Functional analysis of biosynthetic genes of aminocoumarins and production of hybrid antibiotics

Current Medicinal Chemistry: Anti-Infective Agents

Volumn 3, Issue 4, 2004, Pages 279-295

  Li, Shu Ming ^a   Heide, Lutz ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Aminocoumarin; Biosynthetic genes; Chemoenzymatic synthesis; Gene inactivation; Gyrase inhibitor; Heterologous expression; Hybrid antibiotic; Mutasynthesis experiments; Streptomyces

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINOCOUMARIN DERIVATIVE; ANTIBIOTIC AGENT; CLOROBIOCIN; COUMAMYCIN A1; COUMAMYCIN DERIVATIVE; COUMARIN DERIVATIVE; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); GLUTATHIONE TRANSFERASE; GYRASE INHIBITOR; HISTIDINE; HYBRID PROTEIN; ISOCLOROBIOCIN; ISOVANILLOBIOCIN; NEW DRUG; NOVCLOBIOCIN 101; NOVCLOBIOCIN 102; NOVCLOBIOCIN 104; NOVCLOBIOCIN 105; NOVCLOBIOCIN 107; NOVCLOBIOCIN 108; NOVCLOBIOCIN 109; NOVCLOBIOCIN 110; NOVOBIOCIN; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; VANILLOBIOCIN;

ANTIBIOTIC BIOSYNTHESIS; BACTERIAL STRAIN; BINDING COMPETITION; CATALYSIS; COMBINATORIAL CHEMISTRY; DNA SUPERCOILING; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME SUBUNIT; ENZYME SYNTHESIS; ESCHERICHIA COLI; GENE CLUSTER; GENE EXPRESSION; GENE FUNCTION; GENE INACTIVATION; GENETIC ORGANIZATION; MOLECULAR CLONING; MUTATIONAL ANALYSIS; NONHUMAN; REVIEW; SEQUENCE ANALYSIS; STRAIN DIFFERENCE; STREPTOMYCES LIVIDANS;

EID: 9144242554     PISSN: 15680126     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568012043353801     Document Type: Review

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