메뉴 건너뛰기




Volumn 5, Issue 1, 2017, Pages

Engineering CAR-T cells

Author keywords

CAR T cells; Chimeric antigen receptor redirected T cells; Evolution; Production; Structure; Viral vector

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CHIMERIC ANTIGEN RECEPTOR; INTERLEUKIN 2; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; T LYMPHOCYTE RECEPTOR; TUMOR ANTIGEN; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9;

EID: 85081936160     PISSN: None     EISSN: 20507771     Source Type: Journal    
DOI: 10.1186/s40364-017-0102-y     Document Type: Review
Times cited : (394)

References (59)
  • 1
    • 79958023047 scopus 로고    scopus 로고
    • Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy
    • Ramos CA, Dotti G. Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy. Expert Opin Biol Ther. 2011;11(7):855-73.
    • (2011) Expert Opin Biol Ther , vol.11 , Issue.7 , pp. 855-873
    • Ramos, C.A.1    Dotti, G.2
  • 3
    • 85010711853 scopus 로고    scopus 로고
    • Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies
    • Liu J, Zhong JF, Zhang X, Zhang C. Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies. J Hematol Oncol. 2017;10(1):35.
    • (2017) J Hematol Oncol , vol.10 , Issue.1 , pp. 35
    • Liu, J.1    Zhong, J.F.2    Zhang, X.3    Zhang, C.4
  • 4
    • 84993736234 scopus 로고    scopus 로고
    • CD19-redirected chimeric antigen receptor-modified T cells: A promising immunotherapy for children and adults with B-cell acute lymphoblastic leukemia (ALL)
    • Tasian SK, Gardner RA. CD19-redirected chimeric antigen receptor-modified T cells: a promising immunotherapy for children and adults with B-cell acute lymphoblastic leukemia (ALL). Ther Adv Hematol. 2015;6(5):228-41.
    • (2015) Ther Adv Hematol , vol.6 , Issue.5 , pp. 228-241
    • Tasian, S.K.1    Gardner, R.A.2
  • 5
    • 0024834988 scopus 로고
    • Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity
    • Gross G, Waks T, Eshhar Z. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci U S A. 1989;86(24):10024-8.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.24 , pp. 10024-10028
    • Gross, G.1    Waks, T.2    Eshhar, Z.3
  • 6
    • 0027471898 scopus 로고
    • Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
    • Eshhar Z, Waks T, Gross G, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci U S A. 1993;90(2):720-4.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , Issue.2 , pp. 720-724
    • Eshhar, Z.1    Waks, T.2    Gross, G.3    Schindler, D.G.4
  • 7
    • 0034283741 scopus 로고    scopus 로고
    • Chimeric Fv-zeta or Fv-epsilon receptors are not sufficient to induce activation or cytokine production in peripheral T cells
    • Brocker T. Chimeric Fv-zeta or Fv-epsilon receptors are not sufficient to induce activation or cytokine production in peripheral T cells. Blood. 2000; 96(5):1999-2001.
    • (2000) Blood , vol.96 , Issue.5 , pp. 1999-2001
    • Brocker, T.1
  • 8
    • 0043026990 scopus 로고    scopus 로고
    • T-cell activation by recombinant immunore-ceptors: Impact of the intracellular signalling domain on the stability of receptor expression and antigen-speciic activation of grafted T cells
    • Heuser C, Hombach A, Lösch C, Manista K, Abken H. T-cell activation by recombinant immunore-ceptors: impact of the intracellular signalling domain on the stability of receptor expression and antigen-speciic activation of grafted T cells. Gene Ther. 2003;10(17):1408-19.
    • (2003) Gene Ther , vol.10 , Issue.17 , pp. 1408-1419
    • Heuser, C.1    Hombach, A.2    Lösch, C.3    Manista, K.4    Abken, H.5
  • 9
    • 76749120309 scopus 로고    scopus 로고
    • A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity
    • Zhao Y, Wang QJ, Yang S, Kochenderfer JN, Zheng Z, Zhong X, et al. A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity. J Immunol. 2009;183(9):5563-74.
    • (2009) J Immunol , vol.183 , Issue.9 , pp. 5563-5574
    • Zhao, Y.1    Wang, Q.J.2    Yang, S.3    Kochenderfer, J.N.4    Zheng, Z.5    Zhong, X.6
  • 10
    • 77953647938 scopus 로고    scopus 로고
    • The optimal antigen response of chimeric antigen receptors harboring the CD3zeta transmembrane domain is dependent upon incorporation of the receptor into the endogenous TCR/CD3 complex
    • Bridgeman JS, Hawkins RE, Bagley S, Blaylock M, Holland M, Gilham DE. The optimal antigen response of chimeric antigen receptors harboring the CD3zeta transmembrane domain is dependent upon incorporation of the receptor into the endogenous TCR/CD3 complex. J Immunol. 2010;184(12): 6938-49.
    • (2010) J Immunol , vol.184 , Issue.12 , pp. 6938-6949
    • Bridgeman, J.S.1    Hawkins, R.E.2    Bagley, S.3    Blaylock, M.4    Holland, M.5    Gilham, D.E.6
  • 11
    • 33750699642 scopus 로고    scopus 로고
    • A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
    • Kershaw MH, Westwood JA, Parker LL, Wang G, Eshhar Z, Mavroukakis SA, et al. A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res. 2006;12(20 Pt 1):6106-15.
    • (2006) Clin Cancer Res , vol.12 , Issue.20 , pp. 6106-6115
    • Kershaw, M.H.1    Westwood, J.A.2    Parker, L.L.3    Wang, G.4    Eshhar, Z.5    Mavroukakis, S.A.6
  • 12
    • 33947265424 scopus 로고    scopus 로고
    • Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with Neuroblastoma
    • Julie RP, David LD, Marilyn S, Wright C, Naranjo A, Wagner J, et al. Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with Neuroblastoma. Mol Ther. 2007;15(4):825-33.
    • (2007) Mol Ther , vol.15 , Issue.4 , pp. 825-833
    • Julie, R.P.1    David, L.D.2    Marilyn, S.3    Wright, C.4    Naranjo, A.5    Wagner, J.6
  • 13
    • 34848818523 scopus 로고    scopus 로고
    • Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo
    • Lamers CH, Langeveld SC, Groot-van Ruijven CM, Debets R, Sleijfer S, Gratama JW, et al. Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo. Cancer Immunol Immunother. 2007;56(12):1875-83.
    • (2007) Cancer Immunol Immunother , vol.56 , Issue.12 , pp. 1875-1883
    • Lamers, C.H.1    Langeveld, S.C.2    Groot-Van Ruijven, C.M.3    Debets, R.4    Sleijfer, S.5    Gratama, J.W.6
  • 14
    • 55549145071 scopus 로고    scopus 로고
    • Virusspecfic T cells engineered to coexpress tumor-speciic receptors: Persistence and antitumor activity in individuals with neuroblastoma
    • Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, et al. Virusspecfic T cells engineered to coexpress tumor-speciic receptors: Persistence and antitumor activity in individuals with neuroblastoma. Nat Med. 2008; 14(11):1264-70.
    • (2008) Nat Med , vol.14 , Issue.11 , pp. 1264-1270
    • Pule, M.A.1    Savoldo, B.2    Myers, G.D.3    Rossig, C.4    Russell, H.V.5    Dotti, G.6
  • 15
    • 50549096284 scopus 로고    scopus 로고
    • Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
    • Till BG, Jensen MC, Wang J, Chen EY, Wood BL, Greisman HA, et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood. 2008;112(6):2261-71.
    • (2008) Blood , vol.112 , Issue.6 , pp. 2261-2271
    • Till, B.G.1    Jensen, M.C.2    Wang, J.3    Chen, E.Y.4    Wood, B.L.5    Greisman, H.A.6
  • 16
    • 0032531091 scopus 로고    scopus 로고
    • Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
    • Finney HM, Lawson AD, Bebbington CR, Weir AN. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol. 1998;161(6):2791-7.
    • (1998) J Immunol , vol.161 , Issue.6 , pp. 2791-2797
    • Finney, H.M.1    Lawson, A.D.2    Bebbington, C.R.3    Weir, A.N.4
  • 17
    • 70449123840 scopus 로고    scopus 로고
    • Fifteen years of gene therapy based on chimeric antigen receptors: Are we nearly there yet?
    • Dotti G, Savoldo B, Brenner M. Fifteen years of gene therapy based on chimeric antigen receptors: Are we nearly there yet? Hum Gene Ther. 2009; 20(11):1229-39.
    • (2009) Hum Gene Ther , vol.20 , Issue.11 , pp. 1229-1239
    • Dotti, G.1    Savoldo, B.2    Brenner, M.3
  • 18
    • 80054680991 scopus 로고    scopus 로고
    • Treating cancer with genetically engineered T cells
    • Park TS, Rosenberg SA, Morgan RA. Treating cancer with genetically engineered T cells. Trends Biotechnol. 2011;29(11):550-7.
    • (2011) Trends Biotechnol , vol.29 , Issue.11 , pp. 550-557
    • Park, T.S.1    Rosenberg, S.A.2    Morgan, R.A.3
  • 19
    • 0347505003 scopus 로고    scopus 로고
    • CD28-mediated co-stimulation: A quantitative support for TCR signalling
    • Acuto O, Michel F. CD28-mediated co-stimulation: a quantitative support for TCR signalling. Nat Rev Immunol. 2003;3(12):939-51.
    • (2003) Nat Rev Immunol , vol.3 , Issue.12 , pp. 939-951
    • Acuto, O.1    Michel, F.2
  • 20
    • 0347994955 scopus 로고    scopus 로고
    • Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
    • Finney HM, Akbar AN, Lawson AD. Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol. 2004;172(1):104-13.
    • (2004) J Immunol , vol.172 , Issue.1 , pp. 104-113
    • Finney, H.M.1    Akbar, A.N.2    Lawson, A.D.3
  • 21
    • 63149163677 scopus 로고    scopus 로고
    • The role of TNF superfamily members in T-cell function and diseases
    • Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol. 2009;9(4):271-85.
    • (2009) Nat Rev Immunol , vol.9 , Issue.4 , pp. 271-285
    • Croft, M.1
  • 22
    • 84997241574 scopus 로고    scopus 로고
    • Co-infusion of haploidentical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia
    • Cai B, Guo M, Wang Y, Zhang Y, Yang J, Guo Y, et al. Co-infusion of haploidentical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia. J Hematol Oncol. 2016;9(1):131.
    • (2016) J Hematol Oncol , vol.9 , Issue.1 , pp. 131
    • Cai, B.1    Guo, M.2    Wang, Y.3    Zhang, Y.4    Yang, J.5    Guo, Y.6
  • 23
    • 84982181799 scopus 로고    scopus 로고
    • Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy
    • Hu Y, Sun J, Wu Z, Yu J, Cui Q, Pu C, et al. Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy. J Hematol Oncol. 2016;9(1):70.
    • (2016) J Hematol Oncol , vol.9 , Issue.1 , pp. 70
    • Hu, Y.1    Sun, J.2    Wu, Z.3    Yu, J.4    Cui, Q.5    Pu, C.6
  • 24
    • 84940881287 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
    • Porter DL, Hwang WT, Frey NV, Lacey SF, Shaw PA, Loren AW, et al. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Sci Transl Med. 2015; 7(303):303ra139.
    • (2015) Sci Transl Med , vol.7 , Issue.303 , pp. 303ra139
    • Porter, D.L.1    Hwang, W.T.2    Frey, N.V.3    Lacey, S.F.4    Shaw, P.A.5    Loren, A.W.6
  • 25
    • 84962213143 scopus 로고    scopus 로고
    • Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells
    • Frigault MJ, Lee J, Basil MC, Carpenito C, Motohashi S, Scholler J, et al. Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells. Cancer Immunol Res. 2015;3(4):356-67.
    • (2015) Cancer Immunol Res , vol.3 , Issue.4 , pp. 356-367
    • Frigault, M.J.1    Lee, J.2    Basil, M.C.3    Carpenito, C.4    Motohashi, S.5    Scholler, J.6
  • 26
    • 84930765209 scopus 로고    scopus 로고
    • 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
    • Long AH, Haso WM, Shern JF, Wanhainen KM, Murgai M, Ingaramo M, et al. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat Med. 2015;21(6):581-90.
    • (2015) Nat Med , vol.21 , Issue.6 , pp. 581-590
    • Long, A.H.1    Haso, W.M.2    Shern, J.F.3    Wanhainen, K.M.4    Murgai, M.5    Ingaramo, M.6
  • 27
    • 84958648353 scopus 로고    scopus 로고
    • Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells
    • Kawalekar OU, O'Connor RS, Fraietta JA, Guo L, McGettigan SE, Posey AD Jr, et al. Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells. Immunity. 2016;44(2):380-90.
    • (2016) Immunity , vol.44 , Issue.2 , pp. 380-390
    • Kawalekar, O.U.1    O'Connor, R.S.2    Fraietta, J.A.3    Guo, L.4    McGettigan, S.E.5    Posey, A.D.6
  • 28
    • 78649899281 scopus 로고    scopus 로고
    • Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: Improvement of their immune activity by expression of CD33-specific chimeric receptors
    • Marin V, Pizzitola I, Agostoni V, Attianese GM, Finney H, Lawson A, et al. Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors. Haematologica. 2010;95(12):2144-52.
    • (2010) Haematologica , vol.95 , Issue.12 , pp. 2144-2152
    • Marin, V.1    Pizzitola, I.2    Agostoni, V.3    Attianese, G.M.4    Finney, H.5    Lawson, A.6
  • 29
    • 84860333968 scopus 로고    scopus 로고
    • CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: Pilot clinical trial results
    • Till BG, Jensen MC, Wang J, Qian X, Gopal AK, Maloney DG, et al. CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results. Blood. 2012;119(17):3940-50.
    • (2012) Blood , vol.119 , Issue.17 , pp. 3940-3950
    • Till, B.G.1    Jensen, M.C.2    Wang, J.3    Qian, X.4    Gopal, A.K.5    Maloney, D.G.6
  • 30
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, Rosenberg SA. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther. 2010;18(4):843-51.
    • (2010) Mol Ther , vol.18 , Issue.4 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3    Dudley, M.E.4    Laurencot, C.M.5    Rosenberg, S.A.6
  • 31
    • 84936934796 scopus 로고    scopus 로고
    • Trucks: The fourth generation of CARs
    • Chmielewski M, Abken H. TRUCKs: the fourth generation of CARs. Expert Opin Biol Ther. 2015;15(8):1145-54.
    • (2015) Expert Opin Biol Ther , vol.15 , Issue.8 , pp. 1145-1154
    • Chmielewski, M.1    Abken, H.2
  • 32
    • 85011536735 scopus 로고    scopus 로고
    • Chimaeric antigen receptor T-cell therapy for tumour immunotherapy
    • Sha HH, Wang DD, Yan DL, Hu Y, Yang SJ, Liu SW, et al. Chimaeric antigen receptor T-cell therapy for tumour immunotherapy. Biosci Rep. 2017;37(1).
    • (2017) Biosci Rep , vol.37 , Issue.1
    • Sha, H.H.1    Wang, D.D.2    Yan, D.L.3    Hu, Y.4    Yang, S.J.5    Liu, S.W.6
  • 33
    • 0033639189 scopus 로고    scopus 로고
    • Design of retroviral vectors and helper cells for gene therapy
    • Hu WS, Pathak VK. Design of retroviral vectors and helper cells for gene therapy. Pharmacol Rev. 2000;52(4):493-511.
    • (2000) Pharmacol Rev , vol.52 , Issue.4 , pp. 493-511
    • Hu, W.S.1    Pathak, V.K.2
  • 34
    • 44349158394 scopus 로고    scopus 로고
    • DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer
    • Wang GP, Garrigue A, Ciuffi A, Ronen K, Leipzig J, Berry C, et al. DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer. Nucleic Acids Res. 2008;36(9):e49.
    • (2008) Nucleic Acids Res , vol.36 , Issue.9
    • Wang, G.P.1    Garrigue, A.2    Ciuffi, A.3    Ronen, K.4    Leipzig, J.5    Berry, C.6
  • 35
    • 0347365764 scopus 로고    scopus 로고
    • An overview of current delivery systems in cancer gene therapy
    • EI-Aneed A. An overview of current delivery systems in cancer gene therapy. J Control Release. 2004;94(1):1-14.
    • (2004) J Control Release , vol.94 , Issue.1 , pp. 1-14
    • EI-Aneed, A.1
  • 36
    • 84954306120 scopus 로고    scopus 로고
    • Vectors and strategies for nonviral cancer gene therapy
    • Pahle J, Walther W. Vectors and strategies for nonviral cancer gene therapy. Expert Opin Biol Ther. 2016;16(4):443-61.
    • (2016) Expert Opin Biol Ther , vol.16 , Issue.4 , pp. 443-461
    • Pahle, J.1    Walther, W.2
  • 37
    • 13844292517 scopus 로고    scopus 로고
    • Improved production and purification of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo
    • Chen ZY, He CY, Kay MA. Improved production and purification of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo. Hum Gene Ther. 2005;16(1):126-31.
    • (2005) Hum Gene Ther , vol.16 , Issue.1 , pp. 126-131
    • Chen, Z.Y.1    He, C.Y.2    Kay, M.A.3
  • 38
    • 78650028269 scopus 로고    scopus 로고
    • A robust system for production of minicircle DNA vectors
    • Kay MA, He CY, Chen ZY. A robust system for production of minicircle DNA vectors. Nat Biotechnol. 2010;28(12):1287-9.
    • (2010) Nat Biotechnol , vol.28 , Issue.12 , pp. 1287-1289
    • Kay, M.A.1    He, C.Y.2    Chen, Z.Y.3
  • 39
    • 84924690325 scopus 로고    scopus 로고
    • Performance-enhancing drugs: Design and production of redirected chimeric antigen receptor (CAR) T cells
    • Levine BL. Performance-enhancing drugs: design and production of redirected chimeric antigen receptor (CAR) T cells. Cancer Gene Ther. 2015; 22(2):79-84.
    • (2015) Cancer Gene Ther , vol.22 , Issue.2 , pp. 79-84
    • Levine, B.L.1
  • 41
    • 84905996839 scopus 로고    scopus 로고
    • ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
    • 2014
    • Guedan S, Chen X, Madar A, Carpenito C, McGettigan SE, Frigault MJ, et al. (2014). ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells. Blood. 2014;124(7):1070-80.
    • (2014) Blood , vol.124 , Issue.7 , pp. 1070-1080
    • Guedan, S.1    Chen, X.2    Madar, A.3    Carpenito, C.4    McGettigan, S.E.5    Frigault, M.J.6
  • 43
    • 84996572349 scopus 로고    scopus 로고
    • Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies
    • Beatty GL, Haas AR, Maus MV, Torigian DA, Soulen MC, Plesa G, et al. Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies. Cancer Immunol Res. 2014; 2(2):112-20.
    • (2014) Cancer Immunol Res , vol.2 , Issue.2 , pp. 112-120
    • Beatty, G.L.1    Haas, A.R.2    Maus, M.V.3    Torigian, D.A.4    Soulen, M.C.5    Plesa, G.6
  • 45
    • 85015654189 scopus 로고    scopus 로고
    • Automated lentiviral transduction of T cells with CARs using the CliniMACS Prodigy
    • Mock U, Nickolay L, Cheung G, Zhan H, Peggs K, Johnston I, et al. Automated lentiviral transduction of T cells with CARs using the CliniMACS Prodigy. Blood. 2015;11(2):A26-6.
    • (2015) Blood , vol.11 , Issue.2 , pp. A26-A36
    • Mock, U.1    Nickolay, L.2    Cheung, G.3    Zhan, H.4    Peggs, K.5    Johnston, I.6
  • 46
    • 29244443951 scopus 로고    scopus 로고
    • Production scale-up and validation of packaging cell clearance of clinical grade retroviral vector stocks produced in cell factories
    • Przybylowski M, Hakakha A, Stefanski J, Hodges J, Sadelain M, Rivière I. Production scale-up and validation of packaging cell clearance of clinical grade retroviral vector stocks produced in cell factories. Gene Ther. 2006; 13(1):95-100.
    • (2006) Gene Ther , vol.13 , Issue.1 , pp. 95-100
    • Przybylowski, M.1    Hakakha, A.2    Stefanski, J.3    Hodges, J.4    Sadelain, M.5    Rivière, I.6
  • 47
    • 0031710033 scopus 로고    scopus 로고
    • A third-generation lentivirus vector with a conditional packaging system
    • Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, Trono D, et al. A third-generation lentivirus vector with a conditional packaging system. J Virol. 1998;72(11):8463-71.
    • (1998) J Virol , vol.72 , Issue.11 , pp. 8463-8471
    • Dull, T.1    Zufferey, R.2    Kelly, M.3    Mandel, R.J.4    Nguyen, M.5    Trono, D.6
  • 49
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med. 2011;365(8): 725-33.
    • (2011) N Engl J Med , vol.365 , Issue.8 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 50
    • 85016241685 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells: A novel therapy for solid tumors
    • Yu S, Li A, Liu Q, Li T, Yuan X, Han X, et al. Chimeric antigen receptor T cells: a novel therapy for solid tumors. J Hematol Oncol. 2017;10(1):78.
    • (2017) J Hematol Oncol , vol.10 , Issue.1 , pp. 78
    • Yu, S.1    Li, A.2    Liu, Q.3    Li, T.4    Yuan, X.5    Han, X.6
  • 51
    • 85019566250 scopus 로고    scopus 로고
    • Prospects for personalized combination immunotherapy for solid tumors based on adoptive cell therapies and immune checkpoint blockade therapies
    • Kato D, Yaguchi T, Iwata T, Morii K, Nakagawa T, Nishimura R, et al. Prospects for personalized combination immunotherapy for solid tumors based on adoptive cell therapies and immune checkpoint blockade therapies. Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(1):68-77.
    • (2017) Nihon Rinsho Meneki Gakkai Kaishi , vol.40 , Issue.1 , pp. 68-77
    • Kato, D.1    Yaguchi, T.2    Iwata, T.3    Morii, K.4    Nakagawa, T.5    Nishimura, R.6
  • 52
    • 84958230998 scopus 로고    scopus 로고
    • Engineering customized cell sensing and response behaviors using synthetic notch receptors
    • Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, et al. Engineering customized cell sensing and response behaviors using synthetic notch receptors. Cell. 2016;164(4):780-91.
    • (2016) Cell , vol.164 , Issue.4 , pp. 780-791
    • Morsut, L.1    Roybal, K.T.2    Xiong, X.3    Gordley, R.M.4    Coyle, S.M.5    Thomson, M.6
  • 53
    • 84958214384 scopus 로고    scopus 로고
    • Precision tumor recognition by T cells with combinatorial antigen-sensing circuits
    • Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, et al. Precision tumor recognition by T cells with combinatorial antigen-sensing circuits. Cell. 2016;164(4):770-9.
    • (2016) Cell , vol.164 , Issue.4 , pp. 770-779
    • Roybal, K.T.1    Rupp, L.J.2    Morsut, L.3    Walker, W.J.4    McNally, K.A.5    Park, J.S.6
  • 54
    • 84976552978 scopus 로고    scopus 로고
    • Augmentation of CAR T-cell trafficking and antitumor efficacy by blocking protein kinase A localization
    • Newick K, O'Brien S, Sun J, Kapoor V, Maceyko S, Lo A, et al. Augmentation of CAR T-cell trafficking and antitumor efficacy by blocking protein kinase A localization. Cancer Immunol Res. 2016;4(6):541-51.
    • (2016) Cancer Immunol Res , vol.4 , Issue.6 , pp. 541-551
    • Newick, K.1    O'Brien, S.2    Sun, J.3    Kapoor, V.4    Maceyko, S.5    Lo, A.6
  • 55
    • 84937758074 scopus 로고    scopus 로고
    • Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
    • Caruana I, Savoldo B, Hoyos V, Weber G, Liu H, Kim ES, et al. Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes. Nat Med. 2015;21(5):524-9.
    • (2015) Nat Med , vol.21 , Issue.5 , pp. 524-529
    • Caruana, I.1    Savoldo, B.2    Hoyos, V.3    Weber, G.4    Liu, H.5    Kim, E.S.6
  • 57
    • 84904097189 scopus 로고    scopus 로고
    • Current concepts in the diagnosis and management of cytokine release syndrome
    • Lee DW, Gardner R, Porter DL, Louis CU, Ahmed N, Jensen M, et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood. 2014;124(2):188-95.
    • (2014) Blood , vol.124 , Issue.2 , pp. 188-195
    • Lee, D.W.1    Gardner, R.2    Porter, D.L.3    Louis, C.U.4    Ahmed, N.5    Jensen, M.6
  • 59
    • 85014216230 scopus 로고    scopus 로고
    • New development in CAR-T cell therapy
    • Wang Z, Wu Z, Liu Y, Han W. New development in CAR-T cell therapy. J Hematol Oncol. 2017;10(1):53.
    • (2017) J Hematol Oncol , vol.10 , Issue.1 , pp. 53
    • Wang, Z.1    Wu, Z.2    Liu, Y.3    Han, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.