Enzymatic Intermolecular Hetero-Diels-Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes

Journal of the American Chemical Society

Volumn 141, Issue 36, 2019, Pages 14052-14056

  Chen, Qibin ^a   Gao, Jie ^a   Jamieson, Cooper ^b   Liu, Jiawang ^a   Ohashi, Masao ^c   Bai, Jian ^a   Yan, Daojian ^a   Liu, Bingyu ^a   Che, Yongsheng ^d   Wang, Yanan ^a   Houk, K N ^b   Hu, Youcai ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California   (United States)

^d INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; BIOCHEMISTRY; OLEFINS; QUINONE;

BIOSYNTHETIC PATHWAY; DIELS-ALDER REACTION; HETERO DIELS-ALDER REACTION; HETERO-DIELS; INTRAMOLECULAR DIELS-ALDER REACTION; NATURAL PRODUCTS; SESQUITERPENES; SYNTHETIC TRANSFORMATIONS;

BIOSYNTHESIS;

DIELS ALDER CYCLASE; HUMULENOL; LYASE; NEOSETOPHOMONE B; SESQUITERPENE DERIVATIVE; TROPOLONE DERIVATIVE; TROPOLONIC SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG; FUNGAL PROTEIN; METHYLTRANSFERASE; SESQUITERPENE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CIRCULAR DICHROISM; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYMATIC INTRAMOLECULAR HETERO DIELS ALDER REACTION; HYDRATION; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; STEREOSELECTIVITY; CHEMISTRY; CONFORMATION; CYCLOADDITION; METABOLISM;

CYCLOADDITION REACTION; FUNGAL PROTEINS; METHYLTRANSFERASES; MOLECULAR CONFORMATION; SESQUITERPENES;

EID: 85072058127     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.9b06592     Document Type: Article

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