Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults

Diabetes Care

Volumn 26, Issue 3, 2003, Pages 557-562

  Duncan, Glen E ^a,d   Perri, Michael G ^b   Theriaque, Douglas W ^b   Hutson, Alan D ^b   Eckel, Robert H ^c   Stacpoole, Peter W ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; HEPARIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LIPOPROTEIN LIPASE; TRIACYLGLYCEROL LIPASE;

ADULT; ANTHROPOMETRY; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLEARANCE; CLINICAL ARTICLE; ENZYME ACTIVITY; EXERCISE; FEMALE; GLUCOSE METABOLISM; HEART RATE; HUMAN; INSULIN SENSITIVITY; LIPID METABOLISM; MALE; SITTING; TRIACYLGLYCEROL LIPASE BLOOD LEVEL; WEIGHT REDUCTION;

BIOLOGICAL MARKERS; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; EXERCISE; FEMALE; GLUCOSE; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; LIPOPROTEIN LIPASE; MALE; MIDDLE AGED; RISK FACTORS; RISK REDUCTION BEHAVIOR; WEIGHT LOSS;

EID: 0042093749     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.26.3.557     Document Type: Article

References (26)

1. Doherty RO, Stein D, Foley J: Insulin resistance. Diabetologia 40:B10-B15, 1997
2. Kissebah AH, Peiris AN: Biology of body fat distribution: relationship to non-insulin-dependent diabetes mellitus. Diabetes Metab Rev 5:83-109, 1989
3. Purnell JQ, Kahn SE, Albers JJ, Nevin DN, Brunzell JD, Schwartz RS: Effect of weight loss with reduction of intra-abdominal fat on lipid metabolism in older men. J Clin Endocrinol Metab 85:977-982, 2000
4. Lipman RL, Raskin P, Love T, Triebwasser J, Lecocq FR, Schnure JJ: Glucose intolerance during decreased physical activity in man. Diabetes 21:101-107, 1972
5. Houmard JA, Shinebarger MH, Dolan PL, Leggett-Frazier N, Bruner RK, McCammon MR, Israel RG, Dohm GL: Exercise training increases GLUT-4 protein concentration in previously sedentary middle-aged men. Am J Physiol 264:E896-E901, 1993
6. Cox JH, Cortright RN, Dohm GL, Houmard JA: Effect of aging on response to exercise training in humans: skeletal muscle GLUT-4 and insulin sensitivity. J Appl Physiol 86:2019-2025, 1999
7. Lamarche B, Despres JP, Pouliot MC, Moorjani S, Lupien PJ, Theriault G, Tremblay A, Nadeau A, Bouchard C: Is body fat loss a determinant factor in the improvement of carbohydrate and lipid metabolism following aerobic exercise training in obese women? Metabolism 41:1249-1256, 1992
8. Bruce R, Godsland I, Walton C, Crook D, Wynn V: Associations between insulin sensitivity and free fatty acid and triglyceride metabolism independent of uncomplicated obesity. Metabolism 43:1275-1281, 1994
9. Lampman RM, Santinga JT, Savage PJ, Bassett DR, Hydrick CR, Flora JD Jr, Block WD: Effect of exercise training on glucose tolerance, in vivo insulin sensitivity, lipid and lipoprotein concentrations in middle-aged men with mild hypertriglyceridemia. Metabolism 34:205-211, 1985
10. Weintraub MS, Rosen Y, Otto R, Eisenberg S, Breslow JL: Physical exercise conditioning in the absence of weight loss reduces fasting and postprandial triglyceride-rich lipoprotein levels. Circulation 79:1007-1014, 1989
11. Thompson PD, Cullinane EM, Sady SP, Flynn MM, Bernier DN, Kantor MA, Saritelli AL, Herbert PN: Modest changes in high-density lipoprotein concentration and metabolism with prolonged exercise training. Circulation 78:25-34, 1988
12. Zmuda JM, Yurgalevitch SM, Flynn MM, Bausserman LL, Saratelli A, Spannaus-Martin DJ, Herbert PN, Thompson PD: Exercise training has little effect on HDL levels and metabolism in men with initially low HDL cholesterol. Atherosclerosis 137:215-221, 1998
13. Sady SP, Cullinane EM, Saritelli A, Bernier D, Thompson PD: Elevated high-density lipoprotein cholesterol in endurance trained athletes is related to enhanced plasma triglyceride clearance. Metabolism 37:568-572, 1988
14. Eckel RH: Lipoprotein lipase: a multifunctional enzyme relevant to common metabolic diseases. N Engl J Med 320:1060-1068, 1989
15. Reynisdottir S, Angelin B, Langin D, Lithell H, Eriksson M, Holm C, Arner P: Adipose tissue lipoprotein lipase and hormone-sensitive lipase: contrasting findings in familial combined hyperlipidemia and insulin resistance syndrome. Arterioscler Thromb Vasc Biol 17:2287-2292, 1997
16. Maheux P, Azhar S, Kern PA, Chen YDI, Reaven GM: Relationship between insulin-mediated glucose disposal and regulation of plasma and adipose tissue lipoprotein lipase. Diabetologia 40:850-858, 1997
17. Lamarche B, Despres JP, Moorjani S, Nadeau A, Lupien PJ, Tremblay A, Theriault G, Bouchard C: Evidence for a role of insulin in the regulation of abdominal adipose tissue lipoprotein lipase response to exercise training in obese women. Int J Obesity 17:255-261, 1993
18. Despres JP, Pouliot MC, Moorjani S, Nadeau A, Tremblay A, Lupien PJ, Theriault G, Bouchard C: Loss of abdominal fat and metabolic response to exercise training in obese women. Am J Physiol 261: E159-E167, 1991
19. Mendoza SG, Carrasco H, Zerpa A, Briceno Y, Rodriguez F, Speirs J, Glueck CJ: Effect of physical training on lipids, lipoproteins, apolipoproteins, lipases, and endogenous sex hormones in men with premature myocardial infarction. Metabolism 40:368-377, 1991
20. Bergman RN, Finegood DT, Ader M: Assessment of insulin sensitivity in vivo. Endocr Rev 6:45-86, 1985
21. Eckel RH, Goldberg IJ, Steiner L, Yost TJ, Paterniti JR: Plasma lipolytic activity: relationship to postheparin lipolytic activity and evidence for metabolic regulation. Diabetes 37:610-615, 1988
22. Belfrage P, Vaughn M: Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides. J Lipid Res 10:341-344, 1969
23. Tikkanen MJ, Despres JP, Bouchard C: Regulation of hepatic lipase and serum lipoproteins by sex steroids. Am Heart J 113:562-567, 1987
24. Stubbe I, Hansson P, Gustafson A, Nilsson-Ehle P: Plasma lipoproteins and lipolytic enzyme activities during endurance training in sedentary men: changes in high-density lipoprotein subfractions and composition. Metabolism 32:1120-1128, 1983
25. Despres JP, Ferland M, Moorjani S, Nadeau A, Tremblay A, Pupien PJ, Theriault G, Bouchard C: Role of hepatic-triglyceride lipase activity in the association between intra-abdominal fat and plasma HDL cholesterol in obese women. Arteriosclerosis 9:485-492, 1989
26. Baynes C, Henderson AD, Anyaoku V, Richmond W, Hughes CL, Johnston DG, Elkeles RS: The role of insulin insensitivity and hepatic lipase in the dyslipidemia of type 2 diabetes Diabet Med 8:560-566, 1991