Constitutive and lysophosphatidic acid (LPA)-induced LPA production: Role of phospholipase D and phospholipase A2

Clinical Cancer Research

Volumn 6, Issue 6, 2000, Pages 2482-2491

  Eder, Astrid M ^a   Sasagawa, Takayo ^a,c   Mao, Muling ^a   Aoki, Junken ^b   Mills, Gordon B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c OKAYAMA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOPHOSPHATIDIC ACID; PHOSPHOLIPASE A2; PHOSPHOLIPASE D;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL PROLIFERATION; DRUG SENSITIVITY; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; LIPOGENESIS; OVARY CANCER; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BLOTTING, NORTHERN; BREAST NEOPLASMS; CALCIUM; CELL DIVISION; CELL LINE; CHROMATOGRAPHY, THIN LAYER; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; EPIDERMAL GROWTH FACTOR; EPITHELIUM; FEMALE; HUMANS; LYSOPHOSPHOLIPIDS; MAP KINASE SIGNALING SYSTEM; NEOVASCULARIZATION, PATHOLOGIC; OVARIAN NEOPLASMS; OVARY; PANCREAS; PHOSPHOLIPASE D; PHOSPHOLIPASES A; PLATELET-DERIVED GROWTH FACTOR; RNA; RNA, RIBOSOMAL, 18S; TUMOR CELLS, CULTURED;

EID: 0034083409     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. American Cancer Society. Cancer Facts and Figures-1998. Atlanta: American Cancer Society, Inc., 1999.
2. Mills, G. B., May, C., McGill, M., Roifman, C. M., and Mellors, A. A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action. Cancer Res., 48: 1066-1071, 1988.
3. Mills, G. B., May, C., Hill, M., Campbell, S., Shaw, P., and Marks, A. Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells. J. Clin. Investig., 86: 851-855, 1990.
4. Xu, Y., Gaudette, D. C., Boynton, J. D., Frankel, A., Fang, X. J., Sharma, A., Hurteau, J., Casey, G., Goodbody, A., Mellors, A., et al. Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients. Clin. Cancer Res., 1: 1223-1232, 1995.
5. Westermann, A. M., Havik, E., Postma, F. R., Beijnen, J. H., Dalesio, O., Moolenaar, W. H., and Rodenhuis, S. Malignant effusions contain lysophosphatidic acid (LPA)-like activity. Ann. Oncol., 9: 437-442, 1998.
6. Xu, Y., Shen, Z., Wiper, D. W., Wu, M., Morton, R. E., Elson, P., Kennedy, A. W., Belinson, J., Markman, M., and Casey, G. Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers [see comments]. J. Am. Med. Assoc., 280: 719-723, 1998.
7. Sasagawa, T., Okita, M., Murakami, J., Kato, T., and Watanabe, A. Abnormal serum lysophospholipids in multiple myeloma patients. Lipids, 34: 17-21, 1999.
8. Sasagawa, T., Suzuki, K., Shiota, T., Kondo, T., and Okita, M. The significance of plasma lysophospholipids in patients with renal failure on hemodialysis. J. Nutr. Sci. Vitaminol., 44: 809-818, 1998.
9. Moolenaar, W. Lysophosphatidic acid, a multifunctional phospholipid messenger. J. Biol. Chem., 270. 12949-12952, 1995.
10. Moolenaar, W. H., Kranenburg, O., Postma, F. R., and Zondag, G. C. Lysophosphatidic acid: G-protein signalling and cellular responses. Curr. Opin. Cell Biol., 9: 168-173, 1997.
11. Goetzl, E. J., and An, S. Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. FASEB J., 12: 1589-1598, 1998.
12. Fang, X., Gaudette, D., Furui, T., Mao, M., Estrella, V., Eder, A., Pustilnik, T., Sasagawa, T., Lapushin, R., Yu, S., Jaffe, R. B., Wiener, J. R., Erickson, J. R., and Mills, G. B. Lysophospholipid growth factors in the initiation, progression, metastases and management of cancer. Ann. NY Acad. Sci., in press, 2000.
13. Xu, Y., Fang, X. J., Casey, G., and Mills, G. B. Lysophospholipids activate ovarian and breast cancer cells. Biochem. J., 309: 933-940, 1995.
14. Fang, X., Yu, S., Eder, A., Mao, M., Bast, R. C., Jr., Boyd, D., and Mills, G. B. Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. Oncogene, 18: 6635-6640, 1999.
15. Frankel, A., and Mills, G. B. Peptide and lipid growth factors decrease cis-diamminedichloroplatinum-induced cell death in human ovarian cancer cells. Clin. Cancer Res., 2: 1307-1313, 1996.
16. Pustilnik, T. B., Estrelle, V., Wiener, J., Mao, M., Eder, A., Watt, M. A., Bast, R. C., Jr., and Mills, G. B. Lysophosphatidic acid induces urokinase secretion in ovarian cancer cells. Clin. Cancer Res., 11: 3704-3710, 1999.
17. An, S., Goetzl, E. J., and Lee, H. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. Cell. Biochem. Suppl., 31: 147-157, 1998.
18. Hla, T., and Maciag, T. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J. Biol. Chem., 265: 9308-9313, 1990.
19. Lee, M. J., Van Brocklyn, J. R., Thangada, S., Liu, C. H., Hand, A. R., Menzeleev, R., Spiegel, S., and Hla, T. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science (Washington DC), 279: 1552-1555, 1998.
20. Lee, M. J., Thangada, S., Liu, C. H., Thompson, B. D., and Hla, T. Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J. Biol. Chem., 273: 22105-22112, 1998.
21. An, S., Dickens, M. A., Bleu, T., Hallmark, O. G., and Goetzl, E. J. Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. Biochem. Biophys. Res. Commun., 231: 619-622, 1997.
22. Goetzl, E. J., Dolezalova, H., Kong, Y., Hu, Y-L., Jaffe, R. B., Kalli, K. R., and Conover, C. A. Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. Cancer Res., 59: 5370-5375, 1999.
23. Furui, T., LaPushin, R., Mao, M., Kahn, H., Watt, S. R., Watt, M-A. V., Lu, Y., Fang, X., Tsutsui, S., Siddik, Z., Bast, R. C., Jr., and Mills, G. B. Overexpression of Edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid independent manner. Clin. Cancer Res., 5: 4308-4318, 2000.
24. An, S., Bleu, T., Hallmark, O. G., and Goetzl, E. J. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J. Biol. Chem., 273: 7906-7910, 1998.
25. Bandoh, K., Aoki, J., Hosono, H., Kobayashi, S., Kobayashi, T., Murakami-Murofushi, K., Tsujimoto, M., Arai, H., and Inoue, K. Molecular cloning and characterization of a novel human G-protein- coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem., 274: 27776-27785, 1999.
26. Eichholtz, T., Jalink, K., Fahrenfort, I., and Moolenaar, W. H. The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem. J., 291: 677-680, 1993.
27. Fukami, K., and Takenawa, T. Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal. J. Biol. Chem., 267: 10988-10993, 1992.
28. Shen, Z., Belinson, J., Morton, R. E., Xu, Y., and Xu, Y. Phorbol 12-myristate 13-acetate stimulates lysophosphatidic acid secretion from ovarian and cervical cancer cells but not from breast or leukemia cells. Gynecol. Oncol., 71: 364-368, 1998.
29. Jalink, K., Hordijk, P. L., and Moolenaar, W. H. Growth factor-like effects of lysophosphatidic acid, a novel lipid mediator. Biochim. Biophys. Acta, 1198: 185-196, 1994.
30. Gaits, F., Fourcade, O., Le Balle, F., Gueguen, G., Gaige, B., Gassama-Diagne, A., Fauvel, J., Salles, J. P., Mauco, G., Simon, M. F., and Chap, H. Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis. FEBS Lett., 410: 54-58, 1997.
31. Exton, J. H. Regulation of phospholipase D. Biochim Biophys Acta, 1439: 121-133, 1999.
32. Frohman, M. A., Sung, T. C., and Morris, A. J. Mammalian phospholipase D structure and regulation. Biochim. Biophys. Acta, 1439: 175-186, 1999.
33. 2. J. Biol. Chem., 269: 13057-13060, 1994.
34. 2 superfamily of signal transduction enzymes. Trends Biochem. Sci., 1: 1-2, 1997.
35. 2. Biochim. Biophys. Acta, 1170: 217-231, 1993.
36. 2. Semin. Cell Dev. Biol., 3: 297-303, 1997.
37. 2. Lipids Suppl., 34: S49-S55, 1999.
38. 2+ signaling pathways. Curr. Biol., 8: 386-392, 1998.
39. Malcolm, K. C., Elliott, C. M., and Exton, J. H. Evidence for Rho-mediated agonist stimulation of phospholipase D in rat1 fibroblasts. Effects of Clostridium botulinum C3 exoenzyme. J. Biol. Chem., 271: 13135-13139, 1996.
40. Cross, M. J., Roberts, S., Ridley, A. J., Hodgkin, M. N., Stewart, A., Claesson-Welsh, L., and Wakelam, M. J. O. Stimulation of actin stress fiber formation mediated by activation of phospholipase D. Curr. Biol., 6: 588-597, 1996.
41. Qi, C., Park, J. H., Gibbs, T. C., Shirley, D. W., Bradshaw, C. D., Ella, K. M., and Meier, K. E. Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells. J. Cell Physiol., 174: 261-272, 1998.
42. 2. J. Biol. Chem., 272: 16709-16712, 1997.
43. Pai, J. K., Siegel, M. I., Egan, R. W., and Billah, M. M. Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. Biochem. Biophys. Res. Commun., 150: 355-364, 1988.
44. Bonser, R. W., Thompson, N. T., Randall, R. W., and Garland, L. G. Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil. [published erratum appears in Biochem. J., 265: 932, 1990]. Biochem. J., 264: 617-620, 1989.
45. Ohguchi, K., Kasai, T., and Nozawa, Y. Tyrosine phosphorylation of 100-115 kDa proteins by phosphatidic acid generated via phospholipase D activation in HL60 granulocytes. Biochim. Biophys. Acta, 1346: 301-304, 1997.
46. 2 by the marine natural product, manoalide. Biochem. Pharmacol., 39: 1557-1564, 1990.
47. 2 inhibitors. In: J. M. Bailey (ed.), Prostaglandins, Leukotrienes and Lipoxins, pp. 669-676. New York: Plenum Publishing Corp., 1985.
48. Miao, J. Y., Kaji, K., Hayashi, H., and Araki, S. Inhibitors of phospholipase promote apoptosis of human endothelial cells. J. Biochem., 121: 612-618, 1997.
49. Lu, Y., Morley, P., and Durkin, J. P. Signalling events mediating the activation of protein kinase C by interleukin-2 in cytotoxic T cells. Cell. Signal., 11: 275-285, 1999.
50. 2. J. Am. Chem. Soc., 118: 5519-5525, 1996.
51. 2 by bromoenol lactone and trifluoromethyl ketones. J. Biol. Chem., 270: 445-450, 1995.
52. 2 inhibit release of free arachidonate in thrombin-stimulated human platelets. J. Biol. Chem., 269: 15625-15630, 1994.
53. Westermann, A. M., Beijnen, J. H., Moolenaar, W. H., and Rodenhuis, S. Growth factors in human ovarian cancer. Cancer Treat, Rev., 23: 113-131, 1997.
54. 2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells. Cell, 80: 919-927, 1995.
55. 2 and of lysophosphatidic acid synthesis. Adv. Enzyme Regul., 38: 99-107, 1998.
56. le Balle, F., Simon, M. F., Meijer, S., Fourcade, O., and Chap, H. Membrane sidedness of biosynthetic pathways involved in the production of lysophosphatidic acid. Adv. Enzyme Regul., 39: 275-284, 1999.
57. Zwaal, R. F., and Schroit, A. J. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood. 89: 1121-1132, 1997.
58. 2 enzymes present in P388D1 macrophages. J. Biol. Chem., 271: 6758-6765, 1996.
59. 2 that mediates optimal cyclooxygenase-2-dependent delayed prostaglandin E2 generation in rat 3Y1 fibroblasts. J. Biol. Chem., 273: 1733-1740, 1998.
60. 2. J. Biol. Chem., 272: 19891-19897, 1997.
61. 2 in the human astrocytoma cell line 1321N1. J. Biol. Chem., 273: 606-612, 1998.
62. 2 in agonist-stimulated human platelets and HeLa cells. J. Biol. Chem., 273: 4449-4458, 1998.
63. 1. J. Biol. Chem., 263: 1920-1928, 1988.
64. 1 from bovine testis. J. Biol. Chem., 273: 5468-5477, 1998.
65. 2-β. J. Biol. Chem., 274: 17063-17067, 1999.
66. 2. J. Biol. Chem., 273: 21926-19232, 1998.