Multiple redox regulation of the cellular signaling system linked to AP-1 and NFκB: Effects of N-acetylcysteine and H2O2 on the receptor tyrosine kinases, the MAP kinase cascade, and IκB kinases

Annals of the New York Academy of Sciences

Volumn 973, Issue , 2002, Pages 419-422

  Kamata, Hideaki ^a   Manabe, Tomoyuki ^a   Kakuta, Jungo ^a   Oka, Shin Ichi ^a   Hirata, Hajime ^a  

^a UNIVERSITY OF HYOGO   (Japan)

Author keywords

I B kinase; NF B; Redox regulation

Indexed keywords

ACETYLCYSTEINE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FORSKOLIN; HYDROGEN PEROXIDE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN CDC42; PROTEIN TYROSINE KINASE; RAC1 PROTEIN; RAF PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; CELL GROWTH; CELL MEMBRANE; CELL STRAIN; CELL STRAIN COS7; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; GENE ACTIVATION; GENE EXPRESSION; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MONKEY; NERVE CELL DIFFERENTIATION; NONHUMAN; ONCOGENE RAS; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0036959484     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04675.x     Document Type: Conference Paper

References (4)

1. KAMATA, H. & H. HIRATA. 1999. Redox regulation of cellular signalling. Cell Signal. 11: 1-14.
2. 2. Eur. J. Biochem. 267: 1933-1944.
3. KAMATA, H., C. TANAKA, H. YAGISAWA, et al. 1996. Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade. J. Biol. Chem. 271: 33018-33025.
4. OKA, S., H. KAMATA, K. KAMATA, et al. 2000. N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of 1kappaB kinases. FEBS Lett. 472: 196-202.