Modulation of tumor oxygenation

International Journal of Radiation Oncology Biology Physics

Volumn 42, Issue 4, 1998, Pages 843-848

  Vaupel, Peter ^a   Kelleher, Debra K ^a   Thews, Oliver ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Cellular respiration rate; Hypoxia; Microcirculation; Microvascular O2 content; Modulation of O2 supply; O2 availability; Oxygenation strategies; Tumor oxygenation

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CARBON MONOXIDE; FLUNARIZINE; HEMOGLOBIN; ISOTRETINOIN; METHYLXANTHINE DERIVATIVE; NICOTINAMIDE; OXYGEN; PENTOXIFYLLINE; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ERYTHROPOIETIN;

CONFERENCE PAPER; DIFFUSION; HEMOGLOBIN DETERMINATION; HISTOPATHOLOGY; MICROCIRCULATION; OXYGEN TISSUE LEVEL; OXYGEN TRANSPORT; PATHOPHYSIOLOGY; PERFUSION; PRIORITY JOURNAL; TUMOR CELL;

ANEMIA; ANIMALS; CARBOXYHEMOGLOBIN; CELL HYPOXIA; ERYTHROCYTE TRANSFUSION; FORECASTING; HEMOGLOBINS; HUMANS; HYPERBARIC OXYGENATION; MICROCIRCULATION; NEOPLASMS; OXYGEN; OXYGEN CONSUMPTION; PARTIAL PRESSURE;

EID: 0031773394     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(98)00324-1     Document Type: Conference Paper

References (61)

1. Molls M., Vaupel P. Medical radiology - diagnostic imaging and radiation oncology. Blood perfusion and microenvironment of human tumors. Implications for clinical radiooncology. 1998;Springer, Berlin.
2. Vaupel P., Kallinowski F., Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors A review . Cancer Res. 49:1989;6449-6465.
3. Vaupel P.W., Kelleher D.K., Guenderoth M. Tumor oxygenation. 1995;Fischer, Stuttgart, Jena.
4. Vaupel P., Thews O., Hoeckel M. Tumor oxygenation Characterization and clinical implications . Smyth J.F., Boogaerts M.A., Ehmer B.R.-M. rhErythropoietin in cancer supportive treatment. 1996;205-239 Marcel Dekker, New York.
5. Vaupel P. The influence of tumor blood flow and microenvironmental factors on the efficacy of radiation, drugs and localized hyperthermia. Klin Pädiatr. 209:1997;243-249.
6. Hoeckel M., Schlenger K., Aral B., Mitze M., Schaeffer U., Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56:1996;4509-4515.
7. Gatenby R.A., Kessler H.B., Rosenblum J.S., Coia L.R., Moldofsky P.J., Hartz W.H. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys. 14:1988;831-838.
8. Hoeckel M., Vaupel P. The prognostic significance of hypoxia in cervical cancer A radiobiological or tumor biological phenomenon? Molls M., Vaupel P. Medical radiology - diagnostic imaging and radiation oncology Blood perfusion and microenvironment of human tumors. Implications for clinical radiooncology . 1998;73-79 Springer, Berlin.
9. 2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol. 26:1993;45-50.
10. Nordsmark M., Overgaard M., Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol. 41:1996;31-39.
11. Vaupel P. Oxygenation of solid tumors. Teicher B.A. Drug resistance in oncology. 1993;53-85 Marcel Dekker, New York.
12. Vaupel P., Hoeckel M. Oxygenation of human tumors. Molls M., Vaupel P. Medical radiology - diagnostic imaging and radiation oncology Blood perfusion and microenvironment of human tumors. Implications for clinical radiooncology . 1998;63-72 Springer, Berlin.
13. Freitas I., Baronzio G.F. Tumor hypoxia, reoxygenation and oxygenation strategies Possible role in photodynamic therapy . J Photochem Photobiol B; Biol. 11:1991;3-30.
14. Gulledge C.J., Dewhirst M.W. Tumor oxygenation A matter of supply and demand . Anticancer Res. 16:1996;741-750.
15. Hirst D.G. Oxygen delivery to tumors. Int J Radiat Oncol Biol Phys. 12:1986;1271-1277.
16. Horsman M.R. Hypoxia in tumours Its relevance, identification, and modification . Beck-Bornholdt H.-P. Medical radiology. Current topics in clinical radiobiology of tumors. 1993;99-112 Springer-Verlag, Berlin.
17. Siemann D.W., Horsman M.R., Chaplin J.D. Modification of oxygen supply. Molls M., Vaupel P. Medical radiology - diagnostic imaging and radiation oncology Blood perfusion and microenvironment of human tumors. Implications for clinical radiooncology . 1998;209-217 Springer, Berlin.
18. 2 concentrations . Adv Exp Med Biol. 428:1997;79-87.
19. Mueller-Klieser W., Vaupel P., Manz R. Tumor oxygenation under normobaric and hyperbaric conditions. Br J Radiol. 56:1983;559-564.
20. Vaupel P. Hypoxia in neoplastic tissue. Microvasc Res. 13:1977;399-408.
21. Dische S. A review of hypoxic cell radiosensitization. Int J Radiat Oncol Biol Phys. 20:1991;147-152.
22. Grau C., Overgaard J. Significance of hemoglobin concentration for treatment outcome. Molls M., Vaupel P. Medical radiology - diagnostic imaging and radiation oncology Blood perfusion and microenvironment of human tumors. Implications for clinical radiooncology . 1998;101-112 Springer, Berlin.
23. Kelleher D.K., Matthiensen U., Thews O., Vaupel P. Tumor oxygenation in anemic rats Effects of erythropoietin treatment versus red blood cell transfusion . Acta Oncol. 34:1995;379-384.
24. Rockwell S. Use of a perfluorochemical emulsion to improve oxygenation in a solid tumour. Int J Radiat Oncol Biol Phys. 11:1985;97-103.
25. Teicher B.A., Sotomayor E.A., Robinson M.F., Dupuis N.P., Schwartz G.N., Frei E. Tumor oxygenation and radiosensitization by pentoxifylline and perflubron emulsion/carbogen breathing. Int J Oncol. 2:1993;13-21.
26. Vitu-Loas L., Thomas C., Chavaudra N., Guichard M. Radiosensitivity, blood perfusion and tumour oxygenation after perflubron emulsion injection. Radiother Oncol. 27:1993;149-155.
27. Robinson M.F., Dupuis N.P., Kusumoto T., Liu F., Menon K., Teicher B.A. Increased tumor oxygenation and radiation sensitivity in two rat tumors by a hemoglobin-based, oxygen-carrying preparation. Artif Cells Blood Substit Immobil Biotechnol. 23:1995;431-438.
28. Teicher B.A., Dupuis N.P., Liu F., Robinson M.F., Menon K. Administration of a hemoglobin solution decreases hypoxia and increases radiation response in a rat mammary adenocarcinoma. Drug Dev Res. 34:1995;231-240.
29. Hahn J.S., Braun R.D., Dewhirst M.W., Shan S., Snyder S.A., Taube J.M., Ong E.T., Rosner G.L., Dodge R.K., Bonaventura J., Bonaventura C., DeAngelo J., Meyer R.E. Stroma-free human hemoglobin A decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure. Radiat Res. 147:1997;185-194.
30. Mueller-Klieser W., Vaupel P. Tetrachlorodecaoxide improves the oxygenation status of multicellular tumor spheroids. Adv Exp Med Biol. 200:1986;623-632.
31. Chaplin D.J., Trotter M.J. Chemical modifiers of tumor blood flow. Vaupel P., Jain R.K. Tumor blood supply and metabolic microenvironment. 1991;65-85 Fischer, Stuttgart. (Funktionsanalyse biolog. Systeme 20).
32. Jain R.K., Ward-Hartley K. Tumor blood flow Characterization, modifications and role in hyperthermia . IEEE Trans Sonics Ultrasonics. 31:1984;504-526.
33. Jirtle R.L. Chemical modification of tumour blood flow. Int J Hyperthermia. 4:1988;355-371.
34. Song C.W. Modification of blood flow. Molls M., Vaupel P. Medical radiology - diagnostic imaging and radiation oncology. Blood perfusion and microenvironment of human tumors Implications for clinical radiooncology . 1998;193-207 Springer, Berlin.
35. Vaupel P. Pathophysiologie der Durchblutung maligner Tumoren. Funktionsanalyse Biolog. Systeme. 8:1982;155-170.
36. Vaupel P., Menke H. Blood flow, vascular resistance and oxygen availability in malignant tumors upon intravenous flunarizine. Adv Exp Med Biol. 215:1987;393-398.
37. Honess D.J., Dennis I.F., Bleehen N.M. Pentoxifylline Its pharmacokinetics and ability to improve tumour perfusion and radiosensitivity in mice . Radiother Oncol. 28:1993;208-218.
38. 2 in a manner compatible with its availability to increase relative tumour perfusion. Acta Oncol. 34:1995;385-389.
39. Lee I., Boucher T.J., Jain R.K. Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline. Br J Cancer. 69:1994;492-496.
40. Song C.W., Hasegawa T., Kwon H.C., Lyons J.C., Levitt S.H. Increase in tumor oxygenation and radiosensitivity caused by pentoxifylline. Radiat Res. 130:1992;205-210.
41. Vaupel P., Menke H. Effect of various calcium antagonists on blood flow and red blood cell flux in malignant tumors. Progr Appl Microcircul. 14:1989;88-103.
42. Kelleher DK, Thews O, Vaupel P. Regional perfusion and oxygenation of tumors upon methylxanthine derivative administration. Int J Radiat Oncol Biol Phys. 1998, in press (this volume).
43. 2 availability during hemodilution A review . Adv Exp Med Biol. 180:1984;281-291.
44. Horsman M.R. Nicotinamide and other benzamide analogs as agents for overcoming hypoxic cell radiation resistance in tumours A review . Acta Oncol. 34:1995;571-587.
45. Kelleher D.K., Vaupel P.W. Nicotinamide exerts different acute effects on microcirculatory function and tissue oxygenation in rat tumors. Int J Radiat Oncol Biol Phys. 26:1993;95-102.
46. Powell M.E.B., Hill S.A., Saunders M.I., Hoskin P.J., Chaplin D.J. Human tumor blood flow is enhanced by nicotinamide and carbogen breathing. Cancer Res. 57:1997;5261-5264.
47. Vaupel P. Pathophysiological mechanisms of hyperthermia in cancer therapy. Gautherie M. Biological basis of oncologic thermotherapy. 1990;73-134 Springer, Berlin.
48. Vaupel P., Kelleher D.K. Metabolic status and reaction to heat of normal and tumor tissue. Seegenschmiedt M.H., Fessenden P., Vernon C.C. Medical radiology - diagnostic imaging and radiation oncology, thermoradiotherapy and thermochemotherapy. 1995;157-176 Springer, Berlin.
49. Kelleher D.K., Engel T., Vaupel P.W. Changes in microregional perfusion, oxygenation, ATP and lactate distribution in subcutaneous rat tumours upon water-filtered IR-A hyperthermia. Int J Hyperthermia. 11:1995;241-255.
50. Jain R.K. 1995 Whitaker Lecture Delivery of molecules, particles, and cells to solid tumors . Ann Biomed Engin. 24:1996;457-473.
51. Baxter L.T., Jain R.K. Vascular and interstitial transport in tumors. Vaupel P., Jain R.K. Tumor blood supply and metabolic microenvironment. 1991;155-164 Fischer, Stuttgart.
52. Secomb T.W., Hsu R., Ong E.T., Gross J.F., Dewhirst M.W. Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol. 34:1995;313-316.
53. Biaglow J.E., Varnes M.E., Jacobson B., Suit H.D. Effect of calcium channel blocking drugs on tumor cell oxygen utilization. Adv Exp Med Biol. 200:1986;583-589.
54. Vaupel P., Mueller-Klieser W. Verapamil inhibits the respiration rate of cancer cells. Adv Exp Med Biol. 200:1986;645-648.
55. Kuin A., Smets L., Volk T., Paans A., Adams G., Atema A., Jähde E., Maas A., Rajewsky M.F., Visser G. Reduction of intratumoral pH by the mitochondrial inhibitor m-iodobenzylguanidine and moderate hyperglycemia. Cancer Res. 54:1994;3785-3792.
56. Thews O., Kelleher D.K., Vaupel P. In vivo oxygen consumption rate of DS-sarcoma cells upon inhibition of DNA synthesis. Cancer Res. 56:1996;2009-2012.
57. Kelleher D.K., Nauth C., Thews O., Krüger W., Vaupel P. Localised hypothermia Impact on oxygenation, microregional perfusion, metabolic and bio-energetic status of subcutaneous rat tumours . Br J Cancer. 78:1998;56-61.
58. Vaupel P., Thews G. Pathophysiological aspects of glucose uptake by the tumor tissue under various conditions of oxygen and glucose supply. Adv Exp Med Biol. 75:1976;547-553.
59. 2 tension measurements . Cancer Res. 51:1991;6098-6102.
60. 2 tension measurements . Cancer Res. 51:1991;3316-3322.
61. Dunst J, Hänsgen G, Krause U, Füchsel G, Köhler U, Becker A. A 2-week-pretreatment with 13-cis-retinoic acid plus interferon-α-2a prior to definitive radiotherapy improves tumor tissue oxygenation in cervical cancers. Strahlenther Onkol. In press.