Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCs) via inhibition of mitogen-activated protein kinase (MAPK) signaling and alterations in critical cell cycle regulatory proteins

Journal of Biological Chemistry

Volumn 286, Issue 29, 2011, Pages 26238-26249

  Begum, Najma ^a   Hockman, Steven ^a   Manganiello, Vincent C ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL-CYCLE ARREST; CELL-CYCLE PROGRESSION; CRITICAL CELLS; CYCLIC ADENOSINE MONOPHOSPHATE (CAMP); CYCLIC NUCLEOTIDE; DEPHOSPHORYLATIONS; DNA SYNTHESISS; ELEMENT-BINDING PROTEINS; EXTRACELLULAR SIGNAL-REGULATED KINASE; GROWTH EFFECTS; GROWTH RESPONSE; ISOFORMS; MAPK SIGNALING; MITOGEN ACTIVATED PROTEIN KINASE; OVER-EXPRESSION; PHOSPHODIESTERASE 3A; PHOSPHODIESTERASES; PROTEIN KINASE A; REGULATORY PROTEIN; RETINOBLASTOMA PROTEIN; SIGNALING PATHWAYS; SITE-SPECIFIC; VASCULAR SMOOTH MUSCLE CELLS; WILD TYPES;

BODY FLUIDS; CARDIOVASCULAR SYSTEM; CELLS; ENZYME ACTIVITY; ESTERS; FETAL MONITORING; MAMMALS; MUSCLE; NUCLEOTIDES; PHOSPHORYLATION; RESTORATION; RUBIDIUM; SIGNALING;

PROTEINS;

CELL CYCLE PROTEIN; CELL CYCLE REGULATORY PROTEIN; CELL PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN D1; DNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IIIA; PHOSPHODIESTERASE IIIB; PLATELET DERIVED GROWTH FACTOR; PROTEIN P21; PROTEIN P53; PROTEIN WIP1; RAF PROTEIN; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; AORTA; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME REGULATION; GENE DELETION; GENETIC TRANSFECTION; GROWTH REGULATION; KNOCKOUT MOUSE; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEPHOSPHORYLATION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; WILD TYPE;

ANIMALS; BIOCATALYSIS; CELL CYCLE; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; DNA; DUAL SPECIFICITY PHOSPHATASE 1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKOUT TECHNIQUES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; RNA, SMALL INTERFERING;

MURINAE; MUS;

EID: 79960432640     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.214155     Document Type: Article

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