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Volumn 62, Issue , 1997, Pages 217-226

The Smoothened gene and Hedgehog signal transduction in Drosophila and vertebrate development

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MEMBRANE PROTEIN; MESSENGER RNA; SONIC HEDGEHOG PROTEIN; CYSTEINE; FRIZZLED PROTEIN; SERINE; SMOOTHENED PROTEIN; THREONINE; VALINE; WNT1 PROTEIN;

EID: 0031463018     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1997.062.01.027     Document Type: Conference Paper
Times cited : (52)

References (63)
  • 1
    • 0030602796 scopus 로고    scopus 로고
    • The Drosophila smoothened gene encodes a 7-pass membrane-protein, a putative receptor for the hedgehog signal
    • Alcedo J., Ayzenzon M., Vonohlen T., Noll M., and Hooper J.E. 1996. The Drosophila smoothened gene encodes a 7-pass membrane-protein, a putative receptor for the hedgehog signal. Cell 86: 221.
    • (1996) Cell , vol.86 , pp. 221
    • Alcedo, J.1    Ayzenzon, M.2    Vonohlen, T.3    Noll, M.4    Hooper, J.E.5
  • 2
    • 0029001294 scopus 로고
    • Identification of a yeast artificial chromosome clone spanning a translocation breakpoint at 7q32.1 in a Smith-Lemli-Opitz syndrome patient
    • Alley T., Gray B., Lee S., Scherer S., Tsui L., Tint G., Williams C., Zori R., and Wallace M. 1995. Identification of a yeast artificial chromosome clone spanning a translocation breakpoint at 7q32.1 in a Smith-Lemli-Opitz syndrome patient. Am. J. Hum. Genet. 56: 1411.
    • (1995) Am. J. Hum. Genet. , vol.56 , pp. 1411
    • Alley, T.1    Gray, B.2    Lee, S.3    Scherer, S.4    Tsui, L.5    Tint, G.6    Williams, C.7    Zori, R.8    Wallace, M.9
  • 3
    • 0027199026 scopus 로고
    • FGF signaling in the early specification of mesoderm in Xenopus
    • Amaya E., Stein P., Musci T., and Kirschner M. 1993. FGF signaling in the early specification of mesoderm in Xenopus. Development 110: 477.
    • (1993) Development , vol.110 , pp. 477
    • Amaya, E.1    Stein, P.2    Musci, T.3    Kirschner, M.4
  • 4
    • 0023879457 scopus 로고
    • Embryonic and imaginal requirements for wingless, a segment polarity gene in Drosophila
    • Baker N. 1988. Embryonic and imaginal requirements for wingless, a segment polarity gene in Drosophila. Dev. Biol. 125: 96.
    • (1988) Dev. Biol. , vol.125 , pp. 96
    • Baker, N.1
  • 5
    • 0025998891 scopus 로고
    • Roles of wingless in patterning the larval epidermis of Drosophila
    • Bejsovec A. and Martinez Arias A. 1991. Roles of wingless in patterning the larval epidermis of Drosophila. Development 113: 471.
    • (1991) Development , vol.113 , pp. 471
    • Bejsovec, A.1    Martinez Arias, A.2
  • 6
    • 0027386246 scopus 로고
    • Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos
    • Bejsovec A. and Wieschaus E. 1993. Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. Development 119: 501.
    • (1993) Development , vol.119 , pp. 501
    • Bejsovec, A.1    Wieschaus, E.2
  • 11
    • 0029791854 scopus 로고    scopus 로고
    • Spatial regulation of a Zebrafish patched homologue reflects the roles of Sonic hedgehog and protein kinase A in neural tube and somite patterning
    • Concordet J.-P., Lewis K., Moore J., Goodrich L.V., Johnson R.L., Scott M.P., and Ingham P.W. 1996. Spatial regulation of a Zebrafish patched homologue reflects the roles of Sonic hedgehog and protein kinase A in neural tube and somite patterning. Development 122: 2835.
    • (1996) Development , vol.122 , pp. 2835
    • Concordet, J.-P.1    Lewis, K.2    Moore, J.3    Goodrich, L.V.4    Johnson, R.L.5    Scott, M.P.6    Ingham, P.W.7
  • 12
    • 0029585601 scopus 로고
    • Serrate signals through Notch to establish a wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
    • Diaz-Benjumea F. and S. Cohen. 1995. Serrate signals through Notch to establish a wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development 121: 4215.
    • (1995) Development , vol.121 , pp. 4215
    • Diaz-Benjumea, F.1    Cohen, S.2
  • 13
    • 0030604722 scopus 로고    scopus 로고
    • Crystal structure of a complexed and peptide free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
    • Doyle D., Lee A., Lewis J., Kim E., Sheng M., and MacKinnon R. 1996. Crystal structure of a complexed and peptide free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ. Cell 85: 1067.
    • (1996) Cell , vol.85 , pp. 1067
    • Doyle, D.1    Lee, A.2    Lewis, J.3    Kim, E.4    Sheng, M.5    MacKinnon, R.6
  • 14
    • 0030584081 scopus 로고    scopus 로고
    • Two critical periods of Sonic hedgehog signaling required for the specification of motor neuron identity
    • Ericson J., Morton S., Kawakami A., Roelink H., and Jessell T.M. 1996. Two critical periods of Sonic hedgehog signaling required for the specification of motor neuron identity. Cell 87: 661.
    • (1996) Cell , vol.87 , pp. 661
    • Ericson, J.1    Morton, S.2    Kawakami, A.3    Roelink, H.4    Jessell, T.M.5
  • 15
    • 0029041177 scopus 로고
    • Long-range induction of sclerotome by Sonic hedgehog: A direct role for the amino terminal product of autoproteolytic cleavage and modulation by the cyclic AMP signaling pathway
    • Fan C.-M., Porter J.A., Chiang C., Chang D.T., Beachy P.A., and Tessier-Lavigne M. 1995. Long-range induction of sclerotome by Sonic hedgehog: A direct role for the amino terminal product of autoproteolytic cleavage and modulation by the cyclic AMP signaling pathway. Cell 81: 457.
    • (1995) Cell , vol.81 , pp. 457
    • Fan, C.-M.1    Porter, J.A.2    Chiang, C.3    Chang, D.T.4    Beachy, P.A.5    Tessier-Lavigne, M.6
  • 16
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice - Induction of a mouse patched gene by hedgehog
    • Goodrich L.V., Johnson R.L., Milenkovic L., McMahon J.A., and Scott M.P. 1996. Conservation of the hedgehog/patched signaling pathway from flies to mice - Induction of a mouse patched gene by hedgehog. Genes Dev. 10: 301.
    • (1996) Genes Dev. , vol.10 , pp. 301
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.A.4    Scott, M.P.5
  • 19
    • 0030218004 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in development
    • Hogan B. 1996. Bone morphogenetic proteins in development. Curr. Opin. Genet. Dev. 6: 432.
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 432
    • Hogan, B.1
  • 20
    • 0028077841 scopus 로고
    • Distinct pathways for autocrine and paracrine Wingless signaling in Drosophila embryos
    • Hooper J. 1994. Distinct pathways for autocrine and paracrine Wingless signaling in Drosophila embryos. Nature 372: 461.
    • (1994) Nature , vol.372 , pp. 461
    • Hooper, J.1
  • 21
    • 0024468746 scopus 로고
    • The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
    • Hooper J. and Scott M.P. 1989. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 59: 751.
    • (1989) Cell , vol.59 , pp. 751
    • Hooper, J.1    Scott, M.P.2
  • 22
    • 0027761917 scopus 로고
    • Localised hedgehog activity controls spatially restricted transcription of wingless in the Drosophila embryo
    • Ingham P.W. 1993. Localised hedgehog activity controls spatially restricted transcription of wingless in the Drosophila embryo. Nature 366: 560.
    • (1993) Nature , vol.366 , pp. 560
    • Ingham, P.W.1
  • 23
    • 0029121566 scopus 로고
    • Signaling by hedgehog family proteins in Drosophila and vertebrate development
    • _. 1995. Signaling by hedgehog family proteins in Drosophila and vertebrate development. Curr. Opin. Genet. Dev. 5: 492.
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 492
  • 24
    • 0029816344 scopus 로고    scopus 로고
    • Has the quest for a Wnt receptor finally frizzled out?
    • _. 1996. Has the quest for a Wnt receptor finally frizzled out? Trends Genet. 12: 382.
    • (1996) Trends Genet. , vol.12 , pp. 382
  • 25
    • 0027408032 scopus 로고
    • Regulation of wingless transcription in the Drosophila embryo
    • Ingham P.W. and Hidalgo A. 1993. Regulation of wingless transcription in the Drosophila embryo. Development 117: 283.
    • (1993) Development , vol.117 , pp. 283
    • Ingham, P.W.1    Hidalgo, A.2
  • 26
    • 0025815911 scopus 로고
    • Role of the Drosophila patched gene in positional signaling
    • Ingham P.W., Taylor A.M., and Nakano Y. 1991. Role of the Drosophila patched gene in positional signaling. Nature 353: 184.
    • (1991) Nature , vol.353 , pp. 184
    • Ingham, P.W.1    Taylor, A.M.2    Nakano, Y.3
  • 28
    • 0027344852 scopus 로고
    • Structural and functional diversity in the FGF receptor multigene family
    • Johnson D. and Williams L. 1993. Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 60: 1.
    • (1993) Adv. Cancer Res. , vol.60 , pp. 1
    • Johnson, D.1    Williams, L.2
  • 29
    • 0028651869 scopus 로고
    • Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites
    • Johnson R.L., Laufer E., Riddle R.D., and Tabin C. 1994. Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites. Cell 79: 1165.
    • (1994) Cell , vol.79 , pp. 1165
    • Johnson, R.L.1    Laufer, E.2    Riddle, R.D.3    Tabin, C.4
  • 31
    • 0028568147 scopus 로고
    • Signaling by wingless in Drosophila
    • Klingensmith J. and Nusse R. 1994. Signaling by wingless in Drosophila. Dev. Biol. 166: 396.
    • (1994) Dev. Biol. , vol.166 , pp. 396
    • Klingensmith, J.1    Nusse, R.2
  • 32
    • 0027954477 scopus 로고
    • The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal
    • Klingensmith J., Nusse R., and Perrimon N. 1994. The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev. 8: 118.
    • (1994) Genes Dev. , vol.8 , pp. 118
    • Klingensmith, J.1    Nusse, R.2    Perrimon, N.3
  • 34
    • 0027321966 scopus 로고
    • Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF
    • MacNicol A., Muslin A., and Williams L. 1993. Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF. Cell 73: 571.
    • (1993) Cell , vol.73 , pp. 571
    • MacNicol, A.1    Muslin, A.2    Williams, L.3
  • 35
    • 0029948270 scopus 로고    scopus 로고
    • Biochemical-evidence that patched is the hedgehog receptor
    • Marigo V., Davey R., Zuo Y., Cunningham J., and Tabin C. 1996a. Biochemical-evidence that patched is the hedgehog receptor. Nature 384: 176.
    • (1996) Nature , vol.384 , pp. 176
    • Marigo, V.1    Davey, R.2    Zuo, Y.3    Cunningham, J.4    Tabin, C.5
  • 36
    • 0029975823 scopus 로고    scopus 로고
    • Conservation in hedgehog signaling: Induction of a chicken patched homolog by Sonic hedgehog in the developing limb
    • Marigo V., Scott M.P., Johnson R.L., Goodrich L.V., and Tabin C.J. 1996b. Conservation in hedgehog signaling: Induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development 122: 1225.
    • (1996) Development , vol.122 , pp. 1225
    • Marigo, V.1    Scott, M.P.2    Johnson, R.L.3    Goodrich, L.V.4    Tabin, C.J.5
  • 37
    • 0029019627 scopus 로고
    • Requirement of 19kDalton form of Sonic hedgehog for induction of distinct ventral cell types in vertebrate CNS explants
    • Marti E., Bumcrot D.A., Takada R., and McMahon A.P. 1995. Requirement of 19kDalton form of Sonic hedgehog for induction of distinct ventral cell types in vertebrate CNS explants. Nature 375: 322.
    • (1995) Nature , vol.375 , pp. 322
    • Marti, E.1    Bumcrot, D.A.2    Takada, R.3    McMahon, A.P.4
  • 38
    • 0030604542 scopus 로고    scopus 로고
    • TGF-β signaling - Receptors, transducers, and mad proteins
    • Massagué J. 1996. TGF-β signaling - Receptors, transducers, and mad proteins. Cell 85: 947.
    • (1996) Cell , vol.85 , pp. 947
    • Massagué, J.1
  • 39
    • 0030816043 scopus 로고    scopus 로고
    • TGF-β signaling through the Smad pathway
    • Massagué J., Hata A., and Liu F. 1997. TGF-β signaling through the Smad pathway. Trends Cell Biol. 7: 187.
    • (1997) Trends Cell Biol. , vol.7 , pp. 187
    • Massagué, J.1    Hata, A.2    Liu, F.3
  • 40
    • 0026703887 scopus 로고
    • The wnt family of developmental regulators
    • McMahon A. 1992. The wnt family of developmental regulators. Trends Genet. 8: 236.
    • (1992) Trends Genet. , vol.8 , pp. 236
    • McMahon, A.1
  • 41
    • 0024254534 scopus 로고
    • Requirements for hedgehog, a segment polarity gene, in patterning larval and adult cuticle of Drosophila
    • Mohler J. 1988. Requirements for hedgehog, a segment polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics 120: 1061.
    • (1988) Genetics , vol.120 , pp. 1061
    • Mohler, J.1
  • 42
    • 0024440611 scopus 로고
    • The Drosophila segment polarity gene patched encodes a protein with multiple potential membrane spanning domains
    • Nakano Y., Guerrero I., Hidalgo A., Taylor A.M., Whittle R.R.S., and Ingham P.W. 1989. The Drosophila segment polarity gene patched encodes a protein with multiple potential membrane spanning domains. Nature 341: 508.
    • (1989) Nature , vol.341 , pp. 508
    • Nakano, Y.1    Guerrero, I.2    Hidalgo, A.3    Taylor, A.M.4    Whittle, R.R.S.5    Ingham, P.W.6
  • 43
    • 0029960417 scopus 로고    scopus 로고
    • A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing
    • Neumann C. and Cohen S. 1996. A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing. Development 122: 3477.
    • (1996) Development , vol.122 , pp. 3477
    • Neumann, C.1    Cohen, S.2
  • 44
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nüsslein-Volhard C. and Wieschaus E. 1980. Mutations affecting segment number and polarity in Drosophila. Nature 287: 795.
    • (1980) Nature , vol.287 , pp. 795
    • Nüsslein-Volhard, C.1    Wieschaus, E.2
  • 45
    • 0008125299 scopus 로고
    • Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome
    • Nüsslein-Volhard C., Wieschaus E., and Kluding H. 1984. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome. Roux's Arch. Dev. Biol. 193: 267.
    • (1984) Roux's Arch. Dev. Biol. , vol.193 , pp. 267
    • Nüsslein-Volhard, C.1    Wieschaus, E.2    Kluding, H.3
  • 46
    • 0030955557 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice overexpressing Sonic hedgehog
    • Oro A., Higgins K., Hu Z., Bonifas J., Epstein E., and Scott M. 1997. Basal cell carcinomas in mice overexpressing Sonic hedgehog. Science 276: 817.
    • (1997) Science , vol.276 , pp. 817
    • Oro, A.1    Higgins, K.2    Hu, Z.3    Bonifas, J.4    Epstein, E.5    Scott, M.6
  • 47
    • 0029844192 scopus 로고    scopus 로고
    • Cholesterol modification of hedgehog signaling proteins in animal development
    • Porter J., Young K., and Beachy P. 1996. Cholesterol modification of hedgehog signaling proteins in animal development. Science 274: 255.
    • (1996) Science , vol.274 , pp. 255
    • Porter, J.1    Young, K.2    Beachy, P.3
  • 48
    • 0027760995 scopus 로고
    • Sonic hedgehog mediates the polarizing activity of the ZPA
    • Riddle R., Johnson R.L., Laufer E., and Tabin C. 1993. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75: 1401.
    • (1993) Cell , vol.75 , pp. 1401
    • Riddle, R.1    Johnson, R.L.2    Laufer, E.3    Tabin, C.4
  • 49
    • 0028848301 scopus 로고
    • Induction of the LIM homeobox gene Lmx1 by Wnt7a establishes dorsoventral pattern in the vertebrate limb
    • Riddle R., Ensini M., Nelson C., Tsuchida T., Jessell R., and Tabin C. 1995. Induction of the LIM homeobox gene Lmx1 by Wnt7a establishes dorsoventral pattern in the vertebrate limb. Cell 83: 631.
    • (1995) Cell , vol.83 , pp. 631
    • Riddle, R.1    Ensini, M.2    Nelson, C.3    Tsuchida, T.4    Jessell, R.5    Tabin, C.6
  • 50
    • 0029004233 scopus 로고
    • Floor plate and motor neuron induction by different concentrations of the amino terminal cleavage product of Sonic hedgehog autoproteolysis
    • Roelink H., Porter J., Chiang C., Tanabe Y., Chang D.T., Beachy P.A., and Jessell T.M. 1995. Floor plate and motor neuron induction by different concentrations of the amino terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81: 445.
    • (1995) Cell , vol.81 , pp. 445
    • Roelink, H.1    Porter, J.2    Chiang, C.3    Tanabe, Y.4    Chang, D.T.5    Beachy, P.A.6    Jessell, T.M.7
  • 53
    • 0030582677 scopus 로고    scopus 로고
    • Branchless encodes a Drosophila FGF homolog that controls tracheal cell-migration and the pattern of branching
    • Sutherland D., Samakovlis C., and Krasnow M. 1996. branchless encodes a Drosophila FGF homolog that controls tracheal cell-migration and the pattern of branching. Cell 87: 1091.
    • (1996) Cell , vol.87 , pp. 1091
    • Sutherland, D.1    Samakovlis, C.2    Krasnow, M.3
  • 54
    • 0028178786 scopus 로고
    • Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    • Tabata T. and Kornberg T.B. 1994. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76: 89.
    • (1994) Cell , vol.76 , pp. 89
    • Tabata, T.1    Kornberg, T.B.2
  • 55
    • 0028178391 scopus 로고
    • Dishevelled is required during wingless signaling to establish both cell polarity and cell identity
    • Theisen H., Purcell J., Bennett M., Kansagara D., Syed A., and Marsh J.L. 1994. dishevelled is required during wingless signaling to establish both cell polarity and cell identity. Development 120: 347.
    • (1994) Development , vol.120 , pp. 347
    • Theisen, H.1    Purcell, J.2    Bennett, M.3    Kansagara, D.4    Syed, A.5    Marsh, J.L.6
  • 56
  • 58
    • 0029784223 scopus 로고    scopus 로고
    • Smoothened encodes a serpentine protein required for hedgehog signaling
    • van den Heuvel M. and Ingham P.W. 1996. smoothened encodes a serpentine protein required for hedgehog signaling. Nature 382: 547.
    • (1996) Nature , vol.382 , pp. 547
    • Van Den Heuvel, M.1    Ingham, P.W.2
  • 59
    • 0028345115 scopus 로고
    • Smith-Lemli-Opitz syndrome in a female with a de novo, balanced translocation involving 7q32: Probable disruption of an SLOS gene
    • Wallace M., Zori R., Alley R., Whidden E., Gray B., and Williams C. 1994. Smith-Lemli-Opitz syndrome in a female with a de novo, balanced translocation involving 7q32: Probable disruption of an SLOS gene. Am. J. Med. Genet. 50: 368.
    • (1994) Am. J. Med. Genet. , vol.50 , pp. 368
    • Wallace, M.1    Zori, R.2    Alley, R.3    Whidden, E.4    Gray, B.5    Williams, C.6
  • 60
    • 0026611442 scopus 로고
    • ras in Xenopus mesoderm induction
    • ras in Xenopus mesoderm induction. Nature 357: 252.
    • (1992) Nature , vol.357 , pp. 252
    • Whitman, M.1    Melton, D.2
  • 61
    • 0027530340 scopus 로고
    • Pattern-formation in a secondary field - A hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions
    • Williams J., Paddock S., and Carroll S. 1993. Pattern-formation in a secondary field - A hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions. Development 117: 571.
    • (1993) Development , vol.117 , pp. 571
    • Williams, J.1    Paddock, S.2    Carroll, S.3
  • 62
    • 0028799758 scopus 로고
    • Reproducing abnormal cholesterol biosynthesis as seen in the Smith-Lemli-Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in rats
    • Xu G., Salen G., Shefer S., Ness G., Chen T., Zhao A., and Tint G. 1995. Reproducing abnormal cholesterol biosynthesis as seen in the Smith-Lemli-Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in rats. J. Clin. Invest. 95: 76.
    • (1995) J. Clin. Invest. , vol.95 , pp. 76
    • Xu, G.1    Salen, G.2    Shefer, S.3    Ness, G.4    Chen, T.5    Zhao, A.6    Tint, G.7
  • 63
    • 0029118414 scopus 로고
    • Fibroblast growth-factors in mammalian development
    • Yamaguchi T. and Rossant J. 1995. Fibroblast growth-factors in mammalian development. Curr. Opin. Genet. Dev. 5: 485.
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 485
    • Yamaguchi, T.1    Rossant, J.2


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