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Volumn 144, Issue 3, 2015, Pages 431-443

Hypoxic culture conditions enhance the generation of regulatory T cells

Author keywords

Glut1; Oxygenation; PTEN; Reactive oxygen species; Regulatory T cell induction; Sirt1

Indexed keywords


EID: 85139205076     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/IMM.12388     Document Type: Article
Times cited : (22)

References (67)
  • 2
    • 79958814636 scopus 로고    scopus 로고
    • Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease
    • Hippen KL, Merkel SC, Schirm DK et al. Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease. Am J Transplant 2011; 11:1148–57.
    • (2011) Am J Transplant , vol.11 , pp. 1148-1157
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3
  • 3
    • 79956258982 scopus 로고    scopus 로고
    • Massive ex vivo expansion of human natural regulatory T cells (Tregs) with minimal loss of in vivo functional activity
    • Hippen KL, Merkel SC, Schirm DK et al. Massive ex vivo expansion of human natural regulatory T cells (Tregs) with minimal loss of in vivo functional activity. Sci Transl Med 2011; 3:83ra41.
    • (2011) Sci Transl Med , vol.3 , pp. 83ra41
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3
  • 4
    • 84859102273 scopus 로고    scopus 로고
    • Induced regulatory T cells: Mechanisms of conversion and suppressive potential
    • Dons EM, Raimondi G, Cooper DK, Thomson AW. Induced regulatory T cells: Mechanisms of conversion and suppressive potential. Hum Immunol 2012; 73:328–34.
    • (2012) Hum Immunol , vol.73 , pp. 328-334
    • Dons, E.M.1    Raimondi, G.2    Cooper, D.K.3    Thomson, A.W.4
  • 5
    • 84904057246 scopus 로고    scopus 로고
    • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function
    • Macintyre AN, Gerriets VA, Nichols AG et al. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab 2014; 20:61–72.
    • (2014) Cell Metab , vol.20 , pp. 61-72
    • Macintyre, A.N.1    Gerriets, V.A.2    Nichols, A.G.3
  • 6
    • 77953534607 scopus 로고    scopus 로고
    • Metabolism in T cell activation and differentiation
    • Pearce EL. Metabolism in T cell activation and differentiation. Curr Opin Immunol 2010; 22:314–20.
    • (2010) Curr Opin Immunol , vol.22 , pp. 314-320
    • Pearce, E.L.1
  • 7
    • 25444454359 scopus 로고    scopus 로고
    • Regulation of immune cells by local-tissue oxygen tension: HIF1a and adenosine receptors
    • Sitkovsky M, Lukashev D. Regulation of immune cells by local-tissue oxygen tension: HIF1a and adenosine receptors. Nat Rev Immunol 2005; 5:712–21.
    • (2005) Nat Rev Immunol , vol.5 , pp. 712-721
    • Sitkovsky, M.1    Lukashev, D.2
  • 8
    • 44449165597 scopus 로고    scopus 로고
    • Glucose uptake is limiting in T cell activation and requires CD28-mediated Aktdependent and independent pathways
    • Jacobs SR, Herman CE, Maciver NJ, Wofford JA, Wieman HL, Hammen JJ, Rathmell JC. Glucose uptake is limiting in T cell activation and requires CD28-mediated Aktdependent and independent pathways. J Immunol 2008; 180:4476–86.
    • (2008) J Immunol , vol.180 , pp. 4476-4486
    • Jacobs, S.R.1    Herman, C.E.2    Maciver, N.J.3    Wofford, J.A.4    Wieman, H.L.5    Hammen, J.J.6    Rathmell, J.C.7
  • 10
    • 59249103441 scopus 로고    scopus 로고
    • IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes
    • Dure M, Macian F. IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes. Mol Immunol 2009; 46:999–1006.
    • (2009) Mol Immunol , vol.46 , pp. 999-1006
    • Dure, M.1    Macian, F.2
  • 14
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • Delgoffe GM, Kole TP, Zheng Y et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 2009; 30:832–44.
    • (2009) Immunity , vol.30 , pp. 832-844
    • Delgoffe, G.M.1    Kole, T.P.2    Zheng, Y.3
  • 15
    • 34250156673 scopus 로고    scopus 로고
    • Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells
    • Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant 2007; 7 1722–32.
    • (2007) Am J Transplant , vol.7 , pp. 1722-1732
    • Gao, W.1    Lu, Y.2    El Essawy, B.3    Oukka, M.4    Kuchroo, V.K.5    Strom, T.B.6
  • 16
    • 78049287331 scopus 로고    scopus 로고
    • Cobbold SP. mTOR signalling and metabolic regulation of T cell differentiation
    • Peter C, Waldmann H, Cobbold SP. mTOR signalling and metabolic regulation of T cell differentiation. Curr Opin Immunol 2010; 22:655–61.
    • (2010) Curr Opin Immunol , vol.22 , pp. 655-661
    • Peter, C.1    Waldmann, H.2
  • 17
    • 77950127881 scopus 로고    scopus 로고
    • SIRT1 negatively regulates the mammalian target of rapamycin
    • Ghosh HS, McBurney M, Robbins PD. SIRT1 negatively regulates the mammalian target of rapamycin. PLoS ONE 2010; 5:e9199.
    • (2010) Plos ONE , vol.5
    • Ghosh, H.S.1    McBurney, M.2    Robbins, P.D.3
  • 18
    • 84875109253 scopus 로고    scopus 로고
    • Crosstalk between oxidative stress and SIRT1: Impact on the aging process
    • Salminen A, Kaarniranta K, Kauppinen A. Crosstalk between oxidative stress and SIRT1: Impact on the aging process. Int J Mol Sci 2013; 14:3834–59.
    • (2013) Int J Mol Sci , vol.14 , pp. 3834-3859
    • Salminen, A.1    Kaarniranta, K.2    Kauppinen, A.3
  • 19
    • 84863229506 scopus 로고    scopus 로고
    • Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells
    • Kwon HS, Lim HW, Wu J, Schnolzer M, Verdin E, Ott M. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol 2012; 188:2712–21.
    • (2012) J Immunol , vol.188 , pp. 2712-2721
    • Kwon, H.S.1    Lim, H.W.2    Wu, J.3    Schnolzer, M.4    Verdin, E.5    Ott, M.6
  • 21
    • 77649225958 scopus 로고    scopus 로고
    • Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
    • van Loosdregt J, Vercoulen Y, Guichelaar T et al. Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood 2010; 115:965–74.
    • (2010) Blood , vol.115 , pp. 965-974
    • Van Loosdregt, J.1    Vercoulen, Y.2    Guichelaar, T.3
  • 24
    • 0035575975 scopus 로고    scopus 로고
    • Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions
    • Caldwell CC, Kojima H, Lukashev D, Armstrong J, Farber M, Apasov SG, Sitkovsky MV. Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. J Immunol 2001; 167:6140–9.
    • (2001) J Immunol , vol.167 , pp. 6140-6149
    • Caldwell, C.C.1    Kojima, H.2    Lukashev, D.3    Armstrong, J.4    Farber, M.5    Apasov, S.G.6    Sitkovsky, M.V.7
  • 25
    • 0034032737 scopus 로고    scopus 로고
    • Low oxygen tension enhances the stimulation and proliferation of human T lymphocytes in the presence of IL-2
    • Carswell KS, Weiss JW, Papoutsakis ET. Low oxygen tension enhances the stimulation and proliferation of human T lymphocytes in the presence of IL-2. Cytotherapy 2000; 2:25–37.
    • (2000) Cytotherapy , vol.2 , pp. 25-37
    • Carswell, K.S.1    Weiss, J.W.2    Papoutsakis, E.T.3
  • 26
    • 84894029679 scopus 로고    scopus 로고
    • Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible
    • Ohta A, Madasu M, Subramanian M, Kini R, Jones G, Chouker A, Sitkovsky M. Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible. Int Immunol 2014; 26:83–91.
    • (2014) Int Immunol , vol.26 , pp. 83-91
    • Ohta, A.1    Madasu, M.2    Subramanian, M.3    Kini, R.4    Jones, G.5    Chouker, A.6    Sitkovsky, M.7
  • 27
    • 84857521504 scopus 로고    scopus 로고
    • Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammation
    • Ehrentraut H, Westrich JA, Eltzschig HK, Clambey ET. Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammation. PLoS ONE 2012; 7:e32416.
    • (2012) Plos ONE , vol.7
    • Ehrentraut, H.1    Westrich, J.A.2    Eltzschig, H.K.3    Clambey, E.T.4
  • 29
    • 84905657094 scopus 로고    scopus 로고
    • Extracellular adenosine-mediated modulation of regulatory T cells
    • Ohta A, Sitkovsky M. Extracellular adenosine-mediated modulation of regulatory T cells. Front Immunol 2014; 5:304.
    • (2014) Front Immunol , vol.5 , pp. 304
    • Ohta, A.1    Sitkovsky, M.2
  • 31
    • 84867381718 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1a-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    • Clambey ET, McNamee EN, Westrich JA et al. Hypoxia-inducible factor-1a-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A 2012; 109:E2784–93.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E2784-E2E93
    • Clambey, E.T.1    McNamee, E.N.2    Westrich, J.A.3
  • 32
    • 80052277906 scopus 로고    scopus 로고
    • Control of TH17/Treg balance by hypoxia-inducible factor 1
    • Dang EV, Barbi J, Yang HY et al. Control of TH17/Treg balance by hypoxia-inducible factor 1. Cell 2011; 146:772–84.
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1    Barbi, J.2    Yang, H.Y.3
  • 33
    • 79960369458 scopus 로고    scopus 로고
    • HIF1a-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H. HIF1a-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 2011; 208:1367–76.
    • (2011) J Exp Med , vol.208 , pp. 1367-1376
    • Shi, L.Z.1    Wang, R.2    Huang, G.3    Vogel, P.4    Neale, G.5    Green, D.R.6    Chi, H.7
  • 36
    • 0033119241 scopus 로고    scopus 로고
    • Comparison of fixation protocols for adherent cultured cells applied to a GFP fusion protein of the epidermal growth factor receptor
    • Brock R, Hamelers IH, Jovin TM. Comparison of fixation protocols for adherent cultured cells applied to a GFP fusion protein of the epidermal growth factor receptor. Cytometry 1999; 35:353–62.
    • (1999) Cytometry , vol.35 , pp. 353-362
    • Brock, R.1    Hamelers, I.H.2    Jovin, T.M.3
  • 37
    • 33845792555 scopus 로고    scopus 로고
    • Cell Profiler: Image analysis software for identifying and quantifying cell phenotypes
    • Carpenter AE, Jones TR, Lamprecht MR et al. Cell Profiler: Image analysis software for identifying and quantifying cell phenotypes. Genome Biol 2006; 7:R100.
    • (2006) Genome Biol , vol.7 , pp. R100
    • Carpenter, A.E.1    Jones, T.R.2    Lamprecht, M.R.3
  • 39
    • 4444221709 scopus 로고    scopus 로고
    • T cells express a phagocytetype NADPH oxidase that is activated after T cell receptor stimulation
    • Jackson SH, Devadas S, Kwon J, Pinto LA, Williams MS. T cells express a phagocytetype NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol 2004; 5:818–27.
    • (2004) Nat Immunol , vol.5 , pp. 818-827
    • Jackson, S.H.1    Devadas, S.2    Kwon, J.3    Pinto, L.A.4    Williams, M.S.5
  • 41
    • 0041196069 scopus 로고    scopus 로고
    • Metalloporphyrin class of therapeutic catalytic antioxidants
    • Patel M, Day BJ. Metalloporphyrin class of therapeutic catalytic antioxidants. Trends Pharmacol Sci 1999; 20:359–64.
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 359-364
    • Patel, M.1    Day, B.J.2
  • 43
    • 34047219789 scopus 로고    scopus 로고
    • Measurement of reactive oxygen species in cardiovascular studies
    • Dikalov S, Griendling KK, Harrison DG. Measurement of reactive oxygen species in cardiovascular studies. Hypertension 2007; 49:717–27.
    • (2007) Hypertension , vol.49 , pp. 717-727
    • Dikalov, S.1    Griendling, K.K.2    Harrison, D.G.3
  • 44
    • 38149142769 scopus 로고    scopus 로고
    • Detection of 2-hydroxyethidium in cellular systems: A unique marker product of superoxide and hydroethidine
    • Zielonka J, Vasquez-Vivar J, Kalyanaraman B. Detection of 2-hydroxyethidium in cellular systems: A unique marker product of superoxide and hydroethidine. Nat Protoc 2008; 3:8–21.
    • (2008) Nat Protoc , vol.3 , pp. 8-21
    • Zielonka, J.1    Vasquez-Vivar, J.2    Kalyanaraman, B.3
  • 45
    • 43249083765 scopus 로고    scopus 로고
    • PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression
    • Chang CJ, Mulholland DJ, Valamehr B, Mosessian S, Sellers WR, Wu H. PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. Mol Cell Biol 2008; 28:3281–9.
    • (2008) Mol Cell Biol , vol.28 , pp. 3281-3289
    • Chang, C.J.1    Mulholland, D.J.2    Valamehr, B.3    Mosessian, S.4    Sellers, W.R.5    Wu, H.6
  • 47
    • 84878292368 scopus 로고    scopus 로고
    • Intratumor hypoxia promotes immune tolerance by inducing regulatory T cells via TGF-b1 in gastric cancer
    • Deng B, Zhu JM, Wang Y et al. Intratumor hypoxia promotes immune tolerance by inducing regulatory T cells via TGF-b1 in gastric cancer. PLoS ONE 2013; 8:e63777.
    • (2013) Plos ONE , vol.8
    • Deng, B.1    Zhu, J.M.2    Wang, Y.3
  • 48
    • 79251620102 scopus 로고    scopus 로고
    • Hypoxia potentiates glioma-mediated immunosuppression
    • Wei J, Wu A, Kong LY et al. Hypoxia potentiates glioma-mediated immunosuppression. PLoS ONE 2011; 6:e16195.
    • (2011) Plos ONE , vol.6
    • Wei, J.1    Wu, A.2    Kong, L.Y.3
  • 49
    • 4944245398 scopus 로고    scopus 로고
    • Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
    • Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, Reinberg D. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 2004; 16:93–105.
    • (2004) Mol Cell , vol.16 , pp. 93-105
    • Vaquero, A.1    Scher, M.2    Lee, D.3    Erdjument-Bromage, H.4    Tempst, P.5    Reinberg, D.6
  • 50
    • 84906344581 scopus 로고    scopus 로고
    • Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3 T-regulatory cells
    • Akimova T, Xiao H, Liu Y et al. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3 T-regulatory cells. Mucosal Immunol 2014; 7:1209–20.
    • (2014) Mucosal Immunol , vol.7 , pp. 1209-1220
    • Akimova, T.1    Xiao, H.2    Liu, Y.3
  • 51
    • 41149113441 scopus 로고    scopus 로고
    • The AKT-mTOR axis regulates de novo differentiation of CD4+ Foxp3+ cells
    • Haxhinasto S, Mathis D, Benoist C. The AKT-mTOR axis regulates de novo differentiation of CD4+ Foxp3+ cells. J Exp Med 2008; 205:565–74.
    • (2008) J Exp Med , vol.205 , pp. 565-574
    • Haxhinasto, S.1    Mathis, D.2    Benoist, C.3
  • 52
    • 45549098562 scopus 로고    scopus 로고
    • T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
    • Sauer S, Bruno L, Hertweck A et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A 2008; 105:7797–802.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 7797-7802
    • Sauer, S.1    Bruno, L.2    Hertweck, A.3
  • 53
    • 65449135649 scopus 로고    scopus 로고
    • The multiple facets of mTOR in immunity
    • Weichhart T, Saemann MD. The multiple facets of mTOR in immunity. Trends Immunol 2009; 30:218–26.
    • (2009) Trends Immunol , vol.30 , pp. 218-226
    • Weichhart, T.1    Saemann, M.D.2
  • 54
    • 0026572457 scopus 로고
    • Regulation of glucose transport and GLUT1 glucose transporter expression by O2 in muscle cells in culture
    • Bashan N, Burdett E, Hundal HS, Klip A. Regulation of glucose transport and GLUT1 glucose transporter expression by O2 in muscle cells in culture. Am J Physiol 1992; 262:C682–90.
    • (1992) Am J Physiol , vol.262 , pp. C682-CC90
    • Bashan, N.1    Burdett, E.2    Hundal, H.S.3    Klip, A.4
  • 55
    • 0035937715 scopus 로고    scopus 로고
    • Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
    • Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem 2001; 276:9519–25.
    • (2001) J Biol Chem , vol.276 , pp. 9519-9525
    • Chen, C.1    Pore, N.2    Behrooz, A.3    Ismail-Beigi, F.4    Maity, A.5
  • 57
  • 58
    • 84892396749 scopus 로고    scopus 로고
    • The interplay between regulatory T cells and metabolism in immune regulation
    • Zeng H, Chi H. The interplay between regulatory T cells and metabolism in immune regulation. Oncoimmunology 2013; 2:e26586.
    • (2013) Oncoimmunology , vol.2
    • Zeng, H.1    Chi, H.2
  • 59
    • 84886601892 scopus 로고    scopus 로고
    • The mTOR pathway and integrating immune regulation
    • Cobbold SP. The mTOR pathway and integrating immune regulation. Immunology 2013; 140:391–8.
    • (2013) Immunology , vol.140 , pp. 391-398
    • Cobbold, S.P.1
  • 60
    • 78650188983 scopus 로고    scopus 로고
    • An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
    • Procaccini C, De Rosa V, Galgani M et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 2010; 33:929–41.
    • (2010) Immunity , vol.33 , pp. 929-941
    • Procaccini, C.1    De Rosa, V.2    Galgani, M.3
  • 61
    • 84869089695 scopus 로고    scopus 로고
    • Regulatory T cells, mTOR kinase, and metabolic activity
    • Procaccini C, Matarese G. Regulatory T cells, mTOR kinase, and metabolic activity. Cell Mol Life Sci 2012; 69:3975–87.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 3975-3987
    • Procaccini, C.1    Matarese, G.2
  • 62
    • 1542406446 scopus 로고    scopus 로고
    • NOX enzymes and the biology of reactive oxygen
    • Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 2004; 4:181–9.
    • (2004) Nat Rev Immunol , vol.4 , pp. 181-189
    • Lambeth, J.D.1
  • 63
    • 78049317366 scopus 로고    scopus 로고
    • Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species
    • Kraaij MD, Savage ND, van der Kooij SW et al. Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species. Proc Natl Acad Sci U S A 2010; 107:17686–91.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17686-17691
    • Kraaij, M.D.1    Savage, N.D.2    Van Der Kooij, S.W.3
  • 67
    • 9144274479 scopus 로고    scopus 로고
    • Diphenyleneiodonium inhibits the cell redox metabolism and induces oxidative stress
    • Riganti C, Gazzano E, Polimeni M, Costamagna C, Bosia A, Ghigo D. Diphenyleneiodonium inhibits the cell redox metabolism and induces oxidative stress. J Biol Chem 2004; 279:47726–31.
    • (2004) J Biol Chem , vol.279 , pp. 47726-47731
    • Riganti, C.1    Gazzano, E.2    Polimeni, M.3    Costamagna, C.4    Bosia, A.5    Ghigo, D.6


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