TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation

Nature Immunology

Volumn 6, Issue 5, 2005, Pages 455-464

  Meyers, Jennifer Hartt ^a   Chakravarti, Sumone ^a   Schlesinger, David ^a   Illes, Zsolt ^a   Waldner, Hanspeter ^a   Umetsu, Sarah E ^c   Kenny, James ^b   Zheng, Xin Xiao ^b   Umetsu, Dale T ^c   DeKruyff, Rosemarie H ^c   Strom, Terry B ^b   Kuchroo, Vijay K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; IMMUNOGLOBULIN; MUCIN; HAVCR1 PROTEIN, MOUSE; LIGAND; MEMBRANE PROTEIN; TIM 4 PROTEIN, MOUSE; TIM-4 PROTEIN, MOUSE;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CELL POPULATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION; ANIMAL; ANTIGEN PRESENTATION; CYTOLOGY; DRUG EFFECT; FEMALE; HAMSTER; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN BINDING; T LYMPHOCYTE; TH2 CELL;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; CELL PROLIFERATION; CRICETINAE; FEMALE; HUMANS; IMMUNOGLOBULINS; LIGANDS; MEMBRANE PROTEINS; MICE; PROTEIN BINDING; T-LYMPHOCYTES; TH2 CELLS;

EID: 18244399340     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1185     Document Type: Article

References (27)

1. Kuchroo, V.K., Umetsu, D.T., DeKruyff, R.H. & Freeman, G.J. The TIM gene family: emerging roles in immunity and disease. Nat. Rev. Immunol. 3, 454-462 (2003).
2. H1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415, 536-541 (2002).
3. Sabatos, C.A. et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat. Immunol. 4, 1102-1110 (2003).
4. Sanchez-Fueyo, A. et al. Tim-3 inhibits T helper type 1-mediated auto-and alloimmune responses and promotes immunological tolerance. Nat. Immunol. 4, 1093-1101 (2003).
5. Feigelstock, D., Thompson, P., Mattoo, P., Zhang, Y. & Kaplan, G.G. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72, 6621-6628 (1998).
6. Kaplan, G. et al. Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus. EMBO J. 15, 4282-4296 (1996).
7. Ichimura, T. et al. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. 273, 4135-4142 (1998).
8. McIntire, J.J. et al. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat. Immunol. 2, 1109-1116 (2001).
9. McIntire, J.J. et al. Immunology: hepatitis A virus link to atopic disease. Nature 425, 576 (2003).
10. Chae, S.C. et al. Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma. Hum. Immunol. 64, 1177-1182 (2003).
11. Chae, S.C., Song, J.H., Lee, Y.C., Kim, J.W. & Chung, H.T. The association of the exon 4 variations of Tim-1 gene with allergic diseases in a Korean population. Biochem. Biophys. Res. Commun. 312, 346-350 (2003).
12. Khademi, M. et al. T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J. Immunol. 172, 7169-7176 (2004).
13. Matricardi, P.M. et al. Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. Br. Med. J. 314, 999-1003 (1997).
14. Matricardi, P.M., Rosmini, F., Panetta, V., Ferrigno, L. & Bonini, S. Hay fever and asthma in relation to markers of infection in the United States. J. Allergy Clin. Immunol. 110, 381-387 (2002).
15. Rissoan, M.C. et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 283, 1183-1186 (1999).
16. H2 sensitization. Curr. Opin. Immunol. 15, 620-626 (2003).
17. Gilliet, M. et al. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by Flt3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 195, 953-958 (2002).
18. Brasel, K., De Smedt, T., Smith, J.L. & Maliszewski, C.R. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood 96, 3029-3039 (2000).
19. Maraskovsky, E. et al. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J. Exp. Med. 184, 1953-1962 (1996).
20. - dendritic cell subset by a maturation process involving CD8α, DEC-205, and CD24 up-regulation. Blood 99, 999-1004 (2002).
21. Umetsu, S.E. et al. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat. Immunol. (in the press).
22. Shakhov, A.N. et al. SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling. Eur. J. Immunol. 34, 494-503 (2004).
23. Silberstein, E. et al. Alteration of hepatitis A virus (HAV) particles by a soluble form of HAV cellular receptor 1 containing the immunoglobin-and mucin-like regions. J. Virol. 77, 8765-8774 (2003).
24. Carreno, B.M. & Collins, M. The B7 family of ligands and its receptors: New pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol. 20, 29-53 (2002).
25. Kingsmore, S.F., Souryal, C.A., Watson, M.L., Patel, D.D. & Seldin, M.F. Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1. Immunogenetics 42, 59-62 (1995).
26. Plow, E.F., Haas, T.A., Zhang, L., Loftus, J. & Smith, J.W. Ligand binding to integrins. J. Biol. Chem. 275, 21785-21788 (2000).
27. Racioppi, L., Ronchese, F., Matis, L.A. & Germain, R.N. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J. Exp. Med. 177, 1047-1060 (1993).