Efficient replication of adeno-associated virus type 2 vectors: A cis-acting element outside of the terminal repeats and a minimal size

Journal of Virology

Volumn 74, Issue 24, 2000, Pages 11511-11521

  Tullis, G E ^a   Shenk, T ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SINGLE STRANDED DNA; VIRUS DNA; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ARTICLE; DNA REPLICATION; GENOME; LONG TERMINAL REPEAT; PLASMID; PRIORITY JOURNAL; TRANSGENE; VIRUS PARTICLE; VIRUS REPLICATION;

CELL LINE; DEPENDOVIRUS; GENETIC VECTORS; GENOME, VIRAL; HUMANS; REASSORTANT VIRUSES; TERMINAL REPEAT SEQUENCES; VIRUS REPLICATION;

EID: 0034469129     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.24.11511-11521.2000     Document Type: Article

References (69)

1. Effects of genome size on bacteriophage φX174 DNA packaging in vitro
2. Adeno-associated virus Rep78 protein and terminal repeats enhance integration of DNA sequences into the cellular genome
3. Expression from the adeno-associated virus p5 and p19 promoters is negatively regulated in trans by the Rep protein
4. Parvoviridae: The viruses and their replication
5. Rep-mediated nicking of the adeno-associated virus origin requires two biochemical activities, DNA helicase activity and transesterification
6. Analysis of the internal replication sequence indicates that there are three elements required for efficient replication of minute virus of mice minigenomes
7. Organization of the adeno-associated virus (AAV2) capsid gene: Mapping of a minor spliced mRNA coding for virus capsid protein 1
8. Palindromic base sequences and replication of eukaryotic chromosome ends
9. Mutagenesis of an AUG codon in the adeno-associated virus rep gene: Effects on viral DNA replication
10. Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli
11. Determination of adeno-associated virus Rep68 and Rep78 binding site by random sequence oligonucleotide selection
12. Optimization of packaging of adeno-associated virus gene therapy vectors using plasmid transfections
13. Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and Cap
14. The NS-1 polypeptide of minute virus of mice is covalently attached to the 5′ termini of duplex replicative-form DNA and progeny single strands
15. Quantitative analysis of the packaging capacity of recombinant adeno-associated virus
16. Replication of rep-cap genes is essential for the high-efficiency production of recombinant AAV2
17. Titration of AAV2-2 particles via a novel capsid ELISA: Packaging of genomes can limit production of recombinant AAV2-2
18. Specific transcription factors stimulate simian virus 40 and polyomavirus origins of DNA replication
19. Genetics of adeno-associated virus: Isolation and preliminary characterization of adeno-associated virus type 2 mutants
20. Cell lines inducibly expressing the adeno-associated virus (AAV2) rep gene: Requirements for productive replication of rep-negative AAV2 mutants
21. High-level expression of adeno-associated virus (AAV2) Rep78 or Rep68 protein is sufficient for infectious particle formation by a rep-negative mutant
22. Mutational analysis of adeno-associated virus Rep protein-mediated inhibition of heterologous and homologous promoters
23. The AAV2 origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity
24. Packaging cells based on inducible gene amplification for the production of adeno-associated virus vectors
25. HSV/AAV2 hybrid amplicon vectors extend transgene expression in human glioma cells
26. Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells
27. Cis requirements for the efficient production of recombinant DNA vectors based on autonomous parvoviruses
28. Analysis of adeno-associated virus (AAV2) wild-type and mutant Rep proteins for their abilities to negatively regulate AAV2 p5 and p19 mRNA levels
29. 5 Rep binding site and the consensus ATP-binding motif of the AAV2 Rep68 protein
30. Positive and negative autoregulation of the adeno-associated virus type 2 genome
31. Role for highly regulated rep gene expression in adeno-associated virus vector production
32. Production of recombinant adeno-associated virus vectors using a packaging cell line and a hybrid recombinant adenovirus
33. Sequences required for coordinate induction of adeno-associated virus p19 and p40 promoters by Rep protein
34. Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein
35. Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat
36. AAV2 vectors: Is clinical success on the horizon?
37. Advanced mammalian gene transfer high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
38. Cellular proteins required for adeno-associated virus DNA replication in the absence of adenovirus coinfection
39. Highly regulated expression of adeno-associated virus large Rep proteins in stable 293 cell lines using the Cre/IoxP switching system
40. Identification of a DNA-binding domain in the amino terminus of adeno-associated virus Rep proteins
41. The adeno-associated virus (AAV2) Rep protein acts as both a repressor and an activator to regulate AAV2 transcription during a productive infection
42. The adeno-associated virus type 2 p40 promoter requires a proximal Sp1 interaction and a p19 CArG-like element to facilitate Rep transactivation
43. Cloning of adeno-associated virus into pBR322: Rescue of intact virus from the recombinant plasmid in human cells
44. A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication
45. Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gene expression
46. Vaccinia virus, herpes simplex virus, and carcinogens induce DNA amplification in a human cell line and support replication of a helpervirus dependent parvovirus
47. Molecular cloning of adeno-associated virus variant genomes and generation of infectious virus by recombination in mammalian cells
48. Replication of adeno-associated virus DNA. Complementation of naturally occurring rep- mutants by a wild-type genome or an ori- mutant and correction of terminal palindrome deletions
49. Targeted integration of transfected and infected adeno-associated virus vectors containing the neomycin resistance gene
50. The Rep52 gene product of adeno-associated virus is a DNA helicase with 3′-to-5′ polarity
51. Concatemers of alternating plus and minus strands are intermediates in adeno-associated virus DNA synthesis
52. Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome
53. Replication of minute virus of mice mini-genomes: Novel replication elements required for MVM DNA replication
54. Multiple cellular factors bind to cis-regulatory elements found inboard of the 5′ palindrome of minute virus of mice
55. Rolling hairpin model for replication of parvovirus and linear chromosomal DNA
56. Genetic analysis of adeno-associated virus: Properties of deletion mutants constructed in vitro and evidence for an adeno-associated virus replication function
57. Negative and positive regulation in trans of gene expression from adeno-associated virus vectors in mammalian cells by a viral rep gene product
58. Alternate mRNA splicing is required for synthesis of adeno-associated virus VP1 capsid protein
59. The minor capsid protein VP1 of the autonomous parvovirus minute virus of mice is dispensable for encapsidation of progeny single-stranded DNA but is required for infectivity
60. Characterization of the temporal accumulation of minute virus of mice replicative intermediates
61. Analysis of recombinant adeno-associated virus packaging and requirements for rep and cap gene products
62. Mutational analysis of the adeno-associated virus Rep68 protein: Identification of critical residues necessary for site-specific endonuclease activity
63. Rescue and replication signals of the adeno-associated virus type 2 genome
64. Rescue and replication of adeno-associated virus type 2 as well as vector DNA sequences from recombinant plasmids containing deletions in the viral inverted terminal repeats: Selective encapsidation of viral genomes in progeny virions
65. A maltose-binding protein/adeno-associated virus Rep68 fusion protein has DNA-RNA helicase and ATPase activities
66. DNA amplification of adeno-associated virus as a response to cellular genotoxic stress
67. Replication of adeno-associated virus in synchronized cells without the addition of a helper virus
68. Characterization of cell lines that inducibly express the adeno-associated virus Rep proteins
69. Biochemical characterization of adeno-associated virus rep68 DNA helicase and ATPase activities