Hyperinsulinaemia and increased risk of breast cancer: Findings from the British women's heart and health study

Cancer Causes and Control

Volumn 15, Issue 3, 2004, Pages 267-275

  Lawlor, Debbie A ^a   Smith, George Davey ^a   Ebrahim, Shah ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Aetiology; Breast cancer; Diabetes; Hyperinsulinaemia; Insulin resistance

Indexed keywords

INSULIN;

ADULT; AGED; ARTICLE; BODY MASS; BREAST CANCER; CANCER RISK; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HORMONE SUBSTITUTION; HUMAN; HYPERINSULINEMIA; HYSTERECTOMY; INSULIN BLOOD LEVEL; LEG LENGTH; MAJOR CLINICAL STUDY; MENARCHE; MENOPAUSE; ORAL CONTRACEPTION; OVARIECTOMY; PARITY; POSTMENOPAUSE; PREMENOPAUSE; PREVALENCE; PRIORITY JOURNAL; SMOKING; SOCIAL CLASS; STATISTICAL SIGNIFICANCE; UNITED KINGDOM; BREAST TUMOR; CROSS-SECTIONAL STUDY; HYPERINSULINISM; MALE; MIDDLE AGED; RISK; RISK ASSESSMENT;

AGED; BREAST NEOPLASMS; CROSS-SECTIONAL STUDIES; FEMALE; GREAT BRITAIN; HUMANS; HYPERINSULINISM; MALE; MENOPAUSE; MIDDLE AGED; ODDS RATIO; PREVALENCE; RISK ASSESSMENT;

EID: 3242746896     PISSN: 09575243     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:CACO.0000024225.14618.a8     Document Type: Article

References (35)

1. Bruning PF, Bonfrer JM, van Noord PA, Hart AA, Jong-Bakker M, Nooijen WJ (1992) Insulin resistance and breast-cancer risk. Int J Cancer 52: 511-516.
2. Kazer RR (1995) Insulin resistance, insulin-like growth factor I and breast cancer: a hypothesis. Int J Cancer 62: 403-406.
3. Kaaks R (1996) Nutrition, hormones, and breast cancer: is insulin the missing link? Cancer Causes Control 7: 605-625.
4. Stoll BA (2002) Upper abdominal obesity, insulin resistance and breast cancer risk. Int J Obes Relat Metab Disord 26: 747-753.
5. Berrino F, Bellati C, Secreto G, et al. (2001) Reducing bioavailable sex hormones through a comprehensive change in diet: the diet and androgens (DIANA) randomized trial. Cancer Epidemiol Biomarkers Prev 10: 25-33.
6. Druckmann R, Rohr UD (2002) IGF-1 in gynaecology and obstetrics: update 2002. Maturitas 41(Suppl 1): S65-S83.
7. Hankinson SE, Willett WC, Colditz GA, et al. (1998) Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351: 1393-1396.
8. Del Giudice ME, Fantus IG, Ezzat S, McKeown-Eyssen G, Page D, Goodwin PJ (1998) Insulin and related factors in premenopausal breast cancer risk. Breast Cancer Res Treat 47: 111-120.
9. Toniolo P, Bruning PF, Akhmedkhanov A, et al. (2000) Serum insulin-like growth factor-I and breast cancer. Int J Cancer 88: 828-832.
10. Krajcik RA, Borofsky ND, Massardo S, Orentreich N (2002) Insulin-like growth factor I (IGF-I), IGF-binding proteins, and breast cancer. Cancer Epidemiol Biomarkers Prev 11: 1566-1573.
11. Kaaks R, Lundin E, Rinaldi S, et al. (2002) Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in northern and southern Sweden. Cancer Causes Control 13: 307-316.
12. Petridou E, Papadiamantis Y, Markopoulos C, Spanos E, Dessypris N, Trichopoulos D (2000) Leptin and insulin growth factor I in relation to breast cancer (Greece). Cancer Causes Control 11: 383-388.
13. Glicksman AS, Myers WPL, Rawson RW (1956) Diabetes mellitus and carbohydrate metabolism in patients with cancer. Med Clin North Am 40: 887-900.
14. Muck BR, Trotnow S, Hommel G (1975) Cancer of the breast, diabetes and pathological glucose tolerance. Arch Gynakol 220: 73-81.
15. Sinagra D, Amato C, Scarpilta AM, et al. (2002) Metabolic syndrome and breast cancer risk. Eur Rev Med Pharmacol Sci 6: 55-59.
16. Yang G, Lu G, Jin F, et al. (2001) Population-based, case-control study of blood C-peptide level and breast cancer risk. Cancer Epidemiol Biomarkers Prev 10: 1207-1211.
17. Mink PJ, Shahar E, Rosamond WD, Alberg AJ, Folsom AR (2002) Serum insulin and glucose levels and breast cancer incidence: the atherosclerosis risk in communities study. Am J Epidemiol 156: 349-352.
18. Lovegrove JA (2002) Obesity, body fat distribution and breast cancer. Nutr Res Rev 15: 389-412.
19. Okasha M, McCarron P, Gunnell D, Davey Smith G (2003) Exposures in childhood, adolescence and early adulthood and breast cancer risk: a systematic review of the literature. Breast Cancer Res Treat 78: 223-276.
20. Gunnell D (2002) Commentary: can adult anthropometry be used as a 'biomarker' for prenatal and childhood exposures? Int J Epidemiol 31: 390-394.
21. Lawlor DA, Okasha M, Gunnell D, Davey Smith G, Ebrahim S (in press) The associations of adult measures of childhood growth with breast cancer: findings from the British Women's Heart and Health Study. Br J Cancer.
22. Lawlor DA, Ebrahim S, Davey Smith G (2002) The association between components of adult height and type II diabetes and insulin resistance: British Women's Heart and Health Study. Diabetologia 45: 1097-1106.
23. Davey Smith G, Greenwood R, Gunnell D, Sweetnam P, Yarnell J, Elwood P (2001) Leg length, insulin resistance, and coronary heart disease risk: the Caerphilly Study. J Epidemiol Commun Health 55: 867-872.
24. Andersen L, Dinesen B, Jorgensen PN, Poulsen F, Roder ME (1993) Enzyme immunoassay for intact human insulin in serum or plasma. Clin Chem 39: 578-582.
25. Lawlor DA, Davey Smith G, Ebrahim S (2002) Birth weight of offspring and insulin resistance in late adulthood: cross sectional survey. BMJ 325: 359.
26. Office of Population Censuses and Surveys (1980) Classification of Occupations and Coding Index. London: HM Stationary Office.
27. Lawlor DA, Ebrahim S, Davey Smith G (2002) Socioeconomic position in childhood and adulthood and insulin resistance: cross sectional survey using data from the British Women's Heart and Health study. BMJ 325: 805-807.
28. Coleman MP, Babb P, Damecki P, Groscalude P, Hanjos S, Jones J (1999) Cancer Survival Trends in England and Wales 1971-1995: Deprivation and NHS Region. London: stationary Office.
29. Goodwin PJ, Ennis M, Pritchard KI, et al. (2002) Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. J Clin Oncol 20: 42-51.
30. dos Santos Silva I, De Stavola BL (2002) Breast cancer aetiology: where do we go from here? In: Kuh D, Hardy R, eds. A Life Course Approach to Women's Health. Oxford: OUP, pp.45-63.
31. Jernstrom H, Barrett-Connor E (1999) Obesity, weight change, fasting insulin, proinsulin, C-peptide, and insulin-like growth factor-1 levels in women with and without breast cancer: the Rancho Bernardo Study. J Women's Health Gender-Based Med 8: 1265-1272.
32. Okasha M, McCarron P, Gunnell D, Davey Smith G (2003) Exposures in childhood, adolescence and early adulthood and breast cancer risk: a systematic review of the literature. Breast Cancer Res 78: 223-276.
33. Wadsworth MEJ, Hardy RJ, Paul AA, Marshall SF, Cole TJ (2002) Leg and trunk length at 43 years in relation to childhood health, diet and family circumstances; evidence from the 1946 national birth cohort. Int J Epidemiol 31: 383-390.
34. Okasha M, Gunnell D, Holly J, Davey Smith G (2002) Childhood growth and adult cancer. Best Pract Res Clin Endocrinol Metab 16: 225-241.
35. McCarthy HD, Ellis SM, Cole TJ. (2003) Central overweight and obesity in British youth aged 11-16 years: cross sectional surveys of waist circumference. BMJ 326: 624.