A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Human Molecular Genetics

Volumn 28, Issue 15, 2019, Pages 2615-2633

  Sung, Yun Ju ^a   De Las Fuentes, Lisa ^a,b   Winkler, Thomas W ^c   Chasman, Daniel I ^d   Bentley, Amy R ^e   Kraja, Aldi T ^a   Ntalla, Ioanna ^f   Warren, Helen R ^f,g   Guo, Xiuqing ^h   Schwander, Karen ^a   Manning, Alisa K ^i,j   Brown, Michael R ^k   Aschard, Hugues ^l,m   Feitosa, Mary F ^a   Franceschini, Nora ⁿ   Lu, Yingchang ^o   Cheng, Ching Yu ^p,q,r   Sim, Xueling ^s   Vojinovic, Dina ^t   Marten, Jonathan ^u   Musani, Solomon K ^v   Kilpeläinen, Tuomas O ^o,w   Richard, Melissa A ^x   Aslibekyan, Stella ^y   Bartz, Traci M ^z   Dorajoo, Rajkumar ^aa   Li, Changwei ^ab   Liu, Yongmei ^ac   Rankinen, Tuomo ^ad   Smith, Albert Vernon ^ae,af   Tajuddin, Salman M ^ag   Tayo, Bamidele O ^ah   Zhao, Wei ^ai   Zhou, Yanhua ^aj   Matoba, Nana ^ak   Sofer, Tamar ^d,al   Alver, Maris ^am   Amini, Marzyeh ^an   Boissel, Mathilde ^ao   Chai, Jin Fang ^s   Chen, Xu ^ap   Divers, Jasmin ^aq   Gandin, Ilaria ^ar   Gao, Chuan ^aq   Giulianini, Franco ^d   Goel, Anuj ^as,at   Harris, Sarah E ^au   Hartwig, Fernando P ^av,aw   He, Meian ^ax   Horimoto, Andrea R V R ^ai   Hsu, Fang Chi ^aq   Jackson, Anne U ^ay   Kammerer, Candace M ^az   Kasturiratne, Anuradhani ^ba   Komulainen, Pirjo ^bb   Kühnel, Brigitte ^ap,bb   Leander, Karin ^bc   Lee, Wen Jane ^bd   Lin, Keng Hung ^be   Luan, Jian'an ^bf   Lyytikäinen, Leo Pekka ^bg,bh   McKenzie, Colin A ^bi   Nelson, Christopher P ^bj,bk   Noordam, Raymond ^bl   Scott, Robert A ^bf   Sheu, Wayne H H ^bd,bm,bn,bo   Stančáková, Alena ^ba   Takeuchi, Fumihiko ^bp   Van Der Most, Peter J ^an   Varga, Tibor V ^bq   Waken, Robert J ^a   Wang, Heming ^d,al   Wang, Yajuan ^br   Ware, Erin B ^ai   Weiss, Stefan ^bs,bt   Wen, Wanqing ^bu   Yanek, Lisa R ^bv   Zhang, Weihua ^bw,bx   Zhao, Jing Hua ^bf   Afaq, Saima ^bw   Alfred, Tamuno ^o   Amin, Najaf ^t   Arking, Dan E ^bv   Aung, Tin ^p,q,r   Barr, R Graham ^by   Bielak, Lawrence F ^ai   Boerwinkle, Eric ^k,bz   Bottinger, Erwin P ^o   Braund, Peter S ^bj,bk   Brody, Jennifer A ^z   Broeckel, Ulrich ^ca   Cade, Brian ^d   Campbell, Archie ^au   Canouil, Mickaël ^ao   Chakravarti, Aravinda ^bv   Cocca, Massimiliano ^ar   Collins, Francis S ^e   Connell, John M ^cb   De Mutsert, Renée ^bl   De Silva, H Janaka ^az   Dörr, Marcus ^bs,bt   Duan, Qing ^cc   Eaton, Charles B ^cd   Ehret, Georg ^bv,ce   Evangelou, Evangelos ^bw,cf   Faul, Jessica D ^ai   Forouhi, Nita G ^bf   Franco, Oscar H ^t   Friedlander, Yechiel ^cg   Gao, He ^bw   Gigante, Bruna ^bc   Gu, C Charles ^a   Gupta, Preeti ^p   Hagenaars, Saskia P ^au   Harris, Tamara B ^ag   He, Jiang ^ch,ci   Heikkinen, Sami ^ba   Heng, Chew Kiat ^r,s   Hofman, Albert ^t   Howard, Barbara V ^cj,ck   Hunt, Steven C ^cl,cm   Irvin, Marguerite R ^y   Jia, Yucheng ^h   Katsuya, Tomohiro ^cn   Kaufman, Joel ^co   Kerrison, Nicola D ^bf   Khor, Chiea Chuen ^aa,cp   Koh, Woon Puay ^q,s   Koistinen, Heikki A ^cq,cr,cs   Kooperberg, Charles B ^co   Krieger, Jose E ^ai   Kubo, Michiaki ^ak   Kutalik, Zoltan ^ct,cu   Kuusisto, Johanna ^ba   Lakka, Timo A ^ba,bb,cv   Langefeld, Carl D ^aq   Langenberg, Claudia ^bf   Launer, Lenore J ^ag   Lee, Joseph H ^cw   Lehne, Benjamin ^bw   Levy, Daniel ^cx,cy   Lewis, Cora E ^cz   Li, Yize ^a   Lim, Sing Hui ^p   Liu, Ching Ti ^aj   Liu, Jianjun ^s,aa   Liu, Jingmin ^da   Liu, Yeheng ^h   Loh, Marie ^bw,db   Lohman, Kurt K ^aq   Louie, Tin ^co   Mägi, Reedik ^am   Matsuda, Koichi ^dc   Meitinger, Thomas ^bb,dd   Metspalu, Andres ^am   Milani, Lili ^b   Momozawa, Yukihide ^ak   Mosley, J r , Thomas H ^de   Nalls, Mike A ^ag   Nasri, Ubaydah ^h   O'Connell, Jeff R ^df   Ogunniyi, Adesola ^dg   Palmas, Walter R ^dh   Palmer, Nicholette D ^aq   Pankow, James S ^di   Pedersen, Nancy L ^ap   Peters, Annette ^bb,bt   Peyser, Patricia A ^ai   Polasek, Ozren ^dj,dk,dl   Porteous, David ^au   Raitakari, Olli T ^dm,dn   Renström, Frida ^bq,do   Rice, Treva K ^a   Ridker, Paul M ^d   Robino, Antonietta ^dp   Robinson, Jennifer G ^dq   Rose, Lynda M ^d   Rudan, Igor ^dr   Sabanayagam, Charumathi ^p,q   Salako, Babatunde L ^dg   Sandow, Kevin ^h   Schmidt, Carsten O ^bs,bt   Schreiner, Pamela J ^di   Scott, William R ^bw,ds   Sever, Peter ^bw   Sims, Mario ^v   Sitlani, Colleen M ^z   Smith, Blair H ^cb   Smith, Jennifer A ^ai   Snieder, Harold ^an   Starr, John M ^au   Strauch, Konstantin ^bb,dt   Tang, Hua ^du   Taylor, Kent D ^h   Teo, Yik Ying ^s,aa,cp   Tham, Yih Chung ^p   Uitterlinden, André G ^t   Waldenberger, Melanie ^bb,be   Wang, Lihua ^a   Wang, Ya Xing ^dv   Wei, Wen Bin ^dv   Wilson, Gregory ^dw   Wojczynski, Mary K ^a   Xiang, Yong Bing ^dx   Yao, Jie ^h   Yuan, Jian Min ^ay,dy   Zonderman, Alan B ^ag   Becker, Diane M ^bv   Boehnke, Michael ^ai   Bowden, Donald W ^aq   Chambers, John C ^bw,bx   Chen, Yii Der Ida ^h   Weir, David R ^ai   De Faire, Ulf ^ap   Deary, Ian J ^au   Esko, Tõnu ^am,dz   Farrall, Martin ^as,at   Forrester, Terrence ^bh   Freedman, Barry I ^aq   Froguel, Philippe ^ao,bw   Gasparini, Paolo ^ar,cm   Gieger, Christian ^bb,ea   Horta, Bernardo Lessa ^av   Hung, Yi Jen ^eb   Jonas, Jost Bruno ^dv,ec   Kato, Norihiro ^bp   Kooner, Jaspal S ^bx,ds   Laakso, Markku ^ba   Lehtimäki, Terho ^bf,bg   Liang, Kae Woei ^bd,bm,ed   Magnusson, Patrik K E ^ap   Oldehinkel, Albertine J ^an   Pereira, Alexandre C ^al,ax   Perls, Thomas ^ee   Rauramaa, Rainer ^ba   Redline, Susan ^d   Rettig, Rainer ^bs,bt   Samani, Nilesh J ^bj,bk   Scott, James ^ds   Shu, Xiao Ou ^bu   Van Der Harst, Pim ^an   Wagenknecht, Lynne E ^aq   Wareham, Nicholas J ^be   Watkins, Hugh ^as,at   Wickremasinghe, Ananda R ^az   Wu, Tangchun ^bi   Kamatani, Yoichiro ^ak   Laurie, Cathy C ^co   Bouchard, Claude ^ad   Cooper, Richard S ^ah   Evans, Michele K ^ag   Gudnason, Vilmundur ^ae,af   Hixson, James ^k   Kardia, Sharon L R ^ai   Kritchevsky, Stephen B ^aq   Psaty, Bruce M ^z,ef   Van Dam, Rob M ^s,eg   Arnett, Donna K ^eh   Mook Kanamori, Dennis O ^bl   Fornage, Myriam ^x   Fox, Ervin R ^v   Hayward, Caroline ^u   Van Duijn, Cornelia M ^t   Tai, E Shyong ^q,s,eg   Wong, Tien Yin ^p,q,r   Loos, Ruth J F ^o   Reiner, Alex P ^co   Rotimi, Charles N ^e   Bierut, Laura J ^a   Zhu, Xiaofeng ^br   Cupples, L Adrienne ^aj   Province, Michael A ^a   Rotter, Jerome I ^h   Franks, Paul W ^l,bq,do   Rice, Kenneth ^co   Elliott, Paul ^bw   Caulfield, Mark J ^f,g   Gauderman, W James ^ei   Munroe, Patricia B ^f,g   Rao, Dabeeru C ^a   Morrison, Alanna C ^k   more..

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^h HARBOR UCLA MEDICAL CENTER   (United States)

ⁱ MASSACHUSETTS GENERAL HOSPITAL   (United States)

^j BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^k UNIVERSITY OF TEXAS   (United States)

^l HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^m INSTITUT PASTEUR   (France)

ⁿ University of North Carolina at Chapel Hill   (United States)

^o MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^p SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^q DUKE NUS MEDICAL SCHOOL   (Singapore)

^r NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^s NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^t ERASMUS MEDICAL CENTER   (Netherlands)

^u UNIVERSITY OF EDINBURGH   (United Kingdom)

^v UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^w Capital Region   (Denmark)

^x UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^y UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^z UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^aa GENOME INSTITUTE OF SINGAPORE   (Singapore)

^ab UNIVERSITY OF GEORGIA   (United States)

^ac WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^ad PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^ae ICELANDIC HEART ASSOCIATION   (Iceland)

^af UNIVERSITY OF ICELAND   (Iceland)

^ag NATIONAL INSTITUTE ON AGING   (United States)

^ah LOYOLA UNIVERSITY CHICAGO   (United States)

^ai UNIVERSITY OF MICHIGAN   (United States)

^aj BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^ak Institute of Physical and Chemical Research   (Japan)

^al HARVARD MEDICAL SCHOOL   (United States)

^am UNIVERSITY OF TARTU   (Estonia)

^an UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^ao UNIV LILLE   (France)

^ap KAROLINSKA INSTITUTE   (Sweden)

^aq WAKE FOREST SCHOOL OF MEDICINE   (United States)

^ar UNIVERSITY OF TRIESTE   (Italy)

^as UNIVERSITY OF OXFORD   (United Kingdom)

^at UNIVERSITY OF OXFORD   (United Kingdom)

^au UNIVERSITY OF EDINBURGH   (United Kingdom)

^av FEDERAL UNIVERSITY OF PELOTAS   (Brazil)

^aw UNIVERSITY OF BRISTOL   (United Kingdom)

^ax UNIVERSITY OF SÃO PAULO   (Brazil)

^ay UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^az UNIVERSITY OF KELANIYA   (Sri Lanka)

^ba UNIVERSITY OF EASTERN FINLAND   (Finland)

^bb INSTITUTE OF EPIDEMIOLOGY   (Germany)

^bc TUNGHAI UNIVERSITY   (Taiwan)

^bd TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^be UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^bf FIMLAB LABORATORIES   (Finland)

^bg TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^bh UNIVERSITY OF THE WEST INDIES   (Jamaica)

^bi HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^bj UNIVERSITY OF LEICESTER   (United Kingdom)

^bk GLENFIELD HOSPITAL   (United Kingdom)

^bl LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^bm NATIONAL YANG MING UNIVERSITY   (Taiwan)

^bn NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^bo NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^bp NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^bq LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^br CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bs UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^bt DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^bu VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bv JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bw IMPERIAL COLLEGE LONDON   (United Kingdom)

^bx EALING HOSPITAL   (United Kingdom)

^by Department of Medicine   (United States)

^bz BAYLOR COLLEGE OF MEDICINE   (United States)

^ca MEDICAL COLLEGE OF WISCONSIN   (United States)

^cb UNIVERSITY OF DUNDEE   (United Kingdom)

^cc UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^cd BROWN UNIVERSITY   (United States)

^ce GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^cf UNIVERSITY OF IOANNINA   (Greece)

^cg HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^ch TULANE UNIVERSITY   (United States)

^ci TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^cj MEDSTAR RESEARCH INSTITUTE   (United States)

^ck Delaware   (United States)

^cl UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^cm WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^cn OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^co UNIVERSITY OF WASHINGTON   (United States)

^cp NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^cq NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^cr HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^cs MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^ct UNIVERSITY OF LAUSANNE   (Switzerland)

^cu SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^cv KUOPIO UNIVERSITY HOSPITAL   (Finland)

^cw Vagelos College of Physicians and Surgeons   (United States)

^cx FRAMINGHAM HEART STUDY   (United States)

^cy NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^cz University of Alabama at Birmingham   (United States)

^da USA   (United States)

^db AGENCY FOR SCIENCE   (Singapore)

^dc UNIVERSITY OF TOKYO   (Japan)

^dd TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^de UNIVERSITY OF MISSISSIPPI   (United States)

^df UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^dg UNIVERSITY OF IBADAN   (Nigeria)

^dh Och Spine at New York Presbyterian Hospitals   (United States)

^di UNIVERSITY OF MINNESOTA   (United States)

^dj UNIVERSITY OF SPLIT   (Croatia)

^dk Zagreb Fakultet za dentalnu medicinu i zdravstvo Osijek Zdravstveno veleu ili te Zagreb   (Croatia)

^dl Gen Info Ltd   (Croatia)

^dm TURKU UNIVERSITY HOSPITAL   (Finland)

^dn UNIVERSITY OF TURKU   (Finland)

^do UMEÅ UNIVERSITY   (Sweden)

^dp INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^dq UNIVERSITY OF IOWA   (United States)

^dr UNIVERSITY OF EDINBURGH   (United Kingdom)

^ds NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^dt UNIVERSITY OF MUNICH   (Germany)

^du STANFORD UNIVERSITY   (United States)

^dv CAPITAL MEDICAL UNIVERSITY   (China)

^dw JACKSON STATE UNIVERSITY   (United States)

^dx SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^dy UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^dz MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^ea GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^eb TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^ec UNIVERSITY OF HEIDELBERG   (Germany)

^ed CHINA MEDICAL UNIVERSITY   (Taiwan)

^ee BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^ef KAISER PERMANENTE   (United States)

^eg Dept Medicine Endocrinol Diabet   (Singapore)

^eh UNIVERSITY OF KENTUCKY COLLEGE OF PUBLIC HEALTH   (United States)

^ei UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CHLORIDE; ANTIPORTER; AVPR1A PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE 9; CSMD1 PROTEIN, HUMAN; MEMBRANE PROTEIN; SLC26A7 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN; VASOPRESSIN RECEPTOR;

ADULT; ANCESTRY GROUP; APOPTOSIS; ARTICLE; BRAIN; CARDIAC MUSCLE; CIGARETTE SMOKING; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; FOLLOW UP; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HEART CONTRACTION; HEART FAILURE; HUMAN; INSULIN RESISTANCE; KIDNEY OUTER MEDULLA; MALE; MEAN ARTERIAL PRESSURE; META ANALYSIS; MIDDLE AGED; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PULSE PRESSURE; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; VASCULAR SMOOTH MUSCLE CELL; ADOLESCENT; ADVERSE EVENT; AGED; ARTERIAL PRESSURE; BLOOD PRESSURE; CLINICAL TRIAL; ETHNIC GROUP; GENETIC POLYMORPHISM; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HYPERTENSION; MULTICENTER STUDY; SMOKING; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIPORTERS; ARTERIAL PRESSURE; BLOOD PRESSURE; CASPASE 9; CONTINENTAL POPULATION GROUPS; ETHNIC GROUPS; FEMALE; GENE-ENVIRONMENT INTERACTION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; HYPERTENSION; MALE; MEMBRANE PROTEINS; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, VASOPRESSIN; SMOKING; SULFATE TRANSPORTERS; TUMOR SUPPRESSOR PROTEINS; YOUNG ADULT;

EID: 85078574203     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddz070     Document Type: Article

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