High mobility group chromosomal protein 1 binds to the adeno-associated virus replication protein (Rep) and promotes Rep-mediated site-specific cleavage of DNA, ATPase activity and transcriptional repression

EMBO Journal

Volumn 16, Issue 19, 1997, Pages 5943-5954

  Costello, Eithne ^a,d   Saudan, Philippe ^a   Winocour, Ernest ^b   Pizer, Lewis ^c   Beard, Peter ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c UNIVERSITY OF COLORADO   (United States)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

AAV; ATPase; DNA endonuclease; HMG1; Transcription

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CHROMOSOME PROTEIN; HELICASE; HIGH MOBILITY GROUP PROTEIN; NUCLEOPROTEIN; VIRUS DNA; VIRUS PROTEIN;

ADENO ASSOCIATED VIRUS; ARTICLE; CHROMOSOME 19; CONTROLLED STUDY; DNA CLEAVAGE; DNA PROTEIN COMPLEX; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; TRANSCRIPTION REGULATION; VIRUS DNA CELL DNA INTERACTION; VIRUS GENE; VIRUS REPLICATION;

ADENOSINE TRIPHOSPHATASES; BINDING SITES; DEPENDOVIRUS; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; HELA CELLS; HIGH MOBILITY GROUP PROTEINS; HUMANS; PROTEIN BINDING; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC; VIRAL PROTEINS;

ADENO-ASSOCIATED VIRUS; DNA VIRUSES;

EID: 0030868737     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.19.5943     Document Type: Article

References (46)

1. Aiyar,A., Hindmarsh,P., Skalka,A.M. and Leis,J. (1996) Concerted integration of linear retroviral DNA by the avian sarcoma virus integrase in vitro: dependence on both long terminal repeat termini. J. Virol., 70, 3571-3580.
2. Alexandrova,E.A. and Beltchev,B.G. (1988) Acetylated HMG1 protein interacts specifically with homologous DNA polymerase alpha in vitro. Biochem. Biophys. Res. Commun., 154, 918-927.
3. Beaton,A., Palumbo,P. and Berns,K.I. (1989) Expression from the adenoassociated virus p5 and p 19 promoters is negatively regulated in trans by the rep protein. J. Virol., 63, 4450-4454.
4. Berns,K.I. and Linden,R.M. (1995) The cryptic life style of adenoassociated virus. BioEssays, 17, 237-245.
5. Bianchi,M.E., Beltrame,M. and Paonessa,G. (1989) Specific recognition of cruciform DNA by nuclear protein HMG1. Science, 243, 1056-1059.
6. Bustin,M., Lehn,D.A. and Landsman,D. (1990) Structural features of the HMG chromosomal proteins and their genes. Biochim. Biophys. Acta, 1049, 231-243.
7. Chang,L.S., Shi,Y. and Shenk,T. (1989) Adeno-associated virus P5 promoter contains an adenovirus E1A-inducible element and a binding site for the major late transcription factor. J. Virol., 63, 3479-3488.
8. Chiorini,J.A, Weitzman,M.D., Owens,R.A., Urcelay,E., Safer,B. and Kotin,R.M. (1994) Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli. J. Virol., 68, 797-804.
9. Ge,H. and Roeder,R.G. (1994) The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-bindmg protein. J. Biol. Chem., 269, 17136-17140.
10. Giraud,C., Winocour,E. and Berns,K.I. (1994) Site-specific integration by adeno-associated virus is directed by a cellular DNA sequence. Proc. Natl Acad. Sci. USA, 91, 10039-10043.
11. Giraud,C., Winocour,E. and Berns,K.I. (1995) Recombinant junctions formed by site-specific integration of adeno-associated virus into an episome. J. Virol., 69, 6917-6924.
12. Graham,F.L. and van der Eb,A.J. (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology, 52, 456-467.
13. Grosschedl,R., Giese,K. and Pagel,J. (1994) HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet., 10, 94-100.
14. Haykinson,M.J. and Johnson,R.C. (1993) DNA looping and the helical repeat in vitro and in vivo: effect of HU protein and enhancer location on Hin invertosome assembly. EMBO J., 12, 2503-2512.
15. Hermonat,P.L. (1994) Down-regulation of the human c-fos and c-myc proto-oncogene promoters by adeno-associated virus Rep78. Cancer Lett., 81, 129-136.
16. Hermonat,P.L. and Batchu,R.B. (1997) The adeno-associated virus Rep78 major regulatory protein forms multimeric complexes and the domain for this activity is contained within the carboxy-half of the molecule. FEBS Lett., 401, 180-184.
17. Horer,M., Weger,S., Butz,K., Hoppe-Seyler,F., Geisen,C. and Kleinschmidt,J.A. (1995) Mutational analysis of adeno-associated virus Rep protein-mediated inhibition of heterologous and homologous promoters. J. Virol., 69, 5485-5496.
18. Im,D.S. and Muzyczka,N. (1989) Factors that bind to adeno-associated virus terminal repeats. J. Virol., 63, 3095-3104.
19. Im,D.S. and Muzyczka,N. (1990) The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity. Cell, 61, 447-457.
20. Kotin,R.M. (1994) Prospects for the use of adeno-associated virus as a vector for human gene therapy. Hum, Gene Ther., 5, 793-801.
21. Kotin,R.M. et al. (1990) Site-specific integration by adeno-associated virus. Proc. Natl Acad. Sci. USA, 87, 2211-2215.
22. Kotin,R.M., Linden,R.M. and Berns,K.I. (1992) Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. EMBO J., 11, 5071-5078.
23. Kyöstiö,S.R. and Owens,R.A. (1996) Identification of mutant adeno-associated virus Rep proteins which are dominant-negative for DNA helicase activity. Biochem. Biophys. Res. Commun., 220, 294-299.
24. Kyöstiö,S.R., Owens,R.A., Weitzman,M.D., Antoni,B.A., Chejanovsky.N. and Carter,B.J. (1994) Analysis of adeno-associated virus (AAV) wild-type and mutant Rep proteins for their abilities to negatively regulate AAV p5 and p19 mRNA levels. J. Virol., 68, 2947-2957.
25. Kyöstiö,S.R., Wonderling,R.S. and Owens,R.A. (1995) Negative regulation of the adeno-associated virus (AAV) P5 promoter involves both the P5 rep binding site and the consensus ATP-binding motif of the AAV Rep68 prolein. J. Virol., 69, 6787-6796.
26. Laughlin,C.A., Tratschin,J.D., Coon,H. and Carter,B.J. (1983) Cloning of infectious adeno-associated virus genomes in bacterial plasmids. Gene, 23, 65-73.
27. Linden,R.M., Winocour,E. and Berns,K.I. (1996) The recombination signals for adeno-associated virus site-specific integration. Proc. Natl Acad. Sci. USA, 93, 7966-7972.
28. McCarty,D.M., Ryan,J.H., Zolotukhin,S., Zhou,X. and Muzyczka,N. (1994) Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat. J. Virol., 68, 4998-5006.
29. Ogawa,Y., Aizawa,S., Shirakawa,H. and Yoshida,M. (1995) Stimulation of transcription accompanying relaxation of chromatin structure in cells overexpressing high mobility group 1 protein. J. Biol. Chem., 270, 9272-9280.
30. Onate,S.A., Prendergast,P., Wagner,J.P., Nissen,M., Reeves,R., Pettijohn,D.E. and Edwards,D.P. (1994) The DNA-bending protein HMG-1 enhances progesterone receptor binding to its target DNA sequences. Mol. Cell. Biol., 14, 3376-3391.
31. Owens,R.A., Weitzman,M.D., Kyostio,S.R. and Carter,B.J. (1993) Identification of a DNA-binding domain in the amino terminus of adeno-associated virus Rep proteins. J. Virol., 67, 997-1005.
32. Pagano,M., Durst,M., Joswig,S., Draetta,G. and Jansen-Durr,P. (1992) Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells. Oncogene, 7, 1681-1686.
33. Paull,T.T., Haykinson,M.J. and Johnson,R.C. (1993) The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures. Genes Dev., 7, 1521-1534.
34. Pereira,D.J., McCarty,D.M. and Muzyczka,N. (1997) The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infection. J. Virol., 71, 1079-1088.
35. Pil,P.M. and Lippard,S.J. (1992) Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin. Science, 256, 234-237.
36. Pil,P.M., Chow,C.S. and Lippard,S.J. (1993) High-mobility-group 1 protein mediates DNA bending as determined by ring closures. Proc. Natl Acad. Sci. USA, 90, 9465-9469.
37. Samulski,R.J., Chang,L.S. and Shenk,T. (1987) A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J. Virol., 61, 3096-3101.
38. Samulski,R.J., Zhu,X., Xiao,X., Brook,J.D., Housman,D.E., Epstein,N. and Hunter,L.A. (1991) Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J., 10, 3941-3950.
39. Stros,M., Nishikawa,S. and Dixon,G.H. (1994) cDNA sequence and structure of a gene encoding trout testis high-mobility-group-1. Eur. J. Biochem., 225, 581-591.
40. Weitzman,M.D., Kyöstiö,S.R., Kotin,R.M. and Owens,R.A. (1994) Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA. Proc. Natl Acad. Sci. USA. 91, 5808-5812.
41. Wonderling,R.S., Kyöstiö,S.R. and Owens,R.A. (1995) A maltose-binding protein/adeno-associated virus Rep68 fusion protein has DNA-RNA helicase and ATPase activities. J. Virol., 69, 3542-3548.
42. Yakobson,B., Koch,T. and Winocour,E. (1987) Replication of adeno-associated virus in synchronized cells without the addition of a helper virus. J. Virol., 61, 972-981.
43. Yakobson,B., Hrynko,T.A., Peak,M.J. and Winocour,E. (1989) Replication of adeno-associated virus in cells irradiated with UV light at 254 nm. J. Virol., 63, 1023-1030.
44. Yalkinoglu,A.O., Heilbronn,R., Burkle,A., Schlehofer,J.R. and zur Hausen,H. (1988) DNA amplification of adeno-associated virus as a response to cellular genotoxic stress. Cancer Res., 48, 3123-3129.
45. Zappavigna,V., Falciola,L., Citterich,M.H., Mavilio,F. and Bianchi,M.E. (1996) HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation. EMBO J., 15, 4981-4991.
46. Zwilling,S., Konig,H. and Wirth,T. (1995) High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. EMBO J., 14, 1198-1208.