Human blood vessel organoids as a model of diabetic vasculopathy

Nature

Volumn 565, Issue 7740, 2019, Pages 505-510

  Wimmer, Reiner A ^a   Leopoldi, Alexandra ^a   Aichinger, Martin ^b   Wick, Nikolaus ^c   Hantusch, Brigitte ^c   Novatchkova, Maria ^a   Taubenschmid, Jasmin ^a   Hämmerle, Monika ^c   Esk, Christopher ^a   Bagley, Joshua A ^a   Lindenhofer, Dominik ^a   Chen, Guibin ^d   Boehm, Manfred ^d   Agu, Chukwuma A ^a   Yang, Fengtang ^e   Fu, Beiyuan ^e   Zuber, Johannes ^b   Knoblich, Juergen A ^a   Kerjaschki, Dontscho ^c   Penninger, Josef M ^a,f  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; NOTCH1 RECEPTOR; NOTCH3 RECEPTOR; TUMOR NECROSIS FACTOR; COLLAGEN TYPE 4; AUTACOID; DLL4 PROTEIN, HUMAN; NOTCH3 PROTEIN, HUMAN; SECRETASE; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BASEMENT MEMBRANE; BLOOD VESSEL; CAPILLARY; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETIC ANGIOPATHY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLYCEMIA; LETTER; MOUSE; NONHUMAN; ORGANOID; PERICYTE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ELECTRON MICROSCOPY; GENE EXPRESSION PROFILING; H9 CELL LINE; IN VITRO STUDY; MICROVASCULATURE; NON INSULIN DEPENDENT DIABETES MELLITUS; TIGHT JUNCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTERIOLE; ARTERY; BIOLOGICAL MODEL; COMPLICATION; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PATHOLOGY; TRANSPLANTATION; VENULE;

MUS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ARTERIES; ARTERIOLES; BASEMENT MEMBRANE; BLOOD VESSELS; DIABETIC ANGIOPATHIES; ENDOTHELIAL CELLS; HUMANS; HYPERGLYCEMIA; IN VITRO TECHNIQUES; INFLAMMATION MEDIATORS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MODELS, BIOLOGICAL; ORGANOIDS; PERICYTES; PLURIPOTENT STEM CELLS; RECEPTOR, NOTCH3; SIGNAL TRANSDUCTION; VENULES;

EID: 85060379781     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/s41586-018-0858-8     Document Type: Article

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