Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat

DMM Disease Models and Mechanisms

Volumn 10, Issue 3, 2017, Pages 297-306

  Coan, Philip M ^a   Hummel, Oliver ^b   Diaz, Ana Garcia ^c   Barrier, Marjorie ^a   Alfazema, Neza ^a   Norsworthy, Penny J ^c   Pravenec, Michal ^d   Petretto, Enrico ^c,e   Huöbner, Norbert ^b,f,g   Aitman, Timothy J ^a,c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^e DUKE NUS MEDICAL SCHOOL   (Singapore)

^f DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^g CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Congenic; Genomic; Hypertension; Insulin resistance; Rat

Indexed keywords

GLUCOSE; HEAT SHOCK PROTEIN 27; INSULIN; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CHROMOSOME 12; CHROMOSOME 16; COMPUTER MODEL; CONGENIC STRAIN; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENETIC BACKGROUND; GENETIC LINKAGE; GENOME ANALYSIS; GENOME-WIDE ASSOCIATION STUDY; HEART LEFT VENTRICLE MASS; HEART VENTRICLE HYPERTROPHY; HUMAN; HUMAN GENOME; HYPERTENSION; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER; MALE; NONHUMAN; PDGFRL GENE; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; QUANTITATIVE TRAIT LOCUS; RAT; SKELETAL MUSCLE; SYSTOLIC BLOOD PRESSURE; WHOLE GENOME SEQUENCING; ZKSCAN5 GENE; ANIMAL; BODY WEIGHT; CALORIMETRY; CARDIOMEGALY; CHROMOSOME; COMPARATIVE STUDY; DRUG EFFECTS; ENERGY METABOLISM; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; GENOMICS; HEART VENTRICLE; HOMEOSTASIS; METABOLISM; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; BLOOD PRESSURE; BODY WEIGHT; CALORIMETRY; CARDIOMEGALY; CHROMOSOMES, MAMMALIAN; ENERGY METABOLISM; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HEART VENTRICLES; HOMEOSTASIS; HUMANS; HYPERTENSION; INSULIN; INSULIN RESISTANCE; LIVER; MUSCLE, SKELETAL; ORGAN SIZE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RATS, INBRED SHR; TRIGLYCERIDES;

EID: 85018307139     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.026716     Document Type: Article

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