2-pyridinyl-3(4-methylsulfonyl)phenylpyridines: Selective and orally active cyclooxygenase-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 19, 1998, Pages 2777-2782

  Friesen, Richard W ^a   Brideau, Christine ^a   Chan, Chi Chung ^a   Charleson, Stella ^a   Deschênes, Denis ^a   Dubé, Daniel ^a   Ethier, Diane ^a   Fortin, Réjean ^a   Gauthier, Jacques Yves ^a   Girard, Yves ^a   Gordon, Robert ^a   Greig, Gillian M ^a   Riendeau, Denis ^a   Savoie, Chantai ^a   Wang, Zhaoyin ^a   Wong, Elizabeth ^a   Visco, Denise ^a   Xu, Li Jing ^a   Young, Robert N ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLORO 3 (4 METHYLSULFONYL)PHENYL 2 (2 METHYL 5 PYRIDINYL)PYRIDINE; CYCLOOXYGENASE 2 INHIBITOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHO CELLS; CRICETINAE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; EDEMA; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032491270     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00499-5     Document Type: Article

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