TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures

Nature Immunology

Volumn 20, Issue 12, 2019, Pages 1692-1699

  Tu, Ang A ^a,b   Gierahn, Todd M ^a   Monian, Brinda ^a,b   Morgan, Duncan M ^a,b   Mehta, Naveen K ^a,b   Ruiter, Bert ^c,d   Shreffler, Wayne G ^c,d   Shalek, Alex K ^a,b,e   Love, J Christopher ^a,b,e  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b USA   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; CD69 ANTIGEN; MESSENGER RNA; PEANUT EXTRACT; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTOME; ARA H 2 ALLERGEN, ARACHIS HYPOGAEA; IMMUNOGLOBULIN E; LYMPHOCYTE ANTIGEN RECEPTOR; NAPIN; ONCOGENE PROTEIN E7, HUMAN PAPILLOMAVIRUS TYPE 16; PLANT ANTIGEN; PROTEIN E7;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELL CLONING; COMPARATIVE STUDY; CONTROLLED STUDY; DNA FLANKING REGION; GENE LIBRARY; HUMAN; HUMAN CELL; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNIZATION; MOUSE; MRNA EXPRESSION LEVEL; NONHUMAN; ORAL IMMUNOTHERAPY; PEANUT ALLERGY; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA SEQUENCE; RNA TRANSCRIPTION; SINGLE CELL ANALYSIS; T LYMPHOCYTE; TH2 CELL; ANIMAL; C57BL MOUSE; CD8+ T LYMPHOCYTE; CELL CULTURE; COMPLEMENTARITY DETERMINING REGION; FEMALE; GENETICS; HIGH THROUGHPUT SEQUENCING; IMMUNOLOGY; MALE; METABOLISM; TRANSGENIC MOUSE;

2S ALBUMINS, PLANT; ANIMALS; ANTIGENS, PLANT; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COMPLEMENTARITY DETERMINING REGIONS; FEMALE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN E; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PAPILLOMAVIRUS E7 PROTEINS; PEANUT HYPERSENSITIVITY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SINGLE-CELL ANALYSIS; T-CELL ANTIGEN RECEPTOR SPECIFICITY; TH2 CELLS; TRANSCRIPTOME;

EID: 85075212125     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/s41590-019-0544-5     Document Type: Article

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