Exercise and insulin resistance

Cancer Prevention and Management through Exercise and Weight Control

Volumn , Issue , 2016, Pages 131-155

  Frank, Laura Lewis ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85123745403     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (189)

1. American Cancer Society. Advisory Committee on Diet, Nutrition, and Cancer Prevention. Guidelines on diet, nutrition, and cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. Calif Cancer J Clin. 1996; 46:325-342.
2. Pate R et al., Physical activity and public health: a recommendation from the Centers of Disease Control and Prevention and the American College of Sports Medicine. JAMA. 1995; 273:402-407.
3. American Cancer Society Workgroup on Nutrition and Physical Activity for Cancer Survivors. Nutrition after cancer: a guide for informed choices. Calif Cancer J Clin. 2001; 51:153-187.
4. Courneya K, Friedenreich C. Physical exercise and quality of life following cancer diagnosis: a literature review. Ann Behav Med. 1999; 127:61-69.
5. Burnham TR, Wilcox A. Effects of exercise on physiological and psychological variables in cancer survivors. Med Sci Sports Exercise. 2002; 34(12):1863-1867.
6. Ryan AS. Insulin resistance with aging: effects of diet and exercise. Sports Med. 2000; 30(5):327-346.
7. Malin A et al. Evaluation of the synergistic effect of insulin resistance and insulin-like growth factors on the risk of breast carcinoma. Cancer. 2004;100(4):694-700.
8. Schairer C et al. Serum concentrations of IGF-I, IGFBP-3 and c-peptide and risk of hyperplasia and cancer of the breast in postmenopausal women. Int J Cancer. 2004; 108(5):773-779.
9. Hirose K et al. Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women. Asian Pac J Cancer Prev. 2003; 4(3):239-246.
10. Brunning PF, Banfer JMG, van Noord PAH. Insulin resistance and breast cancer risk. Int J Cancer. 1992; 52: 511-516.
11. Yang G et al. Population-based, case-control study of blood C-peptide level and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2001; 10(11):1207-1211.
12. Yam D, Fink A, Mashiah A, Ben-Hur E. Hyperinsulinemia in colon, stomach and breast cancer patients. Cancer Lett. 1996; 104(2):129-32.
13. Saydah SH et al. Association of markers of insulin and glucose control with subsequent colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2003; 12(5):412-418.
14. Kaaks R, Lukanova A. Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc. 2001; Feb; 60(1):91-106.
15. Jee SH et al. Fasting serum glucose level and cancer risk in Korean men and women. JAMA. 2005; 293:194-202.
16. Del Guidice ME et al. Insulin and related factors in premenopausal breast cancer risk. Breast Cancer Res Treat. 1998; 47:111-120.
17. Lawlor DA, Smith GD, Ebrahim S. Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women's Heart and Health Study. Cancer Causes Control. 2004;(3):267-275.
18. Saydah SH, Loria CM, Eberhardt MS, Brancati FL. Abnormal glucose tolerance and the risk of cancer death in the United States. Am J Epidemiol. 2003; 157(12):1092-1100.
19. Ardies CM. Exercise, cachexia, and cancer therapy: a molecular rationale. Nutr Cancer. 2002; 42(2):143-157.
20. Koivisto VA, Yki-Jarvinen H, DeFronzo RA. Physical training and insulin sensitivity. Diabetes Metab Rev. 1988; 1:445-481.
21. Henriksson J. Influence of exercise on insulin sensitivity. J Cardiovasc Risk. 1995; 2:303-309.
22. Segal KR et al. Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. J Appl Physiol. 1991; 71(6):2402-2411.
23. Mikines KJ et al. Effect of training on the dose-response relationship for insulin action in men. J Appl Physiol. 1989;66(2):695-703.
24. Ligtenberg PC et al. Effects of physical training on metabolic control in elderly type 2 diabetes mellitus patients. Clin Sci (Lond). 1997;93(2):127-135.
25. Tudor-Locke C et al. Controlled outcome evaluation of the First Step Program: a daily physical activity intervention for individuals with type II diabetes. Int J Obesity Relat Metab Disord. 2004;28(1):113-119.
26. Friedenreich CM, Orenstein MR. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr. 2002; 132(11 Suppl):3456S-3464S.
27. Frank LL et al. Effects of physical activity on metabolic risk variables in overweight postmenopausal women. A randomized clinical trial. Obesity Res. 2005; 13(3):615-625.
28. Hoffman C, Rice D, Sung H-Y. Persons with chronic conditions. JAMA. 1996; 276(18):1473-1479.
29. Prevalence of overweight and obesity among adults: United States, 1999-2000. National Center of Health Statistics. Centers for Disease Control and Prevention.
30. World Health Organization (WHO). Obesity: Preventing and Managing the Global Epidemic. World Health Organization, Geneva, 1998.
31. Improving Nutrition and Increasing Physical Activity. National Center of Health Statistics. Centers of Disease Control and Prevention. http://www.cdc.gov/nccdphp/bb_nutrition/htm.
32. Colditz G et al. Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med. 1995; 122:481-486.
33. Rexrode K, Buring J, Manson J. Abdominal and total adiposity and risk of coronary heart disease in men. Int J Obesity Relat Metab Disord. 2001; 25(7):1047-1056.
34. Carroll K et al. Obesity as a risk factor for certain types of cancer. Lipids. 1998; 33(11):1055-1059.
35. Giovannucci E et al. Physical activity, obesity, and risk of colorectal adenoma in women (United States). Cancer Causes Control. 1996; 7(2):253-263.
36. Morimoto L et al., Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States). Cancer Causes Control. 2002; 13:741-751.
37. IARC Working Group. IARC Handbook of Cancer Prevention. 2002; vol. 6: Weight Control and Physical Activity. IARC, Lyon.
38. Must A et al. The disease burden associated with overweight and obesity. JAMA. 1999; 282:1523-1529.
39. Jung RT. Obesity as a disease. Br Med Bull. 1997; 53:307-321.
40. DiPietro L. Physical activity, body weight, and adiposity: an epidemiologic perspective. Exercise Sports Sci Rev. 1995; 23:275-303.
41. French SA et al. Predictors of weight change over 2 years among a population of working adults: the Healthy Worker Project. Int J Obesity. 1994; 22:55-62.
42. National Heart Blood Lung Institute. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. The evidence report. 1998; NIH publication No. 98-4083.
43. Garrow JS, Summerbell CD. Meta-analysis: effect of exercise, with or without dieting, on the body composition of overweight subjects. Eur J Clin Nutr. 1995; 49(1):1-10.
44. Kelley DE, Goodpastor BH. Effects of physical activity on insulin action and glucose tolerance in obesity. Med Sci Sports Exercise. 1999; 31:S619-S623.
45. Kang HS et al. Physical training improves insulin resistance syndrome markers in obese adolescents. Med Sci Sports Exercise. 2002; 34(12):1920-1927.
46. CDC-prevalence and trend of DM. http://www.cdc.gov/diabetes/statistics/prev/national/figper-sons.htm. Last accessed June 2004.
47. Harris MI et al. Prevalence of Diabetes, Impaired fasting glucose, and impaired glucose tolerance in U.S. Adults. Diabetes Care. 1998; 21(4): 518-524.
48. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003; 26(11):3160-3167.
49. Davidson MB, Landsman PB, Alexander CM. Lowering the criterion for impaired fasting glucose will not provide clinical benefit. Diabetes Care. 2003; 26(12):3329-3330.
50. British Nutrition Information. http://www.nutrition.org.uk/information/dietandhealth/diabetes.htm. Last accessed June 2004.
51. Reaven GM. Syndrome X. Clin Diabetes. 1994; 12(4):32-36.
52. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among U.S. adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002; 287(3):356-359.
53. Liese AD, Mayer-Davis EJ, Haffner SM. Development of multiple metabolic syndrome: an epidemiological perspective. Epidemiol Rev. 1998; 42:172-179.
54. Abbatecola AM et al. Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly. J Am Geriatr Soc. 2004; 52(3):339-404.
55. CDC Diabetes Fact Sheet. http://www.cdc.gov/omh/AMH/factsheets/diabetes.htm. Last accessed June 2004.
56. Carey VJ et al. Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurse's Health Study. Am J Epidemiol. 1997; 145(7):614-619.
57. Chan JM et al. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care. 1994; 17(9):961-969.
58. Haffner SM et al. Role of obesity and fat distribution in non-insulin-dependent diabetes mellitus in Mexican Americans and non-Hispanic whites. Diabetes Care. 1986; Mar-Apr; 9(2):153-161.
59. Shaten BJ, Smith GD, Kuller LH, Neaton JD. Risk factors for the development of type II diabetes among men enrolled in the usual care group of the Multiple Risk Factor Intervention Trial. Diabetes Care. 1993; 16(10):1331-1339.
60. Dowse GK et al. Abdominal obesity and physical inactivity as risk factors for NIDDM and impaired glucose tolerance in Indian, Creole, and Chinese Mauritians. Diabetes Care. 1991; Apr; 14(4):271-282.
61. Kissebah AH, Peiris AN. Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus. Diabetes Metab Rev. 1989; 5(2):83-109.
62. Ohlson LO et al. The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up of the participants in the study of men born in 1913. Diabetes. 1985; 34(10):1055-1058.
63. Manson JE et al. Physical activity and incidence of non insulin dependent diabetes mellitus in women. Lancet. 1991; 338:774-778.
64. Manson JE et al. A prospective study of exercise and incidence of diabetes among U.S. male physicians. JAMA. 1992; 268:63-67.
65. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS. Physical actvitiy and reduced occurrence of non-insulin dependent diabetes mellitus. N Engl J Med. 1991; 325:147-152.
66. Burchfiel CM et al. Physical activity and diabetes: the Honolulu Heart Program. Am J Epidemiol. 1995; 141:360-368.
67. Lindstrom J et al. Finnish Diabetes Prevention Study Group. The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care. 2003; 26(12):3230-3236.
68. The Diabetes Prevention Program Research Group: Reduction in the incidence of type-2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002; 346:393-403.
69. Wannamethee SG, Shaper AG, Alberti GMM. Physical activity, metabolic factors, and the incidence of coronary heart disease and type 2 diabetes. Arch Intern Med. 2000; 160:2108-2116.
70. Burstein R et al. Effect of an acute bout of exercise on glucose disposal in human obesity. J Appl Physiol. 1990; 69(1):299-304.
71. Devlin JT, Hirshman M, Horton ED, Horton ES. Enhanced peripheral and splanchnic insulin sensitivity in NIDDM men after single bout of exercise. Diabetes. 1987; 36(4):434-439.
72. Rogers MA et al. Improvement in glucose tolerance after 1 wk of exercise in patients with mild NIDDM. Diabetes Care. 1988; 11(8):613-618.
73. Albright A et al. American College of Sports Medicine position stand. Exercise and type-2 diabetes. Med Sci Sports Exercise. 2000; 32(7):1345-1360.
74. Kjaer M et al. Glucoregulation and hormonal responses to maximal exercise in non-insulin-dependent diabetes. J Appl Physiol. 1990; 68(5):2067-2074.
75. Westerlind KC. Physical activity and cancer prevention - mechanisms. Med Sci Sports Exercise. 2003; 35(11):1834-1840.
76. McTiernan A, Ulrich C, Slate S, Potter J. Physical activity and cancer etiology: associations and mechanisms. Cancer Causes Control 1998; 9: 487-509.
77. McTiernan A. Intervention studies in exercise and cancer prevention. Med Sci Sports Exercise. 2003; 35(11):1841-1845.
78. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003; 348(17):1625-1638.
79. Bianchini F, Kaaks R, Vainio H. Weight control and physical activity in cancer prevention. Obesity Rev. 2002; 3(1):5-8.
80. Nagata C et al. Relations of insulin resistance and serum concentrations of estradiol and sex hormonebinding globulin to potential breast cancer risk factors. Jpn J Cancer Res. 2000; 1(9):948-953.
81. Boden G. Pathogenesis of type-2 diabetes. Insulin resistance. Endocrinol Metab Clin North Am. 2001; 30(4): 801-815.
82. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose-fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963; 785-789.
83. Hayashi T, Wojtaszweski JFP, Goodyear LJ. Exercise regulation of glucose transport. Am J Physiol Endocrinol Metab. 1997; 36: E1039-E1051.
84. Perez-Martin A, Raynaud E, Mercier J. Insulin resistance and associated metabolic abnormalities in muscle: effects of exercise. Obesity Rev. 2001; 2(1):47-59.
85. Goodpaster BH, Katsiaras A, Kelley DE. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes. 2003; 52(9):2191-2197.
86. Goodyear LJ, Kahn BB. Exercise, glucose transport, and insulin sensitivity. Annu Rev Med. 1998; 49:235-261.
87. Dela F et al. Physical training increases muscle GLUT4 protein and mRNA in patients with NIDDM. Diabetes. 1994; 43(7):862-865.
88. Kahn BB. Type-2 diabetes: insulin secretion fails to compensate for insulin resistance. Cell. 1998; 92: 593-596.
89. Chibalin AV et al. Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2. Proc Natl Acad Sci USA. 2000; 97(1):38-43.
90. Goodyear LJ et al. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest. 1995; 95(5):2195-2204.
91. Bjornholm M, Kawano Y, Lehtihet M, Zierath JR. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes. 1997; 46(3):524-527.
92. Coderre L, Kandror KV, Vallega G, Pilch PF. Identification and characterization of an exercise-sensitive pool of glucose transporters in skeletal muscle. J Biol Chem. 1995; 270(46):27584-27588.
93. Sherman LA et al. Differential effects of insulin and exercise on Rab4 distribution in rat skeletal muscle. Endocrinology. 1996; 137(1):266-73.
94. Bierman EL, Doyle VP, Roberts TN. An abnormality of nonesterfied fatty acid metabolism in diabetes mellitus. Diabetes 1957; 6:475-479.
95. Roden M. Noninvasive studies of glycogen metabolism in human skeletal muscle using nuclear magnetic resonance spectroscopy. Curr Opin Clin Nutr Metab Care. 2001; 4(4):261-266.
96. Roden M. How free fatty acids inhibit glucose utilization in human skeletal muscle. News Physiol Sci. 2004; 19: 93-96.
97. Dresner A et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest. 1999; 103(2):253-259.
98. Ruderman NB, Dean D. Malonyl CoA, long chain fatty acyl CoA and insulin resistance in skeletal muscle. J Basic Clin Physiol Pharmacol. 1998; 9(2-4):295-308.
99. Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest. 2000; 106:171-176.
100. Vestergaard H. Studies of gene expression and activity of hexokinase, phosphofructokinase, and glucogen synthase in human skeletal muscle in states of altered insulin-stimulated glucose metabolism. Dan Med Bull. 1999; 46(1):13-34.
101. Rothman DL, Shulman RG, Shulman GI. 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J Clin Invest. 1992; 89(4):1069-1075.
102. Rothman DL et al. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA. 1995; 92(4):983-987.
103. Schalin-Jantti C, Harkonen M, Groop LC. Impaired activation of glycogen synthase in people at increased risk for developing NIDDM. Diabetes. 1992; 41(5):598-604.
104. Vaag A, Henriksen JE, Beck-Nielsen H. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1992; 89(3):782-788.
105. Perseghin G et al. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med. 1996; 335(18):1357-1362.
106. Mikines KJ, Sonne B, Tronier B, Galbo H. Effects of acute exercise and detraining on insulin action in trained men. J Appl Physiol. 1989; 66(2):704-711.
107. Goodyear LJ et al. Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle. Am J Physiol. 1996; 271(2 Pt 1):E403-408.
108. Laws A, Reaven GM. Physical activity, glucose tolerance, and diabetes in older adults. Ann Behav Med. 1991; 13:125-131.
109. Pruett ED, Oseid S. Effect of exercise on glucose and insulin response to glucose infusion. Scand J Clin Lab Invest. 1970; 26(3):277-285.
110. Bogardus C et al. Effect of muscle glycogen depletion on in vivo insulin action in man. J Clin Invest. 1983; 72(5):1605-1610.
111. Richter EA, Mikines KJ, Galbo H, Kiens B. Effect of exercise on insulin action in human skeletal muscle. J Appl Physiol. 1989; 66(2):876-885.
112. King DS et al. Insulin action and secretion in endurance-trained and untrained humans. J Appl Physiol. 1987; 63(6):2247-2252.
113. King DS et al. Time course for exercise-induced alterations in insulin action and glucose tolerance in middle-aged people. J Appl Physiol. 1995; 78(1):17-22.
114. Holm G, Bjorntorp P. Metabolic effects of physical training. Acta Paediatr Scand Suppl. 1980; 283:9-14.
115. Duncan GE et al. Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care. 2003; 26(3):557-562.
116. DiPietro L et al. Moderate-intensity aerobic training improves glucose tolerance in aging independent of abdominal adiposity. J Am Geriatr Soc. 1998; 46(7):875-879.
117. Boule NG et al. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA. 2001; 286(10):1218-1227.
118. Goodyear LJ, Hirshman MF, Valyou PM, Horton ES. Glucose transporter number, function, and subcellular distribution in rat skeletal muscle after exercise training. Diabetes. 1992; 41(9):1091-1099.
119. Andersen P, Henriksson J. Capillary supply of the quadriceps femoris muscle of man: adaptive response to exercise. J Physiol. 1977; 270(3):677-690.
120. Ebeling P et al. Mechanism of enhanced insulin sensitivity in athletes. Increased blood flow, muscle glucose transport protein (GLUT-4) concentration, and glycogen synthase activity. J Clin Invest. 1993; 92(4):1623-1631.
121. Borghouts LB, Keizer HA. Exercise and insulin sensitivity: a review. Int J Sports Med. 2000; 21(1):1-12.
122. Kaye SA et al. Increased incidence of diabetes mellitus in relation to abdominal adiposity in older women. J Clin Epidemiol. 1991; 44(3):329-334.
123. Goodpaster BH et al. Association between regional adipose tissue distribution and both type-2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care. 2003; 26(2):372-379.
124. Despres JP, Tremblay A, Nadeau A, Bouchard C. Physical training and changes in regional adipose tissue distribution. Acta Med Scand Suppl. 1988; 723:205-212.
125. Hernandez-Ono A et al. Association of visceral fat with coronary risk factors in a population-based sample of postmenopausal women. Int J Obesity Relat Metab Disord. 2002; 26(1):33-39.
126. Matsuzawa Y et al. Pathophysiology and pathpogenesis of visceral fat obesity. Obesity Res 1995; 3(suppl 2):187S-194S.
127. Brochu M et al. Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women. J Clin Endocrinol Metab. 2000; 85(7):2378-2384.
128. Rendell M et al. Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women. J Clin Endocrinol Metab. 2001; 86(2):744-749.
129. Irwin ML et al. Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial. JAMA. 2003; 289(3):323-330.
130. Ross R et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med. 2000; 133(2):92-103.
131. Boudou P et al. Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type-2 diabetic men. Eur J Endocrinol. 2003; 149(5):421-424.
132. Miyatake N et al. Daily walking reduces visceral adipose tissue areas and improves insulin resistance in Japanese obese subjects. Diabetes Res Clin Pract. 2002; 58(2):101-107.
133. Wong SL et al. Cardiorespiratory fitness is associated with lower abdominal fat independent of body mass index. Med Sci Sports Exercise. 2004; 36(2):286-291.
134. Slentz CA et al. Effects of the amount of exercise on body weight, body composition, and measures of central obesity: STRRIDE - a randomized controlled study. Arch Intern Med. 2004; 164(1):31-39.
135. Lehmann R et al. Loss of abdominal fat and improvement of the cardiovascular risk profile by regular moderate exercise training in patients with NIDDM. Diabetologia. 1995; 38(11):1313-1319.
136. Mourier A et al. Mobilization of visceral adipose tissue related to the improvement in insulin sensitivity in response to physical training in NIDDM. Effects of branched-chain amino acid supplements. Diabetes Care. 1997; 20(3):385-391.
137. Walker KZ et al. Effects of regular walking on cardiovascular risk factors and body composition in normoglycemic women and women with type-2 diabetes. Diabetes Care. 1999; 22(4):555-561.
138. Dengel DR et al. Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men. J Appl Physiol. 1996; 81(1):318-325.
139. Katzel LI et al. Effects of weight loss vs. aerobic exercise training on risk factors for coronary disease in healthy, obese, middle-aged and older men. A randomized controlled trial. JAMA. 1995; 274(24):1915-1921.
140. Ross R et al. Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obesity Res. 2004; 12(5):789-798.
141. Short KR et al. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes. 2003; 52(8):1888-1896.
142. Pratley RE et al. Aerobic exercise training-induced reductions in abdominal fat and glucose-stimulated insulin responses in middle-aged and older men. J Am Geriatr Soc. 2000; 48(9):1055-1061.
143. Potteiger JA, Jacobsen DJ, Donnelly JE, Hill JO. Glucose and insulin responses following 16 months of exercise training in overweight adults: the Midwest Exercise Trial. Metabolism. 2003; 52(9):1175-1181.
144. Watkins LL et al. Effects of exercise and weight loss on cardiac risk factors associated with syndrome X. Arch Intern Med. 2003; 163(16):1889-1895.
145. Hellenius ML, Brismar KE, Berglund BH, de Faire UH. Effects on glucose tolerance, insulin secretion, insulin-like growth factor 1 and its binding protein, IGFBP-1, in a randomized controlled diet and exercise study in healthy, middle-aged men. J Intern Med. 1995; 238(2):121-130.
146. Zimmet PZ et al. Is hyperinsulinaemia a central characteristic of a chronic cardiovascular risk factor clustering syndrome? Mixed findings in Asian Indian, Creole and Chinese Mauritians. Mauritius Noncommunicable Disease Study Group. Diabet Med. 1994; 11(4):388-396.
147. Fontbonne A et al. Hyperinsulinaemia as a predictor of coronary heart disease mortality in a healthy population: the Paris Prospective Study, 15-year follow-up. Diabetologia. 1991; 34(5):356-361.
148. Pyorala M, Miettinen H, Laakso M, Pyorala K. Plasma insulin and all-cause, cardiovascular, and noncardiovascular mortality: the 22-year follow-up results of the Helsinki Policemen Study. Diabetes Care. 2000; 23(8):1097-1102.
149. Donnelly JE et al. The effects of 18 months of intermittent vs. continuous exercise on aerobic capacity, body weight and composition, and metabolic fitness in previously sedentary, moderately obese females. Int J Obesity. 2000; 24: 566-572.
150. Dumortier M et al. Low intensity endurance exercise targeted for lipid oxidation improves body composition and insulin sensitivity in patients with the metabolic syndrome. Diabetes Metab. 2003; 29(5):509-518.
151. Mathews D et al. Homestasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28:412-419.
152. Bonora E et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. 2000; 23:57-63.
153. CuffDJ et al. Effective exercise modality to reduce insulin resistance in women with type-2 diabetes. Diabetes Care. 2003; 26(11):2977-2982.
154. Poehlman ET et al. Effects of resistance training and endurance training on insulin sensitivity in nonobese, young women: a controlled randomized trial. J Clin Endocrinol Metab. 2000; 85(7):2463-2468.
155. Smutok MA et al. Effects of exercise training modality on glucose tolerance in men with abnormal glucose regulation. Int J Sports Med. 1994; 15(6):283-289.
156. Dunstan DW et al. Effects of a short-term circuit weight training program on glycaemic control in NIDDM. Diabetes Res Clin Pract. 1998; 40(1):53-61.
157. Eriksson J et al. Aerobic endurance exercise or circuit-type resistance training for individuals with impaired glucose tolerance? Horm Metab Res. 1998; 30(1):37-41.
158. Wallace MB, Mills BD, Browning CL. Effects of cross-training on markers of insulin resistance/hyper-insulinemia. Med Sci Sports Exercise. 1997; 29(9):1170-1175.
159. Ferrara CM, McCrone SH, Brendle D, Ryan AS, Goldberg AP. Metabolic effects of the addition of resistive to aerobic exercise in older men. Int J Sport Nutr Exercise Metab. 2004; 14(1):73-80.
160. Fenicchia LM et al. Influence of resistance exercise training on glucose control in women with type-2 diabetes. Metabolism. 2004; 53(3):284-289.
161. Ryan AS et al. Insulin action after resistive training in insulin resistant older men and women. J Am Geriatr Soc. 2001; 49(3):247-253.
162. Miller JP et al. Strength training increases insulin action in healthy 50-to 65-year-old men. J Appl Physiol. 1994; 77(3):1122-1127.
163. Ryan AS, Pratley RE, Goldberg AP, Elahi D. Resistive training increases insulin action in postmenopausal women. J Gerontol A Biol Sci Med Sci. 1996; 51(5):M199-205.
164. Joseph LJ et al. Short-term moderate weight loss and resistance training do not affect insulin-stimulated glucose disposal in postmenopausal women. Diabetes Care. 2001; 24(11):1863-1869.
165. Chapman J, Garvin AW, Ward A, Cartee GD. Unaltered insulin sensitivity after resistance exercise bout by postmenopausal women. Med Sci Sports Exercise. 2002; 34(6):936-941.
166. Fluckey JD et al. Effects of resistance exercise on glucose tolerance in normal and glucose-intolerant subjects. J Appl Physiol. 1994; 77(3):1087-1092.
167. Pereira LO, Lancha AH Jr. Effect of insulin and contraction up on glucose transport in skeletal muscle. Prog Biophys Mol Biol. 2004; 84(1):1-27.
168. Castaneda C et al. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type-2 diabetes. Diabetes Care. 2002; 25(12):2335-2341.
169. Durak EP, Jovanovic-Peterson L, Peterson CM. Randomized crossover study of effect of resistance training on glycemic control, muscular strength, and cholesterol in type I diabetic men. Diabetes Care. 1990; 13(10):1039-1043
170. Banz WL et al. Effects of resistance versus aerobic training on coronary artery disease risk factors. Exp Biol Med. 2003; 228:434-440.
171. Hunter GR et al. Resistance training and intra-abdominal adipose tissue in older men and women. Med Sci Sports Exercise. 2002; 34(6):1023-1028.
172. Esposito K et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA. 2003; 289(14):1799-1804.
173. Mensink M et al. Lifestyle intervention according to general recommendations improves glucose tolerance. Obesity Res. 2003; 11(12):1588-1596.
174. McAuley KA et al. Intensive lifestyle changes are necessary to improve insulin sensitivity: a randomized controlled trial. Diabetes Care. 2002; 25(3):445-452.
175. Janssen I, Fortier A, Hudson R, Ross R. Effects of an energy-restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women. Diabetes Care. 2002; 25(3):431-438.
176. Racette SB et al. Modest lifestyle intervention and glucose tolerance in obese African Americans. Obesity Res. 2001; 9(6):348-355.
177. Weinstock RS, Dai H, Wadden TA. Diet and exercise in the treatment of obesity: effects of three interventions on insulin resistance. Arch Intern Med. 1998; 158(22):2477-2483.
178. Yamanouchi K et al. Daily walking combined with diet therapy is a useful means for obese NIDDM patients not only to reduce body weight but also to improve insulin sensitivity. Diabetes Care. 1995; 18(6):775-778.
179. Nilsson PM, Lindholm LH, Schersten BF. Life style changes improve insulin resistance in hyperinsulinaemic subjects: a 1-year intervention study of hypertensives and normotensives in Dalby. J Hypertension. 1992; 10(9):1071-1078.
180. Rice B, Janssen I, Hudson R, Ross R. Effects of aerobic or resistance exercise and/or diet on glucose tolerance and plasma insulin levels in obese men. Diabetes Care. 1999; 22(5):684-691.
181. Joseph LJ et al. Short-term moderate weight loss and resistance training do not affect insulin-stimulated glucose disposal in postmenopausal women. Diabetes Care. 2001; 24(11):1863-1869.
182. Bergman BC et al. Evaluation of exercise and training on muscle lipid metabolism. Am J Physiol. 1999; 276(1 Pt 1):E106-117.
183. Goodpaster BH, Wolfe RR, Kelley DE. Effects of obesity on substrate utilization during exercise. Obesity Res. 2002; 10(7):575-584.
184. Romijn JA et al. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol. 1993; 265(3 Pt 1):E380-391.
185. Hellenius ML, Brismar KE, Berglund BH, de Faire UH. Effects on glucose tolerance, insulin secretion, insulin-like growth factor 1 and its binding protein, IGFBP-1, in a randomized controlled diet and exercise study in healthy, middle-aged men. J Intern Med. 1995; 238(2):121-130.
186. Torjesen PA et al. Lifestyle changes may reverse development of the insulin resistance syndrome. The Oslo Diet and Exercise Study: a randomized trial. Diabetes Care. 1997; 20(1):26-31.
187. Eriksson J et al. Prevention of type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention program. Diabetologia. 1999; 42(7):793-801.
188. Tuomilehto J et al. Finnish Diabetes Prevention Study Group. Prevention of type-2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001; 344(18):1343-1350.
189. Ryan DH. Diabetes Prevention Program Research Group. Diet and exercise in the prevention of diabetes. Int J Clin Pract Suppl. 2003; (134):28-35. Review.