The discovery of [1-(4-Dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phenyl]-(3-methyl-but-2-enyl)-amine, an N-type Ca+2 channel blocker with oral activity for analgesia

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 6, 2000, Pages 1203-1212

  Hu, Lain Yen ^a   Ryder, Todd R ^a   Rafferty, Michael F ^a   Taylor, Charles P ^a   Feng, M Rose ^b   Kuo, Be Sheng ^b   Lotarski, Susan M ^a   Miljanich, George P ^c   Millerman, Elizabeth ^c   Siebers, Krista M ^a   Szoke, Balazs G ^c  

^a PFIZER INC   (United States)

^b Dynam Metab Parke Davis P ^*  (United States)

^c ELAN PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE DERIVATIVE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DEVELOPMENT; MALE; MOUSE; NONHUMAN; WRITHING TEST;

ADMINISTRATION, ORAL; ANALGESICS; ANILINE COMPOUNDS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CELL LINE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICE; MOLECULAR STRUCTURE; PIPERIDINES; RATS; RATS, WISTAR;

EID: 0034047651     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00077-8     Document Type: Article

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