The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling

Science Signaling

Volumn 3, Issue 133, 2010, Pages

  Kwon, Jaeyul ^a,b   Shatynski, Kristen E ^a   Chen, Haiyan ^a   Morand, Stanislas ^b   De Deken, Xavier ^c   Miot, Françoise ^c   Leto, Thomas L ^b   Williams, Mark S ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN GAB 2; ADAPTOR PROTEIN GADS; CALCIUM ION; CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; DITHIOTHREITOL; DUOX 1 PROTEIN; DUOX 2 PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HYDROGEN PEROXIDE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR 1; IONOMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; T LYMPHOCYTE RECEPTOR; THAPSIGARGIN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL STIMULATION; CELL STRAIN; CELL STRAIN HEK293; CELL STRAIN JURKAT E6 1; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PLASMID; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STABLE TRANSFECTION; WESTERN BLOTTING;

EID: 77956635663     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000976     Document Type: Article

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60. Acknowledgments: We thank S. G. Rhee and A. Weiss for providing reagents for this study. We acknowledge J. Winkles and D. Leitenberg for critical review and comments on this manuscript. Funding: This work was supported by U.S. Public Health Service grant AI070823 (to M.S.W.); U.S. NIH Intramural Research Program, National Institute of Allergy and Infectious Diseases (to T.L.L. and J.K.); Fonds de la Recherche Scientific and Actions Concertées de la Communauté Française de Belgique (to X.d.D. and F.M.); and Fonds de la Recherche Scientifique Médicale (to F.M.). Author contributions: J.K., K.E.S., and H.C. performed the experiments; S.M., X.d.D., and F.M. prepared and characterized stable cell lines and antibodies; J.K., T.L.L., and M.S.W. designed the experiments, analyzed data, and wrote the paper. Competing interests: The authors declare that they have no competing interests.