-
1
-
-
1542705021
-
Cystatins
-
Abrahamson, M., Alvarez-Fernandez, M., and Nathanson, C.M. (2003) Cystatins. Biochem Soc Symp 70: 179-199.
-
(2003)
Biochem Soc Symp
, vol.70
, pp. 179-199
-
-
Abrahamson, M.1
Alvarez-Fernandez, M.2
Nathanson, C.M.3
-
2
-
-
0032534577
-
Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a T Helper 1 (TH1) response
-
Alexander, J., Coombs, G.H., and Mottram, J.C. (1998) Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a T Helper 1 (TH1) response. J Immunol 161: 6794-6801.
-
(1998)
J Immunol
, vol.161
, pp. 6794-6801
-
-
Alexander, J.1
Coombs, G.H.2
Mottram, J.C.3
-
3
-
-
0032883457
-
Leishmania species: Models of intracellular parasitism
-
Alexander, J., Satoskar, A.R., and Russell, D.G. (1999) Leishmania species: models of intracellular parasitism. J Cell Sci 112: 2993-3002.
-
(1999)
J Cell Sci
, vol.112
, pp. 2993-3002
-
-
Alexander, J.1
Satoskar, A.R.2
Russell, D.G.3
-
4
-
-
0028809686
-
Isolation of lmcpc, a gene encoding a Leishmania mexicana cathepsin B-like cysteine proteinase
-
Bart, G., Coombs, G.H., and Mottram, J.C. (1995) Isolation of lmcpc, a gene encoding a Leishmania mexicana cathepsin B-like cysteine proteinase. Mol Biochem Parasitol 73: 271-274.
-
(1995)
Mol Biochem Parasitol
, vol.73
, pp. 271-274
-
-
Bart, G.1
Coombs, G.H.2
Mottram, J.C.3
-
5
-
-
0026674542
-
Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms
-
Bates, P.A., Robertson, C.D., Tetley, L., and Coombs, G.H. (1992) Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms. Parasitology 105: 193-202.
-
(1992)
Parasitology
, vol.105
, pp. 193-202
-
-
Bates, P.A.1
Robertson, C.D.2
Tetley, L.3
Coombs, G.H.4
-
6
-
-
0034474592
-
Processing and trafficking of cysteine proteases in Leishmania mexicana
-
Brooks, D.R., Tetley, L., Coombs, G.H., and Mottram, J.C. (2000a) Processing and trafficking of cysteine proteases in Leishmania mexicana. J Cell Sci 113: 4035-4041.
-
(2000)
J Cell Sci
, vol.113
, pp. 4035-4041
-
-
Brooks, D.R.1
Tetley, L.2
Coombs, G.H.3
Mottram, J.C.4
-
7
-
-
0034607789
-
Stable transformation of trypanosomatids through targeted chromosomal integration of the selectable marker gene encoding basticidin S deaminase
-
Brooks, D.R., McCulloch, R., Coombs, G.H., and Mottram, J.C. (2000b) Stable transformation of trypanosomatids through targeted chromosomal integration of the selectable marker gene encoding basticidin S deaminase. FEMS Microbiol Lett 186: 287-291.
-
(2000)
FEMS Microbiol Lett
, vol.186
, pp. 287-291
-
-
Brooks, D.R.1
McCulloch, R.2
Coombs, G.H.3
Mottram, J.C.4
-
8
-
-
0035869563
-
Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response
-
Das, L., Datta, N., Bandyopadhyay, S., and Das, P.K. (2001) Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response. J Immunol 166: 4020-4028.
-
(2001)
J Immunol
, vol.166
, pp. 4020-4028
-
-
Das, L.1
Datta, N.2
Bandyopadhyay, S.3
Das, P.K.4
-
9
-
-
0037189937
-
Leishmania RAB7: Characterisation of terminal endocytic stages in an intracellular parasite
-
Denny, P.W., Lewis, S., Tempero, J.E., Goulding, D., Ivens, A.C., Field, M.C., and Smith, D.F. (2002) Leishmania RAB7: characterisation of terminal endocytic stages in an intracellular parasite. Mol Biochem Parasitol 123:105-113.
-
(2002)
Mol Biochem Parasitol
, vol.123
, pp. 105-113
-
-
Denny, P.W.1
Lewis, S.2
Tempero, J.E.3
Goulding, D.4
Ivens, A.C.5
Field, M.C.6
Smith, D.F.7
-
10
-
-
1942532958
-
Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity
-
Denny, P.W., Goulding, D., Ferguson, M.A.J., and Smith, D.F. (2004) Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity. Mol Microbiol 52: 313-327.
-
(2004)
Mol Microbiol
, vol.52
, pp. 313-327
-
-
Denny, P.W.1
Goulding, D.2
Ferguson, M.A.J.3
Smith, D.F.4
-
11
-
-
0033820138
-
Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction
-
Frame, M.J., Mottram, J.C., and Coombs, G.H. (2000) Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction. Parasitology 121: 367-377.
-
(2000)
Parasitology
, vol.121
, pp. 367-377
-
-
Frame, M.J.1
Mottram, J.C.2
Coombs, G.H.3
-
12
-
-
0035794186
-
The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence
-
Garami, A., and Ilg, T. (2001) The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence. J Biol Chem 276: 6566-6575.
-
(2001)
J Biol Chem
, vol.276
, pp. 6566-6575
-
-
Garami, A.1
Ilg, T.2
-
13
-
-
0035012676
-
Secretory and endocytic pathways converge in a dynamic endosomal system in a primitive protozoan
-
Ghedin, E., Debrabant, A., Engel, J.C., and Dwyer, D.M. (2001) Secretory and endocytic pathways converge in a dynamic endosomal system in a primitive protozoan. Traffic 2: 175-188.
-
(2001)
Traffic
, vol.2
, pp. 175-188
-
-
Ghedin, E.1
Debrabant, A.2
Engel, J.C.3
Dwyer, D.M.4
-
15
-
-
0031826072
-
Structural basis for specificity of papain-like cysteine protease proregions toward their cognate enzymes
-
Groves, M.R., Coulombe, R., Jenkins, J., and Cygler, M. (1998) Structural basis for specificity of papain-like cysteine protease proregions toward their cognate enzymes. Protein-Struct Fund Genet 32: 504-514.
-
(1998)
Protein-Struct Fund Genet
, vol.32
, pp. 504-514
-
-
Groves, M.R.1
Coulombe, R.2
Jenkins, J.3
Cygler, M.4
-
16
-
-
0035490884
-
The endocytic pathway: A mosaic of domains
-
Gruenberg, J. (2001) The endocytic pathway: a mosaic of domains. Nat Rev Mol Cell Biol 2: 721-730.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 721-730
-
-
Gruenberg, J.1
-
17
-
-
0035227644
-
Structural studies of cysteine proteases and their inhibitors
-
Grzonka, Z., Jankowska, E., Kasprzykowski, F., Kasprzykowska, R., Lamkiewicz, L., Wiczk, W., et al. (2001) Structural studies of cysteine proteases and their inhibitors. Acta Biochim Pol 48: 1-20.
-
(2001)
Acta Biochim Pol
, vol.48
, pp. 1-20
-
-
Grzonka, Z.1
Jankowska, E.2
Kasprzykowski, F.3
Kasprzykowska, R.4
Lamkiewicz, L.5
Wiczk, W.6
-
18
-
-
0033016717
-
Correlation between protein and mRNA abundance in yeast
-
Gygi, S.P., Rochon, Y., Franza, B.R., and Aebersold, R. (1999) Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19: 1720-1730.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1720-1730
-
-
Gygi, S.P.1
Rochon, Y.2
Franza, B.R.3
Aebersold, R.4
-
19
-
-
0343267840
-
Use of the green fluorescent protein as a marker in transfected Leishmania
-
Ha, D.S., Schwarz, J.K., Turco, S.J., and Beverley, S.M. (1996) Use of the green fluorescent protein as a marker in transfected Leishmania. Mol Biochem Parasitol 77: 57-64.
-
(1996)
Mol Biochem Parasitol
, vol.77
, pp. 57-64
-
-
Ha, D.S.1
Schwarz, J.K.2
Turco, S.J.3
Beverley, S.M.4
-
20
-
-
0039702904
-
Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif
-
Huete-Pérez, J.A., Engel, J.C., Brinen, L.S., Mottram, J.C., and McKerrow, J.H. (1999) Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif. J Biol Chem 274: 16249-16256.
-
(1999)
J Biol Chem
, vol.274
, pp. 16249-16256
-
-
Huete-Pérez, J.A.1
Engel, J.C.2
Brinen, L.S.3
Mottram, J.C.4
McKerrow, J.H.5
-
21
-
-
0027947483
-
Distribution of parasite cysteine proteinases in lesions of mice infected with Leishmania mexicana amastigotes
-
Ilg, T., Fuchs, M., Gnau, V., Wolfram, M., Harbecke, D., and Overath, P. (1994) Distribution of parasite cysteine proteinases in lesions of mice infected with Leishmania mexicana amastigotes. Mol Biochem Parasitol 67: 193-203.
-
(1994)
Mol Biochem Parasitol
, vol.67
, pp. 193-203
-
-
Ilg, T.1
Fuchs, M.2
Gnau, V.3
Wolfram, M.4
Harbecke, D.5
Overath, P.6
-
22
-
-
0026915084
-
Cystatin-like cysteine proteinase inhibitors of parasitic protozoa
-
Irvine, J.W., Coombs, G.H., and North, M.J. (1992) Cystatin-like cysteine proteinase inhibitors of parasitic protozoa. FEMS Microbiol Lett 96: 67-72.
-
(1992)
FEMS Microbiol Lett
, vol.96
, pp. 67-72
-
-
Irvine, J.W.1
Coombs, G.H.2
North, M.J.3
-
23
-
-
0036198697
-
Secretory pathway of trypanosomatid parasites
-
McConville, M.J., Mullin, K.A., Ilgoutz, S.C., and Teasdale, R.D. (2002a) Secretory pathway of trypanosomatid parasites. Microbiol Mol Biol Rev 66: 122-154.
-
(2002)
Microbiol Mol Biol Rev
, vol.66
, pp. 122-154
-
-
McConville, M.J.1
Mullin, K.A.2
Ilgoutz, S.C.3
Teasdale, R.D.4
-
24
-
-
0036750509
-
Targeting of the GRIP domain to the frans-Golgi network is conserved from protists to animals
-
McConville, M.J., Ilgoutz, S.C., Teasdale, R.D., Foth, B.J., Matthews, A., Mullin, K.A., and Gleeson, P.A. (2002b) Targeting of the GRIP domain to the frans-Golgi network is conserved from protists to animals. Eur J Cell Biol 81: 485-495.
-
(2002)
Eur J Cell Biol
, vol.81
, pp. 485-495
-
-
McConville, M.J.1
Ilgoutz, S.C.2
Teasdale, R.D.3
Foth, B.J.4
Matthews, A.5
Mullin, K.A.6
Gleeson, P.A.7
-
25
-
-
0035052191
-
Practical aspects of fluorescent staining for proteomic applications
-
Malone, J.P., Radabaugh, M.R., Leimgruber, R.M., and Gerstenecker, G.S. (2001) Practical aspects of fluorescent staining for proteomic applications. Electrophoresis 22: 919-932.
-
(2001)
Electrophoresis
, vol.22
, pp. 919-932
-
-
Malone, J.P.1
Radabaugh, M.R.2
Leimgruber, R.M.3
Gerstenecker, G.S.4
-
26
-
-
0242693036
-
Targeted integration into a rRNA locus results in uniform and high level expression of transgenes in Leish-mania amastigotes
-
Misslitz, A., Mottram, J.C., Overath, P., and Aebischer, T. (2000) Targeted integration into a rRNA locus results in uniform and high level expression of transgenes in Leish-mania amastigotes. Mol Biochem Parasitol 107: 251-261.
-
(2000)
Mol Biochem Parasitol
, vol.107
, pp. 251-261
-
-
Misslitz, A.1
Mottram, J.C.2
Overath, P.3
Aebischer, T.4
-
27
-
-
0035189728
-
Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi
-
Monteiro, A.C.S., Abrahamson, M., Lima, A.P.C.A., Vannier-Santos, M.A., and Scharfstein, J. (2001) Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi. J Cell Sci 114: 3933-3942.
-
(2001)
J Cell Sci
, vol.114
, pp. 3933-3942
-
-
Monteiro, A.C.S.1
Abrahamson, M.2
Lima, A.P.C.A.3
Vannier-Santos, M.A.4
Scharfstein, J.5
-
28
-
-
0036861169
-
The kinetoplastida endocytic apparatus. Part I: A dynamic system for nutrition and evasion of host defences
-
Morgan, G.W., Hall, B.S., Denny, P.W., Carrington, M., and Field, M.C. (2002a) The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences. Trends Parasitol 18: 491-496.
-
(2002)
Trends Parasitol
, vol.18
, pp. 491-496
-
-
Morgan, G.W.1
Hall, B.S.2
Denny, P.W.3
Carrington, M.4
Field, M.C.5
-
29
-
-
0036898661
-
The endocytic apparatus of the kinetoplastida. Part II: Machinery and components of the system
-
Morgan, G.W., Hall, B.S., Denny, P.W., Field, M.C., and Carrington, M. (2002b) The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system. Trends Parasitol 18: 540-546.
-
(2002)
Trends Parasitol
, vol.18
, pp. 540-546
-
-
Morgan, G.W.1
Hall, B.S.2
Denny, P.W.3
Field, M.C.4
Carrington, M.5
-
30
-
-
0026708826
-
A developmentally regulated cysteine proteinase gene of Leishmania mexicana
-
Mottram, U.C., Robertson, C.D., Coombs, G.H., and Barry, J.D. (1992) A developmentally regulated cysteine proteinase gene of Leishmania mexicana. Mol Microbiol 6: 1925-1932.
-
(1992)
Mol Microbiol
, vol.6
, pp. 1925-1932
-
-
Mottram, U.C.1
Robertson, C.D.2
Coombs, G.H.3
Barry, J.D.4
-
31
-
-
0029898541
-
Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors
-
Mottram, U.C., Souza, A.E., Hutchison, U.E., Carter, R., Frame, M.J., and Coombs, G.H. (1996) Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors. Proc Natl Acad Sci USA 93: 6008-6013.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 6008-6013
-
-
Mottram, U.C.1
Souza, A.E.2
Hutchison, U.E.3
Carter, R.4
Frame, M.J.5
Coombs, G.H.6
-
32
-
-
0030970429
-
The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes which differ in their stage-regulation and substrate preferences
-
Mottram, U.C., Frame, M.J., Brooks, D.R., Tetley, L., Hutchison, J.E., Souza, A.E., and Coombs, G.H. (1997) The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes which differ in their stage-regulation and substrate preferences. J Biol Chem 272: 14285-14293.
-
(1997)
J Biol Chem
, vol.272
, pp. 14285-14293
-
-
Mottram, U.C.1
Frame, M.J.2
Brooks, D.R.3
Tetley, L.4
Hutchison, J.E.5
Souza, A.E.6
Coombs, G.H.7
-
33
-
-
4143091399
-
Cysteine peptidases as virulence factors of Leishmania
-
Mottram, J.C., Coombs, G.H., and Alexander, J. (2004) Cysteine peptidases as virulence factors of Leishmania. Curr Opin Microbiol 7: 375-381.
-
(2004)
Curr Opin Microbiol
, vol.7
, pp. 375-381
-
-
Mottram, J.C.1
Coombs, G.H.2
Alexander, J.3
-
34
-
-
0035168055
-
Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana
-
Mullin, K.A., Foth, B.J., Ilgoutz, S.C., Callaghan, J.M., Zawadzki, J.L., McFadden, G.I., and McConville, M.J. (2001) Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana. Mol Biol Cell 12: 2364-2377.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 2364-2377
-
-
Mullin, K.A.1
Foth, B.J.2
Ilgoutz, S.C.3
Callaghan, J.M.4
Zawadzki, J.L.5
McFadden, G.I.6
McConville, M.J.7
-
35
-
-
0033592539
-
N-linked glycans containing linear poly-N-acetyllactosamine as sorting signals in endocytosis in Trypanosoma brucei
-
Nolan, D.P., Geuskens, M., and Pays, E. (1999) N-linked glycans containing linear poly-N-acetyllactosamine as sorting signals in endocytosis in Trypanosoma brucei. Curr Biol 9: 1169-1172.
-
(1999)
Curr Biol
, vol.9
, pp. 1169-1172
-
-
Nolan, D.P.1
Geuskens, M.2
Pays, E.3
-
36
-
-
0037088614
-
Differential endocytic functions of Trypanosoma brucei Rab5 isoforms reveal a glycosylphosphatidylinositol-specific endosomal pathway
-
Pal, A., Hall, B.S., Nesbeth, D.N., Field, H.I., and Field, M.C. (2002) Differential endocytic functions of Trypanosoma brucei Rab5 isoforms reveal a glycosylphosphatidylinositol-specific endosomal pathway. J Biol Chem 277: 9529-9539.
-
(2002)
J Biol Chem
, vol.277
, pp. 9529-9539
-
-
Pal, A.1
Hall, B.S.2
Nesbeth, D.N.3
Field, H.I.4
Field, M.C.5
-
37
-
-
0033434080
-
Probability-based protein identification by searching sequence databases using mass spectrometry data
-
Perkins, D.N., Pappin, D.J.C., Creasy, D.M., and Cottrell, J.S. (1999) Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 20: 3551-3567.
-
(1999)
Electrophoresis
, vol.20
, pp. 3551-3567
-
-
Perkins, D.N.1
Pappin, D.J.C.2
Creasy, D.M.3
Cottrell, J.S.4
-
38
-
-
0022479593
-
Leishmania mexicana: Amastigote hydrolases in unusual lysosomes
-
Pupkis, M.F., Tetley, L., and Coombs, G.H. (1986) Leishmania mexicana: amastigote hydrolases in unusual lysosomes. Exp Parasitol 62: 29-39.
-
(1986)
Exp Parasitol
, vol.62
, pp. 29-39
-
-
Pupkis, M.F.1
Tetley, L.2
Coombs, G.H.3
-
39
-
-
0036076146
-
Sequence conservation in the chagasin family suggests a common trend in cysteine proteinase binding by unrelated protein inhibitors
-
Rigden, D.J., Mosolov, V.V., and Galperin, M.Y. (2002) Sequence conservation in the chagasin family suggests a common trend in cysteine proteinase binding by unrelated protein inhibitors. Protein Sci 11: 1971-1977.
-
(2002)
Protein Sci
, vol.11
, pp. 1971-1977
-
-
Rigden, D.J.1
Mosolov, V.V.2
Galperin, M.Y.3
-
40
-
-
0025113919
-
Characterization of 3 groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana
-
Robertson, C.D., and Coombs, G.H. (1990) Characterization of 3 groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana. Mol Biochem Parasitol 42: 269-276.
-
(1990)
Mol Biochem Parasitol
, vol.42
, pp. 269-276
-
-
Robertson, C.D.1
Coombs, G.H.2
-
41
-
-
0035048929
-
Leishmania-sand fly interactions controlling species-specific vector competence
-
Sacks, D.L. (2001) Leishmania-sand fly interactions controlling species-specific vector competence. Cell Microbiol 3: 189-196.
-
(2001)
Cell Microbiol
, vol.3
, pp. 189-196
-
-
Sacks, D.L.1
-
42
-
-
0038025678
-
Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens
-
Sanderson, S.J., Westrop, G.D., Scharfstein, J., Mottram, J.C., and Coombs, G.H. (2003) Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens. FEBS Left 542: 12-16.
-
(2003)
FEBS Left
, vol.542
, pp. 12-16
-
-
Sanderson, S.J.1
Westrop, G.D.2
Scharfstein, J.3
Mottram, J.C.4
Coombs, G.H.5
-
43
-
-
13044256387
-
Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
-
Selzer, P.M., Pingel, S., Hsieh, I., Ugele, B., Chan, V.J., Engel, J.C., et al. (1999) Cysteine protease inhibitors as chemotherapy: lessons from a parasite target. Proc Natl Acad Sci USA 96: 11015-11022.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 11015-11022
-
-
Selzer, P.M.1
Pingel, S.2
Hsieh, I.3
Ugele, B.4
Chan, V.J.5
Engel, J.C.6
-
44
-
-
0242389827
-
Rab5-mediated endosome-endosome fusion regulates hemoglobin endocytosis in Leishmania donovani
-
Singh, S.B., Tandon, R., Krishnamurthy, G., Vikram, R., Sharma, N., Basu, S.K., and Mukhopadhyay, A. (2003) Rab5-mediated endosome-endosome fusion regulates hemoglobin endocytosis in Leishmania donovani. EMBO J 22: 5712-5722.
-
(2003)
EMBO J
, vol.22
, pp. 5712-5722
-
-
Singh, S.B.1
Tandon, R.2
Krishnamurthy, G.3
Vikram, R.4
Sharma, N.5
Basu, S.K.6
Mukhopadhyay, A.7
-
45
-
-
0036829716
-
Developmental changes in lysosome morphology and function Leishmania parasites
-
Waller, R.F., and McConville, M.J. (2002) Developmental changes in lysosome morphology and function Leishmania parasites, Int J Parasitol 32: 1435-1445.
-
(2002)
Int J Parasitol
, vol.32
, pp. 1435-1445
-
-
Waller, R.F.1
McConville, M.J.2
|