T-cell activation by recombinant immunoreceptors: Impact of the intracellular signalling domain on the stability of receptor expression and antigen-specific activation of grafted T cells

Gene Therapy

Volumn 10, Issue 17, 2003, Pages 1408-1419

  Heuser, C ^a   Hombach, A ^a   Losch C ^a   Manista, K ^a   Abken, H ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

CD3 ; Chain; Chimeric T cell receptor; FcERl chain; Immunotherapy

Indexed keywords

ANTIGEN; CD3 ANTIGEN; FC RECEPTOR; GAMMA INTERFERON; LIGAND; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; T LYMPHOCYTE RECEPTOR ZETA CHAIN; UNCLASSIFIED DRUG;

ADOPTIVE IMMUNOTHERAPY; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOLYSIS; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; INHIBITION KINETICS; LYMPHOCYTE CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TARGET CELL;

CELL LINE; CELLS, CULTURED; GENE THERAPY; GENETIC ENGINEERING; HUMANS; IMMUNOGLOBULIN EPSILON-CHAINS; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECOMBINANT PROTEINS; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0043026990     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302023     Document Type: Article

References (31)

1. Abken H, Hombach A, Reinhold U, Ferrone S. Can combined T-cell- and antibody-based immunotherapy outsmart tumor cells? Immunol Today 1998; 19: 2-5.
2. Eshhar Z, Waks T, Gross G, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci USA 1993; 90: 720-724.
3. Hombach A et al. CD4+ T cells engrafted with a recombinant immunoreceptor efficiently lyse target cells in a MHC antigen-and Fas-independent fashion. J Immunol 2001; 167: 1090-1096.
4. Trinchieri G, Valiante N. Receptors for the Fc fragment of IgG on natural killer cells. Nat Immun 1993; 12: 218-234.
5. Malissen B, Schmitt-Verhulst AM. Transmembrane signalling through the T-cell-receptor-CD3 complex. Curr Opin Immunol 1993; 5: 324-333.
6. Paolini R et al. Different roles for the Fc epsilon RI gamma chain as a function of the receptor context. J Exp Med 1995; 181: 247-255.
7. Frank SJ, Engel I, Rutledge TM, Letourneur F. Structure/function analysis of the invariant subunits of the T cell antigen receptor. Semin Immunol 1991; 3: 299-311.
8. Howard FD, Rodewald HR, Kinet JP, Reinherz EL. CD3 zeta subunit can substitute for the gamma subunit of Fc epsilon receptor type I in assembly and functional expression of the high-affinity IgE receptor: evidence for interreceptor complementation. Proc Natl Acad Sci USA 1990; 87: 7015-7019.
9. Liu CP et al. Development and function of T cells in T cell antigen receptor/CD3 zeta knockout mice reconstituted with Fc epsilon RI gamma. Proc Natl Acad Sci USA 1997; 94: 616-621.
10. Patel SD et al. Impact of chimeric immune receptor extracellular protein domains on T cell function. Gene Therapy 1999; 6: 412-419.
11. Hombach A et al. T cell activation by recombinant Fc epsilon RI gamma-chain immune receptors: an extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition. Gene Therapy 2000; 7: 1067-1075.
12. Moritz D, Groner B. A spacer region between the single chain antibody- and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity. Gene Therapy 1995; 2: 539-546.
13. Willemsen RA et al. Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR. Gene Therapy 2000; 7: 1369-1377.
14. Weijtens ME, Hart EH, Bolhuis RL. Functional balance between T cell chimeric receptor density and tumor associated antigen density: CTL mediated cytolysis and lymphokine production. Gene Therapy 2000; 7: 35-42.
15. Kuster H, Thompson H, Kinet JP. Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family. J Biol Chem 1990; 265: 6448-6452.
16. Hombach A et al. T-cell activation by recombinant receptors: CD28 costimulation is required for interleukin 2 secretion and receptor-mediated T-cell proliferation but does not affect receptor-mediated target cell lysis. Cancer Res 2001; 61: 1976-1982.
17. Roberts MR et al. Antigen-specific cytolysis by neutrophils and NK cells expressing chimeric immune receptors bearing zeta or gamma signaling domains. J Immunol 1998; 161: 375-384.
18. Romeo C, Seed B. Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides. Cell 1991; 64: 1037-1046.
19. Ren-Heidenreich L et al. Comparison of the TCR zeta-chain with the FcR gamma-chain in chimeric TCR constructs for T cell activation and apoptosis.PG-417-23. Cancer Immunol Immunother 2002; 51.
20. Haynes NM et al. Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma. J Immunol 2001; 166: 182-187.
21. Irving BA, Chan AC, Weiss A. Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J Exp Med 1993; 177: 1093-1103.
22. Shores EW et al. Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire. J Exp Med 1997; 185: 893-900.
23. Hombach A et al. Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule. J Immunol 2001; 167: 6123-6131.
24. Maher J et al. Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptor. Nat Biotechnol 2002; 20: 70-75.
25. Haynes NM et al. Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood 2002; 100: 3155-3163.
26. Weijtens ME, Willemsen RA, Hart EH, Bolhuis RL. A retroviral vector system 'STITCH' in combination with an optimized single chain antibody chimeric receptor gene structure allows efficient gene transduction and expression in human T lymphocytes. Gene Therapy 1998; 5: 1195-1203.
27. Gata S, Chen A, Itzkowitz SH. Use of model cell lines to study the biosynthesis and biological role of cancer-associated sialosyl-Tn antigen. Cancer Res 1994; 54: 4036-4044.
28. Hombach A et al. An entirely humanized CD3 zeta-chain signaling receptor that directs peripheral blood t cells to specific lysis of carcinoembryonic antigen-positive tumor cells. Int J Cancer 2000; 88: 115-120.
29. Hombach A et al. Chimeric anti-TAG72 receptors with immunoglobulin constant Fc domains and gamma or zeta signalling chains. Int J Mol Med 1998; 2: 99-103.
30. Hombach A et al. T cell targeting of TAG72+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope. Gastroenterology 1997; 113: 1163-1170.
31. Jost LM, Kirkwood JM, Whiteside TL. Improved short- and long-term XTT-based colorimetric cellular cytotoxicity assay for melanoma and other tumor cells. J Immunol Methods 1992; 147: 153-165.