Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection

PLoS Pathogens

Volumn 15, Issue 10, 2019, Pages

  Younan, Patrick ^a,b   Santos, Rodrigo I ^a,b   Ramanathan, Palaniappan ^a,b   Iampietro, Mathieu ^a,b   Nishida, Andrew ^c   Dutta, Mukta ^c   Ammosova, Tatiana ^d   Meyer, Michelle ^a,b   Katze, Michael G ^c,e   Popov, Vsevolod L ^a,b   Nekhai, Sergei ^d   Bukreyev, Alexander ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

^e Washington National Primate Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPEPTIDE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; VIRUS RNA; X BOX BINDING PROTEIN 1; 1E7-03 COMPOUND; INDOLE DERIVATIVE; PHOSPHOPROTEIN PHOSPHATASE 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UREA; VIRAL PROTEIN; VIRUS ANTIGEN; VP30 PROTEIN, EBOLA VIRUS;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGOSOME; BINDING ASSAY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR DISTRIBUTION; CONFOCAL LASER SCANNING MICROSCOPY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DROPLET DIGITAL POLYMERASE CHAIN REACTION; EBOLA HEMORRHAGIC FEVER; EBOLAVIRUS; ENDOPLASMIC RETICULUM STRESS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE SEQUENCE; HUMAN; HUMAN CELL; LYMPHOCYTOPENIA; NEW ZEALAND RABBIT; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PROTEIN PHOSPHORYLATION; RNA ISOLATION; T CELL DEPLETION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; VIRUS ATTACHMENT; VIRUS REPLICATION; WESTERN BLOTTING; ANIMAL; AUTOPHAGY; BIOSYNTHESIS; CELL LINE; CHLOROCEBUS AETHIOPS; GENETICS; HEK293 CELL LINE; HOST PATHOGEN INTERACTION; IMMUNOLOGY; JURKAT CELL LINE; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE; VERO CELL LINE; VIROLOGY;

ANIMALS; ANTIGENS, VIRAL; AUTOPHAGY; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CHLOROCEBUS AETHIOPS; EBOLAVIRUS; ENDOPLASMIC RETICULUM STRESS; HEK293 CELLS; HEMORRHAGIC FEVER, EBOLA; HOST-PATHOGEN INTERACTIONS; HUMANS; INDOLES; JURKAT CELLS; LYMPHOPENIA; PROTEIN PHOSPHATASE 1; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA, VIRAL; TRANSCRIPTION FACTORS; UREA; VERO CELLS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 85074076819     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1008068     Document Type: Article

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