Nonindependent K+ movement through the pore in IRK1 potassium channels

Journal of General Physiology

Volumn 112, Issue 4, 1998, Pages 475-484

  Stampe, Per ^a   Arreola, Jorge ^a   Pérez Cornejo, Patricia ^a   Begenisich, Ted ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Ion permeation; Single channel conductance; Unidirectional flux ratio

Indexed keywords

POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BIOFILTER; CHANNEL GATING; ELECTRIC POTENTIAL; ION CONDUCTANCE; MEMBRANE POTENTIAL; NONHUMAN; NORTHERN BLOTTING; OOCYTE; PERMEABILITY; VOLTAGE CLAMP; XENOPUS;

ANIMALS; ELECTRIC CONDUCTIVITY; ION CHANNEL GATING; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; XENOPUS;

EID: 0031688599     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.112.4.475     Document Type: Article

References (40)

1. + channel reconstituted in lipid bilayers. Biophys. J. 70:2680-2687.
2. Begenisich, T., and M.D. Cahalan. 1980a. Sodium channel permeation in squid axons. I: Reversal potential experiments. J. Physiol. (Camb.). 307:217-242.
3. Begenisich, T., and M.D. Cahalan. 1980b. Sodium channel permeation in squid axons. II: Non-independence and current-voltage relations. J. Physiol. (Camb.). 307:217-242.
4. Begenisich, T., and P. De Weer. 1980. Potassium flux ratio in voltage clamped squid giant axons. J. Gen. Physiol. 76:83-98.
5. Begenisich, T., and C. Smith. 1984. The multi-ion nature of potassium channels in squid axons. In Current Topics in Membranes and Transport. Vol. 22. The Squid Axon. P.F. Baker, editor. Academic Press Inc., New York. 353-369.
6. Bek, S., and E. Jacobsson. 1994. Brownian dynamics study of a multiply-occupied cation channel: application to understanding permeation in potassium channels. Biophys. J. 66:1028-1038.
7. Chen, D., J. Lear, and B. Eisenberg. 1997. Permeation through an open channel: Poisson-Nernst-Planck theory of a synthetic ionic channel. Biophys. J. 72:97-116.
8. Choi, K.L., C. Mossman, C. Aube, and G. Yellen. 1993. The internal quaternary ammonium receptor site of Shaker potassium channels. Neuron. 10:533-541.
9. Dang, T.X., and E.W. McCleskey. 1998. Ion channel selectivity through stepwise changes in binding affinity. J. Gen. Physiol. 111: 185-193.
10. + conduction and selectivity. Science. 280:69-77.
11. Eisenberg, R.S. 1996. Computing the field in proteins and channels. J. Membr. Biol. 150:1-25.
12. + channels. Science. 266:1068-1072.
13. Glasstone, S., K.J. Laidler, and H. Erying. 1941. The theory of rate processes. McGraw-Hill, New York. 611 pp.
14. Goldin, A.L. 1992. Maintenance of Xenopus laevis and oocyte injection. Methods Enzymol. 207:266-279.
15. Heckmann, K. 1972. Single file diffusion. Biomembranes. 3:127-153.
16. + channel signature sequence. Biophys. J. 66: 1061-1067.
17. + channel. Biophys. J. 65:2089-2096.
18. Hille, B., and W. Schwarz. 1978. Potassium channels as multi-ion single-file pores. J. Gen. Physiol. 72:409-442.
19. Hodgkin, A.L., and R.D. Keynes. 1955. The potassium permeability of a giant nerve fibre. J. Physiol. (Camb.). 128:61-88.
20. Horowicz, P., P.W. Gage, and R.S. Eisenberg. 1968. The role of electrochemical gradient in determining potassium fluxes in frog striated muscle. J. Gen. Physiol. 51:193s-203s.
21. + channel. Nature. 353: 86-90.
22. Kielland, J. 1937. Individual activity coefficients of ions in aqueous solutions. J. Am. Chem. Soc. 59:1657-1678.
23. Kiss, L., D. Immke, J. LoTurco, and S.J. Korn. 1998. The interaction of Na and K in voltage-gated potassium channels. Evidence for cation binding sites of different affinity. J. Gen. Physiol. 111:195-206.
24. Kubo, Y., T.J. Baldwin, Y.N. Jan, and L.Y. Jan. 1993. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature. 362:127-133.
25. Lu, Z., and R. MacKinnon. 1994. A conductance maximum observed in an inward-rectifier potassium channel. J. Gen. Physiol. 104:477-486.
26. Levitt, D.G. 1986. Interpretation of biological ion channel flux data: reaction-rate versus continuum theory. Annu. Rev. Biophys. Biophys. Chem. 15:29-57.
27. +] dependence of open-channel conductance of cloned inward rectifier potassium channels (IRK1, Kir2.1). Biophys. J. 71:682-694.
28. Lopatin, A.N., E.N. Makhina, and C.G. Nichols. 1994. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature. 372:366-369.
29. + channel comprises part of the pore. Nature. 367:179-182.
30. + channel. J. Gen. Physiol. 92:569-586.
31. + channels. Biophys. J. 66:1929-1938.
32. + channel. Biophys. J. 63:1032-1044.
33. Slesinger, P.A., Y.N. Jan, and L.Y. Jan. 1993. The S4-S5 loop contributes to the ion-selective pore of potassium channels. Neuron. 11:739-749.
34. Spalding, B.C., O. Senyk, J.G. Swift, and P. Horowicz. 1981. Unidirectional flux ratio for potassium ions in depolarized frog skeletal muscle. Am. J. Physiol. 241:68-75.
35. Stampe, P., and T. Begenisich. 1996. Unidirectional K fluxes through recombinant Shaker potassium channels expressed in single Xenopus oocytes. J. Gen. Physiol. 107:449-457.
36. Stampe, P., and T. Begenisich. 1998. Unidirectional fluxes through ion channels expressed in Xenopus oocytes. Methods Enzymol. 293: 556-564.
37. Ussing, H.H. 1949. The distinction by means of tracers between active transport and diffusion. The transfer of iodide across the isolated frog skin. Acta Physiol. Scand. 19:43-56.
38. + channel of human red cells. J. Membr. Biol. 88:67-75.
39. Wagoner, K.P., and G.S. Oxford. 1987. Cation permeation through the voltage-dependent potassium channel in the squid axon. Characteristics and Mechanisms. J. Gen. Physiol. 90:261-290.
40. + channel. Neuron. 14:1047-1054.