Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (Nature Genetics (2017) DOI: 10.1038/ng.3768);Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Nature Genetics

Volumn 49, Issue 3, 2017, Pages 403-415

  Warren, Helen R ^a,b,aw   Evangelou, Evangelos ^c,d,aw   Cabrera, Claudia P ^a,b,aw   Gao, He ^c,e,aw   Ren, Meixia ^a,b,aw,dh   Mifsud, Borbala ^a,aw   Ntalla, Ioanna ^a   Surendran, Praveen ^f   Liu, Chunyu ^g,h   Cook, James P ⁱ   Kraja, Aldi T ^j   Drenos, Fotios ^k,l   Loh, Marie ^c,m   Verweij, Niek ^n,p   Marten, Jonathan ^q   Karaman, Ibrahim ^c   Segura Lepe, Marcelo P ^c,r   O'Reilly, Paul F ^s   Knight, Joanne ^t   Snieder, Harold ⁿ   Kato, Norihiro ^u   He, Jiang ^v   Shyong Tai, E ^w,x   Abdullah Said, M ⁿ   Porteous, David ^y   Alver, Maris ^z   Poulter, Neil ^aa   Farrall, Martin ^ab,ao   Gansevoort, Ron T ⁿ   Padmanabhan, Sandosh ^y,ac,db   Mägi, Reedik ^z   Stanton, Alice ^ad   Connell, John ^ae   Bakker, Stephan J L ⁿ   Metspalu, Andres ^z   Shields, Denis C ^af   Thom, Simon ^c,ag   Brown, Morris ^a,b   Sever, Peter ^ag   Esko, Tõnu ^o,z,bc   Hayward, Caroline ^q,y   van der Harst, Pim ⁿ   Saleheen, Danish ^f,ah   Chowdhury, Rajiv ^f   Chambers, John C ^c,ai,aj,ak   Chasman, Daniel I ^al,am   Chakravarti, Aravinda ^an   Newton Cheh, Christopher ^o,p   Lindgren, Cecilia M ^o,ao,ap   Levy, Daniel ^g,h   Kooner, Jaspal S ^ag,ai,aj   Keavney, Bernard ^aq,ar   Tomaszewski, Maciej ^aq,ar   Samani, Nilesh J ^as,at   Howson, Joanna M M ^f   Tobin, Martin D ^au   Munroe, Patricia B ^a,b   Ehret, Georg B ^an,av   Wain, Louise V ^au   Barnes, Michael R ^a,b,aw   Tzoulaki, Ioanna ^c,e,aw   Caulfield, Mark J ^a,b,aw   Elliott, Paul ^c,e,aw   Wain, V ^au   Vaez, Ahmad ^n,ax   Jansen, Rick ^ay   Joehanes, Roby ^h,am   van der Most, Peter J ⁿ   Mesut Erzurumluoglu, A ^au   Rose, Lynda M ^al   Verwoert, Germaine C ^az   Hottenga, Jouke Jan ^ay   Strawbridge, Rona J ^ba,bb   Arking, Dan E ^an   Hwang, Shih Jen ^g,h   Guo, Xiuqing ^bd   Kutalik, Zoltan ^be,bf   Trompet, Stella ^bg   Shrine, Nick ^au   Teumer, Alexander ^bh,bi   Ried, Janina S ^bj   Bis, Joshua C ^bk   Smith, Albert V ^bl,bm   Amin, Najaf ^az   Nolte, Ilja M ⁿ   Lyytikäinen, Leo Pekka ^bn,bo   Mahajan, Anubha ^ao   Wareham, Nicholas J ^bp   Hofer, Edith ^bq   Joshi, Peter K ^br   Kristiansson, Kati ^bs   Traglia, Michela ^bt   Havulinna, Aki S ^bs   Goel, Anuj ^ab,ao   Nalls, Mike A ^bu,bv   Sõber, Siim ^bw   Vuckovic, Dragana ^bx,by   Luan, Jian'an ^bp   Fabiola Del Greco, M ^bz,ca   Ayers, Kristin L ^cb   Marrugat, Jaume ^cc   Ruggiero, Daniela ^cd   Lopez, Lorna M ^y,ce   Niiranen, Teemu ^bs   Enroth, Stefan ^cf   Jackson, Anne U ^cg   Nelson, Christopher P ^as,at   Huffman, Jennifer E ^q   Zhang, Weihua ^c,ai   Gandin, Ilaria ^by   Harris, Sarah E ^y   Zemonik, Tatijana ^ch   Lu, Yingchang ^cb   Shah, Nabi ^ae,ci   de Borst, Martin H ⁿ   Mangino, Massimo ^s,cj   Prins, Bram P ^ck   Campbell, Archie ^y   Li Gao, Ruifang ^bg   Chauhan, Ganesh ^cl,cm   Oldmeadow, Christopher ^cn   Abecasis, Gonçalo ^co   Abedi, Maryam ^ax   Barbieri, Caterina M ^bt   Batini, Chiara ^au   Blake, Tineka ^au   Boehnke, Michael ^cg   Bottinger, Erwin P ^cb   Braund, Peter S ^as,at   Brumat, Marco ^by   Campbell, Harry ^br   Cocca, Massimiliano ^by   Collins, Francis ^cp   Cordell, Heather J ^cq   Damman, Jeffrey J ^cr   Davies, Gail ^y   de Geus, Eco J ^ay   de Mutsert, Renée ^bg   Deelen, Joris ^bg   Demirkale, Yusuf ^cs   Doney, Alex S F ^ae   Dörr, Marcus ^bh,bi   Ferreira, Teresa ^ao   Frånberg, Mattias ^ba,bb,ct   Giedraitis, Vilmantas ^cu   Gieger, Christian ^bj   Giulianini, Franco ^al   Gow, Alan J ^y,cv   Hamsten, Anders ^ba,bb   Harris, Tamara B ^bu   Hofman, Albert ^az,cw   Holliday, Elizabeth G ^cn   Jarvelin, Marjo Riitta ^e,cx,cy   Johansson, Åsa ^cf   Johnson, Andrew D ^g,h   Jousilahti, Pekka ^bs   Jula, Antti ^bs   Kähönen, Mika ^bo,cz   Kathiresan, Sekar ^o,p   Khaw, Kay Tee ^f   Kolcic, Ivana ^ch   Koskinen, Seppo ^bs   Langenberg, Claudia ^bp   Larson, Marty ^h   Launer, Lenore J ^bu   Lehne, Benjamin ^c   Liewald, David C M ^y   Lin, Li ^av   Lind, Lars ^cf   Mach, François ^av   Mamasoula, Chrysovalanto ^cq   Menni, Cristina ^s   Milaneschi, Yuri ^ay   Morgan, Anna ^by   Morris, Andrew D ^br   Morrison, Alanna C ^da   Munson, Peter J ^cs   Nandakumar, Priyanka ^an   Nguyen, Quang Tri ^cs   Nutile, Teresa ^cd   Oldehinkel, Albertine J ⁿ   Oostra, Ben A ^az   Org, Elin ^z   Palotie, Aarno ^dc   Paré, Guillaume ^dd   Pattie, Alison ^y   Penninx, Brenda W J H ^ay   Pramstaller, Peter P ^bz,ca,de   Raitakari, Olli T ^df,dg   Rice, Kenneth ^di   Ridker, Paul M ^al,am   Riese, Harriëtte ⁿ   Ripatti, Samuli ^dc   Robino, Antonietta ^dj   Rotter, Jerome I ^bd   Rudan, Igor ^br   Saba, Yasaman ^bq   Saint Pierre, Aude ^bz,ca,dk   Sala, Cinzia F ^bt   Sarin, Antti Pekka ^dc   Schmidt, Reinhold ^bq   Scott, Rodney ^cn,dl,dm   Seelen, Marc A ⁿ   Siscovick, David ^dn   Sorice, Rossella ^cd,do   Stott, David J ^ac   Sundström, Johan ^cf   Swertz, Morris ⁿ   Taylor, Kent D ^bd,dp   Tzourio, Christophe ^cl,cm,dq   Uitterlinden, André G ^az   Völker, Uwe ^bh,bi   Vollenweider, Peter ^dr   Wild, Sarah ^br   Willemsen, Gonneke ^ay   Wright, Alan F ^q   Yao, Jie ^bd   Thériault, Sébastien ^dd   Conen, David ^ds   John, Attia ^cn,dl,dm   Debette, Stéphanie ^cl,cm,dq   Mook Kanamori, Dennis O ^bg   Zeggini, Eleftheria ^ck   Spector, Tim D ^s   Palmer, Colin N A ^ae   Vergnaud, Anne Claire ^c   Loos, Ruth J F ^bq,cb   Polasek, Ozren ^ch   Starr, John M ^y   Girotto, Giorgia ^bx,by   Vitart, Veronique ^q   Tuomilehto, Jaakko ^bs,dt   Gyllensten, Ulf ^cf   Knekt, Paul ^bs   Deary, Ian J ^y   Ciullo, Marina ^cd,do   Elosua, Roberto ^cc   Hicks, Andrew A ^bz,ca   Scott, Robert A ^bp   Gasparini, Paolo ^bx,by   Laan, Maris ^bw   Liu, YongMei ^du   Watkins, Hugh ^ab,ao   Hartman, Catharina A ⁿ   Salomaa, Veikko ^bs   Toniolo, Daniela ^bt   Perola, Markus ^z,br,dc   Wilson, James F ^q,br   Schmidt, Helena ^bq   Zhao, Jing Hua ^bp   Lehtimäki, Terho ^bn,bo   van Duijn, Cornelia M ^az   Gudnason, Vilmundur ^bl,bm   Psaty, Bruce M ^bk,di,dv   Peters, Annette ^bj   Rettig, Rainer ^bh   James, Alan ^dw,dx   Wouter Jukema, J ^bg   Strachan, David P ^dy   Palmas, Walter ^dz   Ingelsson, Erik ^cf,ea   Boomsma, Dorret I ^ay   Franco, Oscar H ^az   Bochud, Murielle ^be   Morris, Andrew P ^i,ao   more..

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF IOANNINA   (Greece)

^e Faculty of Medicine and MRC Health Protection Agency   (United Kingdom)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^h FRAMINGHAM HEART STUDY   (United States)

ⁱ UNIVERSITY OF LIVERPOOL   (United Kingdom)

^j WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k UNIVERSITY OF BRISTOL   (United Kingdom)

^l UNIVERSITY COLLEGE LONDON   (United Kingdom)

^m AGENCY FOR SCIENCE   (Singapore)

ⁿ UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^o BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^p MASSACHUSETTS GENERAL HOSPITAL   (United States)

^q UNIVERSITY OF EDINBURGH   (United Kingdom)

^r BAYER PHARMA AG   (Germany)

^s KING'S COLLEGE LONDON   (United Kingdom)

^t LANCASTER UNIVERSITY   (United Kingdom)

^u NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^v TULANE UNIVERSITY   (United States)

^w NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^x Dept Medicine Endocrinol Diabet   (Singapore)

^y UNIVERSITY OF EDINBURGH   (United Kingdom)

^z UNIVERSITY OF TARTU   (Estonia)

^aa IMPERIAL COLLEGE LONDON   (United Kingdom)

^ab UNIVERSITY OF OXFORD   (United Kingdom)

^ac UNIVERSITY OF GLASGOW   (United Kingdom)

^ad ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^ae UNIVERSITY OF DUNDEE   (United Kingdom)

^af UNIVERSITY COLLEGE DUBLIN   (Ireland)

^ag NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^ah UNIVERSITY OF PENNSYLVANIA   (United States)

^ai EALING HOSPITAL NHS TRUST   (United Kingdom)

^aj IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^ak LEE KONG CHIAN SCHOOL OF MEDICINE   (Singapore)

^al BRIGHAM AND WOMEN S HOSPITAL   (United States)

^am HARVARD MEDICAL SCHOOL   (United States)

^an JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ao UNIVERSITY OF OXFORD   (United Kingdom)

^ap UNIVERSITY OF OXFORD   (United Kingdom)

^aq UNIVERSITY OF MANCHESTER   (United Kingdom)

^ar UNIVERSITY OF MANCHESTER   (United Kingdom)

^as UNIVERSITY OF LEICESTER   (United Kingdom)

^at GLENFIELD HOSPITAL   (United Kingdom)

^au UNIVERSITY OF LEICESTER   (United Kingdom)

^av Canton Hospital of the University of Geneva   (Switzerland)

^aw VU University Medical Center ^*

^ax ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^ay VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^az ERASMUS MEDICAL CENTER   (Netherlands)

^ba KAROLINSKA INSTITUTE   (Sweden)

^bb KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^bc BOSTON CHILDREN S HOSPITAL   (United States)

^bd HARBOR UCLA MEDICAL CENTER   (United States)

^be UNIVERSITY OF LAUSANNE   (Switzerland)

^bf SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^bg LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^bh UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^bi DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^bj INSTITUTE OF EPIDEMIOLOGY   (Germany)

^bk UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^bl ICELANDIC HEART ASSOCIATION   (Iceland)

^bm UNIVERSITY OF ICELAND   (Iceland)

^bn FIMLAB LABORATORIES   (Finland)

^bo TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^bp MRC EPIDEMIOLOGY UNIT   (United Kingdom)

^bq MEDICAL UNIVERSITY OF GRAZ   (Austria)

^br UNIVERSITY OF EDINBURGH   (United Kingdom)

^bs NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^bt SAN RAFFAELE HOSPITAL   (Italy)

^bu NATIONAL INSTITUTE ON AGING   (United States)

^bv Kelly Services   (United States)

^bw UNIVERSITY OF TARTU   (Estonia)

^bx SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

^by UNIVERSITY OF TRIESTE   (Italy)

^bz University of Lubeck   (Italy)

^ca UNIVERSITY OF LÜBECK   (Germany)

^cb MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^cc INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^cd INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^ce UNIVERSITY COLLEGE DUBLIN   (Ireland)

^cf UPPSALA UNIVERSITY   (Sweden)

^cg UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^ch UNIVERSITY OF SPLIT   (Croatia)

^ci National Institute for Health Research Biomedical Research Centre ^*  (Pakistan)

^cj and University of Bristol   (United Kingdom)

^ck WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^cl INSERM U657   (France)

^cm UNIVERSITÉ DE BORDEAUX   (France)

^cn HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^co SPH II   (United States)

^cp NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^cq NEWCASTLE UNIVERSITY   (United Kingdom)

^cr ACADEMIC MEDICAL CENTER   (Netherlands)

^cs NATIONAL INSTITUTES OF HEALTH   (United States)

^ct STOCKHOLM UNIVERSITY   (Sweden)

^cu UPPSALA UNIVERSITY   (Sweden)

^cv HERIOT WATT UNIVERSITY   (United Kingdom)

^cw HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^cx UNIVERSITY OF OULU   (Finland)

^cy OULU UNIVERSITY HOSPITAL   (Finland)

^cz TAMPERE UNIVERSITY HOSPITAL   (Finland)

^da UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^db UNIVERSITY OF GLASGOW   (United Kingdom)

^dc UNIVERSITY OF HELSINKI   (Finland)

^dd MCMASTER UNIVERSITY   (Canada)

^de General Central Hospital   (Italy)

^df TURKU UNIVERSITY HOSPITAL   (Finland)

^dg UNIVERSITY OF TURKU   (Finland)

^dh FUJIAN MEDICAL UNIVERSITY   (China)

^di UNIVERSITY OF WASHINGTON   (United States)

^dj INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^dk ETABLISSEMENT FRANÇAIS DU SANG   (France)

^dl UNIVERSITY OF NEWCASTLE   (Australia)

^dm JOHN HUNTER HOSPITAL   (Australia)

^dn NEW YORK ACADEMY OF MEDICINE   (United States)

^do IRCCS NEUROMED   (Italy)

^dp LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^dq BORDEAUX UNIVERSITY HOSPITAL   (France)

^dr LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^ds MCMASTER UNIVERSITY   (Canada)

^dt DANUBE UNIVERSITY KREMS   (Austria)

^du WAKE FOREST SCHOOL OF MEDICINE   (United States)

^dv GROUP HEALTH RESEARCH INSTITUTE   (United States)

^dw SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^dx UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^dy ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^dz Department of Medicine   (United States)

^ea STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ABHD17C PROTEIN; ACOX1 PROTEIN; CASC15 PROTEIN; CELA2A PROTEIN; CFDP1 PROTEIN; CRK PROTEIN; FBN2 PROTEIN; FERMT2 PROTEIN; FOSL2 PROTEIN; GTF2B PROTEIN; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; MCF2L PROTEIN; METTL21A AC079767.3 PROTEIN; MKLN1 PROTEIN; NADK CPSF3L PROTEIN; NPNT PROTEIN; PPP2R5E PROTEIN; PRKD3 PROTEIN; PROTEIN; RYK PROTEIN; SSPN PROTEIN; TFAP2D PROTEIN; TMEM161B PROTEIN; TRANSCRIPTION FACTOR PAX2; UNCLASSIFIED DRUG; ZFAT PROTEIN;

ALLELE; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; CAPILLARY ENDOTHELIAL CELL; CARDIOVASCULAR RISK; CHROMATIN; DIASTOLIC BLOOD PRESSURE; ENHANCER REGION; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HEART FIBROBLAST; HUMAN; HUMAN CELL; HYPERTENSION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PULSE PRESSURE; QUANTITATIVE TRAIT LOCUS; SYSTOLIC BLOOD PRESSURE; TISSUE SPECIFICITY; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR SMOOTH MUSCLE CELL; VASCULAR TISSUE; ADULT; CARDIOVASCULAR DISEASE; CAUCASIAN; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; MIDDLE AGED; PROCEDURES; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 85010952930     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1017-1558a     Document Type: Erratum

References (76)

1. Muñoz, M. et al. Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank. Nat. Genet. 48, 980-983 (2016).
2. Feinleib, M. et al. The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. Am. J. Epidemiol. 106, 284-285 (1977).
3. Poulter, N.R., Prabhakaran, D. & Caulfield, M. Hypertension. Lancet 386, 801-812 (2015).
4. Mongeau, J.G., Biron, P. & Sing, C.F. The influence of genetics and household environment upon the variability of normal blood pressure: the Montreal Adoption Survey. Clin. Exp. Hypertens. A 8, 653-660 (1986).
5. Forouzanfar, M.H. et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 386, 2287-2323 (2015).
6. Sundström, J. et al. Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet 384, 591-598 (2014).
7. Cabrera, C.P. et al. Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics. Wiley Interdiscip. Rev. Syst. Biol. Med. 7, 73-90 (2015).
8. Ehret, G.B. et al. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat. Genet. 48, 1171-1184 (2016).
9. Surendran, P. et al. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat. Genet. 48, 1151-1161 (2016).
10. Liu, C. et al. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat. Genet. 48, 1162-1170 (2016).
11. Kato, N. et al. Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat. Genet. 47, 1282-1293 (2015).
12. Elliott, P. & Peakman, T.C. The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine. Int. J. Epidemiol. 37, 234-244 (2008).
13. Sudlow, C. et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 12, e1001779 (2015).
14. Huang, J. et al. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Nat. Commun. 6, 8111 (2015).
15. Hoffmann, T.J. et al. Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. Nat. Genet. 49, 54-64 (2017).
16. Staley, J.R. et al. PhenoScanner: a database of human genotype-phenotype associations. Bioinformatics 32, 3207-3209 (2016).
17. Ettehad, D. et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet 387, 957-967 (2016).
18. Kato, N. et al. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat. Genet. 43, 531-538 (2011).
19. Munroe, P.B., Barnes, M.R. & Caulfield, M.J. Advances in blood pressure genomics. Circ. Res. 112, 1365-1379 (2013).
20. den Hoed, M. et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat. Genet. 45, 621-631 (2013).
21. Hamilton, C.A., Brosnan, M.J., McIntyre, M., Graham, D. & Dominiczak, A.F. Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction. Hypertension 37, 529-534 (2001).
22. Shin, S.Y. et al. An atlas of genetic influences on human blood metabolites. Nat. Genet. 46, 543-550 (2014).
23. Raffler, J. et al. Genome-wide association study with targeted and non-targeted NMR metabolomics identifies 15 novel loci of urinary human metabolic individuality. PLoS Genet. 11, e1005487 (2015).
24. van Setten, J. et al. Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction. Atherosclerosis 228, 400-405 (2013).
25. McCarthy, J.J. et al. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. J. Med. Genet. 41, 334-341 (2004).
26. van Meurs, J.B. et al. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am. J. Clin. Nutr. 98, 668-676 (2013).
27. Pu, X. et al. ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. Am. J. Hum. Genet. 92, 366-374 (2013).
28. Rizzoni, D. & Agabiti-Rosei, E. Structural abnormalities of small resistance arteries in essential hypertension. Intern. Emerg. Med. 7, 205-212 (2012).
29. Ray, R. et al. Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo. Arterioscler. Thromb. Vasc. Biol. 31, 1368-1376 (2011).
30. Touyz, R.M. & Montezano, A.C. Vascular Nox4: a multifarious NADPH oxidase. Circ. Res. 110, 1159-1161 (2012).
31. Steppan, J., Barodka, V., Berkowitz, D.E. & Nyhan, D. Vascular stiffness and increased pulse pressure in the aging cardiovascular system. Cardiol. Res. Pract. 2011, 263585 (2011).
32. Yan, F. et al. Nox4 and redox signaling mediate TGF-β-induced endothelial cell apoptosis and phenotypic switch. Cell Death Dis. 5, e1010 (2014).
33. Chan, E.C. et al. Nox4 modulates collagen production stimulated by transforming growth factor β1 in vivo and in vitro. Biochem. Biophys. Res. Commun. 430, 918-925 (2013).
34. Vasa-Nicotera, M. et al. miR-146a is modulated in human endothelial cell with aging. Atherosclerosis 217, 326-330 (2011).
35. Tian, X. et al. Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling. PLoS One 6, e18136 (2011).
36. Takimoto, E. et al. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat. Med. 11, 214-222 (2005).
37. Pérez, N.G. et al. Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction. Hypertension 49, 1095-1103 (2007).
38. Oliver, J.J., Melville, V.P. & Webb, D.J. Effect of regular phosphodiesterase type 5 inhibition in hypertension. Hypertension 48, 622-627 (2006).
39. Levy, D. et al. Genome-wide association study of blood pressure and hypertension. Nat. Genet. 41, 677-687 (2009).
40. Newton-Cheh, C. et al. Genome-wide association study identifies eight loci associated with blood pressure. Nat. Genet. 41, 666-676 (2009).
41. DeStefano, A.L. et al. Autosomal dominant orthostatic hypotensive disorder maps to chromosome 18q. Am. J. Hum. Genet. 63, 1425-1430 (1998).
42. Hong, X. et al. Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS. Methods Find. Exp. Clin. Pharmacol. 29, 3-10 (2007).
43. Takimoto, E. et al. Sodium calcium exchanger plays a key role in alteration of cardiac function in response to pressure overload. FASEB J. 16, 373-378 (2002).
44. Ronaldson, P.T. & Davis, T.P. Targeting transporters: promoting blood-brain barrier repair in response to oxidative stress injury. Brain Res. 1623, 39-52 (2015).
45. Carta, L. et al. Fibrillins 1 and 2 perform partially overlapping functions during aortic development. J. Biol. Chem. 281, 8016-8023 (2006).
46. Kazenwadel, J. et al. Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature. Blood 119, 1283-1291 (2012).
47. Akashi, M., Higashi, T., Masuda, S., Komori, T. & Furuse, M. A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions. Biochem. Biophys. Res. Commun. 413, 224-229 (2011).
48. Cakstina, I. et al. Primary culture of avian embryonic heart forming region cells to study the regulation of vertebrate early heart morphogenesis by vitamin A. BMC Dev. Biol. 14, 10 (2014).
49. Wang, J., Karra, R., Dickson, A.L. & Poss, K.D. Fibronectin is deposited by injuryactivated epicardial cells and is necessary for zebrafish heart regeneration. Dev. Biol. 382, 427-435 (2013).
50. Dietrich, T. et al. ED-B fibronectin (ED-B) can be targeted using a novel single chain antibody conjugate and is associated with macrophage accumulation in atherosclerotic lesions. Basic Res. Cardiol. 102, 298-307 (2007).
51. Stoynev, N. et al. Gene expression in peripheral blood of patients with hypertension and patients with type 2 diabetes. J. Cardiovasc. Med. (Hagerstown) 15, 702-709 (2014).
52. Erdos, B., Backes, I., McCowan, M.L., Hayward, L.F. & Scheuer, D.A. Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats. Am. J. Physiol. Heart Circ. Physiol. 308, H612-H622 (2015).
53. Chan, S.H., Wu, C.W., Chang, A.Y., Hsu, K.S. & Chan, J.Y. Transcriptional upregulation of brain-derived neurotrophic factor in rostral ventrolateral medulla by angiotensin II: significance in superoxide homeostasis and neural regulation of arterial pressure. Circ. Res. 107, 1127-1139 (2010).
54. Crespo, K., Ménard, A. & Deng, A.Y. Retinoblastoma-associated protein 140 as a candidate for a novel etiological gene to hypertension. Clin. Exp. Hypertens. 38, 533-540 (2016).
55. Watanabe, Y. et al. Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study. Hypertens. Res. 33, 129-134 (2010).
56. Gale, D.P., Harten, S.K., Reid, C.D., Tuddenham, E.G. & Maxwell, P.H. Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 mutation. Blood 112, 919-921 (2008).
57. Yndestad, A. et al. Elevated levels of activin A in clinical and experimental pulmonary hypertension. J. Appl. Physiol. 106, 1356-1364 (2009).
58. Sacks, F.M. et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. N. Engl. J. Med. 344, 3-10 (2001).
59. Intersalt Cooperative Research Group. Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Br. Med. J. 297, 319-328 (1988).
60. Whelton, P.K. et al. Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program. J. Am. Med. Assoc. 288, 1882-1888 (2002).
61. Chan, Q. et al. An update on nutrients and blood pressure. J. Atheroscler. Thromb. 23, 276-289 (2016).
62. Khera, A.V. et al. Genetic risk, adherence to a healthy lifestyle, and coronary disease. N. Engl. J. Med. 375, 2349-2358 (2016).
63. Wain, L.V. et al. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir. Med. 3, 769-781 (2015).
64. Tobin, M.D., Sheehan, N.A., Scurrah, K.J. & Burton, P.R. Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure. Stat. Med. 24, 2911-2935 (2005).
65. Marchini, J., Howie, B., Myers, S., McVean, G. & Donnelly, P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet. 39, 906-913 (2007).
66. Willer, C.J., Li, Y. & Abecasis, G.R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190-2191 (2010).
67. Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).
68. Barnes, M.R. Exploring the landscape of the genome. Methods Mol. Biol. 628, 21-38 (2010).
69. Gong, J. et al. Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Hum. Mutat. 33, 254-263 (2012).
70. Pers, T.H. et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nat. Commun. 6, 5890 (2015).
71. Dunham, I., Kulesha, E., Iotchkova, V., Morganella, S. & Birney, E. FORGE: a tool to discover cell specific enrichments of GWAS associated SNPs in regulatory regions. F1000Res. 4, 18 (2015).
72. Dozmorov, M.G., Cara, L.R., Giles, C.B. & Wren, J.D. GenomeRunner: automating genome exploration. Bioinformatics 28, 419-420 (2012).
73. McLean, C.Y. et al. GREAT improves functional interpretation of cis-regulatory regions. Nat. Biotechnol. 28, 495-501 (2010).
74. Elliott, P. et al. The Airwave Health Monitoring Study of police officers and staff in Great Britain: rationale, design and methods. Environ. Res. 134, 280-285 (2014).
75. Petersen, M. et al. Quantification of lipoprotein subclasses by proton nuclear magnetic resonance-based partial least-squares regression models. Clin. Chem. 51, 1457-1461 (2005).
76. Chadeau-Hyam, M. et al. Metabolic profiling and the metabolome-wide association study: significance level for biomarker identification. J. Proteome Res. 9, 4620-4627 (2010).