Design, synthesis and biological activities of antiangiogenic hypoxic cytotoxin, triazine-N-oxide derivatives

Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Volumn 132, Issue 1, 2002, Pages 33-40

  Nagasawa, Hideko ^a   Yamashita, Mao ^a   Mikamo, Naoko ^a   Shimamura, Mariko ^b   Oka, Shigenori ^c   Uto, Yoshihiro ^a   Hori, Hitoshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c Osaka City University Medical School   (Japan)

Author keywords

Angiogenic inhibitor; Apoptosis inducer; Di N oxide; Hypoxia modifier; Hypoxic cytotoxin; p53

Indexed keywords

2,4,6 TRIAMINO 5 NITROSOPYRIMIDINE; ANGIOGENESIS INHIBITOR; CYTOTOXIN; MUTANT PROTEIN; NITROSOPYRIMIDINE; PROTEIN P53; PYRIMIDINE; TIRAPAZAMINE; TRIAZINE DERIVATIVE; TX 1033; TX 1041; TX 1102; TX 402; UNCLASSIFIED DRUG; DNA FRAGMENT;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CHORIOALLANTOIS; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; HYPOXIC CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; TUMOR GROWTH; AEROBIC METABOLISM; ANIMAL; ARTICLE; CELL CULTURE; CELL HYPOXIA; CHEMISTRY; CHICK EMBRYO; DRUG EFFECT; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); SYNTHESIS;

AEROBIOSIS; ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; CELL HYPOXIA; CHICK EMBRYO; CYTOTOXINS; DNA FRAGMENTATION; DRUG DESIGN; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; TRIAZINES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036010210     PISSN: 10956433     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1095-6433(01)00526-8     Document Type: Conference Paper

References (24)

1. The hypoxic cell: A target for selective cancer therapy-Eighteenth Bruce F. Cain memorial award lecture
2. Exploiting the hypoxic cancer cell: Mechanisms and therapeutic strategies
3. The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
4. Tirapazamine: Laboratory data relevant to clinical activity
5. DNA cleavage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (SR4233): Evidence for involvement of hydroxyl radical
6. Pyrimidine N-oxides. Oxidation of 5-nitroso-2,4,6-triaminopyrimidine
7. The design of selectively activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme-prodrug therapies
8. Design, synthesis, and biological activity of anti-angiogenic hypoxic cell radiosensitizer haloacetylcarbamoyl-2-nitroimidazoles
9. Involvement of hydrogen peroxide and hydroxyl radical in chemically induced apoptosis of HL-60 cells
10. An approach to the design and synthesis of mercaptoimidazole derivatives containing oxidized sulfur based on electron affinity sensitization
11. Nitracrine N-oxides: Effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity
12. Tirapazamine (SR 4233) interrupts cell cycle progression and induces apoptosis
13. Combined effects of tirapazamine and mild hyperthermia on anti-angiogenic agent (TNP-470) treated tumors-reference to the effect on intratumor quiescent cells
14. Inhibition of angiogenesis by staurosporine, a potent protein kinase inhibitor
15. Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma
16. Bioreductive therapies: An overview of drugs and their mechanisms of action
17. Microenvironment-induced cancer metastasis
18. A new synthesis of lumichrome
19. Simple synthesis of 3-amino-1,2,4-benzotriazine 1,4-dioxide
20. Optimization of parameters for semi-empirical methods I-method
21. Drug resistance mediated by cellular stress response to the microenvironment of solid tumors
22. Tirapazamine: A new drug producing tumor specific enhancement of platinum-based chemotherapy in non-small-cell lung cancer
23. Structure-activity relationships for benzotriazine di-N-oxides
24. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases