Replication of adeno-associated virus dna

Parvoviruses

Volumn , Issue , 2005, Pages 189-211

  Ward, Peter ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

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EID: 85145141273     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (188)

1. Agrawal, N., Mane, M., Chiriva-Internati, M. et al. 2002. Temporal acceleration of the human papillomavirus life cycle by adeno-associated virus (AAV) type 2 superinfection in natural host tissue. Virology 297: 203-10.
2. Alexander, I. E., Russell, D. W. and Miller, A. D. 1994. DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors. Journal of Virology 68: 8282-7.
3. Alexander, I. E., Russell, D. W., Spence, A. M. and Miller, A. D. 1996. Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno- associated virus vectors. Human Gene Therapy 7: 841-50.
4. Allen, J. M., Halbert, C. L. and Miller, A. D. 2000. Improved adeno- associated virus vector production with transfection of a single helper adenovirus gene, E4orf6. Molecular Therapy 1: 88-95.
5. Ashktorab, H. and Srivastava, A. 1989. Identification of nuclear proteins that specifically interact with adeno-associated virus type 2 inverted terminal repeat hairpin DNA. Journal of Virology 63: 3034-9.
6. Atchison, R. W., Casto, B. C. and Hammon, W. M. 1965. Adenovirus- associated defective virus particles. Science 149: 754-6.
7. Bantel-Schaal, U. and zur Hausen, H. 1988. Dissociation of carcinogen-induced SV40 DNA-amplification and amplification of AAV DNA in a Chinese hamster cell line. Virology 166: 113-22.
8. Berns, K. I. and Adler, S. 1972. Separation of two types of adeno- associated virus particles containing complementary polynucleotide chains. Journal ofVirology 9: 394-6.
9. Berns, K. I. and Hauswirth, W. W. 1979. Adeno-associated viruses. Advances in Virus Research 25: 407 -49.
10. Berns, K. I. and Rose, J. A. 1970. Evidence for a single-stranded adenovirus-associated virus genome: isolation and separation of complementary single strands. Journal ofVirology 5: 693-9.
11. Blacklow, N. R., Dolin, R. and Hoggan, M. D. 1971. Studies of the enhancement of an adenovirus-associated virus by herpes simplex virus. Journal of General Virology 10: 29-36.
12. Blacklow, N. R., Hoggan, M. D. and McClanahan, M. S. 1970. Adenovirus-associated viruses: enhancement by human herpesviruses. Proceedings of Society ofExperimental Biology and Medicine 134: 952-4.
13. Bohenzky, R. A. and Berns, K. I. 1989. Interactions between the termini of adeno-associated virus DNA. Journal of Molecular Biology 206: 91-100.
14. Bohenzky, R. A., LeFebvre, R. B. and Berns, K. I. 1988. Sequence and symmetry requirements within the internal palindromic sequences of the adeno-associated virus terminal repeat. Virology 166: 316-27.
15. Brister, J. R. and Muzyczka, N. 2000. Mechanism of Rep-mediated adeno-associated virus origin nicking. Journal ofVirology 74: 7762-71.
16. Brister, J. R. and Muzyczka, N. 1999. Rep-mediated nicking of the adeno-associated virus origin requires two biochemical activities, DNA helicase activity and transesterification. Journal ofVirology 73: 9325-36.
17. Brown, K. E., Green, S. W. and Young, N. S. 1995. Goose parvovirus-an autonomous member of the dependovirus genus? Virology 210: 283-91.
18. Buller, R. M., Janik, J. E., Sebring, E. D. and Rose, J. A. 1981. Herpes simplex virus types 1 and 2 completely help adenovirus- associated virus replication. Journal ofVirology 40: 241-7.
19. Carter, B. J. 1990a. Adeno-associated virus helper functions. In: P. Tijssen, Handbook of Parvoviruses, Vol. 1. Boca Raton, Fl.: CRC Press, Inc., pp. 255-82.
20. Carter, B. J. 1990b. The growth cycle of adeno-associated virus. In: P. Tijssen, Handbook of Parvoviruses, Vol. 1. Boca Raton, Fl.: CRC Press, Inc., pp. 155-168.
21. Carter, B. J., Khoury, G. and Rose, J. A. 1972. Adenovirus-associated virus multiplication. IX. Extent of transcription of the viral genome in vivo. Journal ofVirology 10: 1118-25.
22. Carter, B. J., Marcus-Sekura, C. J., Laughlin, C. A. and Ketner, G. 1983. Properties of an adenovirus type 2 mutant, Ad2dl807: having a deletion near the right-hand genome terminus: failure to help AAV replication. Virology 126: 505-16.
23. Carter, B. J., Mendelson, E. and Trempe, J. P. 1990. AAV DNA replication, integration and genetics. In: P. Tijssen, Handbook of Parvoviruses, Vol. 1. Boca Raton, Fl.: CRC Press, Inc., pp. 169-226.
24. Carter, B. J., Antoni, B. A. and Klessig, D. F. 1992. Adenovirus containing a deletion of the early region 2A gene allows growth of adeno-associated virus with decreased efficiency. Virology 191: 473-6.
25. Casto, B. C. and Goodheart, C. R. 1972. Inhibition of adenovirus transformation in vitro by AAV1. Proceedings of Society of Experimental Biology and Medicine 140: 72-8.
26. Cathomen, T., Stracker, T. H., Gilbert, L. B. and Weitzman, M. D. 2001. A genetic screen identifies a cellular regulator of adeno- associated virus. Proceedings of NationalAcademy of Sciences USA 98: 14991-6.
27. Cavalier-Smith, T. 1974. Palindromic base sequences and replication of eukaryotic chromosome ends. Nature 250: 467-70.
28. Chadeuf, G., Favre, D., Tessier, J. etal. 2000. Efficient recombinant adeno-associated virus production by a stable rep-cap HeLa cell line correlates with adenovirus-induced amplification of the integrated rep-cap genome. Journal of Gene Medicine 2: 260-8.
29. Challberg, M. D. 1986. A method for identifying the viral genes required for herpesvirus DNA replication. Proceedings of National Academy of Sciences USA 83: 9094-8.
30. Chang, L. S. and Shenk, T. 1990. The adenovirus DNA-binding protein stimulates the rate of transcription directed by adenovirus and adeno-associated virus promoters. Journal ofVirology 64: 2103-9.
31. Chang, L. S., Shi, Y. and Shenk, T. 1989. Adeno-associated virus P5 promoter contains an adenovirus E1A-inducible element and a binding site for the major late transcription factor. Journal of Virology 63: 3479-88.
32. Chejanovsky, N. and Carter, B. J. 1989. Mutagenesis of an AUG codon in the adeno-associated virus rep gene: effects on viral DNA replication. Virology 173: 120-8.
33. Cheung, A. K., Hoggan, M. D., Hauswirth, W. W. and Berns, K. I. 1980. Integration of the adeno-associated virus genome into cellular DNA in latently infected human Detroit 6 cells. Journal of Virology 33: 739-48.
34. Chiorini, J. A., Weitzman, M. D., Owens, R. A. et al. 1994a. Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli. Journal ofVirology 68: 797-804.
35. Chiorini, J. A., Wiener, S. M., Owens, R. A. et al. 1994b. Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats. Journal of Virology 68: 7448-57.
36. Chiorini, J. A., Wendtner, C. M., Urcelay, E. et al. 1995a. High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors. Human Gene Therapy 6: 1531-41.
37. Chiorini, J. A., Yang, L., Safer, B. and Kotin, R. M. 1995b. Determination of adeno-associated virus Rep68 and Rep78 binding sites by random sequence oligonucleotide selection. Journal ofVirology 69: 7334-8.
38. Collaco, R., Prasad, K. M. and Trempe, J. P. 1997. Phosphorylation of the adeno-associated virus replication proteins. Virology 232: 332-6.
39. Conway, J., Rhys, C., Zolotukhin, I. et al. 1999. High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV2 Rep and Cap. Gene Therapy 6: 986-93.
40. Conway, J. E., Zolotukhin, S., Muzyczka, N. et al. 1997. Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and Cap. Journal ofVirology 71: 8780-9.
41. Cossons, N., Zannis-Hadjopoulos, M., Tam, P. et al. 1996. The effect of regulatory sequence elements upon the initiation of DNA replication of the minute virus of mice. Virology 224: 320-5.
42. Costello, E., Saudan, P., Winocour, E. et al. 1997. High mobility group chromosomal protein 1 binds to the adeno-associated virus replication protein (Rep) and promotes Rep-mediated site- specific cleavage of DNA, ATPase activity and transcriptional repression. Embo Journal 16: 5943-54.
43. Cotmore, S. F. and Tattersall, P. 2003. Resolution of parvovirus dimer junctions proceeds through a novel heterocruciform intermediate. Journal ofVirology 77: 6245-54.
44. Crawford, L. V., Follett, E. A., Burdon, M. G. and McGeoch, D. J. 1969. The DNA of a minute virus of mice. Journal of General Virology 4: 37-46.
45. Davis, M. D., Wu, J. and Owens, R. A. 2000. Mutational analysis of adeno-associated virus type 2 Rep68 protein endonuclease activity on partially single-stranded substrates. Journal of Virology 74: 2936-42.
46. de la Maza, L. M. and Carter, B. J. 1980. Molecular structure of adeno- associated virus variant DNA. Journal ofBiological Chemistry 255: 3194-203.
47. Duan, D., Yan, Z., Yue, Y. and Engelhardt, J. F. 1999. Structural analysis of adeno-associated virus transduction circular intermediates. Virology 261: 8-14.
48. Duan, D., Yue, Y., Yan, Z. and Engelhardt, J. F. 2000. A new dual-vector approach to enhance recombinant adeno-associated virus- mediated gene expression through intermolecular cis activation. Natural Medicine 6: 595-8.
49. Dubielzig, R., King, J. A., Weger, S. et al. 1999. Adeno-associated virus type 2 protein interactions: formation of pre-encapsidation complexes. Journal ofVirology 73: 8989-98.
50. Fan, P. D. and Dong, J. Y. 1997. Replication of rep-cap genes is essential for the high-efficiency production of recombinant AAV. Human Gene Therapy 8: 87-98.
51. Ferrari, F. K., Samulski, T., Shenk, T. and Samulski, R. J. 1996. Second- strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. Journal of Virology 70: 3227-34.
52. Fisher, K. J., Gao, G. P., Weitzman, M. D. et al. 1996. Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis. Journal ofVirology 70: 520-32.
53. Fournier, N., Raj, K., Saudan, P. et al. 1999. Expression of human papillomavirus 16 E2 protein in Schizosaccharomyces pombe delays the initiation of mitosis. Oncogene 18: 4015-21.
54. Fraefel, C., Bittermann, A. G., Bueler, H. et al. 2004. Spatial and temporal organization of adeno-associated virus DNA replication in live cells. Journal ofVirology 78: 389-98.
55. Gao, G., Alvira, M. R., Somanathan, S. et al. 2003. Adeno-associated viruses undergo substantial evolution in primates during natural infections. Proceedings of National Academy of Sciences USA 100: 6081-6.
56. Gao, G. P., Lu, F., Sanmiguel, J. C. et al. 2002. rep/cap gene amplification and high-yield production of AAV in an A549 cell line expressing rep/cap. Molecular Therapy 5: 644-9.
57. Gerry, H. W., Kelly, T. J., Jr. and Berns, K. I. 1973. Arrangement of nucleotide sequences in adeno-associated virus DNA. Journal of Molecular Biology 79: 207-25.
58. Gottlieb, J. and Muzyczka, N. 1988. In vitro excision of adeno- associated virus DNA from recombinant plasmids: isolation of an enzyme fraction from HeLa cells that cleaves DNA at poly(G) sequences. Molecular Cell Biology 8: 2513-22.
59. Grifman, M., Chen, N. N., Gao, G. P. et al. 1999. Overexpression of cyclin A inhibits augmentation of recombinant adeno-associated virus transduction by the adenovirus E4orf6 protein. Journal of Virology 73: 10010-19.
60. Grimm, D., Kern, A., Rittner, K. and Kleinschmidt, J. A. 1998. Novel tools for production and purification of recombinant adeno- associated virus vectors. Human Gene Therapy 9: 2745-60.
61. Grossman, Z., Winocour, E. and Berns, K. I. 1984. Recombination between simian virus 40 and adeno-associated virus: virion coinfection compared to DNA cotransfection. Virology 134: 125-37.
62. Grossman, Z., Berns, K. I. and Winocour, E. 1985. Structure of simian virus 40-adeno-associated virus recombinant genomes. Journal of Virology 56: 457-65.
63. Han, S. I., Kawano, M. A., Ishizu, K. et al. 2004. Rep68 protein of adeno- associated virus type 2 interacts with 14-3-3 proteins depending on phosphorylation at serine 535. Virology320: 144-55.
64. Hauswirth, W. W. and Berns, K. I. 1977. Origin and termination of adeno-associated virus DNA replication. Virology 78: 488-99.
65. Hauswirth, W. W. and Berns, K. I. 1979. Adeno-associated virus DNA replication: nonunit-length molecules. Virology 93: 57-68.
66. Heilbronn, R., Schlehofer, J. R. and zur Hausen, H. 1984. Selective killing of carcinogen-treated SV40-transformed Chinese hamster cells by a defective parvovirus. Virology 136: 439-41.
67. Heilbronn, R., Engstler, M., Weger, S. et al. 2003. ssDNA-dependent colocalization of adeno-associated virus Rep and herpes simplex virus ICP8 in nuclear replication domains. NucleicAcids Research 31: 6206-13.
68. Hermonat, P. L. 1991. Inhibition of H-ras expression by the adeno- associated virus Rep78 transformation suppressor gene product. Cancer Research 51: 3373-7.
69. Hermonat, P. L., Labow, M. A., Wright, R. et al. 1984. Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants. Journal of Virology 51: 329-39.
70. Hogan, A. and Faust, E. A. 1984. Short direct repeats mediate spontaneous high-frequency deletions in DNA of minute virus of mice. Molecular Cell Biology 4: 2239-42.
71. Hoggan, M. D. 1970. Adenovirus associated viruses. Progress in Medical Virology 12: 211-39.
72. Hoggan, M. D., Blacklow, N. R. and Rowe, W. P. 1966. Studies of small DNA viruses found in various adenovirus preparations: physical, biological and immunological characteristics. Proceedings of NationalAcademy of Sciences USA 55: 1467-74.
73. Hoggan, M. D., Thomas, G. F., Thomas, F. B. and Fohnson, F. B. 1972. In: Proceedings of the 4th Lepetite Colloquium. Cocoyac, Mexico. Amsterdam: Elsevier-North Holland, pp. 243.
74. Holscher, C., Horer, M., Kleinschmidt, J. A. et al. 1994. Cell lines inducibly expressing the adeno-associated virus (AAV) rep gene: requirements for productive replication of rep-negative AAV mutants. Journal of Virology 68: 7169-77.
75. Holscher, C., Kleinschmidt, J. A. and Burkle, A. 1995. High-level expression of adeno-associated virus (AAV) Rep78 or Rep68 protein is sufficient for infectious-particle formation by a rep-negative AAV mutant. Journal of Virology 69: 6880-5.
76. Hong, G., Ward, P. and Berns, K. I. 1992. In vitro replication of adeno-associated virus DNA. Proceedings of National Academy of Sciences USA 89: 4673-7.
77. Im, D. S. and Muzyczka, N. 1990. The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity. Cell 61: 447-57.
78. Kirschstein, R. L., Smith, K. O. and Peters, E. A. 1968. Inhibition of adenovirus 12 oncogenicity by adeno-associated virus. Proceedings of Society ofExperimental Biology and Medicine 128: 670-3.
79. Kisary, J. 1979. Interaction in replication between goose parvovirus strain B and duck plague herpesvirus. Archives of Virology 59: 81-8.
80. Kitajewski, J., Schneider, R. J., Safer, B. et al. 1986. Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase. Cell 45: 195-200.
81. Koczot, F. J., Carter, B. J., Garon, C. F. and Rose, J. A. 1973. Self- complementarity of terminal sequences within plus or minus strands of adenovirus-associated virus DNA. Proceedings of National Academy ofSciences USA 70: 215-9.
82. Koonin, E. V. 1993. A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication. Nucleic Acids Research 21: 2541-7.
83. Koonin, E. V. and Ilyina, T. V. 1993. Computer-assisted dissection of rolling-circle DNA replication. Biosystems 30: 241-68.
84. Kotin, R. M., Siniscalco, M., Samulski, R. J. et al. 1990. Site-specific integration by adeno-associated virus. Proceedings of National Academy of Sciences USA 87: 2211-5.
85. Kube, D. M., Ponnazhagan, S. and Srivastava, A. 1997. Encapsidation of adeno-associated virus type 2 Rep proteins in wild-type and recombinant progeny virions: Rep-mediated growth inhibition of primary human cells. Journal of Virology 71: 7361-71.
86. Kyostio, S. R., Wonderling, R. S. and Owens, R. A. 1995. Negative regulation of the adeno-associated virus (AAV) P5 promoter involves both the P5 rep binding site and the consensus ATP- binding motif of the AAV Rep68 protein. Journal of Virology 69: 6787-96.
87. Laughlin, C. A., Jones, N. and Carter, B. J. 1982. Effect of deletions in adenovirus early region 1 genes upon replication of adeno- associated virus. Journal of Virology 41: 868-76.
88. Laughlin, C. A., Tratschin, J. D., Coon, H. and Carter, B. J. 1983. Cloning of infectious adeno-associated virus genomes in bacterial plasmids. Gene 23: 65-73.
89. Lechner, R. L. and Kelly, T. J. 1977. The structure of replicating adenovirus 2 DNA molecules. Cell 12: 1007 -20.
90. Lefebvre, R. B., Riva, S. and Berns, K. I. 1984. Conformation takes precedence over sequence in adeno-associated virus DNA replication. Molecular Cell Biology 4: 1416-9.
91. Li, J., Samulski, R. J. and Xiao, X. 1997. Role for highly regulated rep gene expression in adeno-associated virus vector production. Journal of Virology 71: 5236-43.
92. Li, Z., Brister, J. R., Im, D. S. and Muzyczka, N. 2003. Characterization of the adeno-associated virus Rep protein complex formed on the viral origin of DNA replication. Virology 313: 364-76.
93. Lukonis, C. J. and Weller, S. K. 1997. Formation of herpes simplex virus type 1 replication compartments by transfection: requirements and localization to nuclear domain 10. Journal of Virology 71: 2390-9.
94. Lusby, E., Bohenzky, R. and Berns, K. I. 1981. Inverted terminal repetition in adeno-associated virus DNA: independence of the orientation at either end of the genome. Journal of Virology 37: 1083-6.
95. Lusby, E., Fife, K. H. and Berns, K. I. 1980. Nucleotide sequence of the inverted terminal repetition in adeno-associated virus DNA. Journal of Virology 34: 402-9.
96. McCarty, D. M., Pereira, D. J., Zolotukhin, I. etal. 1994a. Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein. Journal of Virology 68: 4988-97.
97. McCarty, D. M., Ryan, J. H., Zolotukhin, S. et al. 1994b. Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat. Journal of Virology 68: 4998-5006.
98. McPherson, R. A., Rosenthal, L. J. and Rose, J. A. 1985. Human cytomegalovirus completely helps adeno-associated virus replication. Virology 147: 217-22.
99. Matsushita, T., Elliger, S., Elliger, C. et al. 1998. Adeno-associated virus vectors can be efficiently produced without helper virus. Gene Therapy 5: 938-45.
100. Mayor, H. D., Torikai, K., Melnick, J. L. and Mandel, M. 1969. Plus and minus single-stranded DNA separately encapsidated in adeno- associated satellite virions. Science 166: 1280-2.
101. Meyers, C., Mane, M., Kokorina, N. et al. 2000. Ubiquitous human adeno-associated virus type 2 autonomously replicates in differentiating keratinocytes of a normal skin model. Virology 272: 338-46.
102. Meyers, C., Alam, S., Mane, M. and Hermonat, P. L. 2001. Altered biology of adeno-associated virus type 2 and human papillomavirus during dual infection of natural host tissue. Virology 287: 30-9.
103. Mori, S., Murakami, M., Takeuchi, T. et al. 2002. Rescue of AAV by antibody-induced Fas-mediated apoptosis from viral DNA integrated in HeLa chromosome. Virology 301: 90-8.
104. Musatov, S., Roberts, J., Pfaff, D. and Kaplitt, M. 2002. A c/s-acting element that directs circular adeno-associated virus replication and packaging. Journal ofVirology 76: 12792-802.
105. Muzyczka, N. 1992. Use of adeno-associated virus as a general transduction vector for mammalian cells. Current Topics in Microbiology and Immunology 158: 97-129.
106. Muzyczka, N. and Berns, K. I. 2001. In: D. E. Griffin (ed.), Field's Virology. Philadelphia: Lippincott, Williams and Wilkins, pp. 2327-59.
107. Myers, M. W. and Carter, B. J. 1981. Adeno-associated virus replication. The effect of L-canavanine or a helper virus mutation on accumulation of viral capsids and progeny single-stranded DNA. Journal of Biological Chemistry 256: 567-70.
108. Naeger, L. K., Cater, J. and Pintel, D. J. 1990. The small non- structural protein NS2 of the parvovirus minute virus of mice is required for efficient DNA replication and infectious virus production in a cell-type-specific manner. Journal ofVirology 64: 6166-75.
109. Nakai, H., Storm, T. A. and Kay, M. A. 2000. Increasing the size of rAAV-mediated expression cassettes in vivo by intermolecular joining of two complementary vectors. Natural Biotechnology 18: 527-32.
110. Ni, T. H., Zhou, X., McCarty, D. M. et al. 1994. In vitro replication of adeno-associated virus DNA. Journal ofVirology 68: 1128-38.
111. Ni, T. H., McDonald, W. F., Zolotukhin, I. et al. 1998. Cellular proteins required for adeno-associated virus DNA replication in the absence of adenovirus coinfection. Journal ofVirology 72: 2777-87.
112. Nony, P., Tessier, J., Chadeuf, G. et al. 2001. Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences. Journal ofVirology 75: 9991-4.
113. Ogston, P., Raj, K. and Beard, P. 2000. Productive replication of adeno- associated virus can occur in human papillomavirus type 16 HPV-16 episome-containing keratinocytes and is augmented by the HPV-16 E2 protein. Journal ofVirology 74: 3494-504.
114. O'Malley, R. P., Mariano, T. M., Siekierka, J. and Mathews, M. B. 1986. A mechanism for the control of protein synthesis by adenovirus VA RNAI. Cell 44: 391-400.
115. Ostrove, J. M. and Berns, K. I. 1980. Adenovirus early region 1b gene function required for rescue of latent adeno-associated virus. Virology 104: 502-5.
116. Prasad, K. M., Zhou, C. and Trempe, J. P. 1997. Characterization of the Rep78/adeno-associated virus complex. Virology 229: 183-92.
117. Qing, K., Wang, X. S., Kube, D. M. et al. 1997. Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression. Proceedings of National Academy of Sciences USA 94: 10879-84.
118. Qing, K., Khuntirat, B., Mah, C. et al. 1998. Adeno-associated virus type 2-mediated gene transfer: correlation of tyrosine phosphorylation of the cellular single-stranded D sequence- binding protein with transgene expression in human cells in vitro and murine tissues in vivo. Journal ofVirology 72: 1593-9.
119. Qing, K., Hansen, J., Weigel-Kelley, K. A. et al. 2001. Adeno-associated virus type 2-mediated gene transfer: role of cellular FKBP52 protein in trans gene expression. Journal ofVirology 75: 8968-76.
120. Qing, K., Li, W., Zhong, L. et al. 2003. Adeno-associated virus type 2- mediated gene transfer: role of cellular T-cell protein tyrosine phosphatase in trans gene expression in established cell lines in vitro and transgenic mice in vivo. Journal ofVirology 77: 2741-6.
121. Redemann, B. E., Mendelson, E. and Carter, B. J. 1989. Adeno- associated virus Rep protein synthesis during productive infection. Journal ofVirology 63: 873-82.
122. Richardson, W. D. and Westphal, H. 1981. A cascade of adenovirus early functions is required for expression of adeno-associated virus. Cell 27: 133-41.
123. Richardson, W. D. and Westphal, H. 1984. Requirement for either early region 1a or early region 1b adenovirus gene products in the helper effect for adeno-associated virus. Journal ofVirology 51: 404-10.
124. Rommelaere, J. and Tattersall, P. 1990. In: P. Tijssen, Handbook of Parvoviruses, Vol. 2. Boca Raton, Fl.: CRC Press, Inc., pp. 41-58.
125. Rose, J. A., Berns, K. I., Hoggan, M. D. and Koczot, F. J. 1969. Evidence for a single-stranded adenovirus-associated virus genome: formation of a DNA density hybrid on release of viral DNA. Proceedings of National Academy of Sciences USA 64: 863-9.
126. Rose, J. A. and Koczot, F. 1972. Adeno-associated virus multiplication VII. Helper requirement for viral deoxyribobucleic acid and ribonucleic acid synthsis. Journal ofVirology 10: 1-8.
127. Russell, D. W., Alexander, I. E. and Miller, A. D. 1995. DNA synthesis and topoisomerase inhibitors increase transduction by adeno- associated virus vectors. Proceedings of NationalAcademy of Sciences USA 92: 5719-23.
128. Ryan, J. H., Zolotukhin, S. and Muzyczka, N. 1996. Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeats. Journal ofVirology 70: 1542-53.
129. Salvetti, A., Oreve, S., Chadeuf, G. etal. 1998. Factors influencing recombinant adeno-associated virus production. Human Gene Therapy 9: 695-706.
130. Salvino, R., Skiadopoulos, M., Faust, E. A. et al. 1991. Two spatially distinct genetic elements constitute a bipartite DNA replication origin in the minute virus of mice genome. Journal ofVirology 65: 1352-63.
131. Samulski, R. J., Berns, K. I., Tan, M. and Muzyczka, N. 1982. Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells. Proceedings of National Academy of Sciences USA 79: 2077-81.
132. Samulski, R. J., Srivastava, A., Berns, K. I. and Muzyczka, N. 1983. Rescue of adeno-associated virus from recombinant plasmids: gene correction within the terminal repeats of AAV. Cell 33: 135-43.
133. Samulski, R. J., Chang, L. S. and Shenk, T. 1987. A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. Journal ofVirology 61: 3096-101.
134. Sanlioglu, S., Duan, D. and Engelhardt, J. F. 1999. Two independent molecular pathways for recombinant adeno-associated virus genome conversion occur after UV-C and E4orf6 augmentation of transduction. Human Gene Therapy 10: 591-602.
135. Schlehofer, J. R., Heilbronn, R., Georg-Fries, B. and zur Hausen, H. 1983. Inhibition of initiator-induced SV40 gene amplification in SV40-transformed Chinese hamster cells by infection with a defective parvovirus. Int J Cancer, 32: 591-5.
136. Schlehofer, J. R., Ehrbar, M. and zur Hausen, H. 1986. Vaccinia virus, herpes simplex virus and carcinogens induce DNA amplification in a human cell line and support replication of a helpervirus dependent parvovirus. Virology 152: 110-7.
137. Schmidt, M., Afione, S. and Kotin, R. M. 2000. Adeno-associated virus type 2 Rep78 induces apoptosis through caspase activation independently of p53. Journal ofVirology 74: 9441-50.
138. Senapathy, P. and Carter, B. J. 1984. Molecular cloning of adeno- associated virus variant genomes and generation of infectious virus by recombination in mammalian cells. Journal ofBiological Chemistry 259: 4661-6.
139. Senapathy, P., Tratschin, J. D. and Carter, B. J. 1984. Replication of adeno-associated virus DNA. Complementation of naturally occurring rep-mutants by a wild-type genome or an ori-mutant and correction of terminal palindrome deletions. Journal of Molecular Biology 179: 1-20.
140. Smith, K. O. and Gehle, W. D. 1967. Replication of an adeno- associated virus in canine and human cells with infectious canine hepatitis virus as a 'helper'. Journal ofVirology 1: 648-9.
141. Smith, R. H. and Kotin, R. M. 2000. An adeno-associated virus (AAV) initiator protein, Rep78: catalyzes the cleavage and ligation of single-stranded AAV ori DNA. Journal ofVirology 74: 3122-9.
142. Smith, R. H., Spano, A.J. and Kotin, R.M. 1997. The Rep78 gene product of adeno-associated virus self-associates to form a hexameric complex in the presence of AAV ori sequences. Journal ofVirology 71: 4461-71.
143. Smith, D. H., Ward, P. and Linden, R. M. 1999. Comparative characterization of Rep proteins from the helper-dependent adeno-associated virus type 2 and the autonomous goose parvovirus. Journal ofVirology 73: 2930-7.
144. Snyder, R. O., Samulski, R. J. and Muzyczka, N. 1990. In vitro resolution of covalently joined AAV chromosome ends. Cell 60: 105-13.
145. Snyder, R. O., Im, D. S., Ni, T. et al. 1993. Features of the adeno- associated virus origin involved in substrate recognition by the viral Rep protein. Journal ofVirology 67: 6096-104.
146. Spear, I. S., Fife, K. H., Hauswirth, W. W. et al. 1977. Evidence for two nucleotide sequence orientations within the terminal repetition of adeno-associated virus DNA. Journal ofVirology 24: 627-34.
147. Stracker, T. H., Carson, C. T. and Weitzman, M. D. 2002. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature 418: 348-52.
148. Stracker, T. H., Cassell, G. D., Ward, P. et al. 2004. The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication. Journal of Virology 78: 441-53.
149. Straus, S. E., Sebring, E. D. and Rose, J. A. 1976. Concatemers of alternating plus and minus strands are intermediates in adenovirus-associated virus DNA synthesis. Proceedings of National Academy ofSciences USA 73: 742-6.
150. Straus, S. E., Sebring, E. D. and Rose, J. A. 1978. In: P. Tattershall (ed.), Replication ofMammalian Parvoviruses. Cold Spring Harbor NL: Cold Spring Harbor Laboratory, pp. 243-63.
151. Sun, L., Li, J. and Xiao, X. 2000. Overcoming adeno-associated virus vector size limitation through viral DNA heterodimerization. Natural Medicine 6: 599-602.
152. Tam, P. and Astell, C. R. 1993. Replication of minute virus of mice minigenomes: novel replication elements required for MVM DNA replication. Virology 193: 812-24.
153. Tam, P. and Astell, C. R. 1994. Multiple cellular factors bind to cis- regulatory elements found inboard of the 5' palindrome of minute virus of mice. Journal ofVirology 68: 2840-8.
154. Tattersall, P. and Ward, D. C. 1976. Rolling-hairpin model for replication of parvovirus and linear chromosomal DNA. Nature 263: 106-9.
155. Tratschin, J. D., Miller, I. L. and Carter, B. J. 1984. Genetic analysis of adeno-associated virus: properties of deletion mutants constructed in vitro and evidence for an adeno-associated virus replication function. Journal ofVirology 51: 611-9.
156. Tullis, G. E. and Shenk, T. 2000. Efficient replication of adeno- associated virus type 2 vectors: a cis-acting element outside of the terminal repeats and a minimal size. Journal ofVirology 74: 11511-21.
157. Uprichard, S. L. and Knipe, D. M. 1997. Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites. Virology 229: 113-25.
158. Urcelay, E., Ward, P., Wiener, S. M. et al. 1995. Asymmetric replication in vitro from a human sequence element is dependent on adeno- associated virus Rep protein. Journal ofVirology 69: 2038-46.
159. Walz, C., Deprez, A., Dupressoir, T. et al. 1997. Interaction of human papillomavirus type 16 and adeno-associated virus type 2 co-infecting human cervical epithelium. Journal of General Virology 78 (Pt 6), 1441-52.
160. Wang, X. S. and Srivastava, A. 1997. A novel terminal resolution-like site in the adeno-associated virus type 2 genome. Journal of Virology 71: 1140-6.
161. Wang, X. S. and Srivastava, A. 1998. Rescue and autonomous replication of adeno-associated virus type 2 genomes containing Rep-binding site mutations in the viral p5 promoter. Journal of Virology 72: 4811-8.
162. Wang, X. S., Ponnazhagan, S. and Srivastava, A. 1995. Rescue and replication signals of the adeno-associated virus 2 genome. Journal of Molecular Biology 250: 573-80.
163. Wang, X. S., Ponnazhagan, S. and Srivastava, A. 1996. Rescue and replication of adeno-associated virus type 2 as well as vector DNA sequences from recombinant plasmids containing deletions in the viral inverted terminal repeats: selective encapsidation of viral genomes in progeny virions. Journal of Virology 70: 1668-77.
164. Wang, X. S., Qing, K., Ponnazhagan, S. and Srivastava, A. 1997. Adeno-associated virus type 2 DNA replication in vivo: mutation analyses of the D sequence in viral inverted terminal repeats. Journal of Virology 71: 3077-82.
165. Ward, P. and Berns, K. I. 1991. In vitro rescue of an integrated hybrid adeno-associated virus/simian virus 40 genome. Journal of Molecular Biology 218: 791-804.
166. Ward, P. and Berns, K. I. 1995. Minimum origin requirements for linear duplex AAV DNA replication in vitro. Virology 209: 692-5.
167. Ward, P. and Berns, K. I. 1996. In vitro replication of adeno-associated virus DNA: enhancement by extracts from adenovirus-infected HeLa cells. Journal of Virology 70: 4495-501.
168. Ward, P. and Linden, R. M. 2000. A role for single-stranded templates in cell-free adeno-associated virus DNA replication. Journal of Virology 74: 744-54.
169. Ward, P., Urcelay, E., Kotin, R. etal. 1994. Adeno-associated virus DNA replication in vitro: activation by a maltose binding protein/Rep68 fusion protein. Journal of Virology 68: 6029-37.
170. Ward, P., Dean, F. B., O'Donnell, M. E. and Berns, K. I. 1998. Role of the adenovirus DNA-binding protein in in vitro adeno- associated virus DNA replication. Journal of Virology 72: 420-7.
171. Ward, P., Falkenberg, M., Elias, P. et al. 2001. Rep-dependent initiation of adeno-associated virus type 2 DNA replication by a herpes simplex virus type 1 replication complex in a reconstituted system. Journal of Virology 75: 10250-8.
172. Ward, P., Elias, P. and Linden, R. M. 2003. Rescue of the adeno- associated virus genome from a plasmid vector: evidence for rescue by replication. Journal ofVirology 77: 11480-90.
173. Weiden, M. D. and Ginsberg, H. S. 1994. Deletion of the E4 region of the genome produces adenovirus DNA concatemers. Proceedings of National Academy of Sciences USA 91: 153-7.
174. Weindler, F. W. and Heilbronn, R. 1991. A subset of herpes simplex virus replication genes provides helper functions for productive adeno-associated virus replication. Journal ofVirology 65: 2476-83.
175. Weitzman, M. D., Fisher, K. J. and Wilson, J. M. 1996. Recruitment of wild-type and recombinant adeno-associated virus into adenovirus replication centers. Journal ofVirology 70: 1845-54.
176. Wistuba, A., Weger, S., Kern, A. and Kleinschmidt, J. A. 1995. Intermediates of adeno-associated virus type 2 assembly: identification of soluble complexes containing Rep and Cap proteins. Journal ofVirology 69: 5311-9.
177. Wistuba, A., Kern, A., Weger, S. et al. 1997. Subcellular compartmentalization of adeno-associated virus type 2 assembly. Journal ofVirology 71: 1341-52.
178. Wonderling, R. S. and Owens, R. A. 1997. Binding sites for adeno- associated virus Rep proteins within the human genome. Journal ofVirology 71: 2528-34.
179. Xiao, X., Xiao, W., Li, J. and Samulski, R. J. 1997. A novel 165-base- pair terminal repeat sequence is the sole cis requirement for the adeno-associated virus life cycle. Journal ofVirology 71: 941-8.
180. Xiao, X., Li, J. and Samulski, R. J. 1998. Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. Journal ofVirology 72: 2224-32.
181. Yakobson, B., Koch, T. and Winocour, E. 1987. Replication of adeno- associated virus in synchronized cells without the addition of a helper virus. Journal ofVirology 61: 972-81.
182. Yakobson, B., Hrynko, T. A., Peak, M. J. and Winocour, E. 1989. Replication of adeno-associated virus in cells irradiated with UV light at 254 nm. Journal ofVirology 63: 1023-30.
183. Yalkinoglu, A. O., Heilbronn, R., Burkle, A. et al. 1988. DNA amplification of adeno-associated virus as a response to cellular genotoxic stress. Cancer Research 48: 3123-9.
184. Yalkinoglu, A. O., Zentgraf, H. and Hubscher, U. 1991. Origin of adeno- associated virus DNA replication is a target of carcinogen- inducible DNA amplification. Journal ofVirology 65: 3175-84.
185. Yang, J., Zhou, W., Zhang, Y. et al. 1999. Concatamerization of adeno- associated virus circular genomes occurs through intermolecular recombination. Journal ofVirology 73: 9468-77.
186. Yoon, M., Smith, D. H., Ward, P. et al. 2001. Amino-terminal domain exchange redirects origin-specific interactions of adeno- associated virus rep78 in vitro. Journal ofVirology 75: 3230-9.
187. Zhong, L., Qing, K., Si, Y. et al. 2004. Heat-shock treatment-mediated increase in transduction by recombinant adeno-associated virus 2 vectors is independent of the cellular heat-shock protein 90. Journal of Biological Chemistry 279: 12714-23.
188. Zhou, X. and Muzyczka, N. 1998. In vitro packaging of adeno- associated virus DNA. Journal ofVirology 72: 3241-7.