Rep68 protein of adeno-associated virus type 2 interacts with 14-3-3 proteins depending on phosphorylation at serine 535

Virology

Volumn 320, Issue 1, 2004, Pages 144-155

  Han, Song Iee ^a   Kawano, Masa Aki ^a   Ishizu, Ken Ichiro ^a   Watanabe, Hajime ^b   Hasegawa, Makoto ^a   Kanesashi, Shin Nosuke ^a   Kim, Yang Su ^a   Nakanishi, Akira ^a   Kataoka, Kohsuke ^a   Handa, Hiroshi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b Okazaki National Research Institutes   (Japan)

Author keywords

14 3 3; AAV; DNA binding; Phosphorylation; Rep; Replication

Indexed keywords

PROTEIN 14 3 3; REP 68 PROTEIN; SERINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADENOVIRUS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA BINDING; DNA REPLICATION ORIGIN; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIFE CYCLE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS REGULATION; REDUCTION; SPECIES COMPARISON; VIRUS GENOME; VIRUS REPLICATION;

14-3-3 PROTEINS; ANIMALS; CELL LINE; CHROMATOGRAPHY, AFFINITY; DEPENDOVIRUS; DNA REPLICATION; DNA, VIRAL; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; LATEX; MUTATION; PHOSPHORYLATION; SERINE; TRANSFECTION; TYROSINE 3-MONOOXYGENASE; VIRAL PROTEINS; VIRUS REPLICATION;

ADENO-ASSOCIATED VIRUS; ADENO-ASSOCIATED VIRUS 2;

EID: 10744233425     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virol.2003.11.024     Document Type: Article

References (54)

1. Batchu R.B., Shammas M.A., Wang J.Y., Munshi N.C. Dual level inhibition of E2F-1 activity by adeno-associated virus Rep78. J. Biol. Chem. 276:2001;24315-24322.
2. Bodnar R.J., Gu M., Li Z., Englund G.D., Du X. The cytoplasmic domain of the platelet glycoprotein Ibalpha is phosphorylated at serine 609. J. Biol. Chem. 274:1999;33474-33479.
3. Brister J.R., Muzyczka N. Mechanism of Rep-mediated adeno-associated virus origin nicking. J. Virol. 74:2000;7762-7771.
4. Chejanovsky N., Carter B.J. Mutagenesis of an AUG codon in the adeno-associated virus rep gene: effects on viral DNA replication. Virology. 173:1989;120-128.
5. Chiorini J.A., Wiener S.M., Owens R.A., Kyostio S.R., Kotin R.M., Safer B. Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats. J. Virol. 68:1994;7448-7457.
6. Collaco R., Prasad K.M., Trempe J.P. Phosphorylation of the adeno-associated virus replication proteins. Virology. 232:1997;332-336.
7. Costello E., Saudan P., Winocour E., Pizer L., Beard P. High mobility group chromosomal protein 1 binds to the adeno-associated virus replication protein (Rep) and promotes Rep-mediated site-specific cleavage of DNA, ATPase activity and transcriptional repression. EMBO J. 16:1997;5943-5954.
8. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1489.
9. Di Pasquale G., Chiorini J.A. PKA/PrKX activity is a modulator of AAV/adenovirus interaction. EMBO J. 22:2003;1716-1724.
10. Di Pasquale G., Stacey S.N. Adeno-associated virus Rep78 protein interacts with protein kinase A and its homolog PRKX and inhibits CREB-dependent transcriptional activation. J. Virol. 72:1998;7916-7925.
11. Fu H., Subramanian R.R., Masters S.C. 14-3-3 proteins: structure, function, and regulation. Annu. Rev. Pharmacol. Toxicol. 40:2000;617-647.
12. Handa H. Purification of transcription factors by using DNA affinity latex particles. Seikagaku. 64:1992;404-407.
13. Hatakeyama M., Ogura Y., Sawada J., Fujimoto K., Handa H., Kawaguchi H. Preparation of dimerized polypeptide-carrying microspheres and purification of specific proteins bound to these microspheres. Colloids Surf., B Biointerfaces. 10:1997;41-49.
14. Hermanns J., Schulze A., Jansen-Dblurr P., Kleinschmidt J.A., Schmidt R., zur Hausen H. Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins. J. Virol. 71:1997;6020-6027.
15. Hirt B. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol. 26:1967;365-369.
16. Hoque M., Shimizu N., Ishizu K., Yajima H., Arisaka F., Suzuki K., Watanabe H., Handa H. Chimeric virus-like particle formation of adeno-associated virus. Biochem. Biophys. Res. Commun. 266:1999;371-376.
17. Horer M., Weger S., Butz K., Hoppe-Seyler F., Geisen C., Kleinschmidt J.A. Mutational analysis of adeno-associated virus Rep protein-mediated inhibition of heterologous and homologous promoters. J. Virol. 69:1995;5485-5496.
18. Im D.S., Muzyczka N. The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity. Cell. 61:1990;447-457.
19. Im D.S., Muzyczka N. Partial purification of adeno-associated virus Rep78, Rep52, and Rep40 and their biochemical characterization. J. Virol. 66:1992;1119-1128.
20. Ishizu K.I., Watanabe H., Han S.I., Kanesashi S.N., Hoque M., Yajima H., Kataoka K., Handa H. Roles of disulfide linkage and calcium ion-mediated interactions in assembly and disassembly of virus-like particles composed of simian virus 40 VP1 capsid protein. J. Virol. 75:2001;61-72.
21. Jones D.H., Ley S., Aitken A. Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins. FEBS Lett. 368:1995;55-58.
22. King J.A., Dubielzig R., Grimm D., Kleinschmidt J.A. DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids. EMBO J. 20:2001;3282-3291.
23. Kube D.M., Ponnazhagan S., Srivastava A. Encapsidation of adeno-associated virus type 2 Rep proteins in wild-type and recombinant progeny virions: Rep-mediated growth inhibition of primary human cells. J. Virol. 71:1997;7361-7371.
24. Kurz E.U., Leader K.B., Kroll D.J., Clark M., Gieseler F. Modulation of human DNA topoisomerase II alpha function by interaction with 14-3-3 epsilon. J. Biol. Chem. 275:2000;13948-13954.
25. Kyostio S.R., Owens R.A., Weitzman M.D., Antoni B.A., Chejanovsky N., Carter B.J. Analysis of adeno-associated virus (AAV) wild-type and mutant Rep proteins for their abilities to negatively regulate AAV p5 and p19 mRNA levels. J. Virol. 68:1994;2947-2957.
26. Laughlin C.A., Tratschin J.D., Coon H., Carter B.J. Cloning of infectious adeno-associated virus genomes in bacterial plasmids. Gene. 23:1983;65-73.
27. Leonard C.J., Berns K.I. Adeno-associated virus type 2: a latent life cycle. Prog. Nucleic Acid Res. Mol. Biol. 48:1994;29-52.
28. Linden R.M., Winocour E., Berns K.I. The recombination signals for adeno-associated virus site-specific integration. Proc. Natl. Acad. Sci. U.S.A. 93:1996;7966-7972.
29. Linden R.M., Ward P., Giraud C., Winocour E., Berns K.I. Site-specific integration by adeno-associated virus. Proc. Natl. Acad. Sci. U.S.A. 93:1996;11288-11294.
30. McCarty D.M., Pereira D.J., Zolotukhin I., Zhou X., Ryan J.H., Muzyczka N. Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein. J. Virol. 68:1994;4988-4997.
31. McCarty D.M., Ryan J.H., Zolotukhin S., Zhou X., Muzyczka N. Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat. J. Virol. 68:1994;4998-5006.
32. Muzyczka N. Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr. Top. Microbiol. Immunol. 158:1992;97-129.
33. Ni T.H., McDonald W.F., Zolotukhin I., Melendy T., Waga S., Stillman B., Muzyczka N. Cellular proteins required for adeno-associated virus DNA replication in the absence of adenovirus coinfection. J. Virol. 72:1998;2777-2787.
34. Pereira D.J., Muzyczka N. The cellular transcription factor SP1 and an unknown cellular protein are required to mediate Rep protein activation of the adeno-associated virus p19 promoter. J. Virol. 71:1997;1747-1756.
35. Pereira D.J., McCarty D.M., Muzyczka N. The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infection. J. Virol. 71:1997a;1079-1088.
36. Ryan J.H., Zolotukhin S., Muzyczka N. Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeats. J. Virol. 70:1996;1542-1553.
37. Samulski R.J., Zhu X., Xiao X., Brook J.D., Housman D.E., Epstein N., Hunter L.A. Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J. 10:1991;3941-3950.
38. Saudan P., Vlach J., Beard P. Inhibition of S-phase progression by adeno-associated virus Rep78 protein is mediated by hypophosphorylated pRb. EMBO J. 19:2000;4351-4361.
39. Shimizu N., Sugimoto K., Tang J., Nishi T., Sato I., Hiramoto M., Aizawa S., Hatakeyama M., Ohba R., Hatori H., Yoshikawa T., Suzuki F., Oomori A., Tanaka H., Kawaguchi H., Watanabe H., Handa H. High-performance affinity beads for identifying drug receptors. Nat. Biotechnol. 18:2000;877-881.
40. Smith R.H., Spano A.J., Kotin R.M. The Rep78 gene product of adeno-associated virus (AAV) self-associates to form a hexameric complex in the presence of AAV ori sequences. J. Virol. 71:1997;4461-4471.
41. Suzuki F., Goto M., Sawa C., Ito S., Watanabe H., Sawada J., Handa H. Functional interactions of transcription factor human GA-binding protein subunits. J. Biol. Chem. 273:1998;29302-29308.
42. van Hemert M.J., Steensma H.Y., van Heusden G.P. 14-3-3 proteins: key regulators of cell division, signalling and apoptosis. BioEssays. 10:2001;936-946.
43. Wada T., Takagi T., Yamaguchi Y., Kawase H., Hiramoto M., Ferdous A., Takayama M., Lee K.A., Hurst H.C., Handa H. Copurification of casein kinase II with transcription factor ATF/E4TF3. Nucleic Acids Res. 24:1996;876-884.
44. Walker S.L., Wonderling R.S., Owens R.A. Mutational analysis of the adeno-associated virus Rep68 protein: identification of critical residues necessary for site-specific endonuclease activity. J. Virol. 71:1997;2722-2730.
45. Walker S.L., Wonderling R.S., Owens R.A. Mutational analysis of the adeno-associated virus type 2 Rep68 protein helicase motifs. J. Virol. 71:1997;6996-7004.
46. Wang X.S., Srivastava A. Rescue and autonomous replication of adeno-associated virus type 2 genomes containing Rep-binding site mutations in the viral p5 promoter. J. Virol. 72:1998;4811-4818.
47. Waterman M.J., Stavridi E.S., Waterman J.L., Halazonetis T.D. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat. Genet. 19:1998;175-178.
48. Weger S., Wendland M., Kleinschmidt J.A., Heilbronn R. The adeno-associated virus type 2 regulatory proteins rep78 and rep68 interact with the transcriptional coactivator PC4. J. Virol. 73:1999;260-269.
49. Weitzman M.D., Kyostio S.R., Kotin R.M., Owens R.A. Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA. Proc. Natl. Acad. Sci. U.S.A. 91:1994;5808-5812.
50. Wonderling R.S., Kyostio S.R., Owens R.A. A maltose-binding protein/adeno-associated virus Rep68 fusion protein has DNA-RNA helicase and ATPase activities. J. Virol. 69:1995;3542-3548.
51. Wu J., Davis M.D., Owens R.A. Factors affecting the terminal resolution site endonuclease, helicase, and ATPase activities of adeno-associated virus type 2 Rep proteins. J. Virol. 73:1999;8235-8244.
52. Yaffe M.B., Rittinger K., Volinia S., Caron P.R., Aitken A., Leffers H., Gamblin S.J., Smerdon S.J., Cantley L.C. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell. 91:1997;961-971.
53. Young S.M. Jr., McCarty D.M., Degtyareva N., Samulski R.J. Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination. J. Virol. 74:2000;3953-3966.
54. Zhou X., Zolotukhin I., Im D.S., Muzyczka N. Biochemical characterization of adeno-associated virus rep68 DNA helicase and ATPase activities. J. Virol. 73:1999;1580-1590.