Heparin-binding epidermal-growth-factor-like growth factor activation of keratinocyte erbB receptors mediates epidermal hyperplasia, a prominent side-effect of retinoid therapy

Journal of Investigative Dermatology

Volumn 117, Issue 6, 2001, Pages 1335-1341

  Varani, James ^a   Zeigler, Mary ^a   Dame, Michael K ^a   Kang, Sewon ^a   Fisher, Gary J ^a   Voorhees, John J ^a   Stoll, Stefan W ^a   Elder, James T ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

c erbB; EGF like growth factor; Epidermal growth factor receptor; Heparin binding; Human skin organ culture; Retinoic acid

Indexed keywords

4 (3 BROMOANILINO) 6 (METHYLAMINO)PYRIDO[3,4 D]PYRIMIDINE; ANTIBODY; CALCIUM; ENZYME INHIBITOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; LIGAND; MESSENGER RNA; PD 169540; PROTEIN; PROTEIN C ERBB; PROTEIN TYROSINE KINASE; RETINOIC ACID; RETINOL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION FUNCTION; ENZYME ACTIVITY; EPIDERMIS HYPERPLASIA; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMAGE ANALYSIS; KERATINOCYTE; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN; SKIN FIBROBLAST;

EID: 0035674328     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202x.2001.01564.x     Document Type: Article

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