The biochemical and genetic odyssey to the function of a nicastrin-like protein

Neurodegenerative Diseases

Volumn 1, Issue 4-5, 2004, Pages 192-195

  Haffner, Christof ^a   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Secretase; Nicalin; Nodal; Nomo

Indexed keywords

GAMMA SECRETASE; GLYCOPROTEIN; MEMBRANE PROTEIN; NICALIN; NICASTRIN; NODAL MODULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL FATE; EMBRYO DEVELOPMENT; FISH; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; MEMBRANE GLYCOPROTEINS; SIGNAL TRANSDUCTION; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 9244263624     PISSN: 16602854     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080985     Document Type: Article

References (19)

1. Selkoe DJ: Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 2001;81:741-766.
2. Fortini ME: γ-Secretase-mediated proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell Biol 2002;3:673-684.
3. Sisodia SS, St George-Hyslop PH: Gammasecretase, Notch, Abeta and Alzheimer's disease: Where do the presenilins fit in? Nat Rev Neurosci 2002;3:281-290.
4. Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 2002;297:353-356.
5. De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R: A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature 1999;398:518-522.
6. Selkoe D, Kopan R: Notch and presenilin: Regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci 2003;26:565-597.
7. Haass C, Steiner H: Alzheimer disease γ-secretase: A complex story of GxGD-type presenilin proteases. Trends Cell Biol 2002;12:556-562.
8. Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C: Reconstitution of γ-secretase activity. Nat Cell Biol 2003;5:486-488.
9. Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ: Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature 1999;398:513-517.
10. Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P: Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and uAPP processing. Nature 2000;407:48-54.
11. Morais VA, Crystal AS, Pijak DS, Carlin D, Costa J, Lee VM, Doms RW: The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gammasecretase complex. J Biol Chem 2003;278:43284-43291.
12. Fagan R, Swindells M, Overington J, Weir M: Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain. Trends Biochem Sci 2001;26:213-214.
13. Shirotani K, Edbauer D, Capell A, Schmitz J, Steiner H, Haass C: γ-Secretase activity is associated with a conformational change of nicastrin. J Biol Chem 2003;278:16474-16477.
14. Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C: Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. EMBO J 2004;23:3041-3050.
15. Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C: A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep 2002;3:688-694.
16. Agathon A, Thisse B, Thisse C: Morpholino knock-down of antivin1 and antivin2 upregulates nodal signaling. Genesis 2001;30:178-182.
17. Blader P, Strahle U: Casting an eye over cyclopia. Nature 1998;395:112-113.
18. Schier AF: Nodal signaling in vertebrate development. Annu Rev Cell Dev Biol 2003;19:589-621.
19. Shi Y, Massague J: Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700.