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Volumn 122, Issue 1, 2004, Pages 130-139

Rosiglitazone Inhibits Proliferation, Motility, and Matrix Metalloproteinase Production in Keratinocytes

Author keywords

Epidermal growth factor; Hyperplasia; Peroxisome proliferator activated receptor gamma (PPAR gamma); Psoriasis; Thiazolinedione

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIMITOTIC AGENT; BP 11017; BP 1107; EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PIOGLITAZONE; PROTEIN C JUN; ROSIGLITAZONE; UNCLASSIFIED DRUG;

EID: 9144237419     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202X.2003.22111.x     Document Type: Article
Times cited : (55)

References (57)
  • 1
    • 0023624729 scopus 로고
    • Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-alpha and epidermal growth factor
    • Barrandon Y, Green H: Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-alpha and epidermal growth factor. Cell 50:1131-1137, 1987
    • (1987) Cell , vol.50 , pp. 1131-1137
    • Barrandon, Y.1    Green, H.2
  • 3
    • 0342757877 scopus 로고    scopus 로고
    • Independent role of p38 and ERK1/2 mitogen-activated kinases in the upregulation of matrix metalloproteinase-1
    • Brauchle M, Gluck D, Di Padova F, Han J, Gram H: Independent role of p38 and ERK1/2 mitogen-activated kinases in the upregulation of matrix metalloproteinase-1. Exp Cell Res 258:135-144, 2000
    • (2000) Exp Cell Res , vol.258 , pp. 135-144
    • Brauchle, M.1    Gluck, D.2    Di Padova, F.3    Han, J.4    Gram, H.5
  • 4
    • 0033081066 scopus 로고    scopus 로고
    • Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
    • Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouyssegur J: Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J 18:664-674, 1999
    • (1999) EMBO J , vol.18 , pp. 664-674
    • Brunet, A.1    Roux, D.2    Lenormand, P.3    Dowd, S.4    Keyse, S.5    Pouyssegur, J.6
  • 5
    • 0028089832 scopus 로고
    • Epidermal growth factor receptor-mediated cell motility: Phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement
    • Chen P, Xie H, Sekar M, Gupta K, Wells A: Epidermal growth factor receptor-mediated cell motility: Phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement. J Cell Biol 127:847-857, 1994
    • (1994) J Cell Biol , vol.127 , pp. 847-857
    • Chen, P.1    Xie, H.2    Sekar, M.3    Gupta, K.4    Wells, A.5
  • 6
    • 0033889654 scopus 로고    scopus 로고
    • Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo
    • Chung JH, Kang S, Varani J, Lin J, Fisher GJ, Voorhees JJ: Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo. J Invest Dermatol 115:177-182, 2000
    • (2000) J Invest Dermatol , vol.115 , pp. 177-182
    • Chung, J.H.1    Kang, S.2    Varani, J.3    Lin, J.4    Fisher, G.J.5    Voorhees, J.J.6
  • 9
    • 0024554077 scopus 로고
    • Overexpression of transforming growth factor alpha in psoriatic epidermis
    • Elder JT, Fisher GJ, Lindquist PB, et al: Overexpression of transforming growth factor alpha in psoriatic epidermis. Science 243:811-814, 1989
    • (1989) Science , vol.243 , pp. 811-814
    • Elder, J.T.1    Fisher, G.J.2    Lindquist, P.B.3
  • 10
    • 0034030527 scopus 로고    scopus 로고
    • Troglitazone improves psoriasis and normalizes models of proliferative skin disease: Ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation
    • Ellis CN, Varani J, Fisher GJ, et al: Troglitazone improves psoriasis and normalizes models of proliferative skin disease: Ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation. Arch Dermatol 136:609-616, 2000
    • (2000) Arch Dermatol , vol.136 , pp. 609-616
    • Ellis, C.N.1    Varani, J.2    Fisher, G.J.3
  • 11
    • 18344418676 scopus 로고    scopus 로고
    • Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo
    • Fisher GJ, Talwar HS, Lin J, et al: Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J Clin Invest 101:1432-1440, 1998
    • (1998) J Clin Invest , vol.101 , pp. 1432-1440
    • Fisher, G.J.1    Talwar, H.S.2    Lin, J.3
  • 12
    • 0027743070 scopus 로고
    • In situ epithelial cell invasion in organ culture
    • Fligiel SE, Varani J: In situ epithelial cell invasion in organ culture. Invasion Metastasis 13:225-233, 1993
    • (1993) Invasion Metastasis , vol.13 , pp. 225-233
    • Fligiel, S.E.1    Varani, J.2
  • 13
    • 0028972025 scopus 로고
    • 15-Deoxy-delta 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
    • Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM: 15-Deoxy-delta 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83:803-812, 1995
    • (1995) Cell , vol.83 , pp. 803-812
    • Forman, B.M.1    Tontonoz, P.2    Chen, J.3    Brun, R.P.4    Spiegelman, B.M.5    Evans, R.M.6
  • 14
    • 0023720550 scopus 로고
    • Psoriasis
    • Fry L: Psoriasis. Br J Dermatol 119:445-461, 1988
    • (1988) Br J Dermatol , vol.119 , pp. 445-461
    • Fry, L.1
  • 16
    • 0027225936 scopus 로고
    • Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus
    • Gonzalez F, Seth A, Raden D, Bowman D, Fay F, Davis R: Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus. J Cell Biol 122:1089-1101, 1993
    • (1993) J Cell Biol , vol.122 , pp. 1089-1101
    • Gonzalez, F.1    Seth, A.2    Raden, D.3    Bowman, D.4    Fay, F.5    Davis, R.6
  • 17
    • 0023857710 scopus 로고
    • Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes
    • Gottlieb AB, Chang CK, Posnett DN, Fanelli B, Tam JP: Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes. J Exp Med 167:670-675, 1988
    • (1988) J Exp Med , vol.167 , pp. 670-675
    • Gottlieb, A.B.1    Chang, C.K.2    Posnett, D.N.3    Fanelli, B.4    Tam, J.P.5
  • 22
    • 0028972026 scopus 로고
    • A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation
    • Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM: A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83:813-819, 1995
    • (1995) Cell , vol.83 , pp. 813-819
    • Kliewer, S.A.1    Lenhard, J.M.2    Willson, T.M.3    Patel, I.4    Morris, D.C.5    Lehmann, J.M.6
  • 23
    • 0033624558 scopus 로고    scopus 로고
    • Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo
    • Komuves LG, Hanley K, Lefebvre AM, et al: Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. J Invest Dermatol 115:353-360, 2000
    • (2000) J Invest Dermatol , vol.115 , pp. 353-360
    • Komuves, L.G.1    Hanley, K.2    Lefebvre, A.M.3
  • 25
    • 0032145363 scopus 로고    scopus 로고
    • Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo
    • Kubota T, Koshizuka K, Williamson EA, et al: Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res 58:3344-3352, 1998
    • (1998) Cancer Res , vol.58 , pp. 3344-3352
    • Kubota, T.1    Koshizuka, K.2    Williamson, E.A.3
  • 26
    • 0032443309 scopus 로고    scopus 로고
    • Tumor-derived EMMPRIN (extracellular matrix metalloproteinase inducer) stimulates collagenase transcription through MAPK p38
    • Lim M, Martinez T, Jablons D, et al: Tumor-derived EMMPRIN (extracellular matrix metalloproteinase inducer) stimulates collagenase transcription through MAPK p38. FEBS Lett 441:88-92, 1998
    • (1998) FEBS Lett , vol.441 , pp. 88-92
    • Lim, M.1    Martinez, T.2    Jablons, D.3
  • 27
    • 1642428488 scopus 로고    scopus 로고
    • Pioglitazone versus placebo in patients with plaque psoriasis pilot trail (the P6 trail): Study design and preliminary results
    • Malhotra S, Safia N, Pandhi P, Kumar B, Jain R, Aggarwal M: Pioglitazone versus placebo in patients with plaque psoriasis pilot trail (the P6 trail): Study design and preliminary results. J Clin Pharmacol 42:1053 (1013A), 2002
    • (2002) J Clin Pharmacol , vol.42 , Issue.1013 A , pp. 1053
    • Malhotra, S.1    Safia, N.2    Pandhi, P.3    Kumar, B.4    Jain, R.5    Aggarwal, M.6
  • 28
    • 0037068369 scopus 로고    scopus 로고
    • Keratinocyte stimulation of matrix metalloproteinase-1 production and proliferation in fibroblasts: Regulation through mitogen-activated protein kinase signaling events
    • Moon SE, Bhagavathula N, Varani J: Keratinocyte stimulation of matrix metalloproteinase-1 production and proliferation in fibroblasts: Regulation through mitogen-activated protein kinase signaling events. Br J Cancer 87:457-464, 2002
    • (2002) Br J Cancer , vol.87 , pp. 457-464
    • Moon, S.E.1    Bhagavathula, N.2    Varani, J.3
  • 29
    • 0031993322 scopus 로고    scopus 로고
    • Terminal differentiation of human breast cancer through PPAR gamma
    • Mueller E, Sarraf P, Tontonoz P, et al: Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell 1:465-470, 1998
    • (1998) Mol Cell , vol.1 , pp. 465-470
    • Mueller, E.1    Sarraf, P.2    Tontonoz, P.3
  • 30
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
    • Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM: Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 93:229-240, 1998
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.3    Chen, H.4    Evans, R.M.5
  • 31
    • 0024353404 scopus 로고
    • Decreased growth inhibition by recombinant gamma interferon is associated with increased transforming growth factor-alpha production in keratinocytes cultured from psoriatic lesions
    • Nickoloff BJ, Mitra RS, Elder JT, Fisher GJ, Voorhees JJ: Decreased growth inhibition by recombinant gamma interferon is associated with increased transforming growth factor-alpha production in keratinocytes cultured from psoriatic lesions. Br J Dermatol 121:161-174, 1989
    • (1989) Br J Dermatol , vol.121 , pp. 161-174
    • Nickoloff, B.J.1    Mitra, R.S.2    Elder, J.T.3    Fisher, G.J.4    Voorhees, J.J.5
  • 32
    • 0023676193 scopus 로고
    • Modulation of keratinocyte motility: Correlation with production of extracellular matrix molecules in response to growth promoting and antiproliferative factors
    • Nickoloff BJ, Mitra RS, Riser BL, Dixit VM, Varani J: Modulation of keratinocyte motility: Correlation with production of extracellular matrix molecules in response to growth promoting and antiproliferative factors. Am J Pathol 132:543-551, 1988
    • (1988) Am J Pathol , vol.132 , pp. 543-551
    • Nickoloff, B.J.1    Mitra, R.S.2    Riser, B.L.3    Dixit, V.M.4    Varani, J.5
  • 33
    • 0028223727 scopus 로고
    • Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis
    • Nickoloff BJ, Mitra RS, Varani J, Dixit VM, Polverini PJ: Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis. Am J Pathol 144:820-828, 1994
    • (1994) Am J Pathol , vol.144 , pp. 820-828
    • Nickoloff, B.J.1    Mitra, R.S.2    Varani, J.3    Dixit, V.M.4    Polverini, P.J.5
  • 34
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists
    • Olefsky JM: Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest 106:467-472, 2000
    • (2000) J Clin Invest , vol.106 , pp. 467-472
    • Olefsky, J.M.1
  • 35
    • 0031738758 scopus 로고    scopus 로고
    • Autocrine regulation of keratinocytes: The emerging role of heparin-binding, epidermal growth factor-related growth factors
    • Piepkorn M, Pittelkow MR, Cook PW: Autocrine regulation of keratinocytes: The emerging role of heparin-binding, epidermal growth factor-related growth factors. J Invest Dermatol 111:715-721, 1998
    • (1998) J Invest Dermatol , vol.111 , pp. 715-721
    • Piepkorn, M.1    Pittelkow, M.R.2    Cook, P.W.3
  • 36
    • 1642510351 scopus 로고    scopus 로고
    • Proliferation-differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes
    • Piepkorn M, Predd H, Underwood R, Cook P: Proliferation-differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes. Arch Dermatol Res 27:27, 2003
    • (2003) Arch Dermatol Res , vol.27 , pp. 27
    • Piepkorn, M.1    Predd, H.2    Underwood, R.3    Cook, P.4
  • 38
    • 0029026860 scopus 로고
    • Association of mitogen-activated protein kinase with the microtubule cytoskeleton
    • Reszka A, Seger R, Diltz C, Krebs E, Fischer E: Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proc Natl Acad Sci USA 92:8881-8885, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8881-8885
    • Reszka, A.1    Seger, R.2    Diltz, C.3    Krebs, E.4    Fischer, E.5
  • 39
    • 0032570825 scopus 로고    scopus 로고
    • Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways
    • Reunanen N, Westermarck J, Hakkinen L, Holmstrom TH, Elo I, Eriksson JE, Kahari VM: Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways. J Biol Chem 273:5137-5145, 1998
    • (1998) J Biol Chem , vol.273 , pp. 5137-5145
    • Reunanen, N.1    Westermarck, J.2    Hakkinen, L.3    Holmstrom, T.H.4    Elo, I.5    Eriksson, J.E.6    Kahari, V.M.7
  • 40
    • 0034004910 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha enhances lipid metabolism in a skin equivalent model
    • Rivier M, Castiel I, Safonova I, Ailhaud G, Michel S: Peroxisome proliferator-activated receptor-alpha enhances lipid metabolism in a skin equivalent model. J Invest Dermatol 114:681-687, 2000
    • (2000) J Invest Dermatol , vol.114 , pp. 681-687
    • Rivier, M.1    Castiel, I.2    Safonova, I.3    Ailhaud, G.4    Michel, S.5
  • 41
    • 0032448111 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes
    • Rivier M, Safonova I, Lebrun P, Griffiths CE, Ailhaud G, Michel S: Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes. J Invest Dermatol 111:1116-1121, 1998
    • (1998) J Invest Dermatol , vol.111 , pp. 1116-1121
    • Rivier, M.1    Safonova, I.2    Lebrun, P.3    Griffiths, C.E.4    Ailhaud, G.5    Michel, S.6
  • 42
    • 0031671246 scopus 로고    scopus 로고
    • Differentiation and reversal of malignant changes in colon cancer through PPARgamma
    • Sarraf P, Mueller E, Jones D, et al: Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med 4:1046-1052, 1998
    • (1998) Nat Med , vol.4 , pp. 1046-1052
    • Sarraf, P.1    Mueller, E.2    Jones, D.3
  • 43
    • 0037075119 scopus 로고    scopus 로고
    • New strategy for antedrug application: Development of metalloproteinase inhibitors as antipsoriatic drugs
    • Sawa M, Tsukamoto T, Kiyoi T, et al: New strategy for antedrug application: Development of metalloproteinase inhibitors as antipsoriatic drugs. J Med Chem 45:930-936, 2002
    • (2002) J Med Chem , vol.45 , pp. 930-936
    • Sawa, M.1    Tsukamoto, T.2    Kiyoi, T.3
  • 46
    • 0022369738 scopus 로고
    • Pulmonary endothelial cell killing by human neutrophils: Possible involvement of hydroxyl radical
    • Varani J, Fligiel SEG, Till GO, Kunkel RG, Ryan US, Ward PA: Pulmonary endothelial cell killing by human neutrophils: Possible involvement of hydroxyl radical. Lab Invest 53:656-663, 1985
    • (1985) Lab Invest , vol.53 , pp. 656-663
    • Varani, J.1    Fligiel, S.E.G.2    Till, G.O.3    Kunkel, R.G.4    Ryan, U.S.5    Ward, P.A.6
  • 47
    • 0033968021 scopus 로고    scopus 로고
    • Collagenolytic and gelatinolytic matrix metalloproteinases and their inhibitors in basal cell carcinoma of skin: Comparison with normal skin
    • Varani J, Hattori Y, Chi Y, et al: Collagenolytic and gelatinolytic matrix metalloproteinases and their inhibitors in basal cell carcinoma of skin: Comparison with normal skin. Br J Cancer 82:657-665, 2000
    • (2000) Br J Cancer , vol.82 , pp. 657-665
    • Varani, J.1    Hattori, Y.2    Chi, Y.3
  • 48
    • 0030279866 scopus 로고    scopus 로고
    • Perfluorocarbon protects lung epithelial cells from neutrophil-mediated injury in an in vitro model of liquid ventilation therapy
    • Varani J, Hirschl RB, Dame M, Johnson K: Perfluorocarbon protects lung epithelial cells from neutrophil-mediated injury in an in vitro model of liquid ventilation therapy. Shock 6:339-344, 1996
    • (1996) Shock , vol.6 , pp. 339-344
    • Varani, J.1    Hirschl, R.B.2    Dame, M.3    Johnson, K.4
  • 49
    • 0031656035 scopus 로고    scopus 로고
    • Human psoriatic skin in organ culture: Comparison with normal skin exposed to exogenous growth factors and effects of an antibody to the EGF receptor
    • Varani J, Kang S, Stoll S, Elder JT: Human psoriatic skin in organ culture: Comparison with normal skin exposed to exogenous growth factors and effects of an antibody to the EGF receptor. Pathobiology 66:253-259, 1998
    • (1998) Pathobiology , vol.66 , pp. 253-259
    • Varani, J.1    Kang, S.2    Stoll, S.3    Elder, J.T.4
  • 50
    • 0028020613 scopus 로고
    • All-trans retinoic acid (RA) stimulates events in organ-cultured human skin that underlie repair: Adult skin from sun-protected and sun-exposed sites responds in an identical manner to RA while neonatal foreskin responds differently
    • Varani J, Perone P, Griffiths CE, Inman DR, Fligiel SE, Voorhees JJ: All-trans retinoic acid (RA) stimulates events in organ-cultured human skin that underlie repair: Adult skin from sun-protected and sun-exposed sites responds in an identical manner to RA while neonatal foreskin responds differently. J Clin Invest 94:1747-1756, 1994
    • (1994) J Clin Invest , vol.94 , pp. 1747-1756
    • Varani, J.1    Perone, P.2    Griffiths, C.E.3    Inman, D.R.4    Fligiel, S.E.5    Voorhees, J.J.6
  • 51
    • 0035674328 scopus 로고    scopus 로고
    • Heparin-binding epidermal-growth-factor-like growth factor activation of keratinocyte ErbB receptors mediates epidermal hyperplasia, a prominent side-effect of retinoid therapy
    • Varani J, Zeigler M, Dame MK, et al: Heparin-binding epidermal-growth- factor-like growth factor activation of keratinocyte ErbB receptors mediates epidermal hyperplasia, a prominent side-effect of retinoid therapy. J Invest Dermatol 117:1335-1341, 2001
    • (2001) J Invest Dermatol , vol.117 , pp. 1335-1341
    • Varani, J.1    Zeigler, M.2    Dame, M.K.3
  • 52
    • 0032432798 scopus 로고    scopus 로고
    • Enhancement of fibroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38
    • Westermarck J, Holmstrom T, Ahonen M, Eriksson JE, Kahari VM: Enhancement of fibroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38. Matrix Biol 17:547-557, 1998
    • (1998) Matrix Biol , vol.17 , pp. 547-557
    • Westermarck, J.1    Holmstrom, T.2    Ahonen, M.3    Eriksson, J.E.4    Kahari, V.M.5
  • 53
    • 0031561762 scopus 로고    scopus 로고
    • Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging
    • Whisler RL, Chen M, Beiqing L, Carle KW: Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging. Cell Immunol 175:41-50, 1997
    • (1997) Cell Immunol , vol.175 , pp. 41-50
    • Whisler, R.L.1    Chen, M.2    Beiqing, L.3    Carle, K.W.4
  • 55
    • 0032990608 scopus 로고    scopus 로고
    • Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes
    • Zeigler ME, Chi Y, Schmidt T, Varani J: Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes. J Cell Physiol 180:271-284, 1999
    • (1999) J Cell Physiol , vol.180 , pp. 271-284
    • Zeigler, M.E.1    Chi, Y.2    Schmidt, T.3    Varani, J.4
  • 56
    • 0029793434 scopus 로고    scopus 로고
    • Growth factor-induced epidermal invasion of the dermis in human skin organ culture: Expression and role of matrix metalloproteinases
    • Zeigler ME, Dutcheshen NT, Gibbs DF, Varani J: Growth factor-induced epidermal invasion of the dermis in human skin organ culture: Expression and role of matrix metalloproteinases. Invasion Metastasis 16:11-18, 1996b
    • (1996) Invasion Metastasis , vol.16 , pp. 11-18
    • Zeigler, M.E.1    Dutcheshen, N.T.2    Gibbs, D.F.3    Varani, J.4
  • 57
    • 0029793310 scopus 로고    scopus 로고
    • Growth factor-induced epidermal invasion of the dermis in human skin organ culture: Dermal invasion correlated with epithelial cell motility
    • Zeigler ME, Krause S, Karmiol S, Varani J: Growth factor-induced epidermal invasion of the dermis in human skin organ culture: Dermal invasion correlated with epithelial cell motility. Invasion Metastasis 16:3-10, 1996a
    • (1996) Invasion Metastasis , vol.16 , pp. 3-10
    • Zeigler, M.E.1    Krause, S.2    Karmiol, S.3    Varani, J.4


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