L-Cysteine based N-type calcium channel blockers: Structure-activity relationships of the C-terminal lipophilic moiety, and oral analgesic efficacy in rat pain models

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 17, 2002, Pages 2267-2269

  Seko, Takuya ^a   Kato, Masashi ^a   Kohno, Hiroshi ^a   Ono, Shizuka ^a   Hashimura, Kazuya ^a   Takenobu, Yoshifumi ^a   Takimizu, Hideyuki ^a   Nakai, Katsuhiko ^a   Maegawa, Hitoshi ^a   Katsube, Nobuo ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM ION; CYSTEINE DERIVATIVE; NITROGEN; CYSTEINE; DRUG DERIVATIVE;

ANALGESIA; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CHRONIC PAIN; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; MOUSE; NEUROPATHY; NONHUMAN; PHYSICAL CHEMISTRY; RAT; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; HYDROPHOBICITY; ORAL DRUG ADMINISTRATION; PAIN; PHARMACOKINETICS; STENOSIS, OCCLUSION AND OBSTRUCTION; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CONSTRICTION, PATHOLOGIC; CYSTEINE; DRUG EVALUATION, PRECLINICAL; HYDROPHOBICITY; INHIBITORY CONCENTRATION 50; PAIN; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THERAPEUTIC EQUIVALENCY;

EID: 18544381669     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00456-0     Document Type: Article

References (19)