Systematic comparison of two animal-to-human transmitted human coronaviruses: SARS-CoV-2 and SARS-CoV

Viruses

Volumn 12, Issue 2, 2020, Pages

  Xu, Jiabao ^a   Zhao, Shizhe ^a   Teng, Tieshan ^a   Abdalla, Abualgasim Elgaili ^b   Zhu, Wan ^c   Xie, Longxiang ^a   Wang, Yunlong ^d   Guo, Xiangqian ^a  

^a HENAN UNIVERSITY   (China)

^b JOUF UNIVERSITY   (Saudi Arabia)

^c STANFORD UNIVERSITY   (United States)

^d Henan Art Center   (China)

Author keywords

Clinical manifestations; Coronaviruses; Genomic comparison; Pathogenic mechanism; Proteomic comparison; SARS CoV; SARS CoV 2

Indexed keywords

ADULT RESPIRATORY DISTRESS SYNDROME; AMINO ACID SEQUENCE; ARTICLE; ARTIFICIAL VENTILATION; BREATHING RATE; CHINA; COMPUTER ASSISTED TOMOGRAPHY; CORONAVIRINAE; CORONAVIRUS DISEASE 2019; COUGHING; DYSPNEA; EPIDEMIC; FATIGUE; GENE SEQUENCE; HOSPITAL PERSONNEL; HOSPITALIZATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTENSIVE CARE UNIT; MIDDLE EAST RESPIRATORY SYNDROME; MORTALITY RATE; MYALGIA; NONHUMAN; NOVEL CORONAVIRUS 2019; NOVEL CORONAVIRUS DISEASE 2019; PHYLOGENY; PNEUMONIA; PREVALENCE; RESPIRATORY DISTRESS; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARS CORONAVIRUS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; UPREGULATION; VIRUS ISOLATION; VIRUS PNEUMONIA; VIRUS REPLICATION; VIRUS TRANSMISSION; ZOONOSIS; ANIMAL; BAT; BETACORONAVIRUS; CHEMISTRY; COMPARATIVE STUDY; CORONAVIRUS INFECTION; DISEASE CARRIER; DISEASE PREDISPOSITION; GENETICS; GLOBAL HEALTH; INCUBATION TIME; PATHOGENICITY; PLACENTAL MAMMAL; SEVERE ACUTE RESPIRATORY SYNDROME; VIROLOGY; VIRUS GENOME;

COVID-19; PROTEOME; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VIRAL PROTEIN;

ANIMALS; BETACORONAVIRUS; CHINA; CHIROPTERA; CORONAVIRUS INFECTIONS; DISEASE RESERVOIRS; DISEASE SUSCEPTIBILITY; EUTHERIA; GENOME, VIRAL; GLOBAL HEALTH; HUMANS; INFECTIOUS DISEASE INCUBATION PERIOD; PNEUMONIA, VIRAL; PROTEOME; SARS VIRUS; SEQUENCE ALIGNMENT; SEVERE ACUTE RESPIRATORY SYNDROME; VIRAL PROTEINS;

EID: 85080049910     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v12020244     Document Type: Article

References (109)

1. Wang, L.F.; Shi, Z.; Zhang, S.; Field, H.; Daszak, P.; Eaton, B.T. Review of bats and SARS. Emerg. Infect. Dis. 2006, 12, 1834. [CrossRef]
2. Ge, X.-Y.; Li, J.; Yang, X.-L.; Chmura, A.; Zhu, G.; Epstein, J.H.; Mazet, J.K.; Hu, B.; Zhang, W.; Peng, C.; et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature 2013, 503, 535-538
3. Chen, Y.; Guo, D. Molecular mechanisms of coronavirus RNA capping and methylation. Virol. Sin. 2016, 31, 3-11
4. Cui, J.; Li, F.; Shi, Z.L. Origin and evolution of pathogenic coronaviruses. Nat. Rev. Microbiol. 2019, 17, 181-192
5. Cauchemez, S.; Van Kerkhove, M.D.; Riley, S.; Donnelly, C.A.; Fraser, C.; Ferguson, N.M. Transmission scenarios for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and how to tell them apart. Euro Surveill. 2013, 18, 18.
6. Gorbalenya, A.E.; Baker, S.C.; Baric, R.S.; de Groot, R.J.; Drosten, C.; Gulyaeva, A.A.; Haagmans, B.L.; Lauber, C.; Leontovich, A.M.; Neuman, B.W.; et al. Severe acute respiratory syndrome-related coronavirus: The species and its viruses-A statement of the Coronavirus Study Group. bioRxiv 2020. [CrossRef]
7. WHO Named the New Pneumonia "COVID-19". Available online: http://www.xinhuanet.com/world/2020-02/12/c1125561389.htm (accessed on 12 February 2020).
8. Guan, Y.; Zheng, B.J.; He, Y.Q.; Liu, X.L.; Zhuang, Z.X.; Cheung, C.L.; Luo, S.W.; Li, P.H.; Zhang, L.J.; Butt, K.M.; et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science 2003, 302, 276-278. [CrossRef]
9. Ki, M. 2015 MERS outbreak in Korea: Hospital-to-hospital transmission. Epidemiol. Health 2015, 37, 37. [CrossRef]
10. Azhar, E.I.; El-Kafrawy, S.A.; Farraj, S.A.; Hassan, A.M.; Al-Saeed, M.S.; Hashem, A.M.; Madani, T.A. Evidence for camel-to-human transmission of MERS coronavirus. N. Engl. J. Med. 2014, 370, 2499-2505. [CrossRef]
11. Chan, J.F.W.; Kok, K.H.; Zhu, Z.; Chu, H.; To, K.K.W.; Yuan, S.; Yuen, K.Y. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg. Microbes. Infect. 2020, 9, 221-236. [CrossRef]
12. Zhao, W.M.; Song, S.H.; Chen, M.L.; Zou, D.; Ma, L.N.; Ma, Y.K.; Li, R.J.; Hao, L.L.; Li, C.P.; Tian, D.M.; et al. The 2019 Novel Coronavirus Resource. Hereditas 2020, 36, 1-9.
13. NCBI Database. 2019-nCoV. Available online: https://www.ncbi.nlm.nih.gov/pubmed/?term=2019-nCoV (accessed on 14 February 2020).
14. GSAID Database. 2020 Coronavirus. Available online: https://www.gisaid.org/CoV2020/ (accessed on 14 February 2020).
15. NCBI Blast. Available online: https://blast.ncbi.nlm.nih.gov/Blast.cgi (accessed on 30 January 2020).
16. Zpicture. Available online: https://zpicture.dcode.org (accessed on 1 February 2020).
17. Kumar, S.; Stecher, G.; Tamura, K. MEGA7: Molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol. Biol. Evol. 2016, 33, 1870-1874
18. Tamura, K.; Nei, M.; Kumar, S. Prospects for inferring very large phylogenies by using the neighbor-joining method. Proc. Natl. Acad. Sci. USA 2004, 101, 11030-11035
19. Cheng, V.C.; Lau, S.K.; Woo, P.C.; Yuen, K.Y. Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin. Microbiol. Rev. 2007, 20, 660-694
20. WorldHealthOrganization. Weekly Epidemiological Record, 2013, vol. 88, 35 [full issue].Wkly. Epidemiol. Rec. 2013, 88, 365-380.
21. Lee, N.; Hui, D.S.;Wu, A.; Chan, P.K.S.; Cameron, P.; Joynt, G.; Ahuja, A.T.; Yung, M.Y.; Leung, C.; To, K.; et al. A major outbreak of severe acute respiratory syndrome in Hong Kong. N. Engl. J. Med. 2003, 348, 1986-1994. [CrossRef]
22. Poutanen, S.; Low, N.E.; Henry, B.; Finkelstein, S.; Rose, D.; Green, K.; Tellier, R.; Draker, R.; Adachi, D.; Ayers, M.; et al. Identification of severe acute respiratory syndrome in Canada. N. Engl. J. Med. 2003, 348, 1995-2005. [CrossRef]
23. Leo, Y.S.; Chen, M.; Heng, B.H.; Lee, C.C. Severe acute respiratory syndrome-Singapore, 2003. MMWR Morb. Mortal. Wkly. Rep. 2003, 52, 405.
24. World Health Organization. Summary of Probable SARS Cases with Onset of Illness from 1 November 2002 to 31 July 2003. Available online: http://www.who.int/csr/sars/country/table20040421/en/index.html. (accessed on 27 January 2020).
25. Nuttall, I.; Dye, C. The SARS wake-up call. Science 2013, 339, 1287-1288. [CrossRef]
26. Al-Tawfiq, J.A.; Zumla, A.; Memish, Z.A. Travel implications of emerging coronaviruses: SARS and MERS-CoV. Travel. Med. Infect. Dis. 2014, 12, 422-428. [CrossRef]
27. Chinese Center for Disease Control and Prevention. Epidemic Update and Risk Assessment of 2019 Novel Coronavirus. Available online: http://www.Chinacdc.cn/yyrdgz/202001/P020200128523354919292.pdf (accessed on 28 January 2020).
28. Gralinski, L.E.; Menachery, V.D. Return of the Coronavirus: 2019-nCoV. Viruses 2020, 12, 135
29. Wang, J.T.; Sheng, W.H.; Fang, C.T.; Chen, Y.C.; Wang, J.L.; Yu, C.J.; Yang, P.C. Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients. Emerg. Infect. Dis. 2004, 10, 818
30. Fehr, A.R.; Channappanavar, R.; Perlman, S. Middle East respiratory syndrome: Emergence of a pathogenic human coronavirus. Annu. Rev. Med. 2017, 68, 387-399
31. National Health Commission of the People's Republic of China. Diagnosis and Treatment of Pneumonia Caused by 2019-nCoV (Trial Version 4). Available online: http://www.nhc.gov.cn/jkj/ s3577/202002/573340613ab243b3a7f61df260551dd4/files/c791e5a7ea5149f680fdcb34dac0f54e.pdf (accessed on 6 February 2020).
32. Yang, F. Pulmonary rehabilitation guidelines in the principle of 4S for patients infected with 2019 novel coronavirus (2019-nCoV). Zhonghua Jie He He Hu Xi Za Zhi 2020, 43, E004.
33. Lessler, J.; Reich, N.G.; Brookmeyer, R.; Perl, T.M.; Nelson, K.E.; Cummings, D.A. Incubation periods of acute respiratory viral infections: A systematic review. Lancet. Infect. Dis. 2009, 9, 291-300. [CrossRef]
34. Meltzer, M.I. Multiple contact dates and SARS incubation periods. Emerg. Infect. Dis. 2004, 10, 207. [CrossRef]
35. Zhu, N.; Zhang, D.; Wang,W.; Li, X.; Yang, B.; Song, J.; Zhao, X.; Huang, B.; Shi,W.; Lu, R.; et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020, 382, 727-733. [CrossRef]
36. Yang, Y.; Lu, Q.; Liu, M.;Wang, Y.; Zhang, A.; Jalali, N.; Dean, N.; Longini, I.; Halloran, M.E.; Xu, B.; et al. Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China. medRxiv 2020. [CrossRef]
37. Chan-Yeung, M.; Xu, R.H. SARS: Epidemiology. Respirology 2003, 8, S9-S14. [CrossRef]
38. Wang, C.; Horby, P.W.; Hayden, F.G.; Gao, G.F. A novel coronavirus outbreak of global health concern. Lancet 2020, 395, 470-473. [CrossRef]
39. Peiris, J.S.; Yuen, K.Y.; Osterhaus, A.D.; Stöhr, K. The severe acute respiratory syndrome. N. Engl. J. Med. 2003, 349, 2431-2441
40. Leung, G.M.; Hedley, A.J.; Ho, L.-M.; Chau, P.; Wong, I.O.; Thach, T.Q.; Ghani, A.C.; Donnelly, C.; Fraser, C.; Riley, S.; et al. The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: An analysis of all 1755 patients. Ann. Intern. Med. 2004, 141, 662-673
41. Infectious Disease Expert Li Lanjuan Responded to Six Questions of 2019-nCoV. Available online: http: //m.news.cctv.com/2020/01/23/ARTIEw78LIxqpgx6Ilm7NkBo200123.shtml (accessed on 23 January 2020).
42. Li, Q.; Guan, X.; Wu, P.; Wang, X.; Zhou, L.; Tong, Y.; Ren, R.; Leung, K.S.; Lau, E.H.; Wong, J.Y.; et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N. Engl. J. Med. 2020
43. Huang, C.; Wang, Y.; Li, X.; Ren, L.; Zhao, J.; Hu, Y.; Zhang, L.; Fan, G.; Xu, J.; Gu, X.; et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020, 395, 497-506. [CrossRef]
44. Chen, N.; Zhou, M.; Dong, X.; Qu, J.; Gong, F.; Han, Y.; Qiu, Y.;Wang, J.; Liu, Y.;Wei, Y.; et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet 2020, 395, 507-513. [CrossRef]
45. Press Conference of the National Health Commission of the People's Republic of China on 3 February 2020. Available online: http://www.nhc.gov.cn/wjw/xwfbh/xwzb.shtml (accessed on 4 February 2020).
46. Yuan, J.; Hon, C.-C.; Li, Y.;Wang, D.; Xu, G.; Zhang, H.; Zhou, P.; Poon, L.; Lam, T.Y.; Leung, F.C.-C.; et al. Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans. J. Gen. Virol. 2010, 91, 1058-1062
47. Phan, T. Novel coronavirus: From discovery to clinical diagnostics. Infect. Genet. Evol. 2020, 79, 104211. [CrossRef]
48. Wang, M.; Yan, M.; Xu, H.; Liang, W.; Kan, B.; Zheng, B.; Chen, H.; Zheng, H.; Xu, Y.; Zhang, E.; et al. SARS-CoV infection in a restaurant from palm civet. Emerg. Infect. Dis. 2005, 11, 1860. [CrossRef]
49. Zhou, P.; Yang, X.-L.; Wang, X.-G.; Hu, B.; Zhang, L.; Zhang, W.; Si, H.-R.; Zhu, Y.; Li, B.; Huang, C.-L.; et al. Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin. bioRxiv 2020. [CrossRef]
50. Guo, Q.; Li, M.; Wang, C.; Wang, P.; Fang, Z.; Tan, J.; Wu, S.; Xiao, Y.; Zhu, H. Host and infectivity prediction ofWuhan 2019 novel coronavirus using deep learning algorithm. bioRxiv 2020. [CrossRef]
51. Ji, W.; Wang, W.; Zhao, X.; Zai, J.; Li, X. Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human. J. Med. Virol. 2020, 92, 433-440. [CrossRef]
52. South China Agricultural University: Pangolin May Be a Potential Intermediate Host of New Coronavirus. Available online: http://www.Chinanews.com/sh/2020/02-07/9082279.shtml (accessed on 7 February 2020).
53. Chowell, G.; Castillo-Chavez, C.; Fenimore, P.W.; Kribs-Zaleta, C.M.; Arriola, L.; Hyman, J.M. Model parameters and outbreak control for SARS. Emerg. Infect. Dis. 2004, 10, 1258
54. Lau, E.H.Y.; Hsiung, C.A.; Cowling, B.J.; Chen, C.-H.; Ho, L.-M.; Tsang, T.; Chang, C.-W.; Donnelly, C.; Leung, G.M. A comparative epidemiologic analysis of SARS in Hong Kong, Beijing and Taiwan. BMC Infect. Dis. 2010, 10, 50
55. Chinese Center for Disease Control and Prevention. Distribution of Pneumonia Infected by 2019-nCoV. Available online: http://2019ncov.Chinacdc.cn/2019-nCoV/ (accessed on 15 February 2020).
56. Real-time Updates of COVID-19 Epidemic in China. Available online: https://ncov.dxy.cn/ncovh5/view/ pneumonia (accessed on 15 February 2020).
57. Nishiura, H.; Jung, S.-M.; Linton, N.; Kinoshita, R.; Yang, Y.; Hayashi, K.; Kobayashi, T.; Yuan, B.; Akhmetzhanov, A.R. The extent of transmission of novel coronavirus inWuhan, China, 2020. J. Clin. Med. 2020, 9, 330. [CrossRef]
58. Li, X.; Zai, J.;Wang, X.; Li, Y. Potential of large 'first generation' human-to-human transmission of 2019-nCoV. J. Med. Virol. 2020, 92, 448-454. [CrossRef]
59. Carlos,W.G.; Dela Cruz, C.S.; Cao, B.; Pasnick, S.; Jamil, S. NovelWuhan (2019-nCoV) Coronavirus. Am. J. Respir. Crit. Care Med. 2020, 201, 7-8. [CrossRef]
60. National Health Commission of the People's Republic of China. The Role of Fecal-Oral Transmission in All transmission Still Need Further Observation and Research. Available online: http://news.cctv.com/2020/02/ 13/ARTISJWExxLSLWoL8mtJos97200213.shtml (accessed on 13 February 2020).
61. Chinese Center for Disease Control and Prevention. There Is No Evidence That the New Coronavirus Can Be Transmitted through Aerosol. Available online: http://news.cctv.com/2020/02/09/ ARTIiVFnLC1ww5sTSMqbcXlz200209.shtml (accessed on 9 February 2020).
62. Lau, J.T.; Tsui, H.; Lau, M.; Yang, X. SARS transmission, risk factors, and prevention in Hong Kong. Emerg. Infect. Dis. 2004, 10, 587. [CrossRef]
63. Lu, H.; Stratton, C.W.; Tang, Y.W. Outbreak of Pneumonia of Unknown Etiology inWuhan China: The Mystery and the Miracle. J. Med. Virol. 2020, 92, 401-402. [CrossRef]
64. Rouquet, P.; Froment, J.-M.; Bermejo, M.; Kilbourn, A.; Karesh, W.; Reed, P.; Kumulungui, B.; Yaba, P.; Delicat, A.; Rollin, P.E.; et al. Wild animal mortality monitoring and human Ebola outbreaks, Gabon and Republic of Congo, 2001-2003. Emerg. Infect. Dis. 2005, 11, 283. [CrossRef]
65. Yoo, J.H. The Fight against the 2019-nCoV Outbreak: An Arduous March Has Just Begun. J. Korean Med. Sci. 2020, 35, e56. [CrossRef]
66. De Wit, E.; van Doremalen, N.; Falzarano, D.; Munster, V.J. SARS and MERS: Recent insights into emerging coronaviruses. Nat. Rev. Microbiol. 2016, 14, 523
67. Chinese Center for Disease Control and Prevention. The First New Coronavirus Species InformationWas Published by the National Pathogen Microorganism Resource Bank. Available online: http://www.Chinacdc. cn/yw9324/202001/t20200124211413.html (accessed on 1 February 2020).
68. Zeng, Q.; Khan, K.; Wu, J.; Zhu, H. The utility of preemptive mass influenza vaccination in controlling a SARS outbreak during flu season. Math. Biosci. Eng. 2007, 4, 739. [PubMed]
69. Wang, N.; Luo, C.; Liu, H.; Yang, X.-L.; Hu, B.; Zhang, W.; Li, B.; Zhu, Y.; Zhu, G.; Shen, X.; et al. Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats. Viruses 2019, 11, 379
70. Bhadra, S.; Jiang, Y.S.; Kumar, M.R.; Johnson, R.F.; Hensley, L.E.; Ellington, A.D. Real-time sequence-validated loop-mediated isothermal amplification assays for detection of Middle East respiratory syndrome coronavirus (MERS-CoV). PLoS ONE 2015, 10, e0123126
71. Chan, J.F.-W.; Choi, G.K.-Y.; Tsang, A.K.-L.; Tee, K.-M.; Lam, H.-Y.; Yip, C.C.-Y.; To, K.K.-W.; Cheng, V.C.-C.; Yeung, M.L.; Lau, S.K.; et al. Development and evaluation of novel real-time reverse transcription-PCR assays with locked nucleic acid probes targeting leader sequences of human-pathogenic coronaviruses. J. Clin. Microbiol. 2015, 53, 2722-2726. [CrossRef]
72. Wu, P.; Hao, X.; Lau, E.H.Y.; Wong, J.Y.; Leung, K.S.M.; Wu, J.T.; Cowling, B.J.; Leung, G.M. Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020. Euro. Surveill. 2020, 25, 2000044. [CrossRef]
73. National Medical Products Administration. National Medical Products Administration Examined and Approved the New Nucleic Acid Test Reagent of Coronavirus Again. Available online: http://www.nmpa. gov.cn/WS04/CL2056/374398.html (accessed on 28 January 2020).
74. Chen, Y.; Liu, Q.; Guo, D. Emerging coronaviruses: Genome structure, replication, and pathogenesis. J. Med. Virol. 2020, 92, 418-423. [CrossRef]
75. Cinatl, J.; Morgenstern, B.; Bauer, G.; Chandra, P.; Rabenau, H.; Doerr, H.W. Treatment of SARS with human interferons. Lancet 2003, 362, 293-294. [CrossRef]
76. Chu, C.M.; Cheng, V.C.C.; Hung, I.F.N.; Wong, M.M.L.; Chan, K.; Kao, R.Y.; Poon, L.; Wong, C.L.P.; Guan, Y.; Peiris, J.S.M.; et al. Role of lopinavir/ritonavir in the treatment of SARS: Initial virological and clinical findings. Thorax 2004, 59, 252-256. [CrossRef]
77. Lu, H. Drug treatment options for the 2019-new coronavirus (2019-nCoV). Biosci. Trends 2020. [CrossRef]
78. Beijing Municipal Health Commission. Explanation on the Situation that Drugs for AIDS Can Be Tried to Treat Pneumonia Caused by 2019-nCoV Infection. Available online: http://wjw.beijing.gov.cn/wjwh/ztzl/ xxgzbd/202001/t202001261621354.html (accessed on 26 January 2020).
79. The Joint Research Team of Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and ShanghaiTech University Discovered a Batch of Old Drugs and Traditional Chinese Medicines with Therapeutic Potential for COVID-19. Available online: http://www.shanghaitech.edu.cn/2020/0125/ c1001a50141/page.htm (accessed on 25 January 2020).
80. High-Resolution Crystal Structure of 2019-nCoV Coronavirus 3CL Hydrolase (Mpro) was Announced by the Joint Research Team of Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and ShanghaiTech University. Available online: http://www.shanghaitech.edu.cn/2020/0126/c1001a50145/page.htm (accessed on 26 January 2020).
81. Xu, Z.; Peng, C.; Shi, Y.; Zhu, Z.; Mu, K.; Wang, X.; Zhu, W. Nelfinavir was predicted to be a potential inhibitor of 2019 nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation. bioRxiv 2020. [CrossRef]
82. Sheahan, T.P.; Sims, A.C.; Leist, S.R.; Schäfer, A.;Won, J.; Brown, A.J.; Montgomery, S.A.; Hogg, A.; Babusis, D.; Clarke, M.O.; et al. Comparative therapeutic Efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat. Commun. 2020, 11, 222
83. Mulangu, S.; Dodd, L.E.; Davey, R.T.; Mbaya, O.T.; Proschan, M.; Mukadi, D.; Manzo, M.L.; Nzolo, D.; Oloma, A.T.; Ibanda, A.; et al. A randomized, controlled trial of Ebola virus disease therapeutics. N. Engl. J. Med. 2019, 381, 2293-2303
84. Holshue, M.L.; DeBolt, C.; Lindquist, S.; Lofy, K.H.; Wiesman, J.; Bruce, H.; Spitters, C.; Ericson, K.; Wilkerson, S.; Tural, A.; et al. First Case of 2019 Novel Coronavirus in the United States. N. Engl. J. Med. 2020. [CrossRef]
85. Song, G.; Cheng, M.Q.; Wei, X.W. Research progress on novel coronavirus (2019-nCoV) related drugs in vitro/vivo. Bing Du Xue Bao 2020. [CrossRef]
86. China-Japan Friendship Hospital: Clinical Experimental Research Work Is Being Carried Out on Remdesivir. Available online: http://www.Chinanews.com/sh/shipin/cns-d/2020/02-12/news847712.shtml (accessed on 12 February 2020).
87. Lai, M.M. Recombination in large RNA viruses: Coronaviruses. Semin. Virol. 1996, 7, 381-388. [CrossRef]
88. Woo, P.C.Y.; Lau, S.K.; Lam, C.S.F.; Lau, C.C.Y.; Tsang, A.K.L.; Lau, J.H.N.; Bai, R.; Teng, J.L.L.; Tsang, C.C.C.; Wang, M.; et al. Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus. J. Virol. 2012, 86, 3995-4008.
89. Lu, R.; Zhao, X.; Li, J.; Niu, P.; Yang, B.; Wu, H.; Wang, W.; Song, H.; Huang, B.; Zhu, N.; et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet 2020, 395, 565-574. [CrossRef]
90. Shi, C.S.; Nabar, N.R.; Huang, N.N.; Kehrl, J.H. SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes. Cell Death Discov. 2019, 5, 101. [CrossRef]
91. Menachery, V.D.; Graham, R.L.; Baric, R.S. Jumping species-A mechanism for coronavirus persistence and survival. Curr. Opin. Virol. 2017, 23, 1-7. [CrossRef]
92. Wang, N.; Li, S.-Y.; Yang, X.-L.; Huang, H.-M.; Zhang, Y.-J.; Guo, H.; Luo, C.-M.; Miller, M.; Zhu, G.; Chmura, A.; et al. Serological evidence of bat SARS-related coronavirus infection in humans, China. Virol. Sin. 2018, 33, 104-107
93. Xia, S.; Yan, L.; Xu,W.; Agrawal, A.S.; Algaissi, A.; Tseng, C.-T.K.;Wang, Q.; Du, L.; Tan,W.;Wilson, I.A.; et al. A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Sci. Adv. 2019, 5, eaav4580
94. Nicholls, J.; DONG, X.P.; Jiang, G.; Peiris, M. SARS: Clinical virology and pathogenesis. Respirology 2003, 8, S6-S8
95. He, L.; Ding, Y.; Zhang, Q.; Che, X.; He, Y.; Shen, H.; Wang, H.; Li, Z.; Zhao, L.; Geng, J.; et al. Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: Relation to the acute lung injury and pathogenesis of SARS. J. Pathol. 2006, 210, 288-297
96. Hamming, I.; Timens, W.; Bulthuis, M.L.C.; Lely, A.T.; Navis, G.J.; van Goor, H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J. Pathol. 2004, 203, 631-637
97. Perlman, S.; Netland, J. Coronaviruses post-SARS: Update on replication and pathogenesis. Nat. Rev. Microbiol. 2009, 7, 439-450. [CrossRef]
98. Ding, Y.;Wang, H.; Shen, H.; Li, Z.; Geng, J.; Han, H.; Cai, J.; Li, X.; Kang,W.;Weng, D.; et al. The clinical pathology of severe acute respiratory syndrome (SARS): A report from China. J. Pathol. 2003, 200, 282-289. [CrossRef]
99. Ding, Y.; He, L.; Zhang, Q.; Huang, Z.; Che, X.-Y.; Hou, J.-L.; Wang, H.; Shen, H.; Qiu, L.; Li, Z.; et al. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: Implications for pathogenesis and virus transmission pathways. J. Pathol. 2004, 203, 622-630. [CrossRef]
100. HUI, D.S.C.; WONG, P.C.; Wang, C. SARS: Clinical features and diagnosis. Respirology 2003, 8, S20-S24. [CrossRef]
101. Millet, J.K.; Whittaker, G.R. Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis. Virus. Res. 2015, 202, 120-134. [CrossRef]
102. Zhou, P.; Yang, X.-L.; Wang, X.-G.; Hu, B.; Zhang, L.; Zhang, W.; Si, H.-R.; Zhu, Y.; Li, B.; Huang, C.-L.; et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020
103. Kuba, K.; Imai, Y.; Rao, S.; Gao, H.; Guo, F.; Guan, B.; Huan, Y.; Yang, P.; Zhang, Y.; Deng, W.; et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat. Med. 2005, 11, 875-879
104. Imai, Y.; Kuba, K.; Rao, S.; Huan, Y.; Guo, F.; Guan, B.; Yang, P.; Sarao, R.; Wada, T.; Leong-Poi, H.; et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature 2005, 436, 112-116
105. Li, W.; Moore, M.J.; Vasilieva, N.; Sui, J.; Wong, S.K.; Berne, M.A.; Somasundaran, M.; Sullivan, J.L.; Luzuriaga, K.; Greenough, T.C.; et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003, 426, 450-454. [CrossRef]
106. Wan, Y.; Shang, J.; Graham, R.; Baric, R.S.; Li, F. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. J. Virol. 2020. [CrossRef]
107. Bassetti, M.; Vena, A.; Roberto Giacobbe, D. The Novel Chinese Coronavirus (2019-nCoV) Infections: Challenges for fighting the storm. Eur. J. Clin. Investig. 2020. [CrossRef]
108. Su, S.; Wong, G.; Shi, W.; Liu, J.; Lai, A.C.; Zhou, J.; Liu, W.; Bi, Y.; Gao, G.F. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends. Microbiol. 2016, 24, 490-502. [CrossRef]
109. Chu, D.K.W.; Poon, L.; Gomaa, M.; Shehata, M.; Perera, R.A.; Abu Zeid, D.; El Rifay, A.S.; Siu, L.Y.; Guan, Y.; Webby, R.J.; et al. MERS coronaviruses in dromedary camels, Egypt. Emerg. Infect. Dis. 2014, 20, 1049. [CrossRef]