Proc. Natl. Acad. Sci. U.S.A., 83, 4908-4912.
30. SIMON, H.M., SCALEA, T., PASKANIK, A. & YANG, B. (1996). Superoxide dismutase (SOD) prevents hypotension after hemorrhagic shock and aortic cross clamping. Am. J. Med. Sci., 312, 155-159.
31. SZABO, A., HAKE, P., SALZMAN, A.L. & SZABO, C. (1998). 3-Aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, improves hemodynamics and prolongs survival in a porcine model of hemorrhagic shock. Shock, 10, 347-353.
32. SZABO, C. (1998). Potential role of peroxynitrite-poly(ADP-ribose) synthetase pathway in a rat model of severe hemorrhagic shock. Shock, 9, 341-344.
33. SZABO, C., SALZMAN, A.L. & ISCHIROPOULOS, H. (1995). Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. FEBS Lett., 372, 229-232.
34. SZABO, C., ZINGARELLI, B. & SALZMAN, A.L. (1996). Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ. Res., 78, 1051-1063.
35. THIEMERMANN, C., RUETTEN, H., WU, C.C. & VANE, J.R. (1995). The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br. J. Pharmacol., 116, 2845-2851.
36. THIEMERMANN, C., BOWES, J., MYINT, F. & VANE, J.R. (1997). Inhibition of the activity of poly (ADP-ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc. Natl. Acad. Sci. U.S.A., 94, 679-683.
37. THIES, R.L. & AUTOR, A.P. (1991). Reactive oxygen injury to cultured pulmonary artery endothelial cells: Mediation by poly (ADP-ribose) polymerase activation causing NAD depletion and altered energy balance. Arch. Biochem. Biophys., 286, 353-363.
38. UEDA, K. & HAYAISHI, O. (1985). ADP-ribosylation. Ann. Rev. Biochem., 54, 73-100.
39. WALLES, T., PIEPER, A.A., ZHANG, J.J., SNYDER, S.H. & ZWEIER, J.L. (1998a). Demonstration that poly (ADP-ribose) accumulation occurs in the post ischemic heart and is associated with myocardial necrosis. Circulation, 98, Suppl. 1-260 (Abstract).
40. WALLES, T., WANG, P., PIEPER, A., SNYDER, S. & ZWEIER, J.L. (1998b). Mice lacking poly (ADP-ribose) polymerase gene show attenuated cellular energy depletion and improved recovery of myocardial function following global ischemia. Circulation, 98, Suppl. 1-260 (Abstract).
41. ZHANG, J., DAWSON, V.L., DAWSON, T.M. & SNYDER, S.H. (1994). Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity. Science, 263, 687-689.
42. ZINGARELLI, B., CUZZOCREA, S., ZSENGELLER, Z., SALZMAN, A.L. & SZABO, C. (1997). Protection against myocardial ischemia and reperfusion injury by 3 aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase. Cardiovasc. Res., 36, 205-215.
43. ZINGARELLI, B., SALZMAN, A.L. & SZABO, C. (1998). Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ. Res., 83, 85-94.
44. ZWEIER, J.L., FLAHERTY, J.T. & WEISFELDT, M.L. (1987). Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc. Natl. Acad. Sci. U.S.A., 84, 1404-1407.