Novobiocin biosynthesis: Inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation

Archives of Microbiology

Volumn 180, Issue 1, 2003, Pages 25-32

  Eustáquio, Alessandra S ^a   Luft, Thomas ^a   Wang, Zhao Xin ^a   Gust, Bertolt ^b   Chater, Keith F ^b   Li, Shu Ming ^a   Heide, Lutz ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b JOHN INNES CENTRE   (United Kingdom)

Author keywords

Clorobiocin; Coumermycin; Gene inactivation; Novobiocin; PCR targeting; Streptomyces spheroides

Indexed keywords

ANTIBIOTIC AGENT; BENZOIC ACID; CLOROBIOCIN; COUMAMYCIN; COUMAMYCIN A1; COUMARIN DERIVATIVE; GENE PRODUCT; NOVOBIOCIN; PHENYLACETIC ACID DERIVATIVE; PHENYLPYRUVIC ACID; PREPHENATE DEHYDROGENASE; PROTEIN CLOF; PROTEIN NOVF; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG SYNTHESIS; GENE CLUSTER; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE SEQUENCE; HYDROXYLATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATOR GENE; SEQUENCE HOMOLOGY; STREPTOMYCES; STREPTOMYCES COELICOLOR; STREPTOMYCES LIVIDANS; STREPTOMYCES RISHIRIENSIS; STREPTOMYCES ROSEOCHROMOGENES; STREPTOMYCES SPHEROIDES;

BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; MULTIGENE FAMILY; NOVOBIOCIN; STREPTOMYCES;

ACTINOBACTERIA (CLASS); OXY; STREPTOMYCES CAERULEUS; STREPTOMYCES COELICOLOR; STREPTOMYCES LIVIDANS; STREPTOMYCES RISHIRIENSIS; STREPTOMYCES ROSEOCHROMOGENES; UNCULTURED ACTINOMYCETE;

EID: 0038104003     PISSN: 03028933     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00203-003-0555-2     Document Type: Article

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