Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16

American Journal of Human Genetics

Volumn 58, Issue 2, 1996, Pages 300-307

  Wijnen, Juul ^b   Meera Khan, P ^a   Vasen, Hans ^b   Menko, Fred ^b   Van Klift, Heleen Der ^b   Van Broek, Marianne Den ^b   Van Leeuwen Cornelisse, Inge ^b   Nagengast, Fokko ^b   Meijers Heijboer, E J ^b   Lindhout, Dick ^b   Griffioen, Gerrit ^b   Cats, Annemieke ^b   Kleibeuker, Jan ^b   Varesco, Liliana ^b   Bertario, Lucio ^b   Bisgaard, Marie Luise ^b   Mohr, Jan ^b   Kolodner, Richard ^b   Fodde, Riccardo ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN;

ARTICLE; COLORECTAL CANCER; DENATURING GRADIENT GEL ELECTROPHORESIS; DNA SEQUENCE; EXON; GENE; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

BASE SEQUENCE; CARRIER PROTEINS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA PRIMERS; DNA REPAIR; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EUROPE; EXONS; FEMALE; GENES, DOMINANT; GERM-LINE MUTATION; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PEDIGREE; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS;

EID: 19144365420     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Aaltonen L, Peltomäki P, Leach FS, Sistonen P, Pylkkänen L, MecklinJ-P,JärvinenH, etal (1993) Clues to the pathogenesis of familial colorectal cancer. Science 260:812-816
2. Aaltonen L, Peltomäki P, Mecklin J-P, Järvinen H, Jass JR, Green JS, Lynch HT, et al (1994) Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res 54:1645-1648
3. Burks RT, Kessis TD, Cho KR, Hedrick L (1994) Microsatellite instability in endometrial carcinoma. Oncogene 9:1163-1166
4. Fishel R, Lescoe MK, Rao MRS, Copeland NG, Jenkins NA, Garber J, Kane M, et al (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75:1027-1038
5. Fodde R, Losekoot M (1994) Mutation detection by denaturing gradient gel electrophoresis (DGGE). Hum Mutat 3:8394