Polyunsaturated fatty acids, insulin resistance, and atherosclerosis: Is inflammation the connecting link?

Metabolic Syndrome and Related Disorders

Volumn 2, Issue 2, 2004, Pages 124-128

  Dubnov, Gal ^a   Berry, Elliot M ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; ESSENTIAL FATTY ACID; LEUKOTRIENE; LINOLEIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN;

ATHEROSCLEROSIS; DIET; FATTY ACID METABOLISM; FISH; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; ISCHEMIC HEART DISEASE; PATHOGENESIS; PLANT; PRIORITY JOURNAL; REVIEW;

EID: 9144238196     PISSN: 15404196     EISSN: None     Source Type: Journal    
DOI: 10.1089/met.2004.2.124     Document Type: Review

References (44)

1. British Nutrition Foundation. Unsaturated Fatty Acids. Nutritional and Physiological Significance. London: Chapman & Hall, 1992.
2. Calder PC. Fatty acid metabolism and eicosanoid synthesis. Clin Nutr 2001;20(suppl 4):1-5.
3. Calder PC. N-3 polyunsaturated fatty acids and cytokine production in health and disease. Ann Nutr Metabol 1997; 41:203-234.
4. Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 2002; 21:495-505.
5. Endres S, Ghorbani R, Kelley VE, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989;320:265-271.
6. James MJ, Gibson RA, Cleland LG. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 2000;71(suppl);343s-348s.
7. Khalfoun B, Thibault F, Watier H, et al. Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human endothelial cell production of interleukin-6. Adv Exp Med Biol 1997;400B:589-597.
8. Mayer K, Merfels M, Muhly-Reinholz M, et al. Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. Am J Physiol Heart Circ Physiol 2002;283:H811-H818.
9. Bagga D, Wang L, Farias-Eisner R, et al. Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Proc Natl Acad Sci USA 2003;100:1751-1756.
10. Dwyer JH, Allayee H, Dwyer KM, et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med 2004;350:29-37.
11. Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 1998;41:1241-1248.
12. Barzilay JI, Freedland ES. Inflammation and its relationship to insulin resistance, type 2 diabetes mellitus, and endothelial dysfunction. Metabol Synd Relat Disord 2003;1:55-67.
13. Bloomgarden ZT. Inflammation and insulin resistance. Diab Care 2003;26:1619-1623,1922-1926.
14. Fernandez-Real JM, Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endo Rev 2003;24:278-301.
15. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999;340:115-126.
16. Danesh J, Collins R, Appleby P, et al. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 1998;279:1477-1482.
17. Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice. A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003;107: 499-511.
18. Ridker PM, Buring JE, Cook NR, et al. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14719 initially healthy American women. Circulation 2003; 107:r20-r26.
19. Ridker PM, Glynn RJ, Hennekens CH. C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation 1998;97:2007-2011.
20. Koenig W, Sund M, Frohlich M, et al. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring trends and determinants in cardiovascular disease) Augsburg Cohort Study, 1984 to 1992. Circulation 1999;99:237-242.
21. Dubnov G, Berry EM. Omega-6/omega-3 fatty acid ratio: the Israeli paradox. World Rev Nutr Diet 2003; 92:81-91.
22. Pella D, Dubnov G, Singh RB, et al. Effects of an Indo-Mediterranean diet on the omega-6/omega-3 ratio in patients at high risk of coronary artery disease: the Indian paradox. World Rev Nutr Diet 2003; 92:74-80.
23. Harper CR, Jacobson TA. The fats of life: the role of omega-3 fatty acids in the prevention of coronary heart disease. Arch Intern Med 2001;161:2185-2192.
24. Kris-Etherton P, Daniels SR, Eckel RH, et al. Summary of the scientific conference on dietary fatty acids and cardiovascular health. Circulation 2001;103: 1034-1039.
25. Salmeron J, Hu FB, Manson JE, et al. Dietary fat intake and risk of type 2 diabetes in women. Am J Clin Nutr 2001; 73:1019-1026.
26. Berry EM. Are diets high in omega 6 polyunsaturated fatty acids unhealthy? Eur Heart J Suppl 2001; 39(suppl D):D37-D41.
27. Berry EM. Who's afraid of n-6 polyunsaturated fatty acids? Methodological considerations for assessing whether they are harmful. Nutr Met Cardiovasc Dis 2001;11:181-188.
28. Raheja BS, Sadikot SM, Phatak RB, et al. Significance of the N-6/N-3 ratio for insulin action in diabetes. Ann NY Acad Sci 1993;683:258-271.
29. Crawford MA. Fatty-acid ratios in free-living and domestic animals. Possible implications for atheroma. Lancet 1968;1:1329-1333.
30. Li D, Ng A, Mann NJ, et al. Contribution of meat fat to dietary arachidonic acid. Lipids 1998;33:437-440.
31. Borkman M, Storlien LH, Pan DA, et al. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N Engl J Med 1993;328:238-244.
32. Andersson A, Nälsén C, Tengblad S, et al. Fatty acid composition of skeletal muscle reflects dietary fat composition in humans. Am J Clin Nutr 2002;76: 1222-1229.
33. Storlien LH, Kraegen EW, Chisholm DJ, et al. Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science 1987;237:885-888.
34. Fernandez-Real JM, Broch M, Vendrell J, et al. Insulin resistaince, inflammation, and serum fatty acid composition. Diabetes Care 2003;26:1362-1368.
35. Montori VM, Farmer A, Wollan PC, et al. Fish oil supplementation in type 2 diabetes: a quantitative systematic review. Diabetes Care 2000;23:1407-1415.
36. Pischon T, Hankinson SE, Hotamisligil GS, et al. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among U.S. men and women. Circulation 2003;108:155-160.
37. Jeremy JY, Mikhailidis DP, Dandona P. Simulating the diabetic environment modifies in vitro prostacyclin synthesis. Diabetes 1983;32:217-221.
38. Mikhailidis DP, Mikhailidis AM, Barradas MA, et al. Effect of nonesterified fatty acids on the stability of prostacyclin activity. Metabolism 1983;32:717-721.
39. Madsen T, Skou HA, Hansen VE, et al. C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease. Am J Cardiol 2001;88:1139-1142.
40. Toborek M, Lee YW, Garrido R, et al. Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells. Am J Clin Nutr 2002;75:119-125.
41. Mori TA, Watts GF, Burke V, et al. Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic-overweight men. Circulation 2000;102:1264-1269.
42. Singh RB, Dubnov G, Niaz MA, et al. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial. Lancet 2002;360:1455-1461.
43. De Lorgeril M, Salen P, Martin JL, et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 1999;99:779-785.
44. GISSI Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999;354:447-455.