Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 4, 2000, Pages 345-347

  Menzler, Stefan ^a   Bikker, Jack A ^b   Suman Chauhan, Nirmala ^a   Horwell, David C ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; DRUG ANALOG; OMEGA CONOTOXIN DERIVATIVE; OMEGA CONOTOXIN MVIIA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM ANTAGONISM; DRUG DESIGN; DRUG INHIBITION; HUMAN; ISCHEMIA; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PAIN; RAT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, N-TYPE; DRUG EVALUATION; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLLUSK VENOMS; MUSCLE, SMOOTH; OMEGA-CONOTOXINS; PHENYL ETHERS; RATS; RATS, INBRED STRAINS; SNAILS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0034696059     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00699-X     Document Type: Article

References (31)

1. Olivera B.M., Gray W.R., Zeikus R., McIntosh J.M., Varga J., Rivier J., de Santos V., Cruz L.J. Science. 230:1985;1338.
2. Olivera B.M., Rivier J., Scott J.K., Hillyard D.R., Cruz L.J. J. Biol. Chem. 266:1991;22067.
3. Olivera B.M., Cruz U., de Santos V., LeCheminant G.W., Griffin D., Zeikus R., McIntosh J.M., Galyean R., Varga J., Gray W.R., Rivier J. Biochemistry. 26:1987;2086.
4. Olivera B.M., Miljanich G.P., Ramachandran J., Adam M.E. Annu. Rev. Biochem. 63:1994;823.
5. Bowersox S.S., Valentino K.L., Luther R.R. Drug News and Perspectives. 7:1994;261.
6. Scraibine, A. Neuroprotection: Fundamental and Clinical Aspects; Marcel Dekker: New York, 1997; pp 27-51.
7. Gilmore J., Dell C., Bowman D., Lodge D. Ann. Report Med. Chem. 30:1995;51.
8. Bowersox S.S., Luther R. Toxicon. 36:1998;1651.
9. Cox B., Denyer J.C. Exp. Opin. Ther. Patents. 8:1998;1237.
10. Miljanich G.P., Ramachandran J. Ann. Rev. Pharmacol. Toxicol. 35:1995;704.
11. Pringle A.K., Benham C.D., Sim L., Kennedy S.J., Iannotti F., Sundstrom L.E. Stroke. 27:1996;2124.
12. Bowersox S.S., Gadbois T., Singh T., Pettus M., Wang Y., Luther R.R. Pharmacol. Exp. Ther. 279:1996;1243.
13. Bowersox S.S., Singh T., Luther R.R. Brain Res. 747:1997;343.
14. Malmberg A.B., Yaksh T.L. Pain. 60:1995;83.
15. Hu L.-Y., Ryder T.R., Rafferty M.F., Cody W.L., Lotarski S.M., Miljanich G.P., Millerman E., Rock D.M., Song Y., Stoehr S.J., Taylor C.P., Weber M.L., Szoke B.G., Vartanian M.G. Bioorg. Med. Chem. Lett. 9:1999;907.
16. Hu L.-Y., Ryder T.R., Nikam S.S., Millerman E., Szoke B.G., Rafferty M.F. Bioorg. Med. Chem. Lett. 9:1999;1121.
17. Ryder T.R., Hu L.-Y., Rafferty M.F., Millerman E., Szoke B.G., Tarczy-Hornoch K. Bioorg. Med. Chem. Lett. 9:1999;1813.
18. Hu L.-Y., Ryder T.R., Rafferty M.F., Dooley D.J., Geer J.J., Lotarski S.M., Miljanich G.P., Millerman E., Rock D.M., Stoehr S.S., Szoke B.G., Taylor C.P., Vartanian M.G. Bioorg. Med. Chem. Lett. 9:1999;2151.
19. Schelkun R.M., Yuen P., Malone T.C., Rock D.M., Stoehr S.S., Szoke B.G., Tarczy-Hornoch K. Bioorg. Med. Chem. Lett. 9:1999;2447.
20. Ryder T.R., Hu L.-Y., Rafferty M.F., Lotarski S.M., Rock D.M., Stoehr S.J., Taylor C.P., Weber M.L., Miljanich G.P., Millerman E., Szoke B.G. Bioorg. Med. Chem. Lett. 9:1999;2453.
21. Kohno T., Kim J.I., Kobayashi K., Kodera Y., Maeda T., Sato K. Biochemistry. 34:1995;10256.
22. Nadasdi L., Yamashiro D., Chung D., Tarczy-Hornoch K., Adriaenssens P., Ramachandran J. Biochemistry. 34:1995;8076.
23. Ramachandran, J.; Nadasdi, L.; Gohil, K.; Kristipati, R.; Tarczy-Hornoch, K.; Gaur, S.; Singh, T.; Bell, J.; Miljanich, G. In Perspectives in Medicinal Chemistry; Testa, B., Ed.; VCH: Weinheim, 1993; pp 374-388.
24. Allen, J. V.; Horwell, D. C.; Lainton, J. A. H.; O'Neill, J. A.; Ratcliffe, G. S. Chem. Commun. 1997, 2121.
25. Menzler S., Bikker J.A., Horwell D.C. Tetrahedron Lett. 39:1998;7622.
26. 2+ channel blocker (nitrendipine). PD 151307 (see ref 14) was run in parallel as a standard in each assay.
27. 2O: C 69.75; H 7.02; N 4.65. Found: C 69.73; H 6.95; N 4.63.
28. Jones G., Willett P., Glen R.C. J. Comp.-Aided Mol. Design. 9:1995;532.
29. Sybyl 6.5. Tripos Assoc. Inc., 1699 S. Hanly Road, St. Louis, MO 63144, USA.
30. +. Nitrendipine was run in parallel as a standard in each assay.
31. Galizzi J.-P., Qar J., Fosset M., Van Renterghem C., Lazdunski M. J. Biol. Chem. 262:1987;6947.