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Volumn 301, Issue 3, 2011, Pages

GLUT1 enhances mTOR activity independently of TSC2 and AMPK

Author keywords

Diabetes; Mesangial cells; MTORC1

Indexed keywords

ADENYLATE KINASE; GLUCOSE; GLUCOSE TRANSPORTER 1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; RHEB PROTEIN; S6 KINASE; TUBERIN;

EID: 80052419165     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00472.2010     Document Type: Article
Times cited : (56)

References (43)
  • 2
    • 15344345378 scopus 로고    scopus 로고
    • Glucose transporters in diabetic nephropathy
    • Brosius FC, Heilig CW. Glucose transporters in diabetic nephropathy. Pediatr Nephrol 20: 447-451, 2005.
    • (2005) Pediatr Nephrol , vol.20 , pp. 447-451
    • Brosius, F.C.1    Heilig, C.W.2
  • 4
    • 15344343768 scopus 로고    scopus 로고
    • Diabetes increases glomerular GLUT1 and antisense-GLUT1 protects against diabetic glomerulosclerosis (Abstract)
    • Chen S, Heilig KO, Brosius FC, Heilig C. Diabetes increases glomerular GLUT1 and antisense-GLUT1 protects against diabetic glomerulosclerosis (Abstract). J Am Soc Nephrol 14: 46A, 2003.
    • (2003) J Am Soc Nephrol , vol.14
    • Chen, S.1    Heilig, K.O.2    Brosius, F.C.3    Heilig, C.4
  • 5
    • 0035217192 scopus 로고    scopus 로고
    • Increased renal GLUT1 abundance and urinary TGF-beta 1 in streptozotocin-induced diabetic rats: Implications for the development of nephropathy complicating diabetes
    • D'Agord Schaan B, Lacchini S, Bertoluci M, Irigoyen M, Machado U, Schmid H. Increased renal GLUT1 abundance and urinary TGF-beta 1 in streptozotocin-induced diabetic rats: implications for the development of nephropathy complicating diabetes. Horm Metab Res 33: 664-669, 2001.
    • (2001) Horm Metab Res , vol.33 , pp. 664-669
    • D'agord1    Schaan, B.2    Lacchini, S.3    Bertoluci, M.4    Irigoyen, M.5    Machado, U.6    Schmid, H.7
  • 6
    • 34547636295 scopus 로고    scopus 로고
    • Mechanical forces in diabetic kidney disease: A trigger for impaired glucose metabolism
    • Gnudi L, Thomas SM, Viberti G. Mechanical forces in diabetic kidney disease: a trigger for impaired glucose metabolism. J Am Soc Nephrol 18: 2226-2232, 2007.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2226-2232
    • Gnudi, L.1    Thomas, S.M.2    Viberti, G.3
  • 10
    • 0028863503 scopus 로고
    • Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype
    • Heilig CW, Concepcion LA, Riser BL, Freytag SO, Zhu M, Cortes P. Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype. J Clin Invest 96: 1802-1814, 1995.
    • (1995) J Clin Invest , vol.96 , pp. 1802-1814
    • Heilig, C.W.1    Concepcion, L.A.2    Riser, B.L.3    Freytag, S.O.4    Zhu, M.5    Cortes, P.6
  • 12
    • 0030979315 scopus 로고    scopus 로고
    • D-Glucose stimulates mesangial cell GLUT1 expression and basal IGF-I-sensitive glucose uptake in rat mesangial cells: Implications for diabetic nephropathy
    • Heilig CW, Liu Y, England RL, Freytag SO, Gilbert JD, Heilig KO, Zhu M, Concepcion LA, Brosius FC. D-Glucose stimulates mesangial cell GLUT1 expression and basal IGF-I-sensitive glucose uptake in rat mesangial cells: implications for diabetic nephropathy. Diabetes 46: 1030-1039, 1997.
    • (1997) Diabetes , vol.46 , pp. 1030-1039
    • Heilig, C.W.1    Liu, Y.2    England, R.L.3    Freytag, S.O.4    Gilbert, J.D.5    Heilig, K.O.6    Zhu, M.7    Concepcion, L.A.8    Brosius, F.C.9
  • 13
    • 0347994902 scopus 로고    scopus 로고
    • Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy
    • Heilig CW, Saunders T, Brosius FC, Moley K, Heilig K, Baggs R, Guo L, Conner D. Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy. Proc Natl Acad Sci USA 100: 15613-15618, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15613-15618
    • Heilig, C.W.1    Saunders, T.2    Brosius, F.C.3    Moley, K.4    Heilig, K.5    Baggs, R.6    Guo, L.7    Conner, D.8
  • 15
    • 33645738458 scopus 로고    scopus 로고
    • Complexity of the TOR signaling network
    • Inoki K, Guan KL. Complexity of the TOR signaling network. Trends Cell Biol 16: 206-212, 2006.
    • (2006) Trends Cell Biol , vol.16 , pp. 206-212
    • Inoki, K.1    Guan, K.L.2
  • 16
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17: 1829-1834, 2003.
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 17
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat Cell Biol 4: 648-657, 2002.
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 18
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577-590, 2003.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 20
    • 79952164558 scopus 로고    scopus 로고
    • Nanoscale mapping and affinity constant measurement of signal-transducing proteins by atomic force microscopy
    • In press
    • Kim IH, Lee MN, Ryu SH, Park JW. Nanoscale mapping and affinity constant measurement of signal-transducing proteins by atomic force microscopy. Analytical Chemistry In press.
    • Analytical Chemistry
    • Kim, I.H.1    Lee, M.N.2    Ryu, S.H.3    Park, J.W.4
  • 21
    • 0028830856 scopus 로고
    • A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer
    • Kobayashi T, Hirayama Y, Kobayashi E, Kubo Y, Hino O. A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat Genet 9: 70-74, 1995.
    • (1995) Nat Genet , vol.9 , pp. 70-74
    • Kobayashi, T.1    Hirayama, Y.2    Kobayashi, E.3    Kubo, Y.4    Hino, O.5
  • 22
  • 24
    • 32244438686 scopus 로고    scopus 로고
    • Renal expression and localization of the facilitative glucosetransporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy
    • Linden KC, DeHaan CL, Zhang Y, Glowacka S, Cox AJ, Kelly DJ, Rogers S. Renal expression and localization of the facilitative glucosetransporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy. Am J Physiol Renal Physiol 290: F205-F213, 2006.
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Linden, K.C.1    Dehaan, C.L.2    Zhang, Y.3    Glowacka, S.4    Cox, A.J.5    Kelly, D.J.6    Rogers, S.7
  • 26
    • 0036830441 scopus 로고    scopus 로고
    • Enhanced glycogen synthase kinase-3 beta activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism
    • Loberg RD, Vesely E, Brosius FC. Enhanced glycogen synthase kinase-3 beta activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism. J Biol Chem 277: 41667-41673, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 41667-41673
    • Loberg, R.D.1    Vesely, E.2    Brosius, F.C.3
  • 27
    • 0033617296 scopus 로고    scopus 로고
    • Glucose uptake and glycolysis reduce hypoxiainduced apoptosis in cultured neonatal rat cardiac myocytes
    • Malhotra R, Brosius FC. Glucose uptake and glycolysis reduce hypoxiainduced apoptosis in cultured neonatal rat cardiac myocytes. J Biol Chem 274: 12567-12575, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 12567-12575
    • Malhotra, R.1    Brosius, F.C.2
  • 28
    • 0036702518 scopus 로고    scopus 로고
    • Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1a levels in cardiac myocytes
    • Malhotra R, Tyson DG, Sone H, Aoki K, Kumagai AK, Brosius FC. Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1a levels in cardiac myocytes. J Mol Cell Cardiol 34: 1063-1073, 2002.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 1063-1073
    • Malhotra, R.1    Tyson, D.G.2    Sone, H.3    Aoki, K.4    Kumagai, A.K.5    Brosius, F.C.6
  • 29
    • 15044350668 scopus 로고    scopus 로고
    • The expanding TOR signaling network
    • Martin DE, Hall MN. The expanding TOR signaling network. Curr Opin Cell Biol 17: 158-166, 2005.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 158-166
    • Martin, D.E.1    Hall, M.N.2
  • 30
    • 0345237257 scopus 로고    scopus 로고
    • GLUT1 and TGF-B: The link between hyperglycaemia and diabetic nephropathy
    • Mogyorosi A, Ziyadeh FN. GLUT1 and TGF-B: the link between hyperglycaemia and diabetic nephropathy. Nephrol Dial Transplant 14: 2827-2829, 1999.
    • (1999) Nephrol Dial Transplant , vol.14 , pp. 2827-2829
    • Mogyorosi, A.1    Ziyadeh, F.N.2
  • 32
    • 80052423453 scopus 로고    scopus 로고
    • NIDDK, USRDS 2010 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
    • NIDDK. US Renal Data System. USRDS 2010 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2010.
    • US Renal Data System , pp. 2010
  • 33
    • 33845654846 scopus 로고    scopus 로고
    • Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: Role of AP-1 and HIF-1alpha
    • Pfafflin A, Brodbeck K, Heilig CW, Haring HU, Schleicher ED, Weigert C. Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha. Cell Physiol Biochem 18: 199-210, 2006.
    • (2006) Cell Physiol Biochem , vol.18 , pp. 199-210
    • Pfafflin, A.1    Brodbeck, K.2    Heilig, C.W.3    Haring, H.U.4    Schleicher, E.D.5    Weigert, C.6
  • 36
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101, 2005.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 37
    • 70349229249 scopus 로고    scopus 로고
    • GLUT1-induced cFLIP expression promotes proliferation and prevents apoptosis in vascular smooth muscle cells
    • Vesely ED, Heilig CW, Brosius FC. GLUT1-induced cFLIP expression promotes proliferation and prevents apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 297: C759-C765, 2009.
    • (2009) Am J Physiol Cell Physiol , vol.297
    • Vesely, E.D.1    Heilig, C.W.2    Brosius, F.C.3
  • 40
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 124: 471-484, 2006.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 41
    • 34748880045 scopus 로고    scopus 로고
    • Rapamycin prevents early steps of the development of diabetic nephropathy in rats
    • Yang Y, Wang J, Qin L, Shou Z, Zhao J, Wang H, Chen Y, Chen J. Rapamycin prevents early steps of the development of diabetic nephropathy in rats. Am J Nephrol 27: 495-502, 2007.
    • (2007) Am J Nephrol , vol.27 , pp. 495-502
    • Yang, Y.1    Wang, J.2    Qin, L.3    Shou, Z.4    Zhao, J.5    Wang, H.6    Chen, Y.7    Chen, J.8
  • 42
    • 0027996238 scopus 로고
    • Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene
    • Yeung RS, Xiao GH, Jin F, Lee WC, Testa JR, Knudson AG. Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene. Proc Natl Acad Sci USA 91: 11413-11416, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11413-11416
    • Yeung, R.S.1    Xiao, G.H.2    Jin, F.3    Lee, W.C.4    Testa, J.R.5    Knudson, A.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.