The APC I1307K allele and cancer risk in a community-based study of Ashkenazi jews

Nature Genetics

Volumn 20, Issue 1, 1998, Pages 62-65

  Woodage, Trevor ^a   King, Sonya M ^a   Wacholder, Sholom ^b   Hartge, Patricia ^b   Struewing, Jeffery P ^b   McAdams, Mary ^c   Laken, Steven J ^d   Tucker, Margaret A ^b   Brody, Lawrence C ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c INFORMATION MANAGEMENT SERVICES INC   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYP; ALLELE; ARTICLE; BREAST CARCINOMA; CANCER RISK; COLORECTAL CANCER; FAMILIAL COLON POLYPOSIS; GENE FREQUENCY; GENOTYPE; HUMAN; INTESTINE POLYP; JEW; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE; ADULT; AGED; BREAST TUMOR; COLORECTAL TUMOR; COMPARATIVE STUDY; ETHNOLOGY; EUROPE; FEMALE; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOTE; MALE; MIDDLE AGED; MUTATION; NEOPLASM; RISK;

APC PROTEIN; BRCA1 PROTEIN; CYTOSKELETON PROTEIN;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ADULT; AGED; AGED, 80 AND OVER; ALLELES; BRCA1 PROTEIN; BREAST NEOPLASMS; COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; EUROPE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMANS; JEWS; MALE; MIDDLE AGED; MUTATION; NEOPLASMS; ODDS RATIO;

EID: 0031595693     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/1722     Document Type: Article

References (20)

1. Petersen, G.M. Knowledge of the adenomatous polyposis coli gene and its clinical application. Ann. Med. 26, 205-208 (1994).
2. Laken, S.J. et al. Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nature Genet. 17, 79-83 (1997).
3. Struewing, J.P. et al. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N. Engl. J. Med. 336, 1401-1408 (1997).
4. Wacholder, S. et al. The kin-cohort study for estimating penetrance. Amer. J. Epidemiology, in press (1998).
5. Feuer, E.J. et al. The lifetime risk of developing breast cancer. J. Natl Cancer Inst. 85, 892-897 (1993).
6. Feuer, E.J. & Wun, L.M. DEVCAN: Probability of DEVeloping CANcer Software National Cancer Institute, Bethesda (1997).
7. Petrukhin, L. et al. The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds. Cancer Res. 57, 5480-5484 (1997).
8. Thompson, A.M. et al. Allele loss from 5q21 (APC/MCC and 18q21 (DCC) and DCC mRNA expression in breast cancer. Br. J. Cancer 68, 64-68 (1993).
9. Kashiwaba, M., Tamura, G. & Ishida, M. Aberrations of the APC gene in primary breast carcinoma. J. Cancer Res. Clin. Oncol. 120, 727-731 (1994).
10. Medeiros, A.C., Nagai, M.A., Neto, M.M. & Brentani, R.R. Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas. Cancer Epidemiol. Biomarkers Prev. 3, 331-333 (1994).
11. Nugent, K.P., Spigelman, A.D. & Phillips, R.K. Risk of extracolonic cancer in familial adenomatous polyposis. Br. J. Surg. 83, 1121-1122 (1996).
12. Min, a mutation in the murine Ape gene, predisposes to mammary carcinomas and focal alveolar hyperplasias. Proc. Natl Acad. Sci. USA 90, 8977-8981 (1993).
13. Redston, M. et al. The APC I1307K polymorphism and breast cancer risk. Nature Genet. 20, 13-14 (1998).
14. Giardiello, F.M. et al. Risk of hepatoblastoma in familial adenomatous polyposis. J. Pediatr. 119, 766-768 (1991).
15. Hamilton, S.R. et al. The molecular basis of Turcot's syndrome. N. Engl. J. Med. 332, 839-847 (1995).
16. Fearon, E.R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759-767 (1990).
17. Morin, P.J. et al. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275, 1787-1790 (1997).
18. Rubinfeld, B. et al. Stabilization of β-catenin by genetic defects in melanoma cell lines. Science 275, 1790-1792 (1997).
19. Caporaso, N., DeBaun, M.R. & Rothman, N. Lung cancer and CYP2D6 (the debrisoquine polymorphism): sources of heterogeneity in the proposed association. Pharmocogenetics 5, S129-134 (1995).
20. Perera, F.P. Environment and cancer: who are susceptible? Science 278, 1068-1073 (1997).