Role of regulatory dendritic cells in allergy and asthma

Current Opinion in Allergy and Clinical Immunology

Volumn 4, Issue 6, 2004, Pages 533-538

  Akbari, Omid ^a   Umetsu, Dale T ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Airway hyperresponsiveness; Asthma; CD8; Dendritic cells; Regulatory T cells

Indexed keywords

ALLERGEN; ANTIGEN;

ALLERGY; ANTIINFLAMMATORY ACTIVITY; ASTHMA; BRONCHUS HYPERREACTIVITY; CELL LINEAGE; CELL SUBPOPULATION; DENDRITIC CELL; HUMAN; IMMUNE RESPONSE; IMMUNITY; IMMUNOLOGICAL TOLERANCE; MEDICAL LITERATURE; MICROENVIRONMENT; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; STEM CELL; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; ASTHMA; DENDRITIC CELLS; HUMANS; RESPIRATORY HYPERSENSITIVITY; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS;

EID: 9644294292     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/00130832-200412000-00010     Document Type: Review

References (62)

1. Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991; 9:271-296.
2. Inaba M, Inaba K, Hosono M, et al. Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells. J Exp Med 1991; 173:549-559.
3. Liu YJ, Kanzler H, Soumelis V, Gilliet M. Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol 2001; 2:585-589.
4. Rissoan M-C, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999; 283:1183-1186.
5. Rissoan MC, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999; 283:1183-1186.
6. Grouard G, Rissoan MC, Filgueira L, et al. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 1997; 185:1101-1111.
7. Grouard G, Rissoan M-C, Filgueira L, et al. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 1997; 185:1101-1112.
8. Matsuda H, Suda T, Hashizume H, et al. Alteration of balance between myeloid dendritic cells and plasmacytoid dendritic cells in peripheral blood of patients with asthma. Am J Respir Crit Care Med 2002; 166:1050-1054.
9. Hagendorens MM, Ebo DG, Schuerwegh AJ, et al. Differences in circulating dendritic cell subtypes in cord blood and peripheral blood of healthy and allergic children. Clin Exp Allergy 2003; 33:633-639.
10. Nakano H, Yanagita M, Gunn MD. CD11c(+)B220(+)Gr-1 (+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J Exp Med 2001; 194:1171-1178.
11. Corcoran L, Ferrero I, Vremec D, et al. The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells. J Immunol 2003; 170:4926-4932.
12. Comeau MR, Van der Vuurst de Vries A-R, Maliszewski CR, Galibert L. CD123 plasmacytoid predendritic cells: progenitors undergoing cell fate conversion? J Immunol 2002; 169:75-83.
13. del Hoyo GM, Martin P, Vargas HH, et al. Characterization of a common precursor population for dendritic cells. Nature 2002; 415:1043-1047.
14. Maldonado-Lopez R, De Smedt T, Michel P, et al. CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J Exp Med 1999; 189:587-592.
15. Pulendran B, Smith JL, Caspary G, et al. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci U S A 1999; 96:1036-1041.
16. LeibundGut-Landmann S, Waldburger J-M, e Sousa CR, et al. MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells. Nat Immunol 2004; 5:899-908.
17. Shigematsu H, Reizis B, Iwasaki H, et al. Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity 2004; 21:43-53.
18. Anderson CF, Lucas M, Gutierrez-Kobeh L, et al. T cell biasing by activated dendritic cells. J Immunol 2004; 173:955-961. The authors demonstrated that dendritic cells respond to immune complexes by altering their cytokine production such as IL-12p70 to induce a Th2-like cytokine response in T cells. Furthermore, the mechanism by which dendritic cells altered their cytokine production in response to immune complexes was shown to be different from macrophages. Macrophages downregulated the transcription of both the p40 and p35 subunits of IL-12, whereas dendritic cells decreased only p35 expression.
19. Gentile DA, Schreiber R, Howe-Adams J, et al. Diminished dendritic cell interleukin 10 production in atopic children. Ann Allergy Asthma Immunol 2004; 92:538-544.
20. Kaser A, Kaser S, Kaneider NC, et al. Interleukin-18 attracts plasmacytoid dendritic cells (DC2s) and promotes Th1 induction by DC2s through IL-18 receptor expression. Blood 2004; 103:648-655.
21. El-Mezayen REH, Matsumoto T. In vitro responsiveness to IL-18 in combination with IL-12 or IL-2 by PBMC from patients with bronchial asthma and atopic dermatitis. Clin Immunol 2004; 111:61-68.
22. Dodge IL, Carr MW, Cernadas M, Brenner MB. IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J Immunol 2003; 170:4457-4464.
23. Watanabe N, Hanabuchi S, Soumelis V, et al. Human thymic stromal lymphopoietin promotes dendritic cell mediated CD4+ T cell homeostatic expansion. Nat Immunol 2004; 5:426-434.
24. Ge Q, Palliser D, Eisen HN, Chen J. Homeostatic T cell proliferation in a T cell-dendritic cell coculture system. Proc Natl Acad Sci U S A 2002; 99:2983-2988.
25. Rohn TA, Boes M, Wolters D, et al. Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization. Nat Immunol 2004; 5:909-918. More than 200 individual MHC class II-associated peptides were found on human dendritic cells and mature dendritic cells were shown to selectively upregulate the self-peptide CLIP. The increased representation of CLIP-MHC class II complexes favored polarization of autologous naive T cells toward the nonpolarized and Th2 phenotype. Thus, the self-peptide CLIP on dendritic cells qualifies as an endogenous regulator in priming of Th cells by antagonizing the polarization toward the Th1 phenotype.
26. Radtke F, Wilson A, Mancini S, MacDonald H. Notch regulation of lymphocyte development and function. Nat Immunol 2004; 5:247-253.
27. Amsen D, Blander J, Lee G, et al. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 2004; 117:515-526.
28. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994; 179:1109-1118.
29. Bender A, Sapp M, Schuler G, et al. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J Immunol Methods 1996; 196:121-135.
30. Romani N, Gruner S, Brang D, et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994; 180:83-93.
31. Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells secreting IL-10 mediate T cell tolerance induced by respiratory exposure to antigen. Nat Immunol 2001; 2:725-731.
32. Maraskovsky E, Brasel K, Teepe M, et al. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med 1996; 184:1953-1962.
33. Belz GT, Behrens GM, Smith CM, et al. The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J Exp Med 2002; 196:1099-1104.
34. Liu K, Iyoda T, Saternus M, et al. Immune tolerance after delivery of dying cells to dendritic cells in situ. J Exp Med 2002; 196:1091-1097.
35. Grohmann U, Fallarino F, Bianchi R, et al. IL-6 inhibits the tolerogenic function of CD8 alpha+ dendritic cells expressing indoleamine 2,3-dioxygenase. J Immunol 2001; 167:708-714.
36. Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 1999; 103:175-183.
37. Randolph DA, Carruthers CJ, Szabo SJ, et al. Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma. J Immunol 1999; 162:2375-2383.
38. Platts-Mills T, Vaughan J, Squillace S, et al. Senshisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 2001; 357:752-756.
39. Ownby D, Johnson C, Peterson E. Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA 2002; 288:963-972.
40. Braun-Fahrlander C, Gassner M, Grize L, et al. Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. SCARPOL team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution. Clin Exp Allergy 1999; 29:28-34.
41. Riedler J, Braun-Fahrlander C, Eder W, et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001; 358:1129-1133.
42. Braun-Fahrlander C, Riedler J, Herz U, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347:869-877.
43. Akdis M, Verhagen J, Taylor A, et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004; 199:1567-1575. Immune response to allergens in health and disease is shown to be the result of a balance between allergen-specific Th1 and Th2 cells. While Th1 cells use multiple suppressive mechanisms, IL-10 and transforming growth factor-β as secreted cytokines, and cytotoxic T-lymphocyte antigen 4 and programmed death 1 as surface molecules, healthy and allergic individuals exhibit all three allergen-specific subsets in different proportions, indicating that a change in the dominant subset may lead to allergy development or recovery. Blocking the suppressor activity of Th1 cells or increasing Th2 cell frequency was found to enhance allergen-specific Th2 cell activation ex vivo.
44. Gambineri E, Torgerson TR, Ochs HD. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr Opin Rheumatol 2003; 15:430-435.
45. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21:685-711.
46. Jonuleit H, Schmitt E, Schuler G, et al. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 2000; 192:1213-1222.
47. Wakkach A, Fournier N, Brun V, et al. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 2003; 18:605-617.
48. Akbari O, Freeman GJ, Meyer EH, et al. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 2002; 8:1024-1032.
49. de Heer HJ, Hammad H, Soullie T, et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 2004; 200:89-98. pDCs were shown to provide intrinsic protection against inflammatory responses to harmless antigens in lungs. Depletion of pDCs during inhalation of normally inert antigen led to airway eosinophilia and asthma. Furthermore, adoptive transfer of pDCs before sensitization prevented disease in a mouse asthma model.
50. Suss G, Shortman K. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J Exp Med 1996; 183:1789-1796.
51. Kronin V, Wu L, Gong S, et al. DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses. Int Immunol 2000; 12:731-735.
52. Reg cells are related to Th1 cells.
53. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:1057-1061.
54. Umetsu D, McIntire J, Macaubas C, et al. Asthma: an epidemic of dysregulated immunity. Nat Immunol 2002; 3:715-720.
55. Jember A, Zuberi R, Liu F, Croft M. Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. J Exp Med 2001; 193:387-392.
56. Salek-Ardakani S, Song J, Halteman B, et al. OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med 2003; 198:315-324.
57. Sharpe AH, Freeman GJ. The B7-CD28 superfamily. Nat Rev Immunol 2002; 2:116-126.
58. McAdam AJ, Greenwald RJ, Levin MA, et al. ICOS is critical for CD40-mediated antibody class switching. Nature 2001; 409:102-105.
59. Coyle A, Gutierrez-Ramos J. The role of ICOS and other costimulatory molecules in allergy and asthma. Springer Semin Immunopathol 2004; 25:349-359.
60. Reg cells in the pancreatic lesion express Foxp3, produce high levels of IL-10 and ICOS. Blockade of ICOS rapidly converts early insulitis to diabetes, which disrupts the balance of Teffs and Tregs and promotes a very broad shift in the expression of the T regulatory-specific profile.
61. Matsumoto K, Inoue H, Nakano T, et al. B7-DC regulates asthmatic response by an IFN-{gamma}-dependent mechanism. J Immunol 2004; 172:2530-2541.
62. Radhakrishnan S, Iijima K, Kobayashi T, et al. Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody. J Immunol 2004; 173:1360-1365.