Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 45, 2004, Pages 15992-15997

  Fearnhead, Nicola S ^a   Wilding, Jennifer L ^a   Winney, Bruce ^a   Tonks, Susan ^a   Bartlett, Sylvia ^a   Bicknell, David C ^a   Tomlinson, Ian P M ^b   Mortensen, Neil J McC ^a   Bodmer, Walter F ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Cancer; Founder; Mismatch repair; Polyposis; Subpolymorphic

Indexed keywords

AXIN; BETA CATENIN;

ADENOMATOUS POLYP; ADULT; AGED; ARTICLE; BLOOD SAMPLING; COLON ADENOMA; COLORECTAL TUMOR; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE; GENE MUTATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GERM LINE; HMLH1 GENE; HMSH2 GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; MISMATCH REPAIR; MULTIFACTORIAL INHERITANCE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECTUM ADENOMA;

ADENOMA; ALLELES; BASE PAIR MISMATCH; BASE SEQUENCE; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA REPAIR; DNA, NEOPLASM; GENE FREQUENCY; GENES, APC; GERM-LINE MUTATION; HUMANS; MICROSATELLITE REPEATS; MODELS, GENETIC; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; VARIATION (GENETICS);

EID: 8644235804     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0407187101     Document Type: Article

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