-
2
-
-
0027745887
-
Basic research and the cost of health care
-
Beary J.F. et al. (1993) Basic research and the cost of health care. Science 262, 1358
-
(1993)
Science
, vol.262
, pp. 1358
-
-
Beary, J.F.1
-
3
-
-
0027905005
-
Improvements in health care
-
Abelson, P.H. (1993) Improvements in health care. Science 260, 11
-
(1993)
Science
, vol.260
, pp. 11
-
-
Abelson, P.H.1
-
4
-
-
0022966891
-
Trends in the development of new medicines by UK-owned pharmaceutical companies (1964- 1980)
-
Prentis, R. A. and Walker, S. R. (1986) Trends in the development of new medicines by UK-owned pharmaceutical companies (1964- 1980). Br. J. Clin. Pharmacol. 21, 437- 443
-
(1986)
Br. J. Clin. Pharmacol.
, vol.21
, pp. 437-443
-
-
Prentis, R.A.1
Walker, S.R.2
-
5
-
-
0023947965
-
Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964- 1985)
-
Prentis, R.A. et al. (1988) Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964- 1985). Br J. Clin.Pharmacol. 25, 387- 396
-
(1988)
Br J. Clin.Pharmacol.
, vol.25
, pp. 387-396
-
-
Prentis, R.A.1
-
6
-
-
0021161989
-
The development of self-originated new drugs by Swiss pharmaceutical firms, 1960- 1980
-
Mattison, N. et al. (1984) The development of self-originated new drugs by Swiss pharmaceutical firms, 1960- 1980. Regul.Toxicol.Pharmacol. 4, 157- 173
-
(1984)
Regul.Toxicol.Pharmacol.
, vol.4
, pp. 157-173
-
-
Mattison, N.1
-
7
-
-
0018860191
-
The measurement of pharmaceutical innovation
-
Wardell, WM. and DiRaddo, J. (1980) The measurement of pharmaceutical innovation. J. Clin. Pharmacol. 20, 1- 9
-
(1980)
J. Clin. Pharmacol.
, vol.20
, pp. 1-9
-
-
Wardell, W.M.1
DiRaddo, J.2
-
8
-
-
0001788422
-
Putting the code to work: The promise of pharmacogenetics and pharmacogenomics
-
Peakman, T. and Arlington, S. (2001) Putting the code to work: the promise of pharmacogenetics and pharmacogenomics. Drug Discov.World 2, 35- 40
-
(2001)
Drug Discov.World
, vol.2
, pp. 35-40
-
-
Peakman, T.1
Arlington, S.2
-
9
-
-
0029692270
-
General principles in the characterization and use of model systems for biopharmaceutical studies
-
Borchardt, R.T. et al. (1996) General principles in the characterization and use of model systems for biopharmaceutical studies. Pharm. Biotechnol. 8, 1- 11
-
(1996)
Pharm. Biotechnol.
, vol.8
, pp. 1-11
-
-
Borchardt, R.T.1
-
10
-
-
0033673839
-
Optimizing the science of drug development: Opportunities for better candidate selection and accelerated evaluation in humans
-
Lesko, L.J. et al. (2000) Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans. J. Clin. Pharmacol. 40, 803- 814
-
(2000)
J. Clin. Pharmacol.
, vol.40
, pp. 803-814
-
-
Lesko, L.J.1
-
11
-
-
0028287202
-
Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development
-
Peck, C.C. et al. (1994) Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. J. Clin. Pharmacol. 34, 111- 119
-
(1994)
J. Clin. Pharmacol.
, vol.34
, pp. 111-119
-
-
Peck, C.C.1
-
12
-
-
0024571757
-
The absolute oral bioavailability of selected drugs
-
Sietsema, WK. (1989) The absolute oral bioavailability of selected drugs. Int. J. Clin. Pharmacol. Ther.Toxicol. 27, 179- 211
-
(1989)
Int. J. Clin. Pharmacol. Ther.Toxicol.
, vol.27
, pp. 179-211
-
-
Sietsema, W.K.1
-
13
-
-
0028818229
-
Species similarities and differences in pharmacokinetics
-
Lin, J.H. (1995) Species similarities and differences in pharmacokinetics. Drug Metab. Dispos. 23, 1008- 1019
-
(1995)
Drug Metab. Dispos.
, vol.23
, pp. 1008-1019
-
-
Lin, J.H.1
-
14
-
-
10644239163
-
Screening acceptable pharmacokinetic qualities in early drug discovery
-
Sinko, P.J., ed. (1999) Screening acceptable pharmacokinetic qualities in early drug discovery, Current Drugs
-
(1999)
Current Drugs
-
-
Sinko, P.J.1
-
15
-
-
0034582010
-
Combining high-throughput pharmacokinetic screens at the hits to leads stage of drug discovery
-
Spalding, D.J.M. et al. (2001) Combining high-throughput pharmacokinetic screens at the hits to leads stage of drug discovery. Drug Discov. Today 5 (Suppl.), S70- S76
-
(2001)
Drug Discov. Today
, vol.5
, Issue.SUPPL.
-
-
Spalding, D.J.M.1
-
16
-
-
0033966128
-
A priori prediction of tissue: Plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery
-
Poulin, P. and Theil, F.P. (2000) A priori prediction of tissue: plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery. J. Pharm. Sci. 89, 16- 35
-
(2000)
J. Pharm. Sci.
, vol.89
, pp. 16-35
-
-
Poulin, P.1
Theil, F.P.2
-
17
-
-
0032189375
-
Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight
-
Camenisch, G. et al. (1998) Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight. Eur. J. Pharm. Sci. 6, 317- 324
-
(1998)
Eur. J. Pharm. Sci.
, vol.6
, pp. 317-324
-
-
Camenisch, G.1
-
18
-
-
0031404654
-
Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statistics
-
Norinder, U. et al. (1997) Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statistics. Pharm. Res. 14, 1786- 1791
-
(1997)
Pharm. Res.
, vol.14
, pp. 1786-1791
-
-
Norinder, U.1
-
19
-
-
0029020035
-
Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: Relationship to absorption in humans
-
Stewart, B.H. et al. (1995) Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans. Pharm. Res. 12, 693- 699
-
(1995)
Pharm. Res.
, vol.12
, pp. 693-699
-
-
Stewart, B.H.1
-
20
-
-
0031774541
-
Use of immobilized artificial membrane chromatography for drug transport applications
-
Stewart, B.H. and Chan, O.H. (1998) Use of immobilized artificial membrane chromatography for drug transport applications. J. Pharm. Sci. 87, 1471- 1478
-
(1998)
J. Pharm. Sci.
, vol.87
, pp. 1471-1478
-
-
Stewart, B.H.1
Chan, O.H.2
-
21
-
-
0031413597
-
Improved prediction of in vivo peroral absorption from in vitro intestinal permeability using an internal standard to control for intra- and inter-rat variability
-
Dowty, M.E. and Dietsch, C.R. (1997) Improved prediction of in vivo peroral absorption from in vitro intestinal permeability using an internal standard to control for intra- and inter-rat variability. Pharm. Res. 14, 1792- 1797
-
(1997)
Pharm. Res.
, vol.14
, pp. 1792-1797
-
-
Dowty, M.E.1
Dietsch, C.R.2
-
22
-
-
0026498978
-
Permeability characteristics of various intestinal regions of rabbit, dog, and monkey
-
Jezyk, N. et al. (1992) Permeability characteristics of various intestinal regions of rabbit, dog, and monkey. Pharm. Res. 9, 1580- 1586
-
(1992)
Pharm. Res.
, vol.9
, pp. 1580-1586
-
-
Jezyk, N.1
-
23
-
-
0024408848
-
A correlation of permeabilities for passively transported compounds in monkey and rabbit jejunum
-
Grass, G.M. and Sweetana, S.A. (1989) A correlation of permeabilities for passively transported compounds in monkey and rabbit jejunum. Pharm.Res. 6, 857- 862
-
(1989)
Pharm.Res.
, vol.6
, pp. 857-862
-
-
Grass, G.M.1
Sweetana, S.A.2
-
24
-
-
0029692312
-
Methods for evaluating intestinal permeability an metabolism in vitro
-
Smith, P.L. (1996) Methods for evaluating intestinal permeability an metabolism in vitro. Pharm. Biotechnol. 8, 13- 34
-
(1996)
Pharm. Biotechnol.
, vol.8
, pp. 13-34
-
-
Smith, P.L.1
-
25
-
-
0025804183
-
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
-
Artursson, P. and Karlsson, J. (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem.Biophys. Res. Commun. 175, 880- 885
-
(1991)
Biochem.Biophys. Res. Commun.
, vol.175
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
26
-
-
0032480901
-
Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach
-
Winiwarter, S. et al. (1998) Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. J. Med. Chem. 41, 4939- 4949
-
(1998)
J. Med. Chem.
, vol.41
, pp. 4939-4949
-
-
Winiwarter, S.1
-
27
-
-
0031780682
-
Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: Comparison with the parental Caco-2 cell line
-
Gres, M.C. et al. (1998) Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line. Pharm. Res. 15, 726- 733
-
(1998)
Pharm. Res.
, vol.15
, pp. 726-733
-
-
Gres, M.C.1
-
28
-
-
0032888376
-
A compartmental absorption and transit model for estimating oral drug absorption
-
Yu, L.X. and Amidon, G.L. (1999) A compartmental absorption and transit model for estimating oral drug absorption. Int. J. Pharm. 186, 119- 125
-
(1999)
Int. J. Pharm.
, vol.186
, pp. 119-125
-
-
Yu, L.X.1
Amidon, G.L.2
-
29
-
-
0025821306
-
Predicting fraction dose absorbed in humans using a macroscopic mass balance approach
-
Sinko, P.J. et al. (1991) Predicting fraction dose absorbed in humans using a macroscopic mass balance approach. Pharm. Res. 8, 979- 988
-
(1991)
Pharm. Res.
, vol.8
, pp. 979-988
-
-
Sinko, P.J.1
-
30
-
-
0033999569
-
Development of predictive pharmacokinetic simulation models for drug discovery
-
Norris, D.A. et al. (2000) Development of predictive pharmacokinetic simulation models for drug discovery. J. Control. Release 65, 55- 62
-
(2000)
J. Control. Release
, vol.65
, pp. 55-62
-
-
Norris, D.A.1
-
31
-
-
0025311288
-
Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
-
Artursson, P. (1990) Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J. Pharm. Sci. 79, 476- 482
-
(1990)
J. Pharm. Sci.
, vol.79
, pp. 476-482
-
-
Artursson, P.1
-
32
-
-
0025804183
-
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
-
Artursson, P. and Karlsson, J. (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun. 175, 880- 885
-
(1991)
Biochem. Biophys. Res. Commun.
, vol.175
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
33
-
-
0023715382
-
Estimating human oral fraction dose absorbed: A correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds
-
Amidon, G.L. et al. (1988) Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds. Pharm. Res. 5, 651- 654
-
(1988)
Pharm. Res.
, vol.5
, pp. 651-654
-
-
Amidon, G.L.1
-
34
-
-
0030030608
-
Correlation of drug absorption with molecular surface properties
-
Palm, K. et al. (1996) Correlation of drug absorption with molecular surface properties. J. Pharm. Sci. 85, 32- 39
-
(1996)
J. Pharm. Sci.
, vol.85
, pp. 32-39
-
-
Palm, K.1
-
35
-
-
0032585545
-
Evaluation of dynamic polar molecular surface area as predictor of drug absorption: Comparison with other computational and experimental predictors
-
Palm, K. et al. (1998) Evaluation of dynamic polar molecular surface area as predictor of drug absorption: comparison with other computational and experimental predictors. J. Med. Chem. 41, 5382- 5392
-
(1998)
J. Med. Chem.
, vol.41
, pp. 5382-5392
-
-
Palm, K.1
-
36
-
-
0034687231
-
Prediction of drug absorption using multivariate statistics
-
Egan, W.J. et al. (2000) Prediction of drug absorption using multivariate statistics. J. Med. Chem. 43, 3867- 3877
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3867-3877
-
-
Egan, W.J.1
-
37
-
-
0025311288
-
Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
-
Artursson, P. (1990) Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J. Pharm. Sci. 79, 476- 482
-
(1990)
J. Pharm. Sci.
, vol.79
, pp. 476-482
-
-
Artursson, P.1
-
38
-
-
0034068583
-
Caco-2 cell permeability vs human gastrointestinal absorption: QSPR analysis
-
Ren, S. and Lien, E.J. (2000) Caco-2 cell permeability vs human gastrointestinal absorption: QSPR analysis. Prog. Drug. Res. 54, 1- 23
-
(2000)
Prog. Drug. Res.
, vol.54
, pp. 1-23
-
-
Ren, S.1
Lien, E.J.2
-
39
-
-
0031026707
-
Simulation models to predict oral drug absorption from in vitro data
-
Grass, G.M. (1997) Simulation models to predict oral drug absorption from in vitro data. Adv. Drug Deliv. Rev. 23, 199- 219
-
(1997)
Adv. Drug Deliv. Rev.
, vol.23
, pp. 199-219
-
-
Grass, G.M.1
-
40
-
-
0031719032
-
Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells
-
Makhey, V.D. et al. (1998) Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells. Pharm. Res. 15, 1160- 1167
-
(1998)
Pharm. Res.
, vol.15
, pp. 1160-1167
-
-
Makhey, V.D.1
-
41
-
-
0023715382
-
Estimating human oral fraction dose absorbed: A correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds
-
Amidon, G. et al. (1988) Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds. Pharm. Res. 5, 651- 654
-
(1988)
Pharm. Res.
, vol.5
, pp. 651-654
-
-
Amidon, G.1
-
42
-
-
0030914681
-
Polar molecular surface properties predict the intestinal absorption of drugs in humans
-
Palm, K. et al. (1997) Polar molecular surface properties predict the intestinal absorption of drugs in humans. Pharm. Res. 14, 568- 571
-
(1997)
Pharm. Res.
, vol.14
, pp. 568-571
-
-
Palm, K.1
|